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Gene Review

MIR155HG  -  MIR155 host gene (non-protein coding)

Homo sapiens

Synonyms: BIC, MIRHG2, NCRNA00172
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Disease relevance of BIC

  • In a previous study we demonstrated high expression of the non-coding BIC gene in the vast majority of Hodgkin's lymphomas (HLs) [1].
  • High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma [2].
  • The last two BRCA2 genetic variants had not been reported in the Breast Cancer Information Core BIC database [3].
  • PATIENTS AND METHODS: Forty patients with stage IV primary or recurrent squamous cell carcinoma of the cervix (19 previously irradiated and 21 nonirradiated) were assigned to treatment with six cycles of BIC: bleomycin, 30 mg bolus on day 1; carboplatin, 200 mg/m2 bolus on day 1; and ifosfamide, 2g/m2 for 3 consecutive days, infused over 2 hours [4].
  • CONCLUSION: BIC can be administered on an outpatient basis and seems to be effective in inducing tumor response and palliation in patients with disseminated squamous cell carcinoma of cervix, with a possible survival benefit for previously nonirradiated patients, with an acceptable toxicity profile [4].

Psychiatry related information on BIC

  • Distinct patterns of Fos distribution were obtained following the freezing and escape reactions induced by MT injections of SMC and BIC, respectively [5].

High impact information on BIC

  • In addition, recent studies suggest the involvement of miRNAs in the initiation and progression of cancer. miR155 and BIC, its host gene, have been reported to accumulate in human B cell lymphomas, especially in diffuse large B cell lymphomas, Hodgkin lymphomas, and certain types of Burkitt lymphomas [6].
  • Similarly, the quantities of BIC RNA are elevated in lymphoma cells, but ratios of the amounts of the two RNAs are not constant, suggesting that the level of miR-155 is controlled by transcription and processing [7].
  • We show that the microRNA miR-155 can be processed from sequences present in BIC RNA, a spliced and polyadenylated but non-protein-coding RNA that accumulates in lymphoma cells [7].
  • To date, over 6300 mutations in BRCA1, involving 1100 distinct sites, have been described and reported in the BIC (breast cancer information core) database [8].
  • PURPOSE: A bleomycin, carboplatin, and ifosfamide (BIC) chemotherapy protocol was designed to evaluate tumor response and palliation in patients with advanced cervical cancer [4].

Chemical compound and disease context of BIC


Biological context of BIC

  • A higher proportion of tumour cells were positive for BIC in DLBCL with activated B cell-like phenotype than in DLBCL with germinal centre B cell-like phenotype [1].
  • BIC RT-PCR in the Burkitt lymphoma-derived cell line Ramos demonstrated a significant up-regulation upon cross-linking of the B-cell receptor (BcR) [12].
  • A BLAST search of the NCBI database revealed that the transcript shared identity with the recently reported human BIC proto-oncogene that encodes a noncoding mRNA (W. Tam, Gene 274 (2001) 157) [13].
  • In this review, we summarize behavioral, immunohistochemical (brain Fos distribution) and electrophysiological (auditory evoked potentials) data obtained with the reduction of GABA transmission by local injections of a GABA receptor blocker (bicuculline, BIC) or a glutamic acid decarboxylase inhibitor (semicarbazide, SMC) into the MT [5].
  • PMN cellular ATP levels and phagocytosis were significantly better in cells exposed to BIC 30 than to CAPD 3 at pH 7.4 (P = 0.043 for both) [14].

Anatomical context of BIC

  • BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas [1].
  • RNA in situ hybridization (ISH) indicated an exclusive nucleolar localization of BIC transcripts in all RS cells in 91% of HL cases, including nodular lymphocyte predominance (NLP) HL and classical HL [12].
  • In normal tissue, BIC is expressed weakly in a minority of germinal center B cells [12].
  • Analyses of normal human tissues revealed BIC transcripts in only a small number of CD20-positive B-cells in lymph node and tonsil tissue, albeit at a much lower level compared to that of RS cells [12].
  • T cell activation induces a noncoding RNA transcript sensitive to inhibition by immunosuppressant drugs and encoded by the proto-oncogene, BIC [13].

