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Gene Review

Dnm3os  -  dynamin 3, opposite strand

Mus musculus

Synonyms: 6030416H16Rik, Hag2, Npn1, P/L01
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Disease relevance of Dnm3os


High impact information on Dnm3os


Chemical compound and disease context of Dnm3os


Biological context of Dnm3os


Anatomical context of Dnm3os


Associations of Dnm3os with chemical compounds


Regulatory relationships of Dnm3os


Other interactions of Dnm3os

  • A 6-kb antisense transcript (Dnm3os) contained within an intron of the mouse Dnm3 gene has been identified in a screen for genes that may be regulated by the basic helix-loop-helix transcription factor Twist during mouse development [13].
  • The tissue inhibitor of metalloproteinases-3 (TIMP-3) gene is specifically down-regulated in neoplastic cells of the mouse JB6 progression model, suggesting a role for TIMP-3 inactivation in neoplastic progression [28].
  • We investigated the hypothesis that there are significant alterations in the levels of apoptotic protein as well as p21 protein expression in the neoplastic progression associated with Barrett's metaplasia [29].
  • In the epidermis of transgenic mice in which expression of the HPV16 E6 and E7 oncogenes are targeted to basal keratinocytes, neoplastic progression occurs and is marked by an expansion of c-myc expressing basal-like cells [30].
  • These observations, together with our recent finding attributing AP-1 non-responsiveness to Erk deficiency in a clonal line of transformation resistant (P-) cells, argue for a requirement for Erks1 and/or 2 activation in AP-1 transactivation in the mouse JB6 neoplastic progression model, and suggest the utility of Erks as a prevention target [31].

