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Chemical Compound Review

Trenbolone     17-hydroxy-13-methyl- 2,6,7,8,14,15,16,17...

Synonyms: AGN-PC-00KL91, SureCN14184150, AC1N3SNV, FT-0630376, FT-0675367, ...
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Disease relevance of Trenbolone

  • The potential role of satellite cells in mediating the effect of trenbolone [17 beta-hydroxyestra-4,9-11-trien-3-one (TBOH)] on skeletal muscle hypertrophy was examined [1].
  • These data showed that late-gestation treatment with 600 mg of trenbolone acetate significantly increased weight gain of dams without demonstrating any androgenizing effects on the growth or physical characteristics of heifer calves [2].
  • Body weight and tissue gain in lambs fed an all-concentrate diet and implanted with trenbolone acetate or grazed on alfalfa [3].
  • However, little is known concerning the toxicity of trenbolone to fish [4].
  • Fifty crossbred cows (38 multiparous and 12 nulliparous) were used to evaluate in utero androgenization of heifer calves with trenbolone acetate [2].

High impact information on Trenbolone


Chemical compound and disease context of Trenbolone


Biological context of Trenbolone

  • Allyl trenbolone (Regumate) was used to synchronize estrus in 13 postpuberal gilts [9].
  • Assay sensitivities for calibration curves in buffer solutions around 0.5 ng ml(-1) in terms of IC50 (concentration of the inhibitor) values were achieved for the beta-agonist clenbuterol and the hormone analogues ethinylestradiol and trenbolone [10].
  • Three 200-mg trenbolone acetate (Finaplix-H) implants were implanted in the ear of treated cows (n = 24) on d 214 +/- 11 of gestation; the remaining animals (n = 26) were used as controls [2].
  • Two trials were conducted to evaluate the effectiveness of a synthetic progestogen, allyl trenbolone, for control of estrus and ovulation in gilts [11].
  • It is concluded that trenbolone acetate affected the ovarian cycle of the cows in several ways through changes other than the modification of tonic luteinising hormone secretion [12].

