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Gene Review

THY1  -  Thy-1 cell surface antigen

Homo sapiens

Synonyms: CD90, CDw90, Thy-1 antigen, Thy-1 membrane glycoprotein
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Disease relevance of THY1

  • We previously demonstrated that the breakpoint of t(11;14)(q23;q32) in the RC-K8 B cell lymphoma cell line lies between CD3 and THY1/ETS1 on chromosome 11q23, and we cloned this region and named it the rck locus [1].
  • THY1 expression is associated with tumor suppression of human ovarian cancer [2].
  • Based on this physical map and on our primary linkage map of the 11q23 region, we are able to confirm a preliminary localization of the gene for ataxia-telangiectasia group A (ATA) to a region centromeric to the interval defined by D11S144 (pYNB3.12) and THY1 [3].
  • These findings suggest that THY1 is a good candidate tumour suppressor gene in NPC, which is significantly associated with lymph node metastases [4].
  • In addition, we showed that the FLI1 region involved in the t(11;22)(q24;q12) in Ewing's sarcoma was more telomeric region that the THY1 gene by analyzing somatic cell hybrids carrying the 11q- and/or 14q+ chromosome of the t(11;14)(q23;q32) translocation, and by PFGE analysis of the YAC clone YTY17 [5].

Psychiatry related information on THY1

  • Therefore, we examined this brain region from individuals with the clinical diagnosis of primary Restless Legs syndrome (RLS) and found the concentration of Thy1 was less than half that of controls [6].

High impact information on THY1


Chemical compound and disease context of THY1


Biological context of THY1


Anatomical context of THY1


Associations of THY1 with chemical compounds

  • The gold probes, coupled to short poly-L-lysine molecules (4 kD) displayed Brownian motion, with a diffusion coefficient in the range 0.1-0.2 micron2/s. A diffusion coefficient in the 0.1 micron2/s range was also observed with 40-nm gold probes coupled to an antibody against the lipid-linked Thy-1 antigen on 3T3 fibroblasts [18].
  • When grown to high density in a serum-poor medium, these cells differentiated further into typical multinucleated myotubes that expressed the M isoform of creatine kinase and increased levels of surface antigen 5.1H11, creatine kinase, and nicotinic acetylcholine receptors, but no detectable Thy 1 antigen [19].
  • Immunohistochemistry was performed using anti-c-kit, OV6, Thy1, CK19, AFP, vWF and Rab3b [20].
  • They were labeled in a transgenic mouse expressing Clomeleon, a chloride-sensitive fluorescent protein, under the control of the thy1 promoter [21].

Other interactions of THY1

  • THY1 and CD3D genes were polymorphic after MspI digestion but no significant association was observed [22].
  • A detailed restriction map of 600 kb of human chromosome band 11q23.3 has been assembled which covers the PBGD, CBL2 and THY1 genes [23].
  • The differential expression levels of eight positional candidate genes, including inflammation-related THY1 and C1QTNF5, were also confirmed [24].
  • Detection of MspI RFLP in human THY1 gene by the polymerase chain reaction [15].
  • The human PGP9.5 gene, described here, spans 10 kb, contains nine exons and displays 5' features some common to many genes and some common with neurofilament neuron-specific enolase and Thy-1-antigen gene 5' regions [25].

Analytical, diagnostic and therapeutic context of THY1


  1. Rearrangements on chromosome 11q23 in hematopoietic tumor-associated t(11;14) and t(11;19) translocations. Akao, Y., Seto, M., Takahashi, T., Saito, M., Utsumi, K.R., Nakazawa, S., Ueda, R. Cancer Res. (1991) [Pubmed]
  2. THY1 expression is associated with tumor suppression of human ovarian cancer. Abeysinghe, H.R., Cao, Q., Xu, J., Pollock, S., Veyberman, Y., Guckert, N.L., Keng, P., Wang, N. Cancer Genet. Cytogenet. (2003) [Pubmed]
  3. Physical mapping of the human chromosome 11q23 region containing the ataxia-telangiectasia locus. Wei, S., Rocchi, M., Archidiacono, N., Sacchi, N., Romeo, G., Gatti, R.A. Cancer Genet. Cytogenet. (1990) [Pubmed]
  4. THY1 is a candidate tumour suppressor gene with decreased expression in metastatic nasopharyngeal carcinoma. Lung, H.L., Bangarusamy, D.K., Xie, D., Cheung, A.K., Cheng, Y., Kumaran, M.K., Miller, L., Liu, E.T., Guan, X.Y., Sham, J.S., Fang, Y., Li, L., Wang, N., Protopopov, A.I., Zabarovsky, E.R., Tsao, S.W., Stanbridge, E.J., Lung, M.L. Oncogene (2005) [Pubmed]
  5. Long-range mapping of the 11q23 region involved in chromosome aberrations in human tumors by pulsed-field gel electrophoresis with a yeast artificial chromosome. Akao, Y., Tsujimoto, Y., Seto, M., Imai, T., Bergeron, D., Berbeau, B., Otsuki, Y. Genes Chromosomes Cancer (1993) [Pubmed]
  6. Thy1 expression in the brain is affected by iron and is decreased in Restless Legs Syndrome. Wang, X., Wiesinger, J., Beard, J., Felt, B., Menzies, S., Earley, C., Allen, R., Connor, J. J. Neurol. Sci. (2004) [Pubmed]
  7. Surface antigen differentiation during human myogenesis in culture. Walsh, F.S., Ritter, M.A. Nature (1981) [Pubmed]
  8. Role of human chromosome 11 in determining surface antigenic phenotype of normal and malignant cells. Somatic cell genetic analysis of eight antigens, including putative human Thy-1. Rettig, W.J., Dracopoli, N.C., Chesa, P.G., Spengler, B.A., Beresford, H.R., Davies, P., Biedler, J.L., Old, L.J. J. Exp. Med. (1985) [Pubmed]
  9. Cloning of a candidate gene for ataxia-telangiectasia group D. Kapp, L.N., Painter, R.B., Yu, L.C., van Loon, N., Richard, C.W., James, M.R., Cox, D.R., Murnane, J.P. Am. J. Hum. Genet. (1992) [Pubmed]
  10. Further mapping of an ataxia-telangiectasia locus to the chromosome 11q23 region. Sanal, O., Wei, S., Foroud, T., Malhotra, U., Concannon, P., Charmley, P., Salser, W., Lange, K., Gatti, R.A. Am. J. Hum. Genet. (1990) [Pubmed]
  11. The role of the THY1 gene in human ovarian cancer suppression based on transfection studies. Abeysinghe, H.R., Pollock, S.J., Guckert, N.L., Veyberman, Y., Keng, P., Halterman, M., Federoff, H.J., Rosenblatt, J.P., Wang, N. Cancer Genet. Cytogenet. (2004) [Pubmed]
  12. THY-1 induction is associated with up-regulation of fibronectin and thrombospondin-1 in human ovarian cancer. Abeysinghe, H.R., Li, L.Q., Guckert, N.L., Reