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Gene Review

Ass1  -  argininosuccinate synthase 1

Rattus norvegicus

Synonyms: ASSA, Argininosuccinate synthase, Ass, Citrulline--aspartate ligase
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Disease relevance of Ass


Psychiatry related information on Ass

  • From the three common alleles (epsilon2, epsilon3 and epsilon4), epsilon4 has been suggested to promote amyloid beta (Ass) plaque fibrillation, one hallmark of Alzheimer's disease [6].

High impact information on Ass


Chemical compound and disease context of Ass


Biological context of Ass


Anatomical context of Ass


Associations of Ass with chemical compounds


Regulatory relationships of Ass


Other interactions of Ass


Analytical, diagnostic and therapeutic context of Ass


  1. beta-Amyloid precursor protein and ss-amyloid peptide immunoreactivity in the rat brain after middle cerebral artery occlusion: effect of age. Popa-Wagner, A., Schröder, E., Walker, L.C., Kessler, C. Stroke (1998) [Pubmed]
  2. Regulation of glucocorticoids of arginase and argininosuccinate synthetase in cultured rat hepatoma cells. Haggerty, D.F., Spector, E.B., Lynch, M., Kern, R., Frank, L.B., Cederbaum, S.D. J. Biol. Chem. (1982) [Pubmed]
  3. Regulation of diaphragmatic nitric oxide synthase expression during hypobaric hypoxia. Javeshghani, D., Sakkal, D., Mori, M., Hussain, S.N. Am. J. Physiol. Lung Cell Mol. Physiol. (2000) [Pubmed]
  4. Hyperammonemia: regulation of argininosuccinate synthetase and argininosuccinate lyase genes in aggregating cell cultures of fetal rat brain. Braissant, O., Honegger, P., Loup, M., Iwase, K., Takiguchi, M., Bachmann, C. Neurosci. Lett. (1999) [Pubmed]
  5. Citrulline-argininosuccinate-arginine cycle coupled to Ca2+-signaling in rat pancreatic beta-cells. Nakata, M., Yada, T., Nakagawa, S., Kobayashi, K., Maruyama, I. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  6. Implication of apoE isoforms in cholesterol metabolism by primary rat hippocampal neurons and astrocytes. Rapp, A., Gmeiner, B., Hüttinger, M. Biochimie (2006) [Pubmed]
  7. Coinduction of nitric oxide synthase, argininosuccinate synthetase, and argininosuccinate lyase in lipopolysaccharide-treated rats. RNA blot, immunoblot, and immunohistochemical analyses. Nagasaki, A., Gotoh, T., Takeya, M., Yu, Y., Takiguchi, M., Matsuzaki, H., Takatsuki, K., Mori, M. J. Biol. Chem. (1996) [Pubmed]
  8. Glucocorticoids regulate inducible nitric oxide synthase by inhibiting tetrahydrobiopterin synthesis and L-arginine transport. Simmons, W.W., Ungureanu-Longrois, D., Smith, G.K., Smith, T.W., Kelly, R.A. J. Biol. Chem. (1996) [Pubmed]
  9. Argininosuccinate synthetase mRNA and activity are induced by immunostimulants in vascular smooth muscle. Role in the regeneration or arginine for nitric oxide synthesis. Hattori, Y., Campbell, E.B., Gross, S.S. J. Biol. Chem. (1994) [Pubmed]
  10. Channeling of urea cycle intermediates in situ in permeabilized hepatocytes. Cheung, C.W., Cohen, N.S., Raijman, L. J. Biol. Chem. (1989) [Pubmed]
  11. Citrulline and ammonia accumulating in citrullinemia reduces antioxidant capacity of rat brain in vitro. Prestes, C.C., Sgaravatti, A.M., Pederzolli, C.D., Sgarbi, M.B., Zorzi, G.K., Wannmacher, C.M., Wajner, M., Wyse, A.T., Dutra Filho, C.S. Metabolic brain disease. (2006) [Pubmed]
  12. Preparation of recombinant argininosuccinate synthetase and argininosuccinate lyase: expression of the enzymes in rat tissues. Yu, Y., Terada, K., Nagasaki, A., Takiguchi, M., Mori, M. J. Biochem. (1995) [Pubmed]
  13. Nucleotide sequence of the cDNA encoding the rat argininosuccinate synthetase. Surh, L.C., Morris, S.M., O'Brien, W.E., Beaudet, A.L. Nucleic Acids Res. (1988) [Pubmed]
