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Chemical Compound Review

His-pro-dkp     (3S,6S)-3-(3H-imidazol-4- ylmethyl)-1,4...

Synonyms: Cyclo(his-pro), HMDB02053, LS-174949, AC1L22OD, Cyclo(histidyl-prolyl), ...
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Disease relevance of His-pro-dkp


Psychiatry related information on His-pro-dkp


High impact information on His-pro-dkp


Chemical compound and disease context of His-pro-dkp

  • Insulin injection normalized blood glucose level and prevented an increase in cyclo(His-Pro) concentration after hyperglycemia [1].
  • Streptozocin-induced hyperglycemia caused a significant increase in cyclo(His-Pro) concentration in the striatum but not in the other brain regions, whereas TRH concentration in any brain region did not differ between control and hyperglycemic groups [1].
  • For example, a) acute pretreatment of rats with increasing amounts of cyclo(His-Pro) produces a progressive decrease in ethanol hypothermia, and b) chronic cyclo(His-Pro) administration augments the development of tolerance to hypothermic effects of alcohol [12].

Biological context of His-pro-dkp


Anatomical context of His-pro-dkp


Associations of His-pro-dkp with other chemical compounds


Gene context of His-pro-dkp


Analytical, diagnostic and therapeutic context of His-pro-dkp


  1. Cyclo(His-Pro) concentration. Changes in brain striatum of hyperglycemic rat. Mori, M., Iriuchijima, T., Yamada, M. Diabetes (1988) [Pubmed]
  2. Detection in human serum by radioimmunoassay of histidyl-proline diketopiperazine, a metabolite of thyrotropin-releasing hormone. Takahara, Y., Battaini, F., Ross, D.D., Akman, S.A., Bachur, N.R., Bailey, K.R., Lakatos, E., Peterkofsky, A. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  3. Amyotrophic lateral sclerosis: thyrotropin-releasing hormone and histidyl proline diketopiperazine in the spinal cord and cerebrospinal fluid. Jackson, I.M., Adelman, L.S., Munsat, T.L., Forte, S., Lechan, R.M. Neurology (1986) [Pubmed]
  4. Pyroglutamyl peptidase-II ("thyroliberinase") activity in human serum: influence of weight and thyroid status. Friedman, T.C., Yanovski, J.A., Jayasvasti, V., Yanovski, S.Z., Koenig, R.J., Wilk, S. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  5. Antagonism of ketamine-induced anesthesia and hypothermia by thyrotropin releasing hormone and cyclo(His-Pro). Bhargava, H.N. Neuropharmacology (1981) [Pubmed]
  6. Role of endogenous cyclo(His-Pro) in voluntary alcohol consumption by alcohol-preferring C57BL mice. Prasad, C. Peptides (2001) [Pubmed]
  7. Influence of thyrotropin releasing hormone and histidyl-proline diketopiperazine on spontaneous locomotor activity and analgesia induced by delta 9-tetrahydrocannabinol in the mouse. Bhargava, H.N., Matwyshyn, G.A. Eur. J. Pharmacol. (1980) [Pubmed]
  8. Histidyl proline diketopiperazine (Cyclo [His-Pro]) in eating disorders. Steiner, H., Wilber, J.F., Prasad, C., Rogers, D., Rosenkranz, R.T. Neuropeptides (1989) [Pubmed]
  9. Inhibition of prolactin secretion by histidyl-proline-diketopiperazine. Bauer, K., Gräf, K.J., Faivre-Bauman, A., Beier, S., Tixier-Vidal, A., Kleinkauf, H. Nature (1978) [Pubmed]
  10. Histidyl-proline diketopiperazine (His-Pro DKP) immunoreactivity is present in the glucagon-containing cells of the human fetal pancreas. Leduque, P., Jackson, I.M., Kervran, A., Aratan-Spire, S., Czernichow, P., Dubois, P.M. J. Clin. Invest. (1987) [Pubmed]
  11. Histidyl-proline diketopiperazine. Novel formation that does not originate from thyrotropin-releasing hormone. Miyashita, K., Murakami, M., Yamada, M., Iriuchijima, T., Mori, M. J. Biol. Chem. (1993) [Pubmed]
