The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Boltage     1-(4-chlorophenyl)-4- (ethoxy...

Synonyms: Voltage, starlet, Pyraclofos, SureCN119518, CHEBI:38876, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of TIA 230

  • Mild acidosis (bath pH = 6.9-7.3) caused a reversible depression of the orthodromic population spike, an increase in the latency of hypoxic spreading depression-like depolarization (HSD), and a decrease in the magnitude of the associated negative Vo shift [1].
  • A few syndromes are mediated by antibodies; they include those resulting from dysfunction of the neuromuscular junction at the pre- or post-synaptic level (Lambert-Eaton myasthenic syndrome, myasthenia gravis) or ion channel dysfunction in the peripheral nervous system (i.e, Voltage-gated potassium channel and neuromyotonia) [2].
  • Molecular Template for a Voltage Sensor in a Novel K+ Channel. I. Identification and Functional Characterization of KvLm, a Voltage-gated K+ Channel from Listeria monocytogenes [3].
  • 1. Voltage-activated Ca2+ channel currents were recorded from cultured rat dorsal root ganglion (DRG) neurones using the whole-cell clamp technique with Ba2+ as the charge carrier [4].
  • 1. Voltage-clamp experiments were performed on single frog internodes after acute demyelination with lysolecithin [5].
 

High impact information on TIA 230

  • Propafenone preferentially blocks the rapidly activating component of delayed rectifier K+ current in guinea pig ventricular myocytes. Voltage-independent and time-dependent block of the slowly activating component [6].
  • The membrane of the myelinated axon expresses a rich repertoire of physiologically active molecules: (1) Voltage-sensitive NA+ channels are clustered at high density (approximately 1,000/microns 2) in the nodal axon membrane and are present at lower density (< 25/microns 2) in the internodal axon membrane under the myelin [7].
  • The Src Homology 3 Domain of the beta-Subunit of Voltage-gated Calcium Channels Promotes Endocytosis via Dynamin Interaction [8].
  • The S4-S5 Linker Directly Couples Voltage Sensor Movement to the Activation Gate in the Human Ether-a-go-go-related Gene (hERG) K+ Channel [9].
  • Mutant Analysis of the Shal (Kv4) Voltage-gated Fast Transient K+ Channel in Caenorhabditis elegans [10].
 

Chemical compound and disease context of TIA 230

 

Biological context of TIA 230

  • (b) Voltage-clamp experiments performed with both NaCl and TTX in the external CaCl2 solution revealed that the TTX-insensitive action potential does not involve a rise in gNa, whereas the experiments performed without TTX showed that the action potential is accompanied by a large rise in gNa [12].
  • CONCLUSIONS: Voltage-sensitive fluorescence resonance energy transfer already gives record-setting performance on single cells and will continue to be rationally improvable [13].
  • BACKGROUND: Voltage of the P300 component of event-related potentials (ERPs) has been proposed as a phenotypic marker of risk for alcoholism [14].
  • 5. Voltage pulses to negative membrane potentials were more effective in triggering Ca2+ release than pulses to positive potentials suggesting that the Ca(2+)-induced Ca2+ release was voltage dependent [15].
  • 6. Voltage-dependent kinetics of Mg2+ block were described using equations based on Eyring rate theory (Woodbury, 1971; Hille, 1984), where the coefficient for voltage dependence (delta) was 0.63 [16].
 

Anatomical context of TIA 230

  • Tyrosine Phosphatases {varepsilon} and {alpha} Perform Specific and Overlapping Functions in Regulation of Voltage-gated Potassium Channels in Schwann Cells [17].
  • Microinjection of connexin-30 cRNA into Xenopus oocytes induced formation of functional gap junction channels that gated somewhat asymmetrically in response to transjunctional voltage and at significantly lower voltage (Vo = +38 and -46 mV) than the closely homologous connexin-26 channels (Vo = 89 mV) [18].
  • In contrast, the mucosal addition of 0.1 mM amiloride to ascending colon decreased Vt by only 30% (p less than 0.02) and Isc by 43% (p less than 0.05), but had no significant effect on Rt [19].
  • The mucosal addition of 0.1 mM amiloride to descending colon totally abolished the transepithelial voltage (Vt) and short-circuit current (Isc), and significantly increased the total tissue resistance (Rt) by 19% (p less than 0.005) [19].
  • Na+ and K+ transport at basolateral membranes of epithelial cells. III. Voltage independence of basolateral membrane Na+ efflux [20].
 