  14. Role of dexamethasone and insulin on the development of the five urea-cycle enzymes in cultured rat foetal hepatocytes. Husson, A., Bouazza, M., Buquet, C., Vaillant, R. Biochem. J. (1985) [Pubmed]
  15. Circadian rhythms of urea formation and argininosuccinate synthetase activity in rat liver. Kato, H., Mizutani-Funahashi, M., Shiosaka, S., Nakagawa, H. J. Nutr. (1978) [Pubmed]
  16. Induction of argininosuccinate synthetase in rat brain glial cells after striatal microinjection of immunostimulants. Heneka, M.T., Schmidlin, A., Wiesinger, H. J. Cereb. Blood Flow Metab. (1999) [Pubmed]
  17. Hormonal regulation of two urea-cycle enzymes in cultured foetal hepatocytes. Husson, A., Bouazza, M., Buquet, C., Vaillant, R. Biochem. J. (1983) [Pubmed]
  18. Argininosuccinate synthetase: localization in astrocytes and role in the production of glial nitric oxide. Schmidlin, A., Wiesinger, H. Glia (1998) [Pubmed]
  19. Inhibition of urea-cycle activity by high concentrations of alanine. Hensgens, H.E., Meijer, A.J. Biochem. J. (1980) [Pubmed]
  20. pH dependence of hormonal regulation of gluconeogenesis and urea synthesis from glutamine in suspensions of hepatocytes. Kashiwagura, T., Erecińska, M., Wilson, D.F. J. Biol. Chem. (1985) [Pubmed]
  21. Molecular cloning of cDNA for rat and human carbamyl phosphate synthetase I. Adcock, M.W., O'Brien, W.E. J. Biol. Chem. (1984) [Pubmed]
  22. Effects of pancreatic hormones and glucocorticosteroids on argininosuccinate synthetase and argininosuccinase activities of rat liver during the perinatal period: in vivo and in vitro studies. Husson, A., Guechairi, M., Fairand, A., Bouazza, M., Ktorza, A., Vaillant, R. Endocrinology (1986) [Pubmed]
  23. Amino acid metabolism and protein synthesis in lactating rats fed on a liquid diet. Barber, T., García de la Asunción, J., Puertes, I.R., Viña, J.R. Biochem. J. (1990) [Pubmed]
  24. Expression of liver functions following sub-lethal and non-lethal doses of allyl alcohol and acetaminophen in the rat. Tygstrup, N., Jensen, S.A., Krog, B., Dalhoff, K. J. Hepatol. (1997) [Pubmed]
  25. Insulin antagonism of dexamethasone-induced increase or argininosuccinate synthetase and argininosuccinate lyase activities in cultured fetal rat liver. Räihä, N.C., Edkins, E. Biol. Neonate (1977) [Pubmed]
  26. Glutamine and regulation of gene expression in rat hepatocytes: the role of cell swelling. Lavoinne, A., Meisse, D., Quillard, M., Husson, A., Renouf, S., Yassad, A. Biochimie (1998) [Pubmed]
  27. Hormonal regulation of three urea cycle enzymes in rat fetal liver. Husson, A., Vaillant, R. Biol. Neonate (1979) [Pubmed]
  28. Adaptations in protein metabolism during lactation in the rat. Naismith, D.J., Robinson, S.M. Br. J. Nutr. (1987) [Pubmed]
  29. NADPH-diaphorase and cytosolic urea cycle enzymes in the rat accessory olfactory bulb. Nakamura, H., Itoh, K., Kawabuchi, M. J. Chem. Neuroanat. (1999) [Pubmed]
  30. Different levels of gene realization in the diurnal control of rat liver enzymes. Hoffmann, J., Hardeland, R. Arch. Int. Physiol. Biochim. (1981) [Pubmed]
  31. Arginine-metabolizing enzymes in the developing rat small intestine. De Jonge, W.J., Dingemanse, M.A., de Boer, P.A., Lamers, W.H., Moorman, A.F. Pediatr. Res. (1998) [Pubmed]
  32. Crystallization and some properties of argininosuccinate synthase from rat liver. Saheki, T., Kusumi, T., Takada, S., Katsunuma, T., Katunuma, N. FEBS Lett. (1975) [Pubmed]
  33. Inability of rat alveolar macrophages to recycle L-citrulline to L-arginine despite induction of argininosuccinate synthetase mRNA and protein, and inhibition of nitric oxide synthesis by exogenous L-citrulline. Hammermann, R., Bliesener, N., Mössner, J., Klasen, S., Wiesinger, H., Wessler, I., Racké, K. Naunyn Schmiedebergs Arch. Pharmacol. (1998) [Pubmed]
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