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Chemical Compound Review

VOSO4     oxovanadium sulfate

Synonyms: CCRIS 4121, CHEBI:33146, HSDB 1026, LS-7749, AC1L1QQU, ...
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Disease relevance of oxovanadium sulfate


High impact information on oxovanadium sulfate


Chemical compound and disease context of oxovanadium sulfate


Biological context of oxovanadium sulfate


Anatomical context of oxovanadium sulfate


Associations of oxovanadium sulfate with other chemical compounds


Gene context of oxovanadium sulfate

  • Herein, we have examined a possible role of PI3-K in the vanadyl sulfate (VS)-mediated increase in the level of ras-MAPK activation as well as the contribution of signaling components upstream to MAPK in this VS response [23].
  • Treatment of the 2-month diabetic rats with vanadyl sulfate resulted in euglycemia, prevented the increase in the basal activity of S6 kinase, and improved the activation of S6 kinase by insulin.(ABSTRACT TRUNCATED AT 250 WORDS)[24]
  • Accordingly, AIRs had no effect on the stimulation of mitogen-activated protein kinase activity or DNA synthesis by vanadyl sulfate, FCS, epidermal growth factor, or platelet-derived growth factor, all of which activate signaling pathways independent of IRS-1/IRS-2 [25].
  • The plasma IAPP levels of the group C animals were not significantly higher than in group A, while after vanadyl sulfate treatment the IAPP levels and IAPP/insulin ratios remained significantly higher [group A--Rec (vanadyl)] [26].
  • In this study we examined whether insulin and vanadyl sulfate (VS) affected adiponectin release and cell content from 3T3-L1 adipocytes, and whether they acted through a similar signaling pathway [27].

