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High impact information on Lampreys


Biological context of Lampreys

  • The presence of glomeruli in myxines and of nephron loops in lampreys suggests that fresh water animals used the preformed glomerular apparatus of early vertebrates, while mechanisms of urinary concentration was associated with the subdivision of the kidney into the renal cortex and medulla [6].
  • Choline acetyltransferase-immunoreactive cells were found in the region identified as the MLR of lampreys and nicotinic antagonists depressed, whereas physostigmine enhanced the compound EPSP evoked in reticulospinal neurons by electrical stimulation of this region [7].
  • In this paper we report successful transfection of neurons in the brain of living lampreys by means of a hand-held Helios Gene Gun [8].
  • Experimental manipulation showed that volume depletion (removal of 40% blood volume) rapidly activated the RAS of lampreys acclimated to water at 576 mOsm kg(-1) (21 p.p.t.), significantly increasing plasma angiotensin concentrations after 30 min and 60 min [9].
  • The role of hormones in initiation of sexual maturation in male river lampreys (Lampetra fluviatilis, L.): gonadotropin and testosterone [10].

Anatomical context of Lampreys


Associations of Lampreys with chemical compounds


Gene context of Lampreys

  • 5. Both NPY and PYY were present in the early vertebrate ancestor because both peptides have been found in lampreys [21].
  • The analysis of the sequences suggests that, like tetrapods, the lampreys possess two types of proteoglycans, both of which are biglycan-like; decorin-like proteoglycans could not be identified in these species [22].
  • In addition, the successful use of antibodies and probes based on the human sequence in the lamprey also provides evidence that the PTHrP molecule may have been conserved from lampreys through to humans [23].
  • In the higher teleosts, magnocellular hypothalamo-neurohypophysial neurones predominate in size and number, whereas smaller periventricular MCH neurones associated with the paraventricular organ, that are prominent in lampreys, early actinopterygians and tetrapods, are reduced in teleosts [24].
  • Compared with heteropolymeric assemblies of NF triplet proteins in mammals, NF in lampreys has been thought to contain only a single subunit (NF180) [25].

