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Chemical Compound Review

Etidocaine     N-(2,6-dimethylphenyl)-2- (ethyl-propyl...

Synonyms: Etidocaina, Etidocainum, CHEMBL492, SureCN57261, AGN-PC-00JTXU, ...
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Disease relevance of Etidocaine


Psychiatry related information on Etidocaine


High impact information on Etidocaine


Chemical compound and disease context of Etidocaine


Biological context of Etidocaine


Anatomical context of Etidocaine

  • In contrast, etidocaine in eight studies caused marked attenuation of the responses recorded from the long tracts of the spinal cord white matter, associated with only minimal corresponding changes at the dorsal entry zone or peripheral nerve levels [18].
  • These results indicate that in the central nervous system, as previously demonstrated in the peripheral nervous system, high concentrations of etidocaine alter vesicular storage of NE, resulting in more NE leaking into the cytoplasm where it is metabolized to an inactive metabolite [19].
  • The presence of etidocaine did not significantly alter the release of NE from synaptosomes superfused with high potassium (40 mM), a calcium-dependent exocytotic release process [19].
  • When changes in isometric tension of helical strips of dog saphenous veins were recorded, etidocaine caused a dose-dependent depression of the contractile responses to nerve stimulation, norepinephrine and K+ [15].
  • Thus, in addition to an inhibitory effect on the responses of smooth muscle cells, amide-linked local anesthetic agents such as etidocaine depress adrenergic neurotransmission in the blood vessel wall, which helps explain their vasodilator properties in the intact organism [15].

Associations of Etidocaine with other chemical compounds


Gene context of Etidocaine

  • Before operation, epidural etidocaine had no significant effects on peak-to-peak amplitude of SEPs to electrical stimulation at the L1, T10 or T6 dermatomal level (P greater than 0.09) [23].
  • At the lower parts of the abdomen (T11), etidocaine gave more profound and longer motor blockade than mepivacaine [22].
  • Etidocaine (1 microgram/ml) was found to bind avidly to a physiological concentration (74 mg/dl) of alpha 1-acid glycoprotein (alpha 1-AGP) (7.23 +/- 0.64%, mean +/- SD, unbound) [24].
  • Also, 4 ml. of etidocaine was found to have a more rapid onset and longer duration than the same volume of bupivacaine, 6.3 vs. 8.3 min. onset, and 487 vs. 449 min. duration, respectively [25].
  • The low ratios of bupivacaine and etidocaine result from extensive binding (90%) of these drugs to maternal alpha1-acid glycoprotein which exceeds corresponding fetal protein binding (50%) [26].

Analytical, diagnostic and therapeutic context of Etidocaine


  1. Etidocaine toxicity in the adult, newborn, and fetal sheep. Morishima, H.O., Pedersen, H., Finster, M., Feldman, H.S., Covino, B.G. Anesthesiology (1983) [Pubmed]
  2. Lidocaine, bupivacaine, etidocaine, and epinephrine-induced arrhythmias during halothane anesthesia in dogs. Chapin, J.C., Kushins, L.G., Munson, E.S., Schick, L.M. Anesthesiology (1980) [Pubmed]
  3. Topical etidocaine during laparoscopic tubal occlusion for postoperative pain relief. McKenzie, R., Phitayakorn, P., Uy, N.T., Tantisira, B., Wadhwa, R.K., Vicinie, A.F. Obstetrics and gynecology. (1986) [Pubmed]
  4. Side effects and skills related to driving after intramuscular administration of bupivacaine and etidocaine. Korttila, K., Häkkinen, S., Linnoila, M. Acta anaesthesiologica Scandinavica. (1975) [Pubmed]
  5. On the mechanism by which bupivacaine conducts protons across the membranes of mitochondria and liposomes. Sun, X., Garlid, K.D. J. Biol. Chem. (1992) [Pubmed]
  6. Local anesthetics potently block a potential insensitive potassium channel in myelinated nerve. Bräu, M.E., Nau, C., Hempelmann, G., Vogel, W. J. Gen. Physiol. (1995) [Pubmed]
  7. Clinical pharmacokinetics of epidural and spinal anaesthesia. Burm, A.G. Clinical pharmacokinetics. (1989) [Pubmed]
  8. Adverse effects of regional anaesthesia in children. Dalens, B.J., Mazoit, J.X. Drug safety : an international journal of medical toxicology and drug experience. (1998) [Pubmed]
  9. Selective vulnerability of unmyelinated fiber Schwann cells in nerves exposed to local anesthetics. Powell, H.C., Kalichman, M.W., Garrett, R.S., Myers, R.R. Lab. Invest. (1988) [Pubmed]
  10. A controlled study on the effect of epidural analgesia with local anaesthetics and morphine on morbidity after abdominal surgery. Hjortsø, N.C., Neumann, P., Frøsig, F., Andersen, T., Lindhard, A., Rogon, E., Kehlet, H. Acta anaesthesiologica Scandinavica. (1985) [Pubmed]
  11. A comparison of etidocaine and lidocaine for retrobulbar anesthesia. Smith, P.H., Smith, E.R. Ophthalmic surgery. (1983) [Pubmed]
  12. Suppression of postoperative pain by the combination of a nonsteroidal anti-inflammatory drug, flurbiprofen, and a long-acting local anesthetic, etidocaine. Dionne, R.A., Wirdzek, P.R., Fox, P.C., Dubner, R. Journal of the American Dental Association (1939) (1984) [Pubmed]
  13. Effects of peridural block: V. Properties, circulatory effects, and blood levels of etidocaine and lidocaine. Stanton-Hicks, M., Murphy, T.M., Bonica, J.J., Berges, P.U., Mather, L.E., Tucker, G.T. Anesthesiology (1975) [Pubmed]
  14. Block of fast axonal transport in vitro by the local anesthetics dibucaine and etidocaine. Lavoie, P.A. J. Pharmacol. Exp. Ther. (1982) [Pubmed]
  15. Effects of amide-linked local anesthetics on adrenergic neuroeffector junction in cutaneous veins of dog. Muldoon, S.M., Verbeuren, T.J., Vanhoutte, P.M. J. Pharmacol. Exp. Ther. (1976) [Pubmed]
  16. Pharmacokinetics of etidocaine in fetal and neonatal lambs and adult sheep. Pedersen, H., Morishima, H.O., Finster, M., Arthur, G.R., Covino, B.G. Anesth. Analg. (1982) [Pubmed]
  17. Etidocaine and extradural somatosensory evoked potentials after posterior tibial nerve stimulation. Loughnan, B.A., McHale, S.P., Welsh, K.R., Hall, G.M. British journal of anaesthesia. (1994) [Pubmed]
  18. Differential neural effects of epidural anesthetics. Cusick, J.F., Myklebust, J.B., Abram, S.E. Anesthesiology (1980) [Pubmed]
  19. The effect of etidocaine on spontaneous and evoked release of norepinephrine from rat brain synaptosomes. Freas, W., Todd, R.A., Tyce, G.M., Muldoon, S.M. Proc. Soc. Exp. Biol. Med. (1985) [Pubmed]
  20. Differential peripheral nerve block by local anesthetics in the cat. Ford, D.J., Raj, P.P., Singh, P., Regan, K.M., Ohlweiler, D. Anesthesiology (1984) [Pubmed]
  21. Fundamental properties of local anesthetics: half-maximal blocking concentrations for tonic block of Na+ and K+ channels in peripheral nerve. Bräu, M.E., Vogel, W., Hempelmann, G. Anesth. Analg. (1998) [Pubmed]
  22. Motor blockade and EMG recordings in epidural anaesthesia. A comparison between mepivacaine 2%, bupivacaine 0.5% and etidocaine 1.5%. Nydahl, P.A., Axelsson, K., Philipson, L., Leissner, P., Larsson, P.G. Acta anaesthesiologica Scandinavica. (1989) [Pubmed]
  23. Effect of thoracic epidural etidocaine 1.5% on somatosensory evoked potentials, cortisol and glucose during cholecystectomy. Dahl, J.B., Rosenberg, J., Kehlet, H. Acta anaesthesiologica Scandinavica. (1992) [Pubmed]
  24. Plasma protein binding of etidocaine during pregnancy and labour. Morgan, D.J., Koay, B.B., Paull, J.D. Eur. J. Clin. Pharmacol. (1982) [Pubmed]
  25. A double-blind crossover study comparing two doses of Duranest (etidocaine) 1% with a fixed dose of Sensorcaine (bupivacaine) 0.5% utilizing infiltration regional blocks of the fifth ray. Techner, L., Hopkins, W., Dobbs, B., Esper, R. The Journal of foot surgery. (1984) [Pubmed]
  26. Clinical pharmacokinetics in pregnancy and perinatology. I. Placental transfer and fetal side effects of local anaesthetic agents. Nau, H. Developmental pharmacology and therapeutics. (1985) [Pubmed]
  27. Bupivacaine and etidocaine for lumbar epidural anesthesia for intra-abdominal pelvic surgery, a double-blind study. Bridenbaugh, P.O., Balfour, R.I., Bridenbaugh, L.D., Lysons, D.F. Anesthesiology (1976) [Pubmed]
  28. Etidocaine, bupivacaine, and lidocaine seizure thresholds in monkeys. Munson, E.S., Tucker, W.K., Ausinsch, B., Malagodi, M.H. Anesthesiology (1975) [Pubmed]
  29. Epidural anesthesia and intrathoracic blood volume. Warner, D.O., Brichant, J.F., Ritman, E.L., Rehder, K. Anesth. Analg. (1993) [Pubmed]
  30. Etidocaine for Caesarean section--effects on mother and baby. Lund, P.C., Cwik, J.C., Gannon, R.T., Vassallo, H.G. British journal of anaesthesia. (1977) [Pubmed]
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