Associations of BIC with chemical compounds

  • Equilibrium constants for the binding of ethyl (EIC), n-butyl (BIC), p-toluenesulphonylmethyl (TMIC) and 2,6-dimethylphenyl isocyanides (DIMPI) to an imidazole-haem complex in toluene and aqueous detergent micelle solutions were determined [15].
  • Exposure of PMN to bicarbonate buffered PDF (BIC 20, 1.5% glucose and BIC 30, 4.25% glucose both at pH 7.2) had no significant effect on cell viability or the CL response [14].
  • Local iontophoretic application of antagonists to receptors for glycine (strychnine, STRY) and gamma-aminobutyric acid (GABA) (bicuculline, BIC) showed that STRY abolished facilitation in 96% of tested units, but BIC eliminated facilitation in only 28% [16].
  • BIC/MAN does not prevent RF, dialysis, or mortality in patients with creatine kinase levels greater than 5,000 U/L [9].
  • In a single air sample from a welding operation in a car repair shop, the highest concentrations found were: MIC, 290; EIC, 60; PIC, 20; BIC, 9; PhI, 27; HDI, 105; IPDI, 39; MDI, 4; and 2,4-TDI and 2,6-TDI 140 microg m(-3) [17].

Other interactions of BIC

  • IkappaBalpha-mediated blocking of NF-kappaB translocation in Ramos did not effect the up-regulation of BIC expression upon BcR triggering, suggesting that activation of NF-kappaB is not involved in regulation of BIC expression [12].
  • Using the BIC Database numbering, the most frequently found mutations in BRCA1 were c.5385dupC (22 cases), c.3819_3823delGTAAA (8 cases) and c.300T>G (6 cases) [18].
  • BIC (a lymphocyte activation marker gene) as well as IFN-gamma messages were also minimally induced by the infection in Molt-4 lymphocytes [19].
  • Several procedures for selecting the best-fit model of evolution for the data at hand have been proposed, like the likelihood ratio test (LRT) and the Akaike (AIC) and Bayesian (BIC) information criteria [20].
  • Pre-exposure of HPMC to CAPD 2, CAPD 3 or BIC 30 for 30 minutes resulted in a significant reduction in cellular ATP content compared to control medium [14].

Analytical, diagnostic and therapeutic context of BIC

  • Surface electromyography (EMG) signals were measured from the biceps brachii (BIC), the brachioradialis (BRD) and the triceps brachii (TRI) of seven young adults with pure spastic quadriplegia and eight normal individuals [21].
  • Measurements were performed during 1-RM testing and resistance exercise (20%, 40%, and 60% of 1-RM using 10 to 15 repetitions) on the one-arm biceps curl (BIC) and bilateral knee extension exercises and compared with measurements of left ventricular function during the symptom-limited graded exercise test (SL-GXT) [22].


