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Chemical Compound Review

Vasartel     1-[(2,3,4-trimethoxyphenyl) methyl]piperazine

Synonyms: TRIMETAZIDINE, Trimetazidina, Trimetazidinum, Dilatan (TN), CHEMBL203266, ...
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Disease relevance of TRIMETAZIDINE

  • Aim of the present study was to evaluate the effects of trimetazidine on left ventricular (LV) function in elderly patients with ischaemic heart disease and reduced LV function [1].
  • A number of experimental studies in this field have demonstrated that trimetazidine exerts direct anti-ischaemic effects, limiting calcium accumulation and acidosis, inflammation and oxygen-derived free radical production following reperfusion [2].
  • Trimetazidine. A review of its use in stable angina pectoris and other coronary conditions [3].
  • Renoprotective effects of trimetazidine against ischemia-reperfusion injury and cold storage preservation: a preliminary study [4].
  • CONCLUSION: These results indicate that the condition of cold preservation may influence long-term kidney graft functions and suggest that, to a certain extent, TMZ reduces the degree of interstitial fibrosis [5].

Psychiatry related information on TRIMETAZIDINE


High impact information on TRIMETAZIDINE


Chemical compound and disease context of TRIMETAZIDINE


Biological context of TRIMETAZIDINE


Anatomical context of TRIMETAZIDINE


Associations of TRIMETAZIDINE with other chemical compounds


Gene context of TRIMETAZIDINE

  • Besides the lack of any effect of trimetazidine, we conclude that endogenous endothelin has no pathophysiological significance in this experimental model while LAT inhibition does [23].
  • Twenty-five compounds (trimetazidine derivatives and other compounds, mostly having a free phenolic group) were examined for their radical scavenging and antioxidant properties [24].
  • TMZ also decreased maximum T wave changes (1.06 +/- 0.24 vs 2.19 +/- 0.3 mV, P = 0.001), and significantly reduced the area under the curve (AUC:mV.s-1) of the i.c. ST segment and T wave changes during balloon inflation (P = 0.002 and P < 0.001 respectively) [25].
  • The cytoprotective action of TMZ also reduced interstitial fibrosis and the numbers of infiltrating CD4- and CD8-positive cells [5].
  • In the trimetazidine-treated group, the plasma BNP increase was significantly lower [26].

