The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

RBP3  -  retinol binding protein 3, interstitial

Homo sapiens

Synonyms: D10S64, D10S65, D10S66, IRBP, Interphotoreceptor retinoid-binding protein, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of RBP3

  • The retinal autoantigens S-antigen (S-Ag) and interphotoreceptor retinoid binding protein (IRBP) can induce autoimmune uveitis in rodent models [1].
  • The analysis of IRBP expression may facilitate the diagnostic recognition of primitive pineal neoplasms and further define the neuroretinal differentiation which occurs in pineal parenchymal tumors [2].
  • Cell-mediated immune responses to human retinal S-antigen, interphotoreceptor retinoid binding protein (IRBP), and crude retinal extract were investigated in patients with onchocerciasis from Sierra Leone, West Africa using a two-step migration-inhibition factor assay [3].
  • Furthermore, the locus that codes for a distinct phenotype, medullary thyroid carcinoma (MTC) with parathyroid tumors (PTs) and no pheochromocytomas (PHEOs) (referred to as MTC with PTs), in one of the families was closely linked to two markers, D10Z1 and RBP3, with lodscores of 2.86 and 3.54, respectively, at theta = 0 [4].
  • Three of the probes map near the locus for multiple endocrine neoplasia type 2A, and one of these probes, BG-JC353 (D10S167), maps between RBP3 and TB14.34 (D10S34) [5].
  • The analysis of IRBP proteolysis is useful as a biomarker for uveitis and suggests that inhibition of proteinases might become a therapeutic strategy in an inflammatory context of a damaged blood-ocular barrier [6].

Psychiatry related information on RBP3

  • We also demonstrate the presence of cross reactive epitopes in the two potent retinal antigens, SAg and IRBP and finally introduce early data on a unique anti S2.4.c5 idiotypic (Id) monoclonal antibody (MAb) which appears to be a site non associated antibody that binds not only to s2.4.c5 but also to SAg [7].

High impact information on RBP3


Chemical compound and disease context of RBP3


Biological context of RBP3


Anatomical context of RBP3


Associations of RBP3 with chemical compounds


Physical interactions of RBP3


Other interactions of RBP3

  • The diagnosis was determined clinically and RBP3 and RDH5 were analyzed by molecular screening methods and direct genomic sequencing [22].
  • Reporter product from CRALBP and IRBP promoter fragments was measured following transient transfection in bovine pigmented and nonpigmented CE cells [17].
  • This enhancement was selective since two other retinal cell proteins, interphotoreceptor binding protein (IRBP) and photo-6, were not affected by IFN-gamma treatment [23].
  • Moreover, oral administration of this MHC-peptide tolerized Lewis rats to the disease induced with two different retinal autoantigens, retinal S-antigen (S-Ag) and IRBP [24].
  • In addition, S-Ag, RPE65 and IRBP were detected by immunostaining in rare cells in sections of human thymi by antibodies against these proteins [25].

