Disease relevance of Feosol

• We treated four patients who were receiving hydroxyurea for sickle cell disease (three who were homozygous for sickle cell anemia and one with sickle beta zero-thalassemia) with escalating doses of intravenous erythropoietin for seven weeks, along with oral iron sulfate [1].
• Mammary tumors in the DMBA-only group were mostly adenomas and adenocarcinomas, while those promoted by iron sulfate included fibroadenomas, adenomas and adenocarcinomas [2].
• We therefore evaluated the efficacy and safety of intravenous iron sucrose as compared with oral iron sulfate for the treatment of iron deficiency anemia (IDA) in patients with IBD [3].
• Escherichia coli L-serine deaminase (L-SD) in crude extracts made in glycylglycine could be activated by incubation with iron sulfate and dithiothreitol [4].
• The results indicate that the rapid oxidation of free Fe2+ into iron(III) forms and the precipitation of iron(III) into larger particles resulted in a low acute toxicity of the river water directly at the iron sulfate dosage site [5].

Psychiatry related information on Feosol

• CONCLUSIONS: Iron sulfate does not appear to be an effective empiric treatment for restless legs syndrome [6].
• The process involves simple equipment, almost no chemicals, but relatively long reaction times, and treatment of iron sulfate containing process water [7].

High impact information on Feosol

• We demonstrate that addition of iron sulfate completely abolished DFX or PA induction of HIF-1 binding and iNOS-HRE activation and abrogated IFN-gamma plus either DFX- or PA-induced iNOS expression [8].
• VEGF upregulation by PA involved iron chelation because iron sulfate prevented this effect whereas the iron-chelating agent DFX induced VEGF production [9].
• Intraperitoneal injection of hemoglobin or iron sulfate before intravenous challenge with this avirulent strain also led to increased virulence [10].
• When hydrogen peroxide plus iron sulfate was used as a strong oxidant in macrophages, GSH concentrations decreased as a result of cell injury [11].
• Neurons maintained in a transferrin-free medium supplemented with 0.4 microM of iron sulfate generally expressed slight increases in transferrin binding [12].

Biological context of Feosol

• The ferritin levels in controls and in patients with iron deficiency anemia during the donation period were almost within the normal range in spite of iron supplementation, which implied a good utilization of iron sulfate for erythropoiesis [13].
• The bioavailability of SFE-171 in this rat model was not altered by the manufacturing process [14].
• Chelation of the bpyPEG(2) macroligands to iron(II) sulfate was studied in aqueous solution by titration and kinetics experiments, which revealed unexpected air sensitivity compared to nonpolymeric iron tris(bipyridine) complexes [15].
• Otherwise healthy persons who had complete blood count (CBC) as routine 'check-up' and found to be anemic (Hb < 12 g/dl) at a preventive medicine clinic were tested for hemoglobin typing, serum ferritin, serum iron, and were given oral iron sulfate (120 mg elemental iron per day for at least 2 months) and a repeat CBC on a follow-up visit [16].
• The importance of understanding indigenous health concerns and notions of ethnophysiology when introducing public health programs is highlighted by a discussion of why many pregnant women are reluctant to comply with iron sulfate, tetanus toxoid, and vitamin therapy as currently presented by primary health care staff [17].

Anatomical context of Feosol

• To accomplish this, we utilized the relatively high level of ferritin present in the hemolymph of this animal and augmented the density of the protein in vivo by injection of iron sulfate [18].
• The simultaneous administration of free peptides (0-192 mg) with the Fe(3+)-peptide complex or iron sulfate did not modify the extent of absorption of iron from both sources, suggesting that the absorption is due to the complex formed and probably not to exchange reactions in the gastrointestinal tract [19].
• We have used an in vitro digestion/Caco-2 cell culture system to measure iron spirulina availability and made a comparison with those of beef, yeast, wheat floor, and iron sulfate plus ascorbic acid as a reference [20].
• Iron sulphate therapy was monitored by bone marrow hemosiderin and serum ferritin values and 15 patients could be followed up for one year [21].
• 1) First experiment: Bile-pancreatic duct was cannulated close to the liver and perfused through the duodenum with (i) normal saline solution, (ii) iron sulfate (FeSO4), (iii) hydrogen peroxide (H2O2), (iv) hydrogen peroxide and iron sulfate simultaneously [22].

Associations of Feosol with other chemical compounds

• OBJECTIVE: We investigated the iron bioavailability of microencapsulated ferrous sulfate (SFE-171) in a diet based on powdered milk by using the prophylactic method in rats [14].
• Microencapsulated ferrous sulfate with soy lecithin (SFE-171) has been used as an iron source for the fortification of milk and dairy products [23].
• These 219 children received treatment with iron sulfate alone (the control group) or with iron sulfate combined with a 2-week course of lansoprazole, clarithromycin, and amoxicillin (the intervention group) [24].
• The method consists in intravenous injection of LPO inductors: 5% ascorbic acid (50 mg/kg), 1 min later 1% iron sulfate (10 mg/kg), and after the appearance of giant T waves on ECG infusion of 10% calcium chloride in a nonarrhythmogenic dose 100 mg/kg [25].

Analytical, diagnostic and therapeutic context of Feosol

• In the present in vivo study, cements with and without iron sulfate were compared concerning their capacity to elicit allergic patch-test reactions in eight chromate-hypersensitive individuals [26].
• On postoperative day 9, patients were randomly assigned to either iron supplementation with iron sulfate 5 mg/kg until day 56 or to a control group [27].
• With the purpose to extend the use of this agent to other kind of foods or even to pharmaceutical preparations for oral administration, the SFE-171 was turned into a fluid powder (SFE-171-P) by means of vacuum drying [23].
• With this purpose, we have studied the iron absorption in mice after the administration of fluid milk and yogurt with FeSO4, stabilized by microencapsulation with soy lecithin (SFE-171) or with FeSO4, both labeled with 59Fe, which was used in the same experimental conditions for comparative purposes [28].

References