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Disease relevance of Ileostomy


Psychiatry related information on Ileostomy


High impact information on Ileostomy

  • Studies of nitrate balance in humans and analyses of fecal and ileostomy samples indicate that nitrite and nitrate are formed de novo in the intestine, possibly by heterotrophic nitrification [7].
  • No increased SP binding was evident in clinically and pathologically quiescent UC colons and normal UC ileostomy samples [8].
  • In patients with defunctioning high ileostomy, FBA output increased markedly (maximum, 3054 mg/day), and serum cholesterol levels were also significantly lower (P less than 0.05) [9].
  • The effects of ursodeoxycholic acid and chenodeoxycholic acid on the small-intestinal absorption of endogenous bile acids were studied in patients with ileostomies who served as a model to investigate small-intestinal absorption in humans [10].
  • Fecal volatile fatty acids, products of anaerobic bacterial fermentation, were also increased in pouch effluent compared with ileostomy effluent (propionate, p less than 0.05; butyrate, p less than 0.01) [11].

Chemical compound and disease context of Ileostomy


Biological context of Ileostomy


Anatomical context of Ileostomy


Associations of Ileostomy with chemical compounds

  • Eight and 48 h later, respectively, 58% and 65% of the dose was recovered in the ileostomy effluents, either as 5-aminosalicylic acid still retained in the preparation, free 5-aminosalicylic acid or acetyl-5-aminosalicylic acid [27].
  • Seventy-five to ninety percent of the drug was excreted in ileostomy effluents of 6 patients as SASP, and only 5% of the dose was sulfapyridine [28].
  • Bisacodyl, 5 mg every 6 hr, increased ileostomy output by 15% when it was fed to 5 patients with established ileostomies [29].
  • The role of the small bowel in absorption and metabolism of SASP was determined by the amount of administered SASP excreted in ileostomy effluents, and the concentration of serum and urinary SASP and its metabolites, sulfapyridine and 5-amino salicylic acid [28].
  • Analyses of human fecal and ileostomy samples by a method that is insensitive and free from interferences indicate that nitrate and nitrite levels in the intestine are lower than reported previously [30].

Gene context of Ileostomy

  • Longstanding ileostomies in patients with FAP or UC should be followed to exclude the development of adenoma, dysplasia, or cancer [31].
  • The postprandial increase of peptide YY in patients with an ileostomy indicates that enteral substrate in the colon is not necessary for stimulation of peptide YY secretion [32].
  • The importance of these colonic L-cells for postprandial GLP-1 was determined in healthy control subjects and in ileostomy patients with minimal small bowel resection (<5 cm) [33].
  • Reduction of the effluent volume in high-output ileostomy patients by a somatostatin analogue, SMS 201-995 [34].
  • Whereas plasma bile acid levels were significantly increased after 30-45 min (p < 0.05), both with and without a loop ileostomy, neurotensin levels were not affected [35].

Analytical, diagnostic and therapeutic context of Ileostomy

  • In cats, ileostomy and portal venous cannulations revealed that 20--30% of administered SASP is absorbed from the small bowel without being metabolized [28].
  • Patients with UC and FAP were stratified separately according to associated factors (age, sex, surgeon's experience, temporary ileostomy, colectomy before IPAA, anastomotic tension, and several factors specific for UC) [36].
  • In a double blind, placebo controlled crossover study, comprising eight similar volunteers, ileostomy fluid output increased (p less than 0.05) in a dose related manner during intake of azodisal sodium (1 g/day vs 2 g/day) compared with placebo or sulphasalazine (2 g/day) [37].
  • The objective of this study was to determine whether soy fiber supplementation of total enteral nutrition formulas affected small intestinal recovery of nitrogen, amino acids, and carbohydrates or mucin output in eight human subjects (four males, four females) with ileostomies [38].
  • METHODS: Gastrointestinal bacterial colonization in 27 patients with an ileal pouch-anal anastomosis and 20 patients with a Brooke ileostomy was assessed using the 14C-glycocholate and glucose-hydrogen breath tests [39].