Associations of TIA 230 with other chemical compounds

  • In PC12, expression of TNF-alpha mRNA, protein and TNF-alpha gene promoter activity was induced by co-stimulation with phorbol ester and either calcium ionophore A23187 or the L-type Voltage Gated Calcium Channel agonist Bay K 8644 [21].
  • The pretreatment of the renal tubule with 5 X 10(-5)M verapamil reduced the Vt stimulated with 200 microU/mliter AVP from 1.7 +/- 0.3 mV to 0.4 +/- 0.4 mV (N = 7, P less than 0.05) [22].
  • 5. Voltage ramps were used to examine effects of muscarine on currents over a range of membrane potentials [23].
  • 1. Sodium currents were measured under voltage-clamp conditions in Ranvier nodes of rat and frog nerve fibres at 20 degrees C. Voltage errors due to the resistance in series with the nodal membrane were minimized by reducing sodium currents with tetrodotoxin in the extracellular solutions [24].
  • 1. Voltage-gated whole-cell K+ currents have been investigated in olfactory bulb (OB) output (mitral/tufted) neurones from neonatal rats, which were retrogradely labelled by rhodamine or Fast Blue and identified after enzymatic dissociation [25].
 

Gene context of TIA 230

  • The main conclusions are as follows: (1) Voltage-dependent inhibition by Mg(2+)(o) of whole-cell NR1/2D receptor responses was at least 4-fold weaker than inhibition of NR1/2A receptor responses at all voltages tested [26].
  • The effects of NMU on IH were voltage-dependent, and NMU shifted the IH conductance-voltage relationship (V1/2) by about 10.8 mV and enhanced IH kinetics without changing the slope constant (k) [27].
  • Mitochondrial porin or VDAC (Voltage Dependent Anion selective Channels) was identified for the first time in 1976, on the basis of the evolutionary similarity between the gram negative and mitochondrial outer membranes [28].
  • Slo3 K+ Channels: Voltage and pH Dependence of Macroscopic Currents [29].
  • Both beta-AR subtypes modulated I(f) activation also in WKY: beta 1-AR shifted V1/2 by 16.0 +/- 1.4 mV (n = 15) and beta 2-AR by 4.2 +/- 1.1 mV (n = 7) [30].
 

Analytical, diagnostic and therapeutic context of TIA 230

  • Ion-selective microelectrodes were positioned in CA1 to record evoked field potentials, extracellular DC voltage (Vo), pHo, and [Ca2+]o. Orthodromic population spike amplitude was used as a measure of slice recovery 2 hr after reoxygenation [1].
  • METHODS: Voltage-gated currents were recorded using the patch-clamp technique on isolated human cones, and especially their voltage-gated Na+ currents were analyzed in detail [31].
  • Dependence of ion flow through channels on the density of fixed charges at the channel opening. Voltage control of inverse titration curves [32].
  • Most of the protocols for the recovery of ancient DNA from palaeontological specimens are time-consuming and tend to yield inconsistent polymerase chain reaction (PCR) results. "Voltage-induced release" is a novel and rapid approach for the extraction of ancient DNA [33].
  • 2. Voltage-clamp experiments combined with local or bath perfusion of the GABAA antagonist bicuculline methiodide (BMI), demonstrated that nRt is a site of GABAA-mediated postsynaptic inhibition that affects inhibitory output onto relay neurons [34].

