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Gene Review

BCAM  -  basal cell adhesion molecule (Lutheran...

Homo sapiens

Synonyms: AU, Auberger B antigen, B-CAM cell surface glycoprotein, Basal cell adhesion molecule, CD239, ...
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Disease relevance of BCAM

  • We have now analyzed laminin binding to murine erythroleukemia cells transfected with various human B-CAM/LU constructs [1].
  • A non-productive, persistent human cytomegalovirus (CMV) infection was developed in human embryo lung (LU) cells by initially using supraoptimal temperatures to restrict the replication of a recent CMB isolate (76-24) [2].
  • The size variable region of EIAV and BIV SU glycoproteins was examined and an AU-rich region and regions of nucleotide sequence identity that may facilitate template switching/strand transfer were identified [3].
  • AU primary lung adenocarcinomas were CK7(+), CK20(-) [4].
  • Acute renal failure due to myoglobinuria, contrast dye, and aminoglycoside toxicity were all associated with urinary ABP greater than 1.0 AU [5].

High impact information on BCAM


Chemical compound and disease context of BCAM


Biological context of BCAM

  • BCAM sterile. "A lesson in asepsis" [10].
  • The LU gene is organized into 15 exons distributed over 12.5 kb [11].
  • We have previously shown that the Lu and B-CAM antigens are encoded by the same gene, LU, and that alternative splicing of the primary transcript most likely accounts for the presence of both antigens on two isoforms that differ by the length of their cytoplasmic tails [11].
  • In the present report, we showed by Southern blot analysis that the Lu and B-CAM cDNAs derived from a unique LU gene which exhibited an HindIII RFLP associated with the Lua/Lub blood group polymorphism [12].
  • In agreement with the wide tissue distribution of the Lu messengers, the GC-rich proximal 5' flanking region of the LU gene does not contain TATA or CAAT boxes, but includes several potential binding sites for the ubiquitous Sp1 transcription factor [11].

Anatomical context of BCAM

  • These spliceoforms corresponded to 2.5 kb and 4.0 kb mRNA species detectable by Northern blot in all tissues and cell lines in which the LU gene is expressed; their primary structures are consistent with the presence of both the Lu and B-CAM antigens on two glycoprotein isoforms [12].
  • Red blood cells from patients with sickle cell disease (SS RBC) adhere to laminin and over-express the high-affinity laminin receptor basal cell adhesion molecule/Lutheran protein (B-CAM/LU) [13].
  • We have identified 43/45 kDa proteins from chick enterocytes and show evidence for their involvement in auxiliary editing activity. p43/45 demonstrates preferential binding to AU-rich RNA and to the Caauuug motif that forms the loop and proximal stem of the apoB mRNA [14].
  • In this study, the mechanisms responsible for the decrease in p21cip1 levels after HCMV infection were investigated by measuring p21cip1 RNA and protein levels in permissive human lung (LU) fibroblasts after HCMV infection [15].
  • Expression of the early lymphocyte activation antigen CD69, a C-type lectin, is regulated by mRNA degradation associated with AU-rich sequence motifs [16].

Associations of BCAM with chemical compounds

  • Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion [8].
  • The chromosome 19 linkage group LDLR, C3, LW, APOC2, LU, SE in man [17].
  • Cyclohexamide applied either at the morula or at the early blastula stages reduced the intensity of the AU-binding factors, while actinomycin D did not, indicating that the levels of these factors during these stages are regulated posttranscriptionally [18].
  • In left ventricular tissue homogenates, spontaneous superoxide generation measured by lucigenin (5 microM) chemiluminescence was markedly increased in heart failure (1338 +/- 419 vs. 419 +/- 102 AU/mg protein, P < 0.05), as were NADPH levels (15.4 +/- 1.5 vs. 7.5 +/- 1.5 micromol/gww, P < 0.05) [19].
  • Following heat inactivation or serum neutralization of HCMV stock or in the presence of papaverine we failed to detect increased levels of IP3 and DG relative to mock-infected LU cultures [9].

Other interactions of BCAM

  • The loci constitute two tightly linked gene clusters, LDLR, C3, LW and APOC2, LU, SE, distinguished by measurable linkage in female meioses within but not between clusters [17].
  • Epinephrine-stimulated adhesion to laminin, mediated primarily via the beta 2-adrenergic receptor, occurred in SS RBC samples from 46% of patients and was blocked by recombinant, soluble BCAM/Lu, implicating this receptor as a target of cAMP signaling [8].

Analytical, diagnostic and therapeutic context of BCAM

  • Sequence comparison between cDNA and genomic PCR fragments indicated that the Lu and B-CAM transcripts previously isolated are generated through the alternative use of internal splice donor and acceptor sites within an exon located at the 3' end of the LU gene [12].
  • Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily [20].
  • Although the LU-76-24 cells were morphologically distinct from LU cell cultures carried in parallel as controls, the LU-76-24 were contact-inhibited in spite of a somewhat disoriented growth pattern [2].
  • The expression of fibrinogen receptor (glycoprotein IIb/IIIa) on platelets, measured by flow-cytometry was also reduced after iloprost treatment (17.1+/-1.5 vs 31.8+/-4.8 AU; p<0.05) and physical exercise (14.6+/-1.5 vs 34.0+/-3.3; p<0.05) [21].


