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MeSH Review

Hypothalamic Area, Lateral

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Disease relevance of Hypothalamic Area, Lateral


Psychiatry related information on Hypothalamic Area, Lateral


High impact information on Hypothalamic Area, Lateral


Chemical compound and disease context of Hypothalamic Area, Lateral


Biological context of Hypothalamic Area, Lateral


Anatomical context of Hypothalamic Area, Lateral


Associations of Hypothalamic Area, Lateral with chemical compounds

  • Studied here were influences on coupling of another monosynaptic input to SON, the histaminergic tuberomammillary nucleus (TM) projection, activation of which selectively excites phasically firing (putative vasopressin) cells [28].
  • In the coronal plane, presynaptic inhibitory sites were located lateral to the PVN and ventral to the fornix, corresponding to the lateral hypothalamic area and the posterior bed nucleus of the stria terminalis (BNST) [29].
  • The lateral hypothalamic area (LHA) contains glucose-sensitive neurons (GSNs) and orexin neurons, both of which are stimulated by falling blood glucose and are implicated in hypoglycemia-induced feeding [30].
  • In urethane-anesthetized rats, CGS21680 inhibited histamine release in both the frontal cortex and medial pre-optic area in a dose-dependent manner, and increased GABA release specifically in the histaminergic tuberomammillary nucleus but not in the frontal cortex [31].
  • These results suggest that the A(2A)R agonist induced sleep by inhibiting the histaminergic system through increasing GABA release in the tuberomammillary nucleus [31].

