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GJA1P1  -  gap junction protein, alpha 1, 43kDa...

Homo sapiens

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Disease relevance of GJA1P1


Psychiatry related information on GJA1P1

  • Role of central alpha-1 adrenoceptors in canine narcolepsy [6].
  • The role of central alpha-1 adrenergic receptors in cataplexy was investigated in genetically narcoleptic Doberman pinschers [6].
  • It was shown that the descending noradrenergic systems were facilitatory to the motor system, and that alpha 1-antagonistic action at the spinal cord and alpha 2-agonistic action at the brainstem inhibited spinal motor activity by blocking spinal alpha 1-receptors and by reducing the release of noradrenaline in the spinal cord, respectively [7].
  • Effect of electroconvulsive therapy on serum concentration of alpha-1-acid glycoprotein [8].
  • alpha-calcium-calmodulin-dependent kinase II is associated with paired helical filaments of Alzheimer's disease [9].

High impact information on GJA1P1


Chemical compound and disease context of GJA1P1

  • The major component of human alpha 1-acid glycoprotein found in plasma is coded by AGP-A, which is expressed in liver and in hepatoma cell lines and is induced by inflammatory stimuli [13].
  • For various reasons, the alpha 1-receptor blocker prazosin has been used infrequently as initial therapy for hypertension [14].
  • Using the dorsal hand vein compliance technique we compared the changes in diameter of superficial veins in response to phenylephrine, an alpha 1 adrenergic receptor agonist, and to nitroglycerin, a venorelaxant, in patients with essential hypertension and in normotensive subjects [15].
  • Treatment of narcoleptic dogs with 25-600 micrograms/kg prazosin, a selective alpha-1 adrenergic receptor blocker, exacerbated cataplexy, whereas treatment with the alpha-1 agonist, methoxamine, ameliorated it [6].
  • Thus, the alpha 1/beta 1 and alpha 6/beta 1 integrin heterodimers each function as LN receptors and act together to mediate the interactions of human JAR choriocarcinoma cells with LN [16].

Biological context of GJA1P1


Anatomical context of GJA1P1


Associations of GJA1P1 with chemical compounds

  • Gap junction function in vascular smooth muscle: influence of serotonin [27].
  • Gap junction mediated intercellular communication was assessed with microinjections and FACS analysis of calcein transfer [28].
  • To ascertain if the features of osteogenesis imperfecta could be due to an abnormality in two genetically distinct collagens, Type III and Type I, we measured, in pepsin digests of skin, the ratio of the alpha 1, (III) to alpha 1 (I) chains derived from the two types, using a method of interrupted polyacrylamide-gel electrophoresis [29].
  • The crystal structure of the rat alpha 1 thyroid hormone receptor ligand-binding domain bound with a thyroid hormone agonist reveals that ligand is completely buried within the domain as part of the hydrophobic core [30].
  • Retinoic acid induction of type IV alpha-1 collagen and Hox-1.3 RNAs is observed with these clones [31].