Analytical, diagnostic and therapeutic context of Lampreys


  1. Do lampreys have lymphocytes? The Spi evidence. Shintani, S., Terzic, J., Sato, A., Saraga-Babic, M., O'hUigin, C., Tichy, H., Klein, J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. Evolutionary implications of the cDNA sequence of the single lactate dehydrogenase of a lamprey. Stock, D.W., Whitt, G.S. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  3. Lampetra fluviatilis neurotrophin homolog, descendant of a neurotrophin ancestor, discloses the early molecular evolution of neurotrophins in the vertebrate subphylum. Hallböök, F., Lundin, L.G., Kullander, K. J. Neurosci. (1998) [Pubmed]
  4. The action of phenytoin on a composite electrical-chemical synapse in the lamprey spinal cord. Selzer, M.E. Ann. Neurol. (1978) [Pubmed]
  5. Primary structure of gonadotropin-releasing hormone from lamprey brain. Sherwood, N.M., Sower, S.A., Marshak, D.R., Fraser, B.A., Brownstein, M.J. J. Biol. Chem. (1986) [Pubmed]
  6. Evolutionary aspects of renal function. Natochin, Y.V. Kidney Int. (1996) [Pubmed]
  7. Nicotinic activation of reticulospinal cells involved in the control of swimming in lampreys. Le Ray, D., Brocard, F., Bourcier-Lucas, C., Auclair, F., Lafaille, P., Dubuc, R. Eur. J. Neurosci. (2003) [Pubmed]
  8. In vivo transfection of lamprey brain neurons by gene gun delivery of DNA. Zhang, G., Selzer, M.E. Exp. Neurol. (2001) [Pubmed]
  9. Activation of the newly discovered cyclostome renin-angiotensin system in the river lamprey Lampetra fluviatilis. Brown, J.A., Cobb, C.S., Frankling, S.C., Rankin, J.C. J. Exp. Biol. (2005) [Pubmed]
  10. The role of hormones in initiation of sexual maturation in male river lampreys (Lampetra fluviatilis, L.): gonadotropin and testosterone. Larsen, L.O. Gen. Comp. Endocrinol. (1987) [Pubmed]
  11. Mosaic structure in the plasma membrane: spiral arrays of subunits in the cytoplasmic tubules of lamprey chloride cells. Hatae, T., Benedetti, E.L. J. Cell. Sci. (1982) [Pubmed]
  12. Modulatory effect of substance P to the brain stem locomotor command in lampreys. Brocard, F., Bardy, C., Dubuc, R. J. Neurophysiol. (2005) [Pubmed]
  13. Glial cells of the lamprey nervous system contain keratin-like proteins. Merrick, S.E., Pleasure, S.J., Lurie, D.I., Pijak, D.S., Selzer, M.E., Lee, V.M. J. Comp. Neurol. (1995) [Pubmed]
  14. Iron loading in the livers of metamorphosing lampreys, Petromyzon marinus L. Youson, J.H., Sargent, P.A., Sidon, E.W. Cell Tissue Res. (1983) [Pubmed]
  15. Glucose and free amino acids in the blood of lampreys (Lampetra fluviatilis L.) and frogs (Rana temporaria L.) under prolonged starvation. Emelyanova, L.V., Koroleva, E.M., Savina, M.V. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2004) [Pubmed]
  16. Lactate dehydrogenase (LDH) gene duplication during chordate evolution: the cDNA sequence of the LDH of the tunicate Styela plicata. Stock, D.W., Quattro, J.M., Whitt, G.S., Powers, D.A. Mol. Biol. Evol. (1997) [Pubmed]
  17. Primary structure and biological activity of a third gonadotropin-releasing hormone from lamprey brain. Sower, S.A., Chiang, Y.C., Lovas, S., Conlon, J.M. Endocrinology (1993) [Pubmed]
  18. A novel glycoprotein in the olfactory and pituitary systems of larval and adult lampreys. Sower, S.A., Takahashi, A., Nozaki, M., Gorbman, A., Youson, J.H., Joss, J., Kawauchi, H. Endocrinology (1995) [Pubmed]
  19. Silver lampreys (Ichthyomyzon unicuspis) lack a gonadotropin-releasing hormone- and FMRFamide-immunoreactive terminal nerve. Eisthen, H.L., Northcutt, R.G. J. Comp. Neurol. (1996) [Pubmed]
  20. Ontogeny of 5-HT neurons in the brainstem of the lamprey, Petromyzon marinus. Antri, M., Cyr, A., Auclair, F., Dubuc, R. J. Comp. Neurol. (2006) [Pubmed]
  21. Evolution of neuropeptide Y and its related peptides. Larhammar, D., Blomqvist, A.G., Söderberg, C. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1993) [Pubmed]
  22. Biglycan-like extracellular matrix genes of agnathans and teleosts. Shintani, S., Sato, A., Toyosawa, S., O'hUigin, C., Klein, J. J. Mol. Evol. (2000) [Pubmed]
  23. Parathyroid hormone-related protein production in the lamprey Geotria australis: developmental and evolutionary perspectives. Trivett, M.K., Potter, I.C., Power, G., Zhou, H., Macmillan, D.L., Martin, T.J., Danks, J.A. Dev. Genes Evol. (2005) [Pubmed]
  24. Neuronal organization of the melanin-concentrating hormone system in primitive actinopterygians: evolutionary changes leading to teleosts. Baker, B.I., Bird, D.J. J. Comp. Neurol. (2002) [Pubmed]
  25. The single neurofilament subunit of lamprey may need another element for filament assembly. Zhang, G., Spencer, P.H., Jin, L.Q., Cohlberg, J.A., Beaulieu, J.M., Julien, J.P., Selzer, M.E. J. Comp. Neurol. (2004) [Pubmed]
  26. Immunohistochemical distribution of tachykinins in the CNS of the lamprey Petromyzon marinus. Auclair, F., Lund, J.P., Dubuc, R. J. Comp. Neurol. (2004) [Pubmed]
  27. Thyrotropin-releasing hormone in lamprey central nervous system. Youngs, L.J., Winokur, A., Selzer, M.E. Brain Res. (1985) [Pubmed]
  28. Three types of GABA-immunoreactive cells in the lamprey spinal cord. Brodin, L., Dale, N., Christenson, J., Storm-Mathisen, J., Hökfelt, T., Grillner, S. Brain Res. (1990) [Pubmed]
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