References

  1. Mild acidosis delays hypoxic spreading depression and improves neuronal recovery in hippocampal slices. Tombaugh, G.C. J. Neurosci. (1994) [Pubmed]
  2. Paraneoplastic neurologic syndromes: pathogenesis and physiopathology. Dalmau, J., Gultekin, H.S., Posner, J.B. Brain Pathol. (1999) [Pubmed]
  3. Molecular Template for a Voltage Sensor in a Novel K+ Channel. I. Identification and Functional Characterization of KvLm, a Voltage-gated K+ Channel from Listeria monocytogenes. Santos, J.S., Lundby, A., Zazueta, C., Montal, M. J. Gen. Physiol. (2006) [Pubmed]
  4. Interaction between calcium channel ligands and guanine nucleotides in cultured rat sensory and sympathetic neurones. Dolphin, A.C., Scott, R.H. J. Physiol. (Lond.) (1989) [Pubmed]
  5. Properties of potassium and sodium channels in frog internode. Grissmer, S. J. Physiol. (Lond.) (1986) [Pubmed]
  6. Propafenone preferentially blocks the rapidly activating component of delayed rectifier K+ current in guinea pig ventricular myocytes. Voltage-independent and time-dependent block of the slowly activating component. Delpón, E., Valenzuela, C., Pérez, O., Casis, O., Tamargo, J. Circ. Res. (1995) [Pubmed]
  7. Molecular dissection of the myelinated axon. Waxman, S.G., Ritchie, J.M. Ann. Neurol. (1993) [Pubmed]
  8. The Src Homology 3 Domain of the beta-Subunit of Voltage-gated Calcium Channels Promotes Endocytosis via Dynamin Interaction. Gonzalez-Gutierrez, G., Miranda-Laferte, E., Neely, A., Hidalgo, P. J. Biol. Chem. (2007) [Pubmed]
  9. The S4-S5 Linker Directly Couples Voltage Sensor Movement to the Activation Gate in the Human Ether-a-go-go-related Gene (hERG) K+ Channel. Ferrer, T., Rupp, J., Piper, D.R., Tristani-Firouzi, M. J. Biol. Chem. (2006) [Pubmed]
  10. Mutant Analysis of the Shal (Kv4) Voltage-gated Fast Transient K+ Channel in Caenorhabditis elegans. Fawcett, G.L., Santi, C.M., Butler, A., Harris, T., Covarrubias, M., Salkoff, L. J. Biol. Chem. (2006) [Pubmed]
  11. Blue news: NTP binding properties of the blue-light sensitive YtvA protein from Bacillus subtilis. Buttani, V., Losi, A., Polverini, E., Gärtner, W. FEBS Lett. (2006) [Pubmed]
  12. Separation of the action potential into a Na-channel spike and a K-channel spike by tetrodotoxin and by tetraethylammonium ion in squid giant axons internally perfused with dilute Na-salt solutions. Inoue, I. J. Gen. Physiol. (1980) [Pubmed]
  13. Improved indicators of cell membrane potential that use fluorescence resonance energy transfer. González, J.E., Tsien, R.Y. Chem. Biol. (1997) [Pubmed]
  14. Visual P3a in male subjects at high risk for alcoholism. Rodríguez Holguín, S., Porjesz, B., Chorlian, D.B., Polich, J., Begleiter, H. Biol. Psychiatry (1999) [Pubmed]
  15. Regulation of the cytosolic Ca2+ concentration by Ca2+ stores in single smooth muscle cells from rat cerebral arteries. Kamishima, T., McCarron, J.G. J. Physiol. (Lond.) (1997) [Pubmed]
  16. Dual effects of intracellular magnesium on muscarinic potassium channel current in single guinea-pig atrial cells. Horie, M., Irisawa, H. J. Physiol. (Lond.) (1989) [Pubmed]
  17. Tyrosine Phosphatases {varepsilon} and {alpha} Perform Specific and Overlapping Functions in Regulation of Voltage-gated Potassium Channels in Schwann Cells. Tiran, Z., Peretz, A., Sines, T., Shinder, V., Sap, J., Attali, B., Elson, A. Mol. Biol. Cell (2006) [Pubmed]