  1. Effects of preprovasoactive intestinal polypeptide-derived peptides on ileal output. Calam, J., Yiangou, Y., Nikou, G.C., Chrysanthou, B.J., Beacham, J.L., Bloom, S.R. Gastroenterology (1990) [Pubmed]
  2. Gut hormone responses after reconstructive surgery for ulcerative colitis. Greenberg, G.R., Buchan, A.M., McLeod, R.S., Preston, P., Cohen, Z. Gut (1989) [Pubmed]
  3. Inhibition of S-fimbria-mediated adhesion to human ileostomy glycoproteins by a protein isolated from bovine colostrum. Ouwehand, A.C., Conway, P.L., Salminen, S.J. Infect. Immun. (1995) [Pubmed]
  4. Ammonium acid urate calculi: a reevaluation of risk factors. Soble, J.J., Hamilton, B.D., Streem, S.B. J. Urol. (1999) [Pubmed]
  5. Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin. Keshavarzian, A., Isaacs, P., McColl, I., Sladen, G.E. Am. J. Gastroenterol. (1983) [Pubmed]
  6. Central pontine myelinolysis induced by hypophosphatemia following Wernicke's encephalopathy. Falcone, N., Compagnoni, A., Meschini, C., Perrone, C., Nappo, A. Neurol. Sci. (2004) [Pubmed]
  7. Nitrite and nitrate are formed by endogenous synthesis in the human intestine. Tannenbaum, S.R., Fett, D., Young, V.R., Land, P.D., Bruce, W.R. Science (1978) [Pubmed]
  8. Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis. Mantyh, C.R., Vigna, S.R., Bollinger, R.R., Mantyh, P.W., Maggio, J.E., Pappas, T.N. Gastroenterology (1995) [Pubmed]
  9. Fecal and stomal bile acid composition after ileostomy or ileoanal anastomosis in patients with chronic ulcerative colitis and adenomatosis coli. Natori, H., Utsunomiya, J., Yamamura, T., Benno, Y., Uchida, K. Gastroenterology (1992) [Pubmed]
  10. Acute effects of ursodeoxycholic and chenodeoxycholic acid on the small intestinal absorption of bile acids. Stiehl, A., Raedsch, R., Rudolph, G. Gastroenterology (1990) [Pubmed]
  11. Ileal ecology after pouch-anal anastomosis or ileostomy. A study of mucosal morphology, fecal bacteriology, fecal volatile fatty acids, and their interrelationship. Nasmyth, D.G., Godwin, P.G., Dixon, M.F., Williams, N.S., Johnston, D. Gastroenterology (1989) [Pubmed]
  12. Balance studies and polymeric glucose solution to optimize therapy after massive intestinal resection. Camilleri, M., Prather, C.M., Evans, M.A., Andresen-Reid, M.L. Mayo Clin. Proc. (1992) [Pubmed]
  13. Subcutaneous gentamycin implant to reduce wound infections after loop-ileostomy closure: a randomized, double-blind, placebo-controlled trial. Haase, O., Raue, W., Böhm, B., Neuss, H., Scharfenberg, M., Schwenk, W. Dis. Colon Rectum (2005) [Pubmed]
  14. Stapled ileoanal anastomosis without a temporary ileostomy. Sugerman, H.J., Newsome, H.H. Am. J. Surg. (1994) [Pubmed]
  15. Gastric emptying function after ileal J pouch-anal anastomosis for ulcerative colitis. Tomita, R., Fujisaki, S., Tanjoh, K. Surgery (2004) [Pubmed]
  16. Effects of colectomy on bile composition, cholesterol saturation and cholesterol crystal formation in humans. Akerlund, J.E., Einarsson, C. International journal of colorectal disease. (2000) [Pubmed]
  17. 'Low sodium' diuresis and ileal loss in patients with ileostomies: effect of desmopressin. Sutters, M., Carmichael, D.J., Unwin, R.J., Sozi, C., Hunter, M., Calam, J., Lightman, S.L., Peart, W.S. Gut (1991) [Pubmed]
  18. The effect of resection of the distal ileum on gastric emptying, small bowel transit and absorption after proctocolectomy. Neal, D.E., Williams, N.S., Barker, M.C., King, R.F. The British journal of surgery. (1984) [Pubmed]
  19. Topical and systemic availability of 5-aminosalicylate: comparisons of three controlled release preparations in man. Christensen, L.A., Fallingborg, J., Abildgaard, K., Jacobsen, B.A., Sanchez, G., Hansen, S.H., Bondesen, S., Hvidberg, E.F., Rasmussen, S.N. Aliment. Pharmacol. Ther. (1990) [Pubmed]
  20. Kinetics of gastro-intestinal transit and carotenoid absorption and disposal in ileostomy volunteers fed spinach meals. Faulks, R.M., Hart, D.J., Brett, G.M., Dainty, J.R., Southon, S. European journal of nutrition. (2004) [Pubmed]