  1. Critical factors in basal cell adhesion molecule/lutheran-mediated adhesion to laminin. Zen, Q., Cottman, M., Truskey, G., Fraser, R., Telen, M.J. J. Biol. Chem. (1999) [Pubmed]
  2. Characterization of human cells persistently infected with cytomegalovirus and exposed to a chemical carcinogen. Li, J.L., Albrecht, T. Int. J. Cancer (1982) [Pubmed]
  3. Cis-acting sequences may contribute to size variation in the surface glycoprotein of bovine immunodeficiency virus. Li, Y., Carpenter, S. J. Gen. Virol. (2001) [Pubmed]
  4. Villin, cytokeratin 7, and cytokeratin 20 expression in pulmonary adenocarcinoma with ultrastructural evidence of microvilli with rootlets. Tan, J., Sidhu, G., Greco, M.A., Ballard, H., Wieczorek, R. Hum. Pathol. (1998) [Pubmed]
  5. Diagnosis of renal proximal tubular injury by urinary immunoassay for a proximal tubular antigen, the adenosine deaminase binding protein. Tolkoff-Rubin, N.E., Thompson, R.E., Piper, D.J., Hansen, W.P., Bander, N.H., Cordon-Cardo, C., Finstad, C.J., Klotz, L.H., Old, L.J., Rubin, R.H. Nephrol. Dial. Transplant. (1987) [Pubmed]
  6. Intron creation and polyadenylation in maize are directed by AU-rich RNA. Luehrsen, K.R., Walbot, V. Genes Dev. (1994) [Pubmed]
  7. Role of Rap1 in promoting sickle red blood cell adhesion to laminin via BCAM/LU. Murphy, M.M., Zayed, M.A., Evans, A., Parker, C.E., Ataga, K.I., Telen, M.J., Parise, L.V. Blood (2005) [Pubmed]
  8. Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion. Hines, P.C., Zen, Q., Burney, S.N., Shea, D.A., Ataga, K.I., Orringer, E.P., Telen, M.J., Parise, L.V. Blood (2003) [Pubmed]
  9. Hydrolysis of inositol lipids: an early signal of human cytomegalovirus infection. Valyi-Nagy, T., Bandi, Z., Boldogh, I., Albrecht, T. Arch. Virol. (1988) [Pubmed]
  10. BCAM sterile. "A lesson in asepsis". Leonard, R. Canadian operating room nursing journal. (1995) [Pubmed]
  11. Organization of the human LU gene and molecular basis of the Lu(a)/Lu(b) blood group polymorphism. El Nemer, W., Rahuel, C., Colin, Y., Gane, P., Cartron, J.P., Le Van Kim, C. Blood (1997) [Pubmed]
  12. A unique gene encodes spliceoforms of the B-cell adhesion molecule cell surface glycoprotein of epithelial cancer and of the Lutheran blood group glycoprotein. Rahuel, C., Le Van Kim, C., Mattei, M.G., Cartron, J.P., Colin, Y. Blood (1996) [Pubmed]
  13. B-CAM/LU expression and the role of B-CAM/LU activation in binding of low- and high-density red cells to laminin in sickle cell disease. Zen, Q., Batchvarova, M., Twyman, C.A., Eyler, C.E., Qiu, H., De Castro, L.M., Telen, M.J. Am. J. Hematol. (2004) [Pubmed]
  14. Secondary structure for the apolipoprotein B mRNA editing site. Au-binding proteins interact with a stem loop. Richardson, N., Navaratnam, N., Scott, J. J. Biol. Chem. (1998) [Pubmed]
  15. Degradation of p21cip1 in cells productively infected with human cytomegalovirus. Chen, Z., Knutson, E., Kurosky, A., Albrecht, T. J. Virol. (2001) [Pubmed]
  16. Expression of the early lymphocyte activation antigen CD69, a C-type lectin, is regulated by mRNA degradation associated with AU-rich sequence motifs. Santis, A.G., López-Cabrera, M., Sánchez-Madrid, F., Proudfoot, N. Eur. J. Immunol. (1995) [Pubmed]
  17. The chromosome 19 linkage group LDLR, C3, LW, APOC2, LU, SE in man. Lewis, M., Kaita, H., Coghlan, G., Philipps, S., Belcher, E., McAlpine, P.J., Coopland, G.R., Woods, R.A. Ann. Hum. Genet. (1988) [Pubmed]
  18. Induction of cytoplasmic factors that bind to the 3' AU-rich region of human interferon beta mRNA during early development of Xenopus laevis. Grafi, G., Galili, G. FEBS Lett. (1993) [Pubmed]
  19. Glucose-6-phosphate dehydrogenase-derived NADPH fuels superoxide production in the failing heart. Gupte, S.A., Levine, R.J., Gupte, R.S., Young, M.E., Lionetti, V., Labinskyy, V., Floyd, B.C., Ojaimi, C., Bellomo, M., Wolin, M.S., Recchia, F.A. J. Mol. Cell. Cardiol. (2006) [Pubmed]
  20. Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily. Campbell, I.G., Foulkes, W.D., Senger, G., Trowsdale, J., Garin-Chesa, P., Rettig, W.J. Cancer Res. (1994) [Pubmed]
  21. Vascular adhesion molecule-1 and markers of platelet function before and after a treatment with iloprost or a supervised physical exercise program in patients with peripheral arterial disease. Arosio, E., Minuz, P., Prior, M., Zuliani, V., Gaino, S., De Marchi, S., Fontana, L., Andrioli, G., Lechi, C., Lechi, A. Life Sci. (2001) [Pubmed]
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