Analytical, diagnostic and therapeutic context of TRIMETAZIDINE


  1. Trimetazidine improves left ventricular function and quality of life in elderly patients with coronary artery disease. Vitale, C., Wajngaten, M., Sposato, B., Gebara, O., Rossini, P., Fini, M., Volterrani, M., Rosano, G.M. Eur. Heart J. (2004) [Pubmed]
  2. Rationale for trimetazidine administration in myocardial ischaemia-reperfusion syndrome. de Leiris, J., Boucher, F. Eur. Heart J. (1993) [Pubmed]
  3. Trimetazidine. A review of its use in stable angina pectoris and other coronary conditions. McClellan, K.J., Plosker, G.L. Drugs (1999) [Pubmed]
  4. Renoprotective effects of trimetazidine against ischemia-reperfusion injury and cold storage preservation: a preliminary study. Baumert, H., Goujon, J.M., Richer, J.P., Lacoste, L., Tillement, J.P., Eugene, M., Carretier, M., Hauet, T. Transplantation (1999) [Pubmed]
  5. Influence of cold-storage conditions on renal function of autotransplanted large pig kidneys. Goujon, J.M., Vandewalle, A., Baumert, H., Carretier, M., Hauet, T. Kidney Int. (2000) [Pubmed]
  6. Comparison of trimetazidine plus sildenafil to chronic nitrates in the control of myocardial ischemia during sexual activity in patients with coronary artery disease. Rosano, G.M., Marazzi, G., Patrizi, R., Cerquetani, E., Vitale, C., Volterrani, M., Fini, M., Mercuro, G. Am. J. Cardiol. (2005) [Pubmed]
  7. A randomized clinical trial of trimetazidine, a partial free fatty acid oxidation inhibitor, in patients with heart failure. Fragasso, G., Palloshi, A., Puccetti, P., Silipigni, C., Rossodivita, A., Pala, M., Calori, G., Alfieri, O., Margonato, A. J. Am. Coll. Cardiol. (2006) [Pubmed]
  8. Prevention of gentamicin induced ototoxicity by trimetazidine in animal model. Unal, O.F., Ghoreishi, S.M., Ataş, A., Akyürek, N., Akyol, G., Gürsel, B. Int. J. Pediatr. Otorhinolaryngol. (2005) [Pubmed]
  9. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Kantor, P.F., Lucien, A., Kozak, R., Lopaschuk, G.D. Circ. Res. (2000) [Pubmed]
  10. Effect of trimetazidine and verapamil on the cardiomyopathic hamster myosin phenotype. D'hahan, N., Taouil, K., Janmot, C., Morel, J.E. Br. J. Pharmacol. (1998) [Pubmed]
  11. Attenuation of myocardial ischemia-reperfusion injury by trimetazidine derivatives functionalized with antioxidant properties. Kutala, V.K., Khan, M., Mandal, R., Ganesan, L.P., Tridandapani, S., Kalai, T., Hideg, K., Kuppusamy, P. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  12. Trimetazidine normalizes postischemic function of hypertrophied rat hearts. Saeedi, R., Grist, M., Wambolt, R.B., Bescond-Jacquet, A., Lucien, A., Allard, M.F. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  13. Effects of trimetazidine on the contractile response of chronically dysfunctional myocardium to low-dose dobutamine in ischaemic cardiomyopathy. Belardinelli, R., Purcaro, A. Eur. Heart J. (2001) [Pubmed]
  14. Combination treatment in stable effort angina using trimetazidine and metoprolol: results of a randomized, double-blind, multicentre study (TRIMPOL II). TRIMetazidine in POLand. Szwed, H., Sadowski, Z., Elikowski, W., Koronkiewicz, A., Mamcarz, A., Orszulak, W., Skibińska, E., Szymczak, K., Swiatek, J., Winter, M. Eur. Heart J. (2001) [Pubmed]
  15. Therapeutic value of a cardioprotective agent in patients with severe ischaemic cardiomyopathy. Brottier, L., Barat, J.L., Combe, C., Boussens, B., Bonnet, J., Bricaud, H. Eur. Heart J. (1990) [Pubmed]
  16. Trimetazidine protects low-density lipoproteins from oxidation and cultured cells exposed to H(2)O(2) from DNA damage. Tselepis, A., Doulias, P., Lourida, E., Glantzounis, G., Tsimoyiannis, E., Galaris, D. Free Radic. Biol. Med. (2001) [Pubmed]
  17. Neuromuscular defect after suppression of ion conductance. Takamori, M., Ide, Y., Kasai, M. Neurology (1979) [Pubmed]
  18. Pre-treatment with trimetazidine increases sarcolemmal mechanical resistance in reoxygenated myocytes. Ruiz-Meana, M., Garcia-Dorado, D., Juliá, M., González, M.A., Inserte, J., Soler-Soler, J. Cardiovasc. Res. (1996) [Pubmed]
  19. Dinitrophenol, cyclosporin A, and trimetazidine modulate preconditioning in the isolated rat heart: support for a mitochondrial role in cardioprotection. Minners, J., van den Bos, E.J., Yellon, D.M., Schwalb, H., Opie, L.H., Sack, M.N. Cardiovasc. Res. (2000) [Pubmed]
  20. Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions. Stanley, W.C., Lopaschuk, G.D., Hall, J.L., McCormack, J.G. Cardiovasc. Res. (1997) [Pubmed]
  21. Metabolic and endothelial effects of trimetazidine on forearm skeletal muscle in patients with type 2 diabetes and ischemic cardiomyopathy. Monti, L.D., Setola, E., Fragasso, G., Camisasca, R.P., Lucotti, P., Galluccio, E., Origgi, A., Margonato, A., Piatti, P. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
  22. Beneficial effects of trimetazidine on mitochondrial function and superoxide production in the cardiac muscle of monocrotaline-treated rats. Guarnieri, C., Muscari, C. Biochem. Pharmacol. (1988) [Pubmed]
  23. Thimerosal attenuates ischaemia-reperfusion arrhythmias in rats: no modification by anti-ischaemic agent trimetazidine or endothelin receptor antagonist bosentan. Iskit, A.B., Guc, M.O. Pharmacol. Res. (1996) [Pubmed]
  24. Structure-property relationships of trimetazidine derivatives and model compounds as potential antioxidants. Ancerewicz, J., Migliavacca, E., Carrupt, P.A., Testa, B., Brée, F., Zini, R., Tillement, J.P., Labidalle, S., Guyot, D., Chauvet-Monges, A.M., Crevat, A., Le Ridant, A. Free Radic. Biol. Med. (1998) [Pubmed]
  25. Myocardial cytoprotection during percutaneous transluminal coronary angioplasty. Kober, G., Pennaforte, S., Buck, T., Sievert, H., Vallbracht, C. Eur. Heart J. (1993) [Pubmed]
  26. Prevention of heart failure in rats by trimetazidine treatment: a consequence of accelerated phospholipid turnover? Tabbi-Anneni, I., Helies-Toussaint, C., Morin, D., Bescond-Jacquet, A., Lucien, A., Grynberg, A. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  27. Trimetazidine reduces renal dysfunction by limiting the cold ischemia/reperfusion injury in autotransplanted pig kidneys. Hauet, T., Goujon, J.M., Vandewalle, A., Baumert, H., Lacoste, L., Tillement, J.P., Eugene, M., Carretier, M. J. Am. Soc. Nephrol. (2000) [Pubmed]
  28. Myocardial protection during percutaneous transluminal coronary angioplasty: effects of trimetazidine. Kober, G., Buck, T., Sievert, H., Vallbracht, C. Eur. Heart J. (1992) [Pubmed]
  29. Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosine triphosphate ratio in patients with heart failure. Fragasso, G., Perseghin, G., De Cobelli, F., Esposito, A., Palloshi, A., Lattuada, G., Scifo, P., Calori, G., Del Maschio, A., Margonato, A. Eur. Heart J. (2006) [Pubmed]
  30. Trimetazidine prevents renal injury in the isolated perfused pig kidney exposed to prolonged cold ischemia. Hauet, T., Mothes, D., Goujon, J.M., Caritez, J.C., Carretier, M., le Moyec, L., Eugene, M., Tillement, J.P. Transplantation (1997) [Pubmed]
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