Gene context of Hypothalamic Area, Lateral


Analytical, diagnostic and therapeutic context of Hypothalamic Area, Lateral


  1. The region of the pontine parabrachial nucleus is a major target of dehydration-sensitive CRH neurons in the rat lateral hypothalamic area. Kelly, A.B., Watts, A.G. J. Comp. Neurol. (1998) [Pubmed]
  2. Thyroid status regulates CART but not AgRP mRNA levels in the rat hypothalamus. López, M., Seoane, L., Tovar, S., Señarís, R.M., Diéguez, C. Neuroreport (2002) [Pubmed]
  3. An interaction between glucose and estrogen in gastric acid secretion in the lateral hypothalamic area of female rats. Sakaguchi, T., Sandoh, N., Aono, T., Ohtake, M. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1994) [Pubmed]
  4. The effect of dexamethasone on neuropeptide Y concentrations in specific hypothalamic regions. McKibbin, P.E., Cotton, S.J., McCarthy, H.D., Williams, G. Life Sci. (1992) [Pubmed]
  5. Hypothalamic dopamine and serotonin in the regulation of food intake. Meguid, M.M., Fetissov, S.O., Varma, M., Sato, T., Zhang, L., Laviano, A., Rossi-Fanelli, F. Nutrition (Burbank, Los Angeles County, Calif.) (2000) [Pubmed]
  6. Extracellular serotonin in the lateral hypothalamic area is increased during the postejaculatory interval and impairs copulation in male rats. Lorrain, D.S., Matuszewich, L., Friedman, R.D., Hull, E.M. J. Neurosci. (1997) [Pubmed]
  7. Wakefulness-inducing effects of histamine in the basal forebrain of freely moving rats. Ramesh, V., Thakkar, M.M., Strecker, R.E., Basheer, R., McCarley, R.W. Behav. Brain Res. (2004) [Pubmed]
  8. The tuberomammillary nucleus region as a reinforcement inhibiting substrate: facilitation of ipsihypothalamic self-stimulation by unilateral ibotenic acid lesions. Wagner, U., Segura-Torres, P., Weiler, T., Huston, J.P. Brain Res. (1993) [Pubmed]
  9. Forebrain activation in REM sleep: an FDG PET study. Nofzinger, E.A., Mintun, M.A., Wiseman, M., Kupfer, D.J., Moore, R.Y. Brain Res. (1997) [Pubmed]
  10. Clonidine and phenylephrine injected into the lateral hypothalamus inhibits water intake in rats. Ferrari, A.C., Camargo, L.A., Saad, W.A., Renzi, A., De Luca Junior, L.A., Menani, J.V. Brain Res. (1990) [Pubmed]
  11. The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway. Nelson, L.E., Guo, T.Z., Lu, J., Saper, C.B., Franks, N.P., Maze, M. Nat. Neurosci. (2002) [Pubmed]
  12. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Elias, C.F., Aschkenasi, C., Lee, C., Kelly, J., Ahima, R.S., Bjorbaek, C., Flier, J.S., Saper, C.B., Elmquist, J.K. Neuron (1999) [Pubmed]
  13. Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep. Mizoguchi, A., Eguchi, N., Kimura, K., Kiyohara, Y., Qu, W.M., Huang, Z.L., Mochizuki, T., Lazarus, M., Kobayashi, T., Kaneko, T., Narumiya, S., Urade, Y., Hayaishi, O. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  14. Arousal effect of orexin A depends on activation of the histaminergic system. Huang, Z.L., Qu, W.M., Li, W.D., Mochizuki, T., Eguchi, N., Watanabe, T., Urade, Y., Hayaishi, O. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  15. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. de Lecea, L., Kilduff, T.S., Peyron, C., Gao, X., Foye, P.E., Danielson, P.E., Fukuhara, C., Battenberg, E.L., Gautvik, V.T., Bartlett, F.S., Frankel, W.N., van den Pol, A.N., Bloom, F.E., Gautvik, K.M., Sutcliffe, J.G. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  16. Feeding behavior elicited by electrical stimulation of the lateral hypothalamic area in the rat: role of the adrenergic pathways and receptors. Homrich, J.G., Gentil, C.G., Peres-Polon, V.L., Covian, M.R. Braz. J. Med. Biol. Res. (1985) [Pubmed]
  17. Gastric damage and body weight loss in LHA-lesioned rats: effects of cytoprotective geranylgeranylacetone. Namiki, T., Egawa, M., Inoue, S., Tominaga, S., Takamura, Y. Am. J. Physiol. (1994) [Pubmed]
  18. Sex difference in the response of melanin-concentrating hormone neurons in the lateral hypothalamic area to glucose, as revealed by the expression of phosphorylated cyclic adenosine 3',5'-monophosphate response element-binding protein. Mogi, K., Funabashi, T., Mitsushima, D., Hagiwara, H., Kimura, F. Endocrinology (2005) [Pubmed]
  19. Evidence for the involvement of histaminergic neurones in the regulation of the rat oxytocinergic system during pregnancy and parturition. Luckman, S.M., Larsen, P.J. J. Physiol. (Lond.) (1997) [Pubmed]
  20. Lateral hypothalamus: early developmental expression and response to hypocretin (orexin). Van Den Pol, A.N., Patrylo, P.R., Ghosh, P.K., Gao, X.B. J. Comp. Neurol. (2001) [Pubmed]