  18. Molecular cloning and functional expression of mouse connexin-30,a gap junction gene highly expressed in adult brain and skin. Dahl, E., Manthey, D., Chen, Y., Schwarz, H.J., Chang, Y.S., Lalley, P.A., Nicholson, B.J., Willecke, K. J. Biol. Chem. (1996) [Pubmed]
  19. Electrophysiology of the human colon: evidence of segmental heterogeneity. Sandle, G.I., Wills, N.K., Alles, W., Binder, H.J. Gut (1986) [Pubmed]
  20. Na+ and K+ transport at basolateral membranes of epithelial cells. III. Voltage independence of basolateral membrane Na+ efflux. Cox, T.C., Helman, S.I. J. Gen. Physiol. (1986) [Pubmed]
  21. Calcium-dependent expression of TNF-alpha in neural cells is mediated by the calcineurin/NFAT pathway. Canellada, A., Cano, E., Sánchez-Ruiloba, L., Zafra, F., Redondo, J.M. Mol. Cell. Neurosci. (2006) [Pubmed]
  22. Modulation by verapamil of hormonal action on the Henle's loop of mice. Takeda, K., Torikai, S., Asano, Y., Imai, M. Kidney Int. (1986) [Pubmed]
  23. Effects of muscarine on single rat adrenal chromaffin cells. Neely, A., Lingle, C.J. J. Physiol. (Lond.) (1992) [Pubmed]
  24. A comparison of sodium currents in rat and frog myelinated nerve: normal and modified sodium inactivation. Neumcke, B., Schwarz, J.R., Stämpfli, R. J. Physiol. (Lond.) (1987) [Pubmed]
  25. Whole-cell K+ currents in identified olfactory bulb output neurones of rats. Wang, X.Y., McKenzie, J.S., Kemm, R.E. J. Physiol. (Lond.) (1996) [Pubmed]
  26. NR2 subunit-dependence of NMDA receptor channel block by external Mg2+. Qian, A., Buller, A.L., Johnson, J.W. J. Physiol. (Lond.) (2005) [Pubmed]
  27. Neuromedin U depolarizes rat hypothalamic paraventricular nucleus neurons in vitro by enhancing IH channel activity. Qiu, D.L., Chu, C.P., Shirasaka, T., Nabekura, T., Kunitake, T., Kato, K., Nakazato, M., Katoh, T., Kannan, H. J. Neurophysiol. (2003) [Pubmed]
  28. New functions of an old protein: the eukaryotic porin or voltage dependent anion selective channel (VDAC). De Pinto, V., Messina, A., Accardi, R., Aiello, R., Guarino, F., Tomasello, M.F., Tommasino, M., Tasco, G., Casadio, R., Benz, R., De Giorgi, F., Ichas, F., Baker, M., Lawen, A. Ital. J. Biochem. (2003) [Pubmed]
  29. Slo3 K+ Channels: Voltage and pH Dependence of Macroscopic Currents. Zhang, X., Zeng, X., Lingle, C.J. J. Gen. Physiol. (2006) [Pubmed]
  30. Modulation of the pacemaker current If by beta-adrenoceptor subtypes in ventricular myocytes isolated from hypertensive and normotensive rats. Cerbai, E., Pino, R., Rodriguez, M.L., Mugelli, A. Cardiovasc. Res. (1999) [Pubmed]
  31. Suppression by an h current of spontaneous Na+ action potentials in human cone and rod photoreceptors. Kawai, F., Horiguchi, M., Ichinose, H., Ohkuma, M., Isobe, R., Miyachi, E. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  32. Dependence of ion flow through channels on the density of fixed charges at the channel opening. Voltage control of inverse titration curves. Lindemann, B. Biophys. J. (1982) [Pubmed]
  33. Voltage-induced release of nucleic acids from palaeontological samples. Bachmann, L., Scholz, M., Broghammer, M., Giddings, I., Pusch, C.M. Electrophoresis (2000) [Pubmed]
  34. Clonazepam suppresses GABAB-mediated inhibition in thalamic relay neurons through effects in nucleus reticularis. Huguenard, J.R., Prince, D.A. J. Neurophysiol. (1994) [Pubmed]
 
WikiGenes - Universities