Analytical, diagnostic and therapeutic context of Dnm3os


  1. Immune enhancement of skin carcinogenesis by CD4+ T cells. Daniel, D., Meyer-Morse, N., Bergsland, E.K., Dehne, K., Coussens, L.M., Hanahan, D. J. Exp. Med. (2003) [Pubmed]
  2. A critical role for the inflammatory response in a mouse model of preneoplastic progression. Schwertfeger, K.L., Xian, W., Kaplan, A.M., Burnett, S.H., Cohen, D.A., Rosen, J.M. Cancer Res. (2006) [Pubmed]
  3. Sensitivity of the cervical transformation zone to estrogen-induced squamous carcinogenesis. Elson, D.A., Riley, R.R., Lacey, A., Thordarson, G., Talamantes, F.J., Arbeit, J.M. Cancer Res. (2000) [Pubmed]
  4. Expression of calcyclin in human melanoma cell lines correlates with metastatic behavior in nude mice. Weterman, M.A., Stoopen, G.M., van Muijen, G.N., Kuznicki, J., Ruiter, D.J., Bloemers, H.P. Cancer Res. (1992) [Pubmed]
  5. Tumorigenic transformation and neoplastic progression of human uroepithelial cells after exposure in vitro to 4-aminobiphenyl or its metabolites. Bookland, E.A., Swaminathan, S., Oyasu, R., Gilchrist, K.W., Lindstrom, M., Reznikoff, C.A. Cancer Res. (1992) [Pubmed]
  6. Proliferation, senescence, and neoplastic progression of beta cells in hyperplasic pancreatic islets. Teitelman, G., Alpert, S., Hanahan, D. Cell (1988) [Pubmed]
  7. Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis. Koh, T.J., Bulitta, C.J., Fleming, J.V., Dockray, G.J., Varro, A., Wang, T.C. J. Clin. Invest. (2000) [Pubmed]
  8. Survey of int region DNA rearrangements in C3H and BALB/cfC3H mouse mammary tumor system. Pathak, V.K., Strange, R., Young, L.J., Morris, D.W., Cardiff, R.D. J. Natl. Cancer Inst. (1987) [Pubmed]
  9. Monoclonal antibodies raised against cell membrane components of human bladder tumor tissue recognizing subpopulations in normal urothelium. Summerhayes, I.C., McIlhinney, R.A., Ponder, B.A., Shearer, R.J., Pocock, R.D. J. Natl. Cancer Inst. (1985) [Pubmed]
  10. Differential growth inhibition by the aspirin metabolite salicylate in human colorectal tumor cell lines: enhanced apoptosis in carcinoma and in vitro-transformed adenoma relative to adenoma relative to adenoma cell lines. Elder, D.J., Hague, A., Hicks, D.J., Paraskeva, C. Cancer Res. (1996) [Pubmed]
  11. Neoplastic change of squamo-columnar junction in uterine cervix and vaginal epithelium by exogenous estrogen in hpv-18 URR E6/E7 transgenic mice. Park, J.S., Rhyu, J.W., Kim, C.J., Kim, H.S., Lee, S.Y., Kwon, Y.I., Namkoong, S.E., Sin, H.S., Um, S.J. Gynecol. Oncol. (2003) [Pubmed]
  12. Neoplastic progression evidenced in the L929 cell system. II. In vitro growth properties and biochemical characteristics of cell variants with different malignant behavior. Gavilondo, J., Lage, A., Pérez, R., Baeza, B., Tormo, B., Hernández, S. Neoplasma (1982) [Pubmed]
  13. A conserved noncoding intronic transcript at the mouse Dnm3 locus. Loebel, D.A., Tsoi, B., Wong, N., Tam, P.P. Genomics (2005) [Pubmed]
  14. Molecular cloning of five messenger RNAs differentially expressed in preneoplastic or neoplastic JB6 mouse epidermal cells: one is homologous to human tissue inhibitor of metalloproteinases-3. Sun, Y., Hegamyer, G., Colburn, N.H. Cancer Res. (1994) [Pubmed]
  15. TIMP-1 alters susceptibility to carcinogenesis. Rhee, J.S., Diaz, R., Korets, L., Hodgson, J.G., Coussens, L.M. Cancer Res. (2004) [Pubmed]
  16. Neoplastic progression of human and rat intestinal cell lines after transfer of the ras and polyoma middle T oncogenes. Chastre, E., Empereur, S., Di Gioia, Y., el Mahdani, N., Mareel, M., Vleminckx, K., Van Roy, F., Bex, V., Emami, S., Spandidos, D.A. Gastroenterology (1993) [Pubmed]
  17. Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells. Lochter, A., Galosy, S., Muschler, J., Freedman, N., Werb, Z., Bissell, M.J. J. Cell Biol. (1997) [Pubmed]
  18. 12-O-tetradecanoylphorbol-13-acetate induces clonal expansion of potentially malignant keratinocytes in a tissue model of early neoplastic progression. Karen, J., Wang, Y., Javaherian, A., Vaccariello, M., Fusenig, N.E., Garlick, J.A. Cancer Res. (1999) [Pubmed]
  19. Expression of keratin and vimentin intermediate filaments in rabbit bladder epithelial cells at different stages of benzo[a]pyrene-induced neoplastic progression. Summerhayes, I.C., Cheng, Y.S., Sun, T.T., Chen, L.B. J. Cell Biol. (1981) [Pubmed]