  21. Ibotenic acid lesions of the lateral hypothalamus: comparison with the electrolytic lesion syndrome. Winn, P., Tarbuck, A., Dunnett, S.B. Neuroscience (1984) [Pubmed]
  22. Activation of lateral hypothalamic neurons stimulates brown adipose tissue thermogenesis. Cerri, M., Morrison, S.F. Neuroscience (2005) [Pubmed]
  23. Glucoregulatory effects of intrahypothalamic injections of bombesin and other peptides. Iguchi, A., Matsunaga, H., Nomura, T., Gotoh, M., Sakamoto, N. Endocrinology (1984) [Pubmed]
  24. Thyroidectomy induces Fos-like immunoreactivity within thyrotropin-releasing hormone-expressing neurons located in the paraventricular nucleus of the adult rat hypothalamus. Koibuchi, N., Gibbs, R.B., Suzuki, M., Pfaff, D.W. Endocrinology (1991) [Pubmed]
  25. Amplification of rewarding hypothalamic stimulation following a unilateral lesion in the region of the tuberomammillary nucleus. Wagner, U., Weiler, H.T., Huston, J.P. Neuroscience (1993) [Pubmed]
  26. Localization of quinolinic acid metabolizing enzymes in the rat brain. Immunohistochemical studies using antibodies to 3-hydroxyanthranilic acid oxygenase and quinolinic acid phosphoribosyltransferase. Köhler, C., Eriksson, L.G., Okuno, E., Schwarcz, R. Neuroscience (1988) [Pubmed]
  27. Plasma membrane and vesicular glutamate transporter mRNAs/proteins in hypothalamic neurons that regulate body weight. Collin, M., Bäckberg, M., Ovesjö, M.L., Fisone, G., Edwards, R.H., Fujiyama, F., Meister, B. Eur. J. Neurosci. (2003) [Pubmed]
  28. Synaptically released histamine increases dye coupling among vasopressinergic neurons of the supraoptic nucleus: mediation by H1 receptors and cyclic nucleotides. Hatton, G.I., Yang, Q.Z. J. Neurosci. (1996) [Pubmed]
  29. Physiological mapping of local inhibitory inputs to the hypothalamic paraventricular nucleus. Boudaba, C., Szabó, K., Tasker, J.G. J. Neurosci. (1996) [Pubmed]
  30. Orexin a preferentially excites glucose-sensitive neurons in the lateral hypothalamus of the rat in vitro. Liu, X.H., Morris, R., Spiller, D., White, M., Williams, G. Diabetes (2001) [Pubmed]
  31. An adenosine A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats. Hong, Z.Y., Huang, Z.L., Qu, W.M., Eguchi, N., Urade, Y., Hayaishi, O. J. Neurochem. (2005) [Pubmed]
  32. Characterization of expression of hypothalamic appetite-regulating peptides in obese hyperleptinemic brown adipose tissue-deficient (uncoupling protein-promoter-driven diphtheria toxin A) mice. Tritos, N.A., Elmquist, J.K., Mastaitis, J.W., Flier, J.S., Maratos-Flier, E. Endocrinology (1998) [Pubmed]
  33. Highly regionalized neuronal expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) in rat brain: Evidence for its colocalization with neurotransmitters and neuropeptides. Banisadr, G., Gosselin, R.D., Mechighel, P., Kitabgi, P., Rostène, W., Parsadaniantz, S.M. J. Comp. Neurol. (2005) [Pubmed]
  34. Opioid precursor gene expression in the human hypothalamus. Sukhov, R.R., Walker, L.C., Rance, N.E., Price, D.L., Young, W.S. J. Comp. Neurol. (1995) [Pubmed]
  35. The hypothalamus and the regulation of energy homeostasis: lifting the lid on a black box. Williams, G., Harrold, J.A., Cutler, D.J. The Proceedings of the Nutrition Society. (2000) [Pubmed]
  36. Brainstem afferents to the tuberomammillary nucleus in the rat brain with special reference to monoaminergic innervation. Ericson, H., Blomqvist, A., Köhler, C. J. Comp. Neurol. (1989) [Pubmed]
  37. Histaminergic modulation of hippocampal acetylcholine release in vivo. Mochizuki, T., Okakura-Mochizuki, K., Horii, A., Yamamoto, Y., Yamatodani, A. J. Neurochem. (1994) [Pubmed]
  38. Functional and anatomical organization of cardiovascular pressor and depressor sites in the lateral hypothalamic area. II. Ascending projections. Allen, G.V., Cechetto, D.F. J. Comp. Neurol. (1993) [Pubmed]
  39. Complex effects of stromal cell-derived factor-1 alpha on melanin-concentrating hormone neuron excitability. Guyon, A., Banisadr, G., Rovère, C., Cervantes, A., Kitabgi, P., Melik-Parsadaniantz, S., Nahon, J.L. Eur. J. Neurosci. (2005) [Pubmed]
  40. GABA-like immunoreactivity in the tuberomammillary nucleus: an electron microscopic study in the rat. Ericson, H., Köhler, C., Blomqvist, A. J. Comp. Neurol. (1991) [Pubmed]
  41. Enterostatin increases extracellular serotonin and dopamine in the lateral hypothalamic area in rats measured by in vivo microdialysis. Koizumi, M., Kimura, S. Neurosci. Lett. (2002) [Pubmed]
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