Chemical Compound Review:
PubChem2676 2-(9-methoxy-7,10- dioxabicyclo[4.4.0]deca...
Synonyms:
CHEMBL10332, SureCN2494824, KBioSS_002301, CHEBI:73287, CHEBI:106680, ...
- Relative importance of medullary brain nuclei for the sympatho-inhibitory actions of rilmenidine in the anaesthetized rabbit. Head, G.A., Burke, S.L. J. Hypertens. (1998)
- Covariation of alpha 2-adrenoceptor density and function following irreversible antagonism with EEDQ. Durcan, M.J., Morgan, P.F., Van Etten, M.L., Linnoila, M. Br. J. Pharmacol. (1994)
- The effects of idazoxan and other alpha 2-adrenoceptor antagonists on food and water intake in the rat. Jackson, H.C., Griffin, I.J., Nutt, D.J. Br. J. Pharmacol. (1991)
- Effect of a 7-day treatment with idazoxan and its 2-methoxy derivative RX 821002 [correction of RX 821001] on alpha 2-adrenoceptors and non-adrenoceptor idazoxan binding sites in rabbits. Portillo, M., Reverte, M., Langin, D., Senard, J.M., Tran, M.A., Berlan, M., Montastruc, J.L. Br. J. Pharmacol. (1991)
- Post-hypoxia frequency decline in rats: sensitivity to repeated hypoxia and alpha2-adrenoreceptor antagonism. Bach, K.B., Kinkead, R., Mitchell, G.S. Brain Res. (1999)
- The alpha 2 adrenoceptor antagonists RX 821002 and yohimbine delay-dependently impair choice accuracy in a delayed non-matching-to-position task in rats. McAllister, K.H. Psychopharmacology (Berl.) (2001)
- Regulation of the alpha 2A-adrenergic receptor in the HT29 cell line. Effects of insulin and growth factors. Devedjian, J.C., Fargues, M., Denis-Pouxviel, C., Daviaud, D., Prats, H., Paris, H. J. Biol. Chem. (1991)
- Estradiol reduction of the agonist high affinity form of the alpha 2-adrenoceptor in the hypothalamus of female rats: identification as the alpha 2D subtype. Karkanias, G.B., Etgen, A.M. Mol. Pharmacol. (1994)
- Binding of [3H]idazoxan and of its methoxy derivative [3H] RX821002 in human fat cells: [3H]idazoxan but not [3H] RX821002 labels additional non-alpha 2-adrenergic binding sites. Langin, D., Paris, H., Lafontan, M. Mol. Pharmacol. (1990)
- Contribution of imidazoline receptors and alpha2-adrenoceptors in the rostral ventrolateral medulla to sympathetic baroreflex inhibition by systemic rilmenidine. Chan, C.K., Burke, S.L., Head, G.A. J. Hypertens. (2007)
- The role of 5-HT(1A)-receptors in fentanyl-induced bulbospinal inhibition of a spinal withdrawal reflex in the rabbit. Clarke, R.W., Ward, R.E. Pain (2000)
- Imidazoline I(2)-receptors and spinal reflexes in the decerebrated rabbit. Clarke, R.W., Harris, J., Ogilvie, J. Neuropharmacology (2000)
- Effect of RX 821002 at 5-HT1A-receptors in rabbit spinal cord in vivo. Ogilvie, J., Clarke, R.W. Br. J. Pharmacol. (1998)
- Identification of human platelet alpha 2-adrenoceptors with a new antagonist [3H]-RX821002, a 2-methoxy derivative of idazoxan. Galitzky, J., Senard, J.M., Lafontan, M., Stillings, M., Montastruc, J.L., Berlan, M. Br. J. Pharmacol. (1990)
- Imidazoline binding sites in fat cells. Localization and pharmacologic differentiation from alpha 2-adrenergic receptors. Lafontan, M., Langin, D., Portillo, M., Paris, H. Am. J. Hypertens. (1992)