  20. Synergism of v-myc and v-Ha-ras in the in vitro neoplastic progression of murine lymphoid cells. Schwartz, R.C., Stanton, L.W., Riley, S.C., Marcu, K.B., Witte, O.N. Mol. Cell. Biol. (1986) [Pubmed]
  21. Influence of beta1 integrins on epidermal squamous cell carcinoma formation in a transgenic mouse model: alpha3beta1, but not alpha2beta1, suppresses malignant conversion. Owens, D.M., Watt, F.M. Cancer Res. (2001) [Pubmed]
  22. Associated effects of bromocriptine on neoplastic progression of mouse mammary preneoplastic hyperplastic alveolar nodule line C4 and on hyperplastic alveolar nodule-infiltrating and splenic lymphocyte function. Tsai, S.J., Loeffler, D.A., Heppner, G.H. Cancer Res. (1992) [Pubmed]
  23. Direct action of estrogen on sequence of progression of human preneoplastic breast disease. Shekhar, M.P., Nangia-Makker, P., Wolman, S.R., Tait, L., Heppner, G.H., Visscher, D.W. Am. J. Pathol. (1998) [Pubmed]
  24. Synergy of IL-7 and v-Ha-ras in the in vitro neoplastic progression of murine pre-B cells. Chen, S.C., Redenius, D., Young, J.C., Schwartz, R.C. Oncogene (1993) [Pubmed]
  25. Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation. Cmarik, J.L., Min, H., Hegamyer, G., Zhan, S., Kulesz-Martin, M., Yoshinaga, H., Matsuhashi, S., Colburn, N.H. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  26. Complete regression of established spontaneous mammary carcinoma and the therapeutic prevention of genetically programmed neoplastic transition by IL-12/pulse IL-2: induction of local T cell infiltration, Fas/Fas ligand gene expression, and mammary epithelial apoptosis. Wigginton, J.M., Park, J.W., Gruys, M.E., Young, H.A., Jorcyk, C.L., Back, T.C., Brunda, M.J., Strieter, R.M., Ward, J., Green, J.E., Wiltrout, R.H. J. Immunol. (2001) [Pubmed]
  27. K-ras proto-oncogene exhibits tumor suppressor activity as its absence promotes tumorigenesis in murine teratomas. James, R.M., Arends, M.J., Plowman, S.J., Brooks, D.G., Miles, C.G., West, J.D., Patek, C.E. Mol. Cancer Res. (2003) [Pubmed]
  28. Specific methylation events contribute to the transcriptional repression of the mouse tissue inhibitor of metalloproteinases-3 gene in neoplastic cells. Pennie, W.D., Hegamyer, G.A., Young, M.R., Colburn, N.H. Cell Growth Differ. (1999) [Pubmed]
  29. Barrett's esophagus, apoptosis and cell cycle regulation: correlation of p53 with Bax, Bcl-2 and p21 protein expression. Woodward, T.A., Klingler, P.D., Genko, P.V., Wolfe, J.T. Anticancer Res. (2000) [Pubmed]
  30. Regulation of Myc and Mad during epidermal differentiation and HPV-associated tumorigenesis. Hurlin, P.J., Foley, K.P., Ayer, D.E., Eisenman, R.N., Hanahan, D., Arbeit, J.M. Oncogene (1995) [Pubmed]
  31. Expression of dominant negative Erk2 inhibits AP-1 transactivation and neoplastic transformation. Watts, R.G., Huang, C., Young, M.R., Li, J.J., Dong, Z., Pennie, W.D., Colburn, N.H. Oncogene (1998) [Pubmed]
  32. Regulation of apoptosis by low serum in cells of different stages of neoplastic progression: enhanced susceptibility after loss of a senescence gene and decreased susceptibility after loss of a tumor suppressor gene. Preston, G.A., Lang, J.E., Maronpot, R.R., Barrett, J.C. Cancer Res. (1994) [Pubmed]
  33. Consistent expression of an epithelial cell adhesion molecule (C-CAM) during human prostate development and loss of expression in prostate cancer: implication as a tumor suppressor. Kleinerman, D.I., Troncoso, P., Lin, S.H., Pisters, L.L., Sherwood, E.R., Brooks, T., von Eschenbach, A.C., Hsieh, J.T. Cancer Res. (1995) [Pubmed]
  34. Preneoplastic and neoplastic growth of xenotransplanted lung-derived human cell lines using deepithelialized rat tracheas. Baba, M., Klein-Szanto, A.J., Trono, D., Obara, T., Yoakum, G.H., Masui, T., Harris, C.C. Cancer Res. (1987) [Pubmed]
  35. Suppression of melanotroph carcinogenesis leads to accelerated progression of pituitary anterior lobe tumors and medullary thyroid carcinomas in Rb+/- mice. Zhou, Z., Flesken-Nikitin, A., Levine, C.G., Shmidt, E.N., Eng, J.P., Nikitina, E.Y., Spencer, D.M., Nikitin, A.Y. Cancer Res. (2005) [Pubmed]
  36. Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor). Tolg, C., Poon, R., Fodde, R., Turley, E.A., Alman, B.A. Oncogene (2003) [Pubmed]
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