Analytical, diagnostic and therapeutic context of RBP3


  1. Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate. Howard, O.M., Dong, H.F., Su, S.B., Caspi, R.R., Chen, X., Plotz, P., Oppenheim, J.J. Blood (2005) [Pubmed]
  2. Differential expression of retinal proteins in a pineal parenchymal tumor. Lopes, M.B., Gonzalez-Fernandez, F., Scheithauer, B.W., VandenBerg, S.R. J. Neuropathol. Exp. Neurol. (1993) [Pubmed]
  3. Cell-mediated immunity against human retinal extract, S-antigen, and interphotoreceptor retinoid binding protein in onchocercal chorioretinopathy. Van der Lelij, A., Rothova, A., Stilma, J.S., Hoekzema, R., Kijlstra, A. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  4. The mutation for medullary thyroid carcinoma with parathyroid tumors (MTC with PTs) is closely linked to the centromeric region of chromosome 10. Carson, N.L., Wu, J.S., Jackson, C.E., Kidd, K.K., Simpson, N.E. Am. J. Hum. Genet. (1990) [Pubmed]
  5. Characterization of radiation/fusion hybrids containing parts of human chromosome 10 and their use in mapping chromosome 10-specific probes. Rothschild, C.B., Noll, W.W., Gravius, T.C., Schuster, M.K., Nutile-McMenemy, N., Jones, C., Bowden, D.W. Genomics (1992) [Pubmed]
  6. Interphotoreceptor retinoid-binding protein as biomarker in systemic autoimmunity with eye inflictions. Descamps, F.J., Kangave, D., Cauwe, B., Martens, E., Geboes, K., Abu El-Asrar, A., Opdenakker, G. J. Cell. Mol. Med. (2008) [Pubmed]
  7. Epitopes and idiotypes in experimental autoimmune uveitis: a review. Dua, H.S., Abrams, M., Barrett, J.A., Gregerson, D.S., Forrester, J.V., Donoso, L.A. Curr. Eye Res. (1992) [Pubmed]
  8. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Helin, K., Lees, J.A., Vidal, M., Dyson, N., Harlow, E., Fattaey, A. Cell (1992) [Pubmed]
  9. Assignment of multiple endocrine neoplasia type 2A to chromosome 10 by linkage. Simpson, N.E., Kidd, K.K., Goodfellow, P.J., McDermid, H., Myers, S., Kidd, J.R., Jackson, C.E., Duncan, A.M., Farrer, L.A., Brasch, K. Nature (1987) [Pubmed]
  10. A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10. Mathew, C.G., Chin, K.S., Easton, D.F., Thorpe, K., Carter, C., Liou, G.I., Fong, S.L., Bridges, C.D., Haak, H., Kruseman, A.C. Nature (1987) [Pubmed]
  11. Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. Devoss, J., Hou, Y., Johannes, K., Lu, W., Liou, G.I., Rinn, J., Chang, H., Caspi, R., Fong, L., Anderson, M.S. J. Exp. Med. (2006) [Pubmed]
  12. Transcription factor E2F binds DNA as a heterodimer. Huber, H.E., Edwards, G., Goodhart, P.J., Patrick, D.R., Huang, P.S., Ivey-Hoyle, M., Barnett, S.F., Oliff, A., Heimbrook, D.C. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  13. Interstitial retinol binding protein in the developing human retina: a proposed explanation for vitamin E suppression of retinopathy of prematurity. Johnson, A.T., Kretzer, F.L. Prog. Clin. Biol. Res. (1985) [Pubmed]
  14. Characterization and comparative structural features of the gene for human interstitial retinol-binding protein. Fong, S.L., Fong, W.B., Morris, T.A., Kedzie, K.M., Bridges, C.D. J. Biol. Chem. (1990) [Pubmed]
  15. Internal quadruplication in the structure of human interstitial retinol-binding protein deduced from its cloned cDNA. Fong, S.L., Bridges, C.D. J. Biol. Chem. (1988) [Pubmed]
  16. Human interstitial retinol-binding protein (IRBP): cloning, partial sequence, and chromosomal localization. Liou, G.I., Fong, S.L., Gosden, J., van Tuinen, P., Ledbetter, D.H., Christie, S., Rout, D., Bhattacharya, S., Cook, R.G., Li, Y. Somat. Cell Mol. Genet. (1987) [Pubmed]
  17. Retinoid processing proteins in the ocular ciliary epithelium. Salvador-Silva, M., Ghosh, S., Bertazolli-Filho, R., Boatright, J.H., Nickerson, J.M., Garwin, G.G., Saari, J.C., Coca-Prados, M. Mol. Vis. (2005) [Pubmed]
  18. Hypomethylation of the interphotoreceptor retinoid-binding protein (IRBP) promotor and first exon is linked to expression of the gene. Albini, A., Toffenetti, J., Zhu, Z., Chader, G.J., Noonan, D.M. Nucleic Acids Res. (1990) [Pubmed]
  19. N-terminal sequence homologies in interstitial retinol-binding proteins from 10 vertebrate species. Fong, S.L., Cook, R.G., Alvarez, R.A., Liou, G.I., Landers, R.A., Bridges, C.D. FEBS Lett. (1986) [Pubmed]
  20. Interphotoreceptor retinoid-binding protein contains three retinoid binding sites. Shaw, N.S., Noy, N. Exp. Eye Res. (2001) [Pubmed]
  21. An interpretation of retinopathy of prematurity in terms of spindle cells: relationship to vitamin E prophylaxis and cryotherapy. Kretzer, F.L., McPherson, A.R., Hittner, H.M. Graefes Arch. Clin. Exp. Ophthalmol. (1986) [Pubmed]
  22. 11-cis retinol dehydrogenase mutations as a major cause of the congenital night-blindness disorder known as fundus albipunctatus. Gonzalez-Fernandez, F., Kurz, D., Bao, Y., Newman, S., Conway, B.P., Young, J.E., Han, D.P., Khani, S.C. Mol. Vis. (1999) [Pubmed]
  23. Interferon-gamma enhances the expression of retinal S-antigen, a specific neuronal cell marker. Hooks, J.J., Chader, G., Evans, C.H., Detrick, B. J. Neuroimmunol. (1990) [Pubmed]
  24. Molecular mimicry as a therapeutic approach for an autoimmune disease: oral treatment of uveitis-patients with an MHC-peptide crossreactive with autoantigen--first results. Thurau, S.R., Diedrichs-Möhring, M., Fricke, H., Arbogast, S., Wildner, G. Immunol. Lett. (1997) [Pubmed]
  25. Thymic expression of peripheral tissue antigens in humans: a remarkable variability among individuals. Takase, H., Yu, C.R., Mahdi, R.M., Douek, D.C., Dirusso, G.B., Midgley, F.M., Dogra, R., Allende, G., Rosenkranz, E., Pugliese, A., Egwuagu, C.E., Gery, I. Int. Immunol. (2005) [Pubmed]
  26. PCR detection of the BgIII RFLP at the RBP3 locus. Rodriguez, J.A., Liou, G.I., Daiger, S.P. Nucleic Acids Res. (1990) [Pubmed]
  27. Isolation and high-resolution mapping of new DNA markers from the pericentromeric region of chromosome 10. Miller, D.L., Dill, F.J., Lichter, J.B., Kidd, K.K., Goodfellow, P.J. Genomics (1992) [Pubmed]
  28. Ordering of markers in the pericentromeric region of chromosome 10. Hofstra, R.M., Stelwagen, T., Pasini, B., van der Veen, A.Y., Ponder, B.A., Nakamura, Y., Romeo, G., Buys, C.H. Hum. Genet. (1995) [Pubmed]
  29. Mapping of the genes around MEN2A locus using pulsed-field gel electrophoresis. Tanaka, N., Miki, T., Yamamoto, M., Nakura, J., Okazaki, M., Miya, A., Mori, T., Takai, S. Jinrui Idengaku Zasshi (1990) [Pubmed]
WikiGenes - Universities