Regulatory relationships of GJA1P1


Other interactions of GJA1P1


Analytical, diagnostic and therapeutic context of GJA1P1


  1. Gap junction-mediated bystander effect in primary cultures of human malignant gliomas with recombinant expression of the HSVtk gene. Asklund, T., Appelskog, I.B., Ammerpohl, O., Langmoen, I.A., Dilber, M.S., Aints, A., Ekström, T.J., Almqvist, P.M. Exp. Cell Res. (2003) [Pubmed]
  2. Increased susceptibility to urethane-induced lung tumors in mice with decreased expression of connexin43. Avanzo, J.L., Mesnil, M., Hernandez-Blazquez, F.J., Mackowiak, I.I., Mori, C.M., da Silva, T.C., Oloris, S.C., Gárate, A.P., Massironi, S.M., Yamasaki, H., Dagli, M.L. Carcinogenesis (2004) [Pubmed]
  3. Heterogeneous loss of connexin43 protein in nonischemic dilated cardiomyopathy with ventricular tachycardia. Kitamura, H., Ohnishi, Y., Yoshida, A., Okajima, K., Azumi, H., Ishida, A., Galeano, E.J., Kubo, S., Hayashi, Y., Itoh, H., Yokoyama, M. J. Cardiovasc. Electrophysiol. (2002) [Pubmed]
  4. The duplicated human alpha-globin genes: their relative expression as measured by RNA analysis. Orkin, S.H., Goff, S.C. Cell (1981) [Pubmed]
  5. Enhancement by an ACE inhibitor of first-dose hypotension caused by an alpha 1-blocker. Baba, T., Tomiyama, T., Takebe, K. N. Engl. J. Med. (1990) [Pubmed]
  6. Role of central alpha-1 adrenoceptors in canine narcolepsy. Mignot, E., Guilleminault, C., Bowersox, S., Rappaport, A., Dement, W.C. J. Clin. Invest. (1988) [Pubmed]
  7. Pharmacology of descending noradrenergic systems in relation to motor function. Ono, H., Fukuda, H. Pharmacol. Ther. (1995) [Pubmed]
  8. Effect of electroconvulsive therapy on serum concentration of alpha-1-acid glycoprotein. DeVane, C.L., Lim, C., Carson, S.W., Tingle, D., Hackett, L., Ware, M.R. Biol. Psychiatry (1991) [Pubmed]
  9. alpha-calcium-calmodulin-dependent kinase II is associated with paired helical filaments of Alzheimer's disease. Xiao, J., Perry, G., Troncoso, J., Monteiro, M.J. J. Neuropathol. Exp. Neurol. (1996) [Pubmed]
  10. Plasma membrane channels formed by connexins: their regulation and functions. Saez, J.C., Berthoud, V.M., Branes, M.C., Martinez, A.D., Beyer, E.C. Physiol. Rev. (2003) [Pubmed]
  11. B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50. Neri, A., Chang, C.C., Lombardi, L., Salina, M., Corradini, P., Maiolo, A.T., Chaganti, R.S., Dalla-Favera, R. Cell (1991) [Pubmed]
  12. Antiepileptic drugs and alpha 1-acid glycoprotein. Tiula, E., Neuvonen, P.J. N. Engl. J. Med. (1982) [Pubmed]
  13. Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice. Dente, L., Rüther, U., Tripodi, M., Wagner, E.F., Cortese, R. Genes Dev. (1988) [Pubmed]
  14. Alpha-blocker therapy of hypertension. An unfulfilled promise. Khoury, A.F., Kaplan, N.M. JAMA (1991) [Pubmed]
  15. Responsiveness of superficial hand veins to phenylephrine in essential hypertension. Alpha adrenergic blockade during prazosin therapy. Eichler, H.G., Ford, G.A., Blaschke, T.F., Swislocki, A., Hoffman, B.B. J. Clin. Invest. (1989) [Pubmed]
  16. The alpha 1/beta 1 and alpha 6/beta 1 integrin heterodimers mediate cell attachment to distinct sites on laminin. Hall, D.E., Reichardt, L.F., Crowley, E., Holley, B., Moezzi, H., Sonnenberg, A., Damsky, C.H. J. Cell Biol. (1990) [Pubmed]
  17. ATP- and gap junction-dependent intercellular calcium signaling in osteoblastic cells. Jorgensen, N.R., Geist, S.T., Civitelli, R., Steinberg, T.H. J. Cell Biol. (1997) [Pubmed]
  18. Structure of cardiac gap junction intercellular channels. Yeager, M. J. Struct. Biol. (1998) [Pubmed]
  19. Gap junction protein phenotypes of the human heart and conduction system. Davis, L.M., Rodefeld, M.E., Green, K., Beyer, E.C., Saffitz, J.E. J. Cardiovasc. Electrophysiol. (1995) [Pubmed]
  20. Presence of functional gap junctions in human embryonic stem cells. Wong, R.C., Pébay, A., Nguyen, L.T., Koh, K.L., Pera, M.F. Stem Cells (2004) [Pubmed]
  21. v-Src Tyrosine Phosphorylation of Connexin43: Regulation of Gap Junction Communication and Effects on Cell Transformation. Lin, R., Martyn, K.D., Guyette, C.V., Lau, A.F., Warn-Cramer, B.J. Cell Commun. Adhes. (2006) [Pubmed]