  21. Effects of meal frequency and high-fibre rye-bread diet on glucose and lipid metabolism and ileal excretion of energy and sterols in ileostomy subjects. Lundin, E.A., Zhang, J.X., Lairon, D., Tidehag, P., Aman, P., Adlercreutz, H., Hallmans, G. European journal of clinical nutrition. (2004) [Pubmed]
  22. Primary bile acid malabsorption: defective in vitro ileal active bile acid transport. Heubi, J.E., Balistreri, W.F., Fondacaro, J.D., Partin, J.C., Schubert, W.K. Gastroenterology (1982) [Pubmed]
  23. Incorporation of urea and ammonia nitrogen into ileal and fecal microbial proteins and plasma free amino acids in normal men and ileostomates. Metges, C.C., Petzke, K.J., El-Khoury, A.E., Henneman, L., Grant, I., Bedri, S., Regan, M.M., Fuller, M.F., Young, V.R. Am. J. Clin. Nutr. (1999) [Pubmed]
  24. Degradation products of bran phytate formed during digestion in the human small intestine: effect of extrusion cooking on digestibility. Sandberg, A.S., Andersson, H., Carlsson, N.G., Sandström, B. J. Nutr. (1987) [Pubmed]
  25. Role of the gut flora in the reduction of sulfinpyrazone in humans. Strong, H.A., Oates, J., Sembi, J., Renwick, A.G., George, C.F. J. Pharmacol. Exp. Ther. (1984) [Pubmed]
  26. Orally ingested human lactoferrin is digested and secreted in the upper gastrointestinal tract in vivo in women with ileostomies. Troost, F.J., Saris, W.H., Brummer, R.J. J. Nutr. (2002) [Pubmed]
  27. 5-aminosalicylic acid in a slow-release preparation: bioavailability, plasma level, and excretion in humans. Rasmussen, S.N., Bondesen, S., Hvidberg, E.F., Hansen, S.H., Binder, V., Halskov, S., Flachs, H. Gastroenterology (1982) [Pubmed]
  28. Small bowel absorption of sulfasalazine and its hepatic metabolism in human beings, cats, and rats. Das, K.M., Chowdhury, J.R., Zapp, B., Fara, J.W. Gastroenterology (1979) [Pubmed]
  29. Effect of bisacodyl on the structure and function of rodent and human intestine. Saunders, D.R., Sillery, J., Rachmilewitz, D., Rubin, C.E., Tytgat, G.N. Gastroenterology (1977) [Pubmed]
  30. Reevaluation of nitrate and nitrite levels in the human intestine. Saul, R.L., Kabir, S.H., Cohen, Z., Bruce, W.R., Archer, M.C. Cancer Res. (1981) [Pubmed]
  31. Familial adenomatous polyposis: a case report and histologic mucin study. Mimura, T., Kuramoto, S., Yamasaki, K., Kaminishi, M. J. Clin. Gastroenterol. (1999) [Pubmed]
  32. Gut hormones in preterm infants with necrotizing enterocolitis during starvation and reintroduction of enteral nutrition. Sharman-Koendjbiharie, M., Hopman, W.P., Piena-Spoel, M., Albers, M.J., Jansen, J.B., Tibboel, D. J. Pediatr. Gastroenterol. Nutr. (2002) [Pubmed]
  33. The influence of the colon on postprandial glucagon-like peptide 1 (7-36) amide concentration in man. Robertson, M.D., Livesey, G., Morgan, L.M., Hampton, S.M., Mathers, J.C. J. Endocrinol. (1999) [Pubmed]
  34. Reduction of the effluent volume in high-output ileostomy patients by a somatostatin analogue, SMS 201-995. Kusuhara, K., Kusunoki, M., Okamoto, T., Sakanoue, Y., Utsunomiya, J. International journal of colorectal disease. (1992) [Pubmed]
  35. Intestinal intraluminal continuity is a prerequisite for the distal bowel motility response to feeding. Hallgren, T., Oresland, T., Cantor, P., Fasth, S., Hultén, L. Scand. J. Gastroenterol. (1995) [Pubmed]
  36. Risk factors for ileoanal J pouch-related septic complications in ulcerative colitis and familial adenomatous polyposis. Heuschen, U.A., Hinz, U., Allemeyer, E.H., Autschbach, F., Stern, J., Lucas, M., Herfarth, C., Heuschen, G. Ann. Surg. (2002) [Pubmed]
  37. Effect of azodisal sodium and sulphasalazine on ileostomy output of fluid and PGE2 and PGF2 alpha in subjects with a permanent ileostomy. Sandberg-Gertzén, H., Järnerot, G., Bukhave, K., Lauritsen, K., Rask-Madsen, J. Gut (1986) [Pubmed]
  38. Ileal recovery of nutrients and mucin in humans fed total enteral formulas supplemented with soy fiber. Lien, K.A., McBurney, M.I., Beyde, B.I., Thomson, A.B., Sauer, W.C. Am. J. Clin. Nutr. (1996) [Pubmed]
  39. Functional assessment of bacterial colonization in patients with ileal pouch-anal anastomosis and Brooke ileostomy. Kelly, S., Yeo, J., Robertson, G.M., Chapman, B., Wells, J.E., Frizelle, F.A. Dis. Colon Rectum (2004) [Pubmed]
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