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Chemical Compound Review

AR-1K3309     3-[(1-aminocarbonyl-2- phenyl...

Synonyms: LS-105731, AC1L1KB2, AC1Q5IW7
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Disease relevance of Gastrin tetrapeptide

  • With this treatment, the incidence of adenocarcinoma was similar to that of treatment with tetragastrin (1 mg/kg) [1].
  • Administration of cimetidine at 20 mg, but not 10 mg, per kg body weight with tetragastrin significantly reduced the gastric acid secretion induced by tetragastrin alone but did not influence the labeling index of the antral mucosa or the inhibitory effect of tetragastrin on gastric carcinogenesis [2].
  • However, concomitant administration of propranolol (2 mg/kg) and tetragastrin (0.2 mg/kg) caused a significant increase in gastric acid secretion and a reduction in the incidence of gastric carcinomas [1].
  • These findings suggest that the effect of tetragastrin in decreasing the incidences of erosions, ulcerations, and atypical regenerative glandular hyperplasias in the colonic mucosa during instillation of MNNG is related to its effect in reducing the development of colonic tumors [3].
  • At week 52, prolonged administration of tetragastrin alone resulted in a significant reduction in the incidence and number of gastric cancers and a significant increase or decrease in the labelling indices of the fundic and antral mucosae, respectively [4].

Psychiatry related information on Gastrin tetrapeptide


High impact information on Gastrin tetrapeptide


Chemical compound and disease context of Gastrin tetrapeptide


Biological context of Gastrin tetrapeptide


Anatomical context of Gastrin tetrapeptide


Associations of Gastrin tetrapeptide with other chemical compounds


Gene context of Gastrin tetrapeptide


Analytical, diagnostic and therapeutic context of Gastrin tetrapeptide


  1. Enhancement by propranolol of the inhibitory effect of tetragastrin on gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. Tatsuta, M., Iishi, H., Yamamura, H., Taniguchi, H. Cancer Res. (1987) [Pubmed]
  2. Effect of cimetidine on inhibition by tetragastrin of carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. Tatsuta, M., Iishi, H., Yamamura, H., Baba, M., Yamamoto, R., Taniguchi, H. Cancer Res. (1988) [Pubmed]
  3. Effect of tetragastrin on the colonic mucosa of rats during intrarectal administration of N-methyl-N'-nitro-N-nitrosoguanidine. Tatsuta, M., Iishi, H., Ichii, M., Noguchi, S., Yamamura, H., Taniguchi, H. Cancer Res. (1986) [Pubmed]
  4. Effect of ornithine decarboxylase inhibitor on tetragastrin treatment of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. Tatsuta, M., Iishi, H., Baba, M., Taniguchi, H. Int. J. Cancer (1990) [Pubmed]
  5. Induced panic attacks shift gamma-aminobutyric acid type A receptor modulatory neuroactive steroid composition in patients with panic disorder: preliminary results. Ströhle, A., Romeo, E., di Michele, F., Pasini, A., Hermann, B., Gajewsky, G., Holsboer, F., Rupprecht, R. Arch. Gen. Psychiatry (2003) [Pubmed]
  6. Behavioral and endocrine response to cholecystokinin tetrapeptide in patients with posttraumatic stress disorder. Kellner, M., Wiedemann, K., Yassouridis, A., Levengood, R., Guo, L.S., Holsboer, F., Yehuda, R. Biol. Psychiatry (2000) [Pubmed]
  7. Pentagastrin has panic-inducing properties in obsessive compulsive disorder. de Leeuw, A.S., Den Boer, J.A., Slaap, B.R., Westenberg, H.G. Psychopharmacology (Berl.) (1996) [Pubmed]
  8. In healthy volunteers responses to challenge with cholecystokinin tetrapeptide differ between administration during REM and delta sleep. Kronenberg, G., Schredl, M., Fiedler, K., Heuser, I. Depression and anxiety. (2001) [Pubmed]
  9. Complementary peptide to the carboxyl-terminal tetrapeptide of gastrin. McGuigan, J.E., Campbell-Thompson, M. Gastroenterology (1992) [Pubmed]
  10. Structure-activity relationships of gastrointestinal hormones: motilin, GIP, and [27-TYR]CCK-PZ. Yajima, H., Kai, Y., Ogawa, H., Kubota, M., Mori, Y. Gastroenterology (1977) [Pubmed]
  11. Anxiolyticlike effects of atrial natriuretic peptide on cholecystokinin tetrapeptide-induced panic attacks: preliminary findings. Wiedemann, K., Jahn, H., Yassouridis, A., Kellner, M. Arch. Gen. Psychiatry (2001) [Pubmed]
  12. Effect of 6-hydroxydopamine on gastric carcinogenesis and tetragastrin inhibition of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. Tatsuta, M., Iishi, H., Baba, M., Taniguchi, H. Cancer Res. (1989) [Pubmed]
  13. Influence of clonidine on psychopathological, endocrine and respiratory effects of cholecystokinin tetrapeptide in patients with panic disorder. Kellner, M., Yassouridis, A., Jahn, H., Wiedemann, K. Psychopharmacology (Berl.) (1997) [Pubmed]
  14. Tryptophan depletion does not modify response to CCK-4 challenge in patients with panic disorder after treatment with citalopram. Tõru, I., Shlik, J., Maron, E., Vasar, V., Nutt, D.J. Psychopharmacology (Berl.) (2006) [Pubmed]
  15. Randomized, double-blind study of SR142801 (Osanetant). A novel neurokinin-3 (NK3) receptor antagonist in panic disorder with pre- and posttreatment cholecystokinin tetrapeptide (CCK-4) challenges. Kronenberg, G., Berger, P., Tauber, R.F., Bandelow, B., Henkel, V., Heuser, I. Pharmacopsychiatry (2005) [Pubmed]
  16. Factors related to gastric hypersecretion during pregnancy and lactation in rats. Takeuchi, K., Okabe, S. Dig. Dis. Sci. (1984) [Pubmed]
  17. Effects of KW-5805, a new antiulcer agent, on experimental gastric and duodenal ulcers, gastric mucosal lesions by necrotizing agents and gastric acid secretion. Kosaka, N., Tanaka, H., Tomaru, A., Ishii, A., Shuto, K. Jpn. J. Pharmacol. (1994) [Pubmed]