  22. Gap junction channel activity in short-term cultured human detrusor myocyte cell pairs: gating and unitary conductances. Wang, H.Z., Brink, P.R., Christ, G.J. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  23. Gap junction protein connexin 43 serves as a negative marker for a stem cell-containing population of human limbal epithelial cells. Chen, Z., Evans, W.H., Pflugfelder, S.C., Li, D.Q. Stem Cells (2006) [Pubmed]
  24. Sphingosine 1-Phosphate Induces Myoblast Differentiation through Cx43 Protein Expression: A Role for a Gap Junction-dependent and -independent Function. Squecco, R., Sassoli, C., Nuti, F., Martinesi, M., Chellini, F., Nosi, D., Zecchi-Orlandini, S., Francini, F., Formigli, L., Meacci, E. Mol. Biol. Cell (2006) [Pubmed]
  25. Gap junction protein connexin-43 interacts directly with microtubules. Giepmans, B.N., Verlaan, I., Hengeveld, T., Janssen, H., Calafat, J., Falk, M.M., Moolenaar, W.H. Curr. Biol. (2001) [Pubmed]
  26. Selective permeability of different connexin channels to the second messenger inositol 1,4,5-trisphosphate. Niessen, H., Harz, H., Bedner, P., Krämer, K., Willecke, K. J. Cell. Sci. (2000) [Pubmed]
  27. Gap junction function in vascular smooth muscle: influence of serotonin. Moore, L.K., Burt, J.M. Am. J. Physiol. (1995) [Pubmed]
  28. Dexamethasone inhibits the HSV-tk/ ganciclovir bystander effect in malignant glioma cells. Robe, P.A., Nguyen-Khac, M., Jolois, O., Rogister, B., Merville, M.P., Bours, V. BMC Cancer (2005) [Pubmed]
  29. Altered relation of two collagen types in osteogenesis imperfecta. Sykes, B., Francis, M.J., Smith, R. N. Engl. J. Med. (1977) [Pubmed]
  30. A structural role for hormone in the thyroid hormone receptor. Wagner, R.L., Apriletti, J.W., McGrath, M.E., West, B.L., Baxter, J.D., Fletterick, R.J. Nature (1995) [Pubmed]
  31. Retinoic acid receptor expression vector inhibits differentiation of F9 embryonal carcinoma cells. Espeseth, A.S., Murphy, S.P., Linney, E. Genes Dev. (1989) [Pubmed]
  32. Gap junction formation between cultured embryonic lens cells is inhibited by antibody to N-cadherin. Frenzel, E.M., Johnson, R.G. Dev. Biol. (1996) [Pubmed]
  33. Gap junction communications influence upon fibroblast synthesis of Type I collagen and fibronectin. Ehrlich, H.P., Sun, B., Saggers, G.C., Kromath, F. J. Cell. Biochem. (2006) [Pubmed]
  34. Dynamic modulation of interendothelial gap junctional communication by 11,12-epoxyeicosatrienoic acid. Popp, R., Brandes, R.P., Ott, G., Busse, R., Fleming, I. Circ. Res. (2002) [Pubmed]
  35. In vivo and in vitro expression of connexins in the human corneal epithelium. Shurman, D.L., Glazewski, L., Gumpert, A., Zieske, J.D., Richard, G. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  36. A novel GJA 1 mutation in oculo-dento-digital dysplasia with curly hair and hyperkeratosis. Kelly, S.C., Ratajczak, P., Keller, M., Purcell, S.M., Griffin, T., Richard, G. European journal of dermatology : EJD. (2006) [Pubmed]
  37. Functional role of the carboxyl terminal domain of human connexin 50 in gap junctional channels. Xu, X., Berthoud, V.M., Beyer, E.C., Ebihara, L. J. Membr. Biol. (2002) [Pubmed]
  38. Gap junction development in the human fetal hair follicle and bulge region. Arita, K., Akiyama, M., Tsuji, Y., McMillan, J.R., Eady, R.A., Shimizu, H. Br. J. Dermatol. (2004) [Pubmed]
  39. Effect of protein kinase Cgamma on gap junction disassembly in lens epithelial cells and retinal cells in culture. Wagner, L.M., Saleh, S.M., Boyle, D.J., Takemoto, D.J. Mol. Vis. (2002) [Pubmed]
  40. The structure of a human alpha-globin pseudogene and its relationship to alpha-globin gene duplication. Proudfoot, N.J., Maniatis, T. Cell (1980) [Pubmed]
  41. The 3' untranslated regions of the duplicated human alpha-globin genes are unexpectedly divergent. Michelson, A.M., Orkin, S.H. Cell (1980) [Pubmed]
  42. Collagen COL4A3 knockout: a mouse model for autosomal Alport syndrome. Cosgrove, D., Meehan, D.T., Grunkemeyer, J.A., Kornak, J.M., Sayers, R., Hunter, W.J., Samuelson, G.C. Genes Dev. (1996) [Pubmed]
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