  12. Cyclo(His-Pro) and the development of tolerance to the hypothermic effect of ethanol. Prasad, C., Balasubramanian, P. Neuropeptides (1988) [Pubmed]
  13. Intraventricular administration of cyclo(His-Pro), a metabolite of thyrotropin-releasing hormone (TRH), decreases water intake in the rat. Ishihara, H., Mori, M., Kobayashi, I., Kobayashi, S. Proc. Soc. Exp. Biol. Med. (1985) [Pubmed]
  14. Effect of low intravenous doses of TRH, acid-TRH and cyclo(His-Pro) on cerebral and peripheral blood flows. Koskinen, L.O. Br. J. Pharmacol. (1986) [Pubmed]
  15. Properties of histidyl-proline diketopiperazine [cyclo(His-Pro)] binding sites in rat liver. Hirose, Y., Ogawa, N., Mori, A. Regul. Pept. (1985) [Pubmed]
  16. Histidyl-proline diketopiperazine decreases food intake in rats. Morley, J.E., Levine, A.S., Prasad, C. Brain Res. (1981) [Pubmed]
  17. The subcellular and organ distribution and natural form of histidyl-proline diketopiperazine in rat brain determined by a specific radioimmunoassay. Yanagisawa, T., Prasad, C., Peterkofsky, A. J. Biol. Chem. (1980) [Pubmed]
  18. Cyclo(His-Pro): its distribution, origin and function in the human. Prasad, C. Neuroscience and biobehavioral reviews. (1988) [Pubmed]
  19. Ontogeny of thyrotropin-releasing hormone and histidyl proline diketopiperazine in the rat central nervous system and pancreas. Lamberton, R.P., Lechan, R.M., Jackson, I.M. Endocrinology (1984) [Pubmed]
  20. Antinociceptive activity of TRH metabolites in the mouse. Reny-Palasse, V., Rips, R. Pain (1987) [Pubmed]
  21. Intraventricular administration of histidyl-proline-diketopiperazine [Cyclo(His-Pro)] suppresses prolactin secretion and synthesis: a possible role of Cyclo(His-Pro) as dopamine uptake blocker in rat hypothalamus. Jikihara, H., Ikegami, H., Koike, K., Wada, K., Morishige, K., Kurachi, H., Hirota, K., Miyake, A., Tanizawa, O. Endocrinology (1993) [Pubmed]
  22. Characterization and solubilization of cyclo(His-Pro) binding from rat liver membranes. Mori, M., Yamada, M., Iriuchijima, T., Murakami, M., Kobayashi, S. Proc. Soc. Exp. Biol. Med. (1989) [Pubmed]
  23. Antagonism of ethanol-induced decrease in rat brain cGMP concentration by histidyl-proline diketopiperazine, a thyrotropin releasing hormone metabolite. Yanagisawa, T., Prasad, C., Williams, J., Peterkofsky, A. Biochem. Biophys. Res. Commun. (1979) [Pubmed]
  24. Effects of thyrotropin-releasing hormone and its metabolites, Cyclo(His-Pro) and TRH-OH, on growth hormone and prolactin synthesis in primary cultured pituitary cells of the common carp, Cyprinus carpio. Kagabu, Y., Mishiba, T., Okino, T., Yanagisawa, T. Gen. Comp. Endocrinol. (1998) [Pubmed]
  25. Unresponsiveness of GH cells to cyclo(histidyl-proline), a metabolite of thyrotropin releasing hormone. Battaini, F., Dannies, P.S., Peterkofsky, A. Life Sci. (1984) [Pubmed]
  26. Lack of effect of histidyl-proline diketopiperazine on basal level and TRH-induced response of cytosolic calcium concentration in rat lactotrophs. Yamada, M., Izumi, S., Makino, T., Mori, M. Endocrinol. Jpn. (1991) [Pubmed]
  27. Neuropeptide-dopamine interactions. III. Cyclo(His-Pro) and persistence of dopaminergic supersensitivity on withdrawal from one year continuous neuroleptic treatment. Prasad, C. Schizophr. Res. (1988) [Pubmed]
  28. Histidyl-proline diketopiperazine suppresses prolactin secretion in human pituitary tumour cell cultures. Melmed, S., Carlson, H.E., Hershman, J.M. Clin. Endocrinol. (Oxf) (1982) [Pubmed]
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