- 5-Isothiocyanato-2-benzofuranyl-2-imidazoline (BU99006) an irreversible imidazoline(2) binding site ligand: in vitro and in vivo characterisation in rat brain. Tyacke, R.J., Robinson, E.S., Nutt, D.J., Hudson, A.L. Neuropharmacology (2002)
- Does [3H]2-methoxy-idazoxan (RX 821002) detect more alpha-2-adrenoceptor agonist high-affinity sites than [3H]rauwolscine? A comparison of nine tissues and cell lines. Erdbrügger, W., Raulf, M., Otto, T., Michel, M.C. J. Pharmacol. Exp. Ther. (1995)
- Inhibition of [(11)C]mirtazapine binding by alpha(2)-adrenoceptor antagonists studied by positron emission tomography in living porcine brain. Smith, D.F., Dyve, S., Minuzzi, L., Jakobsen, S., Munk, O.L., Marthi, K., Cumming, P. Synapse (2006)
- Noradrenaline inhibits glutamate release in the rat bed nucleus of the stria terminalis: in vivo microdialysis studies. Forray, M.I., Bustos, G., Gysling, K. J. Neurosci. Res. (1999)
- In vitro mechanism of action on insulin release of S-22068, a new putative antidiabetic compound. Le Brigand, L., Virsolvy, A., Manechez, D., Godfroid, J.J., Guardiola-Lemaître, B., Gribble, F.M., Ashcroft, F.M., Bataille, D. Br. J. Pharmacol. (1999)
- Characterization of brain imidazoline receptors in normotensive and hypertensive rats: differential regulation by chronic imidazoline drug treatment. Olmos, G., Miralles, A., Barturen, F., Garcia-Sevilla, J.A. J. Pharmacol. Exp. Ther. (1992)
- alpha2a adrenoceptors regulate phosphorylation of microtubule-associated protein-2 in cultured cortical neurons. Song, Z.M., Abou-Zeid, O., Fang, Y.Y. Neuroscience (2004)
- Imidazoline(2) (I(2)) binding site- and alpha(2)-adrenoceptor-mediated modulation of central noradrenergic and HPA axis function in control rats and chronically stressed rats with adjuvant-induced arthritis. Finn, D.P., Lalies, M.D., Harbuz, M.S., Jessop, D.S., Hudson, A.L., Nutt, D.J. Neuropharmacology (2002)
- alpha2C adrenoceptors inhibit adenylyl cyclase in mouse striatum: potential activation by dopamine. Zhang, W., Klimek, V., Farley, J.T., Zhu, M.Y., Ordway, G.A. J. Pharmacol. Exp. Ther. (1999)
- Evidence that an alpha 2A-adrenoceptor subtype mediates antinociception in mice. Millan, M.J. Eur. J. Pharmacol. (1992)
- Stimulation of interleukin-12 production in mouse macrophages via activation of p38 mitogen-activated protein kinase by alpha2-adrenoceptor agonists. Kang, B.Y., Lee, S.W., Kim, T.S. Eur. J. Pharmacol. (2003)
- Evidence for central alpha-2 adrenoceptors, not imidazoline binding sites, mediating the ethanol-attenuating properties of alpha-2 adrenoceptor antagonists. Durcan, M.J., Lister, R.G., Linnoila, M. J. Pharmacol. Exp. Ther. (1991)
- Renal effects of infusion of rilmenidine and guanabenz in conscious dogs: contribution of peripheral and central nervous system alpha 2-adrenoceptors. Evans, R.G., Anderson, W.P. Br. J. Pharmacol. (1995)
- The involvement of opioidergic and noradrenergic mechanisms in nefopam antinociception. Gray, A.M., Nevinson, M.J., Sewell, R.D. Eur. J. Pharmacol. (1999)
- Evaluation of xylazine hydrochloride as the sole immobilizing agent in moose and caribou--and its subsequent reversal with idazoxan. Doherty, T.J., Tweedie, D.P. J. Wildl. Dis. (1989)