  1. BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas. Kluiver, J., Poppema, S., de Jong, D., Blokzijl, T., Harms, G., Jacobs, S., Kroesen, B.J., van den Berg, A. J. Pathol. (2005) [Pubmed]
  2. High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma. Metzler, M., Wilda, M., Busch, K., Viehmann, S., Borkhardt, A. Genes Chromosomes Cancer (2004) [Pubmed]
  3. RNA-based analysis of BRCA1 and BRCA2 gene alterations. Bonatti, F., Pepe, C., Tancredi, M., Lombardi, G., Aretini, P., Sensi, E., Falaschi, E., Cipollini, G., Bevilacqua, G., Caligo, M.A. Cancer Genet. Cytogenet. (2006) [Pubmed]
  4. Phase II trial of bleomycin, ifosfamide, and carboplatin in metastatic cervical cancer. Murad, A.M., Triginelli, S.A., Ribalta, J.C. J. Clin. Oncol. (1994) [Pubmed]
  5. Gabaergic regulation of the neural organization of fear in the midbrain tectum. Brandão, M.L., Borelli, K.G., Nobre, M.J., Santos, J.M., Albrechet-Souza, L., Oliveira, A.R., Martinez, R.C. Neuroscience and biobehavioral reviews. (2005) [Pubmed]
  6. Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E{micro}-miR155 transgenic mice. Costinean, S., Zanesi, N., Pekarsky, Y., Tili, E., Volinia, S., Heerema, N., Croce, C.M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  7. Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Eis, P.S., Tam, W., Sun, L., Chadburn, A., Li, Z., Gomez, M.F., Lund, E., Dahlberg, J.E. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  8. Of mice and (wo)men: genotype-phenotype correlations in BRCA1. Hohenstein, P., Fodde, R. Hum. Mol. Genet. (2003) [Pubmed]
  9. Preventing renal failure in patients with rhabdomyolysis: do bicarbonate and mannitol make a difference? Brown, C.V., Rhee, P., Chan, L., Evans, K., Demetriades, D., Velmahos, G.C. The Journal of trauma. (2004) [Pubmed]
  10. Antiproliferative and apoptotic effects of rofecoxib on esophageal cancer in vitro(1). Vona-Davis, L., Riggs, D.R., Jackson, B.J., McFadden, D.W. J. Surg. Res. (2004) [Pubmed]
  11. Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cells. Kassis, E.S., Zhao, M., Hong, J.A., Chen, G.A., Nguyen, D.M., Schrump, D.S. J. Thorac. Cardiovasc. Surg. (2006) [Pubmed]
  12. High expression of B-cell receptor inducible gene BIC in all subtypes of Hodgkin lymphoma. van den Berg, A., Kroesen, B.J., Kooistra, K., de Jong, D., Briggs, J., Blokzijl, T., Jacobs, S., Kluiver, J., Diepstra, A., Maggio, E., Poppema, S. Genes Chromosomes Cancer (2003) [Pubmed]
  13. T cell activation induces a noncoding RNA transcript sensitive to inhibition by immunosuppressant drugs and encoded by the proto-oncogene, BIC. Haasch, D., Chen, Y.W., Reilly, R.M., Chiou, X.G., Koterski, S., Smith, M.L., Kroeger, P., McWeeny, K., Halbert, D.N., Mollison, K.W., Djuric, S.W., Trevillyan, J.M. Cell. Immunol. (2002) [Pubmed]
  14. Biocompatibility of bicarbonate buffered peritoneal dialysis fluids: influence on mesothelial cell and neutrophil function. Topley, N., Kaur, D., Petersen, M.M., Jörres, A., Passlick-Deetjen, J., Coles, G.A., Williams, J.D. Kidney Int. (1996) [Pubmed]
  15. Alkyl and aromatic isocyanide binding to haem complexes. Patel, M.J., Kassner, R.J. Biochem. J. (1989) [Pubmed]
  16. Roles of inhibition in creating complex auditory responses in the inferior colliculus: facilitated combination-sensitive neurons. Nataraj, K., Wenstrup, J.J. J. Neurophysiol. (2005) [Pubmed]
  17. Airborne thermal degradation products of polyurethene coatings in car repair shops. Karlsson, D., Spanne, M., Dalene, M., Skarping, G. Journal of environmental monitoring : JEM. (2000) [Pubmed]
  18. BRCA1 and BRCA2 mutations in women with familial or early-onset breast/ovarian cancer in the Czech Republic. Foretova, L., Machackova, E., Navratilova, M., Pavlu, H., Hruba, M., Lukesova, M., Valik, D. Hum. Mutat. (2004) [Pubmed]
  19. Cytokine response of lymphocytes persistently infected with Chlamydia pneumoniae. Takano, R., Yamaguchi, H., Sugimoto, S., Nakamura, S., Friedman, H., Yamamoto, Y. Curr. Microbiol. (2005) [Pubmed]
  20. The effect of branch length variation on the selection of models of molecular evolution. Posada, D. J. Mol. Evol. (2001) [Pubmed]
  21. EMG analysis of voluntary elbow movements in subjects with spasticity. Feng, C.J., Mak, A.F. Electromyography and clinical neurophysiology. (1998) [Pubmed]
  22. Left ventricular function during strength testing and resistance exercise in patients with left ventricular dysfunction. Werber-Zion, G., Goldhammer, E., Shaar, A., Pollock, M.L. Journal of cardiopulmonary rehabilitation. (2004) [Pubmed]
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