Analytical, diagnostic and therapeutic context of oxovanadium sulfate


  1. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. Cohen, N., Halberstam, M., Shlimovich, P., Chang, C.J., Shamoon, H., Rossetti, L. J. Clin. Invest. (1995) [Pubmed]
  2. Vanadyl sulfate lowers plasma insulin and blood pressure in spontaneously hypertensive rats. Bhanot, S., McNeill, J.H. Hypertension (1994) [Pubmed]
  3. Comparison of the glucose-lowering properties of vanadyl sulfate and bis(maltolato)oxovanadium(IV) following acute and chronic administration. Yuen, V.G., Orvig, C., McNeill, J.H. Can. J. Physiol. Pharmacol. (1995) [Pubmed]
  4. Vanadium and diabetes. Poucheret, P., Verma, S., Grynpas, M.D., McNeill, J.H. Mol. Cell. Biochem. (1998) [Pubmed]
  5. Beneficial effects of a vanadium complex with cysteine, administered at low doses on benzo(alpha)pyrene-induced leiomyosarcomas in Wistar rats. Liasko, R., Kabanos, T.A., Karkabounas, S., Malamas, M., Tasiopoulos, A.J., Stefanou, D., Collery, P., Evangelou, A. Anticancer Res. (1998) [Pubmed]
  6. Inhibition of vagally mediated immune-to-brain signaling by vanadyl sulfate speeds recovery from sickness. Johnson, D.R., O'Connor, J.C., Dantzer, R., Freund, G.G. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  7. Glucose transporter upregulation improves ischemic tolerance in hypertrophied failing heart. Takeuchi, K., McGowan, F.X., Glynn, P., Moran, A.M., Rader, C.M., Cao-Danh, H., del Nido, P.J. Circulation (1998) [Pubmed]
  8. Arsenite exposure of cultured airway epithelial cells activates kappaB-dependent interleukin-8 gene expression in the absence of nuclear factor-kappaB nuclear translocation. Jaspers, I., Samet, J.M., Reed, W. J. Biol. Chem. (1999) [Pubmed]
  9. Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects. Halberstam, M., Cohen, N., Shlimovich, P., Rossetti, L., Shamoon, H. Diabetes (1996) [Pubmed]
  10. Vanadyl sulfate prevents fructose-induced hyperinsulinemia and hypertension in rats. Bhanot, S., McNeill, J.H., Bryer-Ash, M. Hypertension (1994) [Pubmed]
  11. An assessment of the genotoxicity of vanadium. Owusu-Yaw, J., Cohen, M.D., Fernando, S.Y., Wei, C.I. Toxicol. Lett. (1990) [Pubmed]
  12. Effect of oral vanadyl sulfate treatment on serum enzymes and lipids of streptozotocin-diabetic young rats. Pepato, M.T., Magnani, M.R., Kettelhut, I.C., Brunetti, I.L. Mol. Cell. Biochem. (1999) [Pubmed]
  13. Normal rat kidney cells secrete both phosphorylated and nonphosphorylated forms of osteopontin showing different physiological properties. Nemir, M., DeVouge, M.W., Mukherjee, B.B. J. Biol. Chem. (1989) [Pubmed]
  14. Vanadium-induced kappaB-dependent transcription depends upon peroxide-induced activation of the p38 mitogen-activated protein kinase. Jaspers, I., Samet, J.M., Erzurum, S., Reed, W. Am. J. Respir. Cell Mol. Biol. (2000) [Pubmed]
  15. Vanadyl sulfate inhibits NO production via threonine phosphorylation of eNOS. Li, Z., Carter, J.D., Dailey, L.A., Huang, Y.C. Environ. Health Perspect. (2004) [Pubmed]
  16. Characterization of vanadyl sulfate effect on vascular contraction: roles of calcium and tyrosine phosphorylation. Cadène, A., Grigorescu, F., Serrano, J.J., Cros, G. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  17. Dexamethasone-induced insulin resistance and pancreatic adaptive response in aging rats are not modified by oral vanadyl sulfate treatment. Barbera, M., Fierabracci, V., Novelli, M., Bombara, M., Masiello, P., Bergamini, E., De Tata, V. Eur. J. Endocrinol. (2001) [Pubmed]
  18. Protective effect of vanadyl sulfate on the pancreas of streptozotocin-induced diabetic rats. Bolkent, S., Bolkent, S., Yanardag, R., Tunali, S. Diabetes Res. Clin. Pract. (2005) [Pubmed]
  19. Insulin-mimetic vanadyl(IV) complexes as evaluated by both glucose-uptake and inhibition of free fatty acids (FFA)-release in isolated rat adipocytes. Adachi, Y., Sakurai, H. Chem. Pharm. Bull. (2004) [Pubmed]
  20. Vanadyl sulfate can differentially damage DNA in human lymphocytes and HeLa cells. Wozniak, K., Blasiak, J. Arch. Toxicol. (2004) [Pubmed]
  21. Vanadium(IV) and vanadium(V) complexes of salicyladimine ligands. Smith, K.I., Borer, L.L., Olmstead, M.M. Inorganic chemistry. (2003) [Pubmed]
  22. Comparative erythropoietic effects of three vanadium compounds. Hogan, G.R. Sci. Total Environ. (2000) [Pubmed]
  23. Phosphatidylinositol 3-kinase requirement in activation of the ras/C-raf-1/MEK/ERK and p70(s6k) signaling cascade by the insulinomimetic agent vanadyl sulfate. Pandey, S.K., Théberge, J.F., Bernier, M., Srivastava, A.K. Biochemistry (1999) [Pubmed]
  24. Skeletal muscle mitogen-activated protein kinases and ribosomal S6 kinases. Suppression in chronic diabetic rats and reversal by vanadium. Hei, Y.J., Chen, X., Pelech, S.L., Diamond, J., McNeill, J.H. Diabetes (1995) [Pubmed]
  25. Antiinsulin receptor autoantibodies induce insulin receptors to constitutively associate with insulin receptor substrate-1 and -2 and cause severe cell resistance to both insulin and insulin-like growth factor I. Auclair, M., Vigouroux, C., Desbois-Mouthon, C., Deibener, J., Kaminski, P., Lascols, O., Cherqui, G., Capeau, J., Caron, M. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  26. Islet amyloid polypeptide in Psammomys obesus (sand rat): effects of nutritionally induced diabetes and recovery on low-energy diet or vanadyl sulfate treatment. Leckström, A., Ziv, E., Shafrir, E., Westermark, P. Pancreas (1997) [Pubmed]
  27. Vanadium and insulin increase adiponectin production in 3T3-L1 adipocytes. Seale, A.P., de Jesus, L.A., Park, M.C., Kim, Y.S. Pharmacol. Res. (2006) [Pubmed]
  28. Vanadium salts induce cytogenetic effects in in vivo treated mice. Ciranni, R., Antonetti, M., Migliore, L. Mutat. Res. (1995) [Pubmed]
  29. Improvement of diabetic states in streptozotocin-induced type 1 diabetic rats by vanadyl sulfate in enteric-coated capsules. Fugono, J., Yasui, H., Sakurai, H. J. Pharm. Pharmacol. (2005) [Pubmed]
  30. The effect of oral vanadyl sulfate on body composition and performance in weight-training athletes. Fawcett, J.P., Farquhar, S.J., Walker, R.J., Thou, T., Lowe, G., Goulding, A. International journal of sport nutrition. (1996) [Pubmed]
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