  18. Effect of prolonged administration of gastrin on experimental carcinogenesis in rat colon induced by intrarectal instillation of N-methyl-N'-nitro-N-nitrosoguanidine. Tatsuta, M., Yamamura, H., Ichii, M., Taniguchi, H. Cancer Res. (1983) [Pubmed]
  19. The acute antipanic activity of aerobic exercise. Ströhle, A., Feller, C., Onken, M., Godemann, F., Heinz, A., Dimeo, F. The American journal of psychiatry. (2005) [Pubmed]
  20. The effect of cholecystokinin tetrapeptide on respiratory resistance in healthy volunteers. Shlik, J., Vasar, V., Aluoja, A., Kingisepp, P.H., Jagomägi, K., Vasar, E., Rägo, L., Bradwejn, J. Biol. Psychiatry (1997) [Pubmed]
  21. Effect of tetragastrin on azaserine-induced carcinogenesis in rat pancreas. Tatsuta, M., Iishi, H., Baba, M., Nakaizumi, A. Int. J. Cancer (1990) [Pubmed]
  22. Enhanced permeability of tetragastrin across the rat intestinal membrane and its reduced degradation by acylation with various fatty acids. Yodoya, E., Uemura, K., Tenma, T., Fujita, T., Murakami, M., Yamamoto, A., Muranishi, S. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  23. Chemical conversion of aspartyl peptides to isoaspartyl peptides. A method for generating new methyl-accepting substrates for the erythrocyte D-aspartyl/L-isoaspartyl protein methyltransferase. McFadden, P.N., Clarke, S. J. Biol. Chem. (1986) [Pubmed]
  24. Enhancement by tetragastrin of experimental induction of gastric epithelium in the duodenum. Tatsuta, M., Iishi, H., Yamamura, H., Yamamoto, R., Taniguchi, H. Gut (1989) [Pubmed]
  25. Cholesterol lowering and cerebrospinal fluid neurotransmitters: increased levels of the anxiogenic cholecystokinin-tetrapeptide during simvastatin administration to healthy male volunteers. Eriksson, M., Eklundh, T., Sjöberg, S., Angelin, B., Nordin, C. Biol. Psychiatry (1996) [Pubmed]
  26. Cimetidine partially blocks gastrin's activation of gastric mucosal guanylate cyclase. Vesely, D.L., Meiners, S.E. Endocrinology (1983) [Pubmed]
  27. Acute and chronic role of 5-HT3 neuronal system on behavioral and neuroendocrine changes induced by intravenous cholecystokinin tetrapeptide administration in humans. Dépôt, M., Caillé, G., Mukherjee, J., Katzman, M.A., Cadieux, A., Bradwejn, J. Neuropsychopharmacology (1999) [Pubmed]
  28. Vigabatrin decreases cholecystokinin-tetrapeptide (CCK-4) induced panic in healthy volunteers. Zwanzger, P., Baghai, T.C., Schuele, C., Ströhle, A., Padberg, F., Kathmann, N., Schwarz, M., Möller, H.J., Rupprecht, R. Neuropsychopharmacology (2001) [Pubmed]
  29. The cholecystokinin-B receptor antagonist CI-988 failed to affect CCK-4 induced symptoms in panic disorder patients. van Megen, H.J., Westenberg, H.G., den Boer, J.A., Slaap, B., van Es-Radhakishun, F., Pande, A.C. Psychopharmacology (Berl.) (1997) [Pubmed]
  30. CCK-8 excites substantia nigra dopaminergic neurons by increasing a cationic conductance. Wu, T., Wang, H.L. Neurosci. Lett. (1994) [Pubmed]
  31. Effects of glucagon, Neurotensin, and vasoactive intestinal polypeptide on somatostatin release from perifused rat hypothalamus. Shimatsu, A., Kato, Y., Matsushita, N., Katakami, H., Yanaihara, N., Imura, H. Endocrinology (1982) [Pubmed]
  32. Characterization of SNF 9007, a novel cholecystokinin/opoid ligand in mouse ileum in vitro: evidence for involvement of cholecystokininA and cholecystokininB receptors in regulation of ion transport. Rao, R.K., Levenson, S., Fang, S.N., Hruby, V.J., Yamamura, H.I., Porreca, F. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  33. Arginine-vasopressin and oxytocin response to cholecystokinin-tetrapeptide. Le Mellédo, J.M., Bradwejn, J., Koszycki, D., Bellavance, F., Bichet, D. Peptides (2001) [Pubmed]
  34. Functional neuroanatomy of CCK4-induced anxiety in normal healthy volunteers. Benkelfat, C., Bradwejn, J., Meyer, E., Ellenbogen, M., Milot, S., Gjedde, A., Evans, A. The American journal of psychiatry. (1995) [Pubmed]
  35. A new endoscopic method of gastric acid secretory testing. Iijima, K., Ohara, S., Sekine, H., Koike, T., Kubota, Y., Kato, K., Asaki, S., Toyota, T. Am. J. Gastroenterol. (1998) [Pubmed]
  36. Morphological studies on the translocation of tubulovesicular system toward the intracellular canaliculus during stimulation of the gastric parietal cell. Ogata, T., Yamasaki, Y. Microsc. Res. Tech. (2000) [Pubmed]
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