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Chemical Compound Review

AC1NURYM     2-[[(2S)-2-[2-[[(2S,4R)-1- [(2S)-1-(2...

Synonyms: Atrial peptide, 81771-37-1, Antiarrhythmic peptide, Gly-pro-hypro-gly-ala-gly, Gly-pro-4-hyp-gly-ala-gly, ...
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Disease relevance of Atrial peptide


High impact information on Atrial peptide

  • A linear relation was found between right atrial pressure and right atrial peptide concentration (r = 0.835, P less than 0.001) and between pulmonary wedge pressure and the systemic arterial peptide concentration (r = 0.866, P less than 0.001) [6].
  • The fact that atrial peptide works to oppose the renin system at four points suggests that this new hormone could have a major complementary role in long-term regulation of blood pressure and electrolyte homeostasis [7].
  • Atrial natriuretic peptide (ANP)(31-67), a portion of the atrial peptide prohormone, circulates in humans, and its plasma level varies with atrial pressure [8].
  • The results of model experiments suggest that the binding of this atrial peptide to the target cell membrane is associated with the induction of beta-sheet structure and that it is this latter conformation that is predominant in the active form of the hormone [9].
  • These results suggest that atrial peptide can pass from atrial granules into caveolae by transiently open pathways between the interiors of granules and caveolae [10].

Chemical compound and disease context of Atrial peptide


Biological context of Atrial peptide

  • Mesenteric blood flow was reduced significantly, and mesenteric vascular resistance was increased markedly in all three groups of rats during infusion of the atrial peptide [12].
  • Dynamics of atrial peptide secretion in the coronary circulation of the conscious dog [13].
  • To test this hypothesis, blood volume expansion and atrial peptide binding studies were performed in this model [2].
  • Between clipped and nonclipped kidneys, the association constant (5.26 +/- 0.89 versus 5.17 +/- 0.64 x 10(9)/mol) and apparent binding site density (575 +/- 92 versus 500 +/- 74 fmol/mg protein) for atrial peptide binding in isolated glomeruli did not differ [2].
  • The atrial peptide partially inhibited ACTH-stimulated cAMP formation (IC50, approximately 10(-8) M) and partially antagonized basal and ACTH-stimulated steroidogenesis [14].

Anatomical context of Atrial peptide


Associations of Atrial peptide with other chemical compounds


Gene context of Atrial peptide


Analytical, diagnostic and therapeutic context of Atrial peptide


  1. Prognostic value of N-terminal proatrial natriuretic factor plasma levels measured within the first 12 hours after myocardial infarction. Thrombolysis in Myocardial Infarction (TIMI) II Investigators. Hall, C., Cannon, C.P., Forman, S., Braunwald, E. J. Am. Coll. Cardiol. (1995) [Pubmed]
  2. Renal atrial peptide receptors and natriuresis in two-kidney, one clip hypertension. Paul, R.V. Hypertension (1991) [Pubmed]
  3. Atrial secretion of B-type natriuretic peptide. Goetze, J.P., Friis-Hansen, L., Rehfeld, J.F., Nilsson, B., Svendsen, J.H. Eur. Heart J. (2006) [Pubmed]
  4. Atriopeptin alters the vasopressin and renin responses elicited by hemorrhage. Wang, B.C., Leadley, R.J., Goetz, K.L. Proc. Soc. Exp. Biol. Med. (1990) [Pubmed]
  5. The effects of atrial peptide in humans with chronic renal failure. Windus, D.W., Stokes, T.J., Morgan, J.R., Klahr, S. Am. J. Kidney Dis. (1989) [Pubmed]
  6. Atrial natriuretic peptide and atrial pressure in patients with congestive heart failure. Raine, A.E., Erne, P., Bürgisser, E., Müller, F.B., Bolli, P., Burkart, F., Bühler, F.R. N. Engl. J. Med. (1986) [Pubmed]
  7. Atrial natriuretic hormone, the renin-aldosterone axis, and blood pressure-electrolyte homeostasis. Laragh, J.H. N. Engl. J. Med. (1985) [Pubmed]
  8. Atrial natriuretic peptide(31-67) inhibits Na+ transport in rabbit inner medullary collecting duct cells. Role of prostaglandin E2. Gunning, M.E., Brady, H.R., Otuechere, G., Brenner, B.M., Zeidel, M.L. J. Clin. Invest. (1992) [Pubmed]
  9. Infrared spectroscopic evidence of conformational transitions of an atrial natriuretic peptide. Surewicz, W.K., Mantsch, H.H., Stahl, G.L., Epand, R.M. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  10. Localization of atrial natriuretic peptide in caveolae of in situ atrial myocytes. Page, E., Upshaw-Earley, J., Goings, G.E. Circ. Res. (1994) [Pubmed]
  11. Decreased binding capacity for alpha-human atrial natriuretic peptide in aldosterone-producing adrenocortical adenoma. Ohashi, M., Higuchi, K., Hashiguchi, T., Takayanagi, R., Nawata, H. Fukuoka Igaku Zasshi (1991) [Pubmed]
  12. Effects of atrial natriuretic factor on the vasoconstrictor actions of the renin-angiotensin system in conscious rats. Lappe, R.W., Todt, J.A., Wendt, R.L. Circ. Res. (1987) [Pubmed]
  13. Dynamics of atrial peptide secretion in the coronary circulation of the conscious dog. Hintze, T.H., Wang, J., Patel, M., Schustek, M., Ochoa, M., Dean, R., Chiruzzo, F., Zeballos, G. Circ. Res. (1990) [Pubmed]
  14. Y-1 adrenocortical tumor cells contain atrial natriuretic peptide receptors which regulate cyclic nucleotide metabolism and steroidogenesis. Heisler, S., Tallerico-Melnyk, T., Yip, C., Schimmer, B.P. Endocrinology (1989) [Pubmed]
  15. The antiarrhythmic peptide analog rotigaptide (ZP123) stimulates gap junction intercellular communication in human osteoblasts and prevents decrease in femoral trabecular bone strength in ovariectomized rats. Jørgensen, N.R., Teilmann, S.C., Henriksen, Z., Meier, E., Hansen, S.S., Jensen, J.E., Sørensen, O.H., Petersen, J.S. Endocrinology (2005) [Pubmed]
  16. Volume status influences atrial peptide-induced water conductivity changes in leopard frog mesenteric capillaries. Meyer, D.J., Huxley, V.H., McKay, M.K. J. Physiol. (Lond.) (1992) [Pubmed]
  17. The antiarrhythmic peptide rotigaptide (ZP123) increases gap junction intercellular communication in cardiac myocytes and HeLa cells expressing connexin 43. Clarke, T.C., Thomas, D., Petersen, J.S., Evans, W.H., Martin, P.E. Br. J. Pharmacol. (2006) [Pubmed]
  18. Body fluids and plasma atrial peptide after its chronic infusion in hypertensive rats. Garcia, R., Cantin, M., Genest, J., Gutkowska, J., Thibault, G. Proc. Soc. Exp. Biol. Med. (1987) [Pubmed]
  19. Pathophysiological role and diuretic efficacy of atrial natriuretic peptide in renal patients. De Nicola, L., Bellizzi, V., Cianciaruso, B., Minutolo, R., Colucci, G., Balletta, M., Fuiano, G., Conte, G. J. Am. Soc. Nephrol. (1997) [Pubmed]
  20. A comparison of the vasodilator responses to atrial peptides in the pulmonary and renal arteries of the pig in vitro. Jansen, T.L., Morice, A.H., Brown, M.J. Br. J. Pharmacol. (1987) [Pubmed]
  21. Atrial natriuretic peptide and the baroreflex control of circulation. Volpe, M. Am. J. Hypertens. (1992) [Pubmed]
  22. Increased levels of a humoral digitalis-like factor in deoxycorticosterone acetate-induced hypertension in the pig. Hamlyn, J.M. J. Endocrinol. (1989) [Pubmed]
  23. The hemodynamic response of conscious normotensive rats to atriopeptin III: Lack of a role of the parasympathetic nervous system. Waeber, B., Matsueda, G.R., Aubert, J.F., Nussberger, J., Brunner, H.R. Eur. J. Pharmacol. (1986) [Pubmed]
  24. Kallikrein activation of a high molecular weight atrial peptide. Currie, M.G., Geller, D.M., Chao, J., Margolius, H.S., Needleman, P. Biochem. Biophys. Res. Commun. (1984) [Pubmed]
  25. Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123). Axelsen, L.N., Stahlhut, M., Mohammed, S., Larsen, B.D., Nielsen, M.S., Holstein-Rathlou, N.H., Andersen, S., Jensen, O.N., Hennan, J.K., Kjølbye, A.L. J. Mol. Cell. Cardiol. (2006) [Pubmed]
  26. The vascular ANF-C receptor: role in atrial peptide signalling. Smyth, E.M., Keenan, A.K. Cell. Signal. (1994) [Pubmed]
  27. Atrial natriuretic factor enhances induced salivary secretion in the rat. Bianciotti, L.G., Elverdin, J.C., Vatta, M.S., Colatrella, C., Fernández, B.E. Regul. Pept. (1994) [Pubmed]
  28. Are the atrial peptides a natriuretic hormone? MacGregor, G.A., Sagnella, G.A. Eur. Heart J. (1987) [Pubmed]
  29. Atrial peptide natriuresis in the rat without genuine rise in filtration rate or wash-out of medullary electrolytes. Badzyńska, B., Sadowski, J., Dobrowolski, L. J. Physiol. (Lond.) (1990) [Pubmed]
  30. Rotigaptide (ZP123) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs. Hennan, J.K., Swillo, R.E., Morgan, G.A., Keith, J.C., Schaub, R.G., Smith, R.P., Feldman, H.S., Haugan, K., Kantrowitz, J., Wang, P.J., Abu-Qare, A., Butera, J., Larsen, B.D., Crandall, D.L. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  31. Natriuretic peptide and echocardiography after operation of atrial septal defect. Groundstroem, K.W., Iivainen, T.E., Lahtela, J.T., Talvensaari, T.J., Paakkala, T.A., Pasternack, A.I., Uusitalo, A.J. International journal of cardiology. (2003) [Pubmed]
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