Anatomical context of Trenbolone


Associations of Trenbolone with other chemical compounds


Gene context of Trenbolone


Analytical, diagnostic and therapeutic context of Trenbolone


  1. Trenbolone alters the responsiveness of skeletal muscle satellite cells to fibroblast growth factor and insulin-like growth factor I. Thompson, S.H., Boxhorn, L.K., Kong, W.Y., Allen, R.E. Endocrinology (1989) [Pubmed]
  2. Late-gestation treatment of pregnant cows with trenbolone acetate does not increase subsequent growth of heifer calves. Harting, M.A., de Avila, D.M., Johnson, K.A., Reeves, J.J. J. Anim. Sci. (1997) [Pubmed]
  3. Body weight and tissue gain in lambs fed an all-concentrate diet and implanted with trenbolone acetate or grazed on alfalfa. McClure, K.E., Solomont, M.B., Loerch, S.C. J. Anim. Sci. (2000) [Pubmed]
  4. Effects of the androgenic growth promoter 17-beta-trenbolone on fecundity and reproductive endocrinology of the fathead minnow. Ankley, G.T., Jensen, K.M., Makynen, E.A., Kahl, M.D., Korte, J.J., Hornung, M.W., Henry, T.R., Denny, J.S., Leino, R.L., Wilson, V.S., Cardon, M.C., Hartig, P.C., Gray, L.E. Environ. Toxicol. Chem. (2003) [Pubmed]
  5. IGF-I mRNA levels in bovine satellite cell cultures: effects of fusion and anabolic steroid treatment. Kamanga-Sollo, E., Pampusch, M.S., Xi, G., White, M.E., Hathaway, M.R., Dayton, W.R. J. Cell. Physiol. (2004) [Pubmed]
  6. Study of various transforming effects of the anabolic agents trenbolone and testosterone on Syrian hamster embryo cells. Lasne, C., Lu, Y.P., Orfila, L., Ventura, L., Chouroulinkov, I. Carcinogenesis (1990) [Pubmed]
  7. Growth performance and shedding of some pathogenic bacteria in feedlot cattle treated with different growth-promoting agents. Lefebvre, B., Malouin, F., Roy, G., Giguère, K., Diarra, M.S. J. Food Prot. (2006) [Pubmed]
  8. Antibiotic resistance and hypermutability of Escherichia coli O157 from feedlot cattle treated with growth-promoting agents. Lefebvre, B., Diarra, M.S., Giguère, K., Roy, G., Michaud, S., Malouin, F. J. Food Prot. (2005) [Pubmed]
  9. Development of in vivo-matured porcine oocytes following intracytoplasmic sperm injection. Martin, M.J. Biol. Reprod. (2000) [Pubmed]
  10. Sensor chip preparation and assay construction for immunobiosensor determination of beta-agonists and hormones. Johansson, M.A., Hellenäs, K.E. The Analyst. (2001) [Pubmed]
  11. Control of estrus in gilts with a progestogen. Davis, D.L., Knight, J.W., Killian, D.B., Day, B.N. J. Anim. Sci. (1979) [Pubmed]
  12. Effect of trenbolone acetate on ovarian function in culled dairy cows. Peters, A.R. Vet. Rec. (1987) [Pubmed]
  13. Activation of cellular oncogenes by chemical carcinogens in Syrian hamster embryo fibroblasts. Ebert, R., Barrett, J.C., Wiseman, R.W., Pechan, R., Reiss, E., Röllich, G., Schiffmann, D. Environ. Health Perspect. (1990) [Pubmed]
  14. Immunotoxicity of trenbolone acetate in Japanese quail. Quinn, M.J., McKernan, M., Lavoie, E.T., Ottinger, M.A. J. Toxicol. Environ. Health Part A (2007) [Pubmed]
  15. Effects of zeranol and trenbolone acetate on testis function, live weight gain and carcass traits of bulls. Silcox, R.W., Keeton, J.T., Johnson, B.H. J. Anim. Sci. (1986) [Pubmed]
  16. The effect of trenbolone acetate on performance, plasma lipids, and carcass characteristics of growing ram and ewe lambs. Lough, D.S., Kahl, S., Solomon, M.B., Rumsey, T.S. J. Anim. Sci. (1993) [Pubmed]
  17. Morphological transformation of Syrian hamster embryo fibroblasts by the anabolic agent trenbolone. Schiffmann, D., Metzler, M., Neudecker, T., Henschler, D. Arch. Toxicol. (1985) [Pubmed]
  18. Identification of metabolites of trenbolone acetate in androgenic runoff from a beef feedlot. Durhan, E.J., Lambright, C.S., Makynen, E.A., Lazorchak, J., Hartig, P.C., Wilson, V.S., Gray, L.E., Ankley, G.T. Environ. Health Perspect. (2006) [Pubmed]
  19. Proceedings: The determination by radioimmunoassay of residues of an anabolic steroid in tissues of calves treated with a combined preparation of trenbolone acetate and oestradiol-17 beta. Heitzman, R.J., Oettel, G., Hoffmann, B. J. Endocrinol. (1976) [Pubmed]
  20. Evaluation of the model anti-androgen flutamide for assessing the mechanistic basis of responses to an androgen in the fathead minnow (Pimephales promelas). Ankley, G.T., Defoe, D.L., Kahl, M.D., Jensen, K.M., Makynen, E.A., Miracle, A., Hartig, P., Gray, L.E., Cardon, M., Wilson, V. Environ. Sci. Technol. (2004) [Pubmed]
  21. Stability of zeranol, nandrolone and trenbolone in bovine urine. van der Merwe, P.J., Pieterse, J.W. The Analyst. (1994) [Pubmed]
  22. Stimulation of circulating insulin-like growth factor I (IGF-I) and insulin-like growth factor binding proteins (IGFBP) due to administration of a combined trenbolone acetate and estradiol implant in feedlot cattle. Johnson, B.J., Hathaway, M.R., Anderson, P.T., Meiske, J.C., Dayton, W.R. J. Anim. Sci. (1996) [Pubmed]
  23. Gonadotropin-independent mechanisms participate in ovarian responses to realimentation in feed-restricted prepubertal gilts. Cosgrove, J.R., Tilton, J.E., Hunter, M.G., Foxcroft, G.R. Biol. Reprod. (1992) [Pubmed]
  24. Androgen receptors in skeletal muscle cytosol from sheep treated with trenbolone acetate. Sinnett-Smith, P.A., Palmer, C.A., Buttery, P.J. Horm. Metab. Res. (1987) [Pubmed]
  25. Effects of restricted feeding, low-energy diet, and implantation of trenbolone acetate plus estradiol on growth, carcass traits, and circulating concentrations of insulin-like growth factor (IGF)-I and IGF-binding protein-3 in finishing barrows. Lee, C.Y., Lee, H.P., Jeong, J.H., Baik, K.H., Jin, S.K., Lee, J.H., Sohnt, S.H. J. Anim. Sci. (2002) [Pubmed]
  26. Physiological data including evaluation of immuno-response in relation to anabolic effects on veal calves. Gropp, J., Herlyn, D., Boehncke, E., Schulz, V., Sandersleben, J.V., Hänichen, T., Geisel, O. Environmental quality and safety. Supplement. (1976) [Pubmed]
  27. Detection of trenbolone residues in meat and organs of slaughtered animals by thin-layer chromatography. Laitem, L., Gaspar, P., Bello, I. J. Chromatogr. (1978) [Pubmed]
  28. Determination of trenbolone and zeranol in bovine muscle and liver by liquid chromatography-electrospray mass spectrometry. Hori, M., Nakazawa, H. Journal of chromatography. A. (2000) [Pubmed]
  29. Estrus synchronisation and fertility in gilts using a synthetic progestagen (Allyl Trenbolone) and inseminated with fresh stored or frozen semen. O' Reilly, P.J., Mc Cormack, R., O' Mahony, K., Murphy, C. Theriogenology (1979) [Pubmed]
  30. Development of a sensitive microtitration plate enzyme-immunoassay for the anabolic steroid trenbolone. Meyer, H.H., Hoffmann, S. Food additives and contaminants. (1987) [Pubmed]
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