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Chemical Compound Review

FB-?     disodium2-(2,4,5,7-tetraiodo- 6-oxido-3...

Synonyms: AGN-PC-0D74CN, TIF Na, E8886_SIGMA, SBB058454, NSC 36685, ...
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Disease relevance of Erythrosine B


Psychiatry related information on Erythrosine B


High impact information on Erythrosine B


Chemical compound and disease context of Erythrosine B


Biological context of Erythrosine B

  • Other inhibitors of IMAC which are found to block anion uniport in potato mitochondria include propranolol (IC50 = 14 microM, Hill coefficient = 1.28), tributyltin (IC50 = 4 nmol/mg, Hill coefficient = 2.0), and the nucleotide analogs Erythrosin B and Cibacron Blue 3GA [16].
  • To investigate rotational dynamics of the active enzyme, we labeled SERCA with erythrosin 5'-iodoacetamide, which binds to the phosphorylation domain and has a minimal effect on the calcium-dependent ATPase activity [17].
  • Erythrosin isothiocyanate selectively labels lysine464 within an ATP-protectable binding site on the Ca-ATPase in skeletal sarcoplasmic reticulum membranes [18].
  • The rotational motions of the type I receptor for the Fc epsilon domains (Fc epsilon RI) present on mast cells were investigated by measuring the phosphorescence emission and anisotropy decay kinetics of erythrosin (Er) covalently bound to several Fc epsilon RI-specific macromolecular ligands [19].
  • Up to 70% of the cells can be maintained transiently permeable to erythrosin B for periods of at least 1 h at 20 degrees C. Electrical conditions optimal for transient permeabilization were also optimal for efficient DNA transfection by pSV2neo [20].

Anatomical context of Erythrosine B

  • HR was measured by a fluorometric assay, viability of purified eosinophils was assessed by erythrosin B dye exclusion, and expression of VCAM-1 was measured by flow cytometry [21].
  • In sham-operated rats, the exposed sciatic nerve was irradiated for 2 min without prior injection of the erythrosin B [22].
  • Presynaptic effect of Erythrosin B at the frog neuromuscular junction: ion and photon sensitivity [23].
  • Female rats were intravenously injected with Erythrosin B and the T10 vertebra was irradiated with a laser beam for 1, 5 or 10 min [24].
  • Within 2 h of incubation at 37 degrees C with EA, the perinuclear cytoplasm of the CHO cells became highly refractile, and in 4 h, most of the cells were round; however, the majority of rounded cells excluded erythrosin B while remaining firmly attached to the culture dish plastic [25].

Associations of Erythrosine B with other chemical compounds


Gene context of Erythrosine B

  • DNA-damaging chemotherapeutic agents and Red Dye No. 3 were found to increase p53 site-specific DNA binding in breast cancer cells, but EMF exposure did not [31].
  • The measurements were based on the time-resolved phosphorescence anisotropy [r(t)] of erythrosin-labeled F(ab) fragments [Er-F(ab)] of monoclonal antibodies bound to alpha IIb beta 3 [32].
  • We used time-resolved phosphorescence anisotropy of an erythrosin isothiocyanate label attached selectively and rigidly to the Ca-ATPase, to detect the microsecond rotational motion of the Ca-ATPase in the two preparations [33].
  • Erythrosin-labeled immunoglobulin E (IgE) and time-resolved phosphorescence anisotropy were used to monitor the rotational dynamics of transfected wild-type (alpha beta gamma 2) and four mutant Fc epsilon RI receptors in the monomeric and dimeric state on P815 cells [34].
  • At dose levels of 100, 200 and 300 micrograms/ml of medium, erythrosine was non-mutagenic to V79 cells at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) and sodium, potassium ATPase (Na+, K+ -ATPase) gene loci and did not increase the frequency of sister-chromatid exchanges with or without rat hepatocyte-mediated activation [35].

Analytical, diagnostic and therapeutic context of Erythrosine B

  • During the growth-inhibitory period, erythrosin B dye was excluded equally well (greater than 94%) by control and treated cells, and no morphological differences were detected by phase contrast microscopy [36].
  • RESULTS: For rats injected with 17 mg/kg erythrosin B and irradiated for 2 minutes with a ring beam intensity of 0.92 W/cm2 (beam power of 65 mW), carbon black infusion at times up to 4 hours demonstrated a shallow cortical ring lesion encircling a fully patent zone at risk, which by 24 hours evinced an essentially complete perfusion deficit [37].
  • After the intravenous injection of a photosensitizing dye, erythrosin B, the exposed nerve was irradiated just proximal to the nerve trifurcation with light from an argon laser [22].
  • Erythrosine is a potential photosensitizer for the photodynamic therapy of oral plaque biofilms [4].
  • Separation and quantitation of components in FD&C Red No. 3 using capillary electrophoresis [38].


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  16. Anion uniport in plant mitochondria is mediated by a Mg(2+)-insensitive inner membrane anion channel. Beavis, A.D., Vercesi, A.E. J. Biol. Chem. (1992) [Pubmed]
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  19. Rotational dynamics of the Fc epsilon receptor on mast cells monitored by specific monoclonal antibodies and IgE. Pecht, I., Ortega, E., Jovin, T.M. Biochemistry (1991) [Pubmed]
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  22. Photochemically-induced ischemia of the rat sciatic nerve produces a dose-dependent and highly reproducible mechanical, heat and cold allodynia, and signs of spontaneous pain. Kupers, R., Yu, W., Persson, J.K., Xu, X.J., Wiesenfeld-Hallin, Z. Pain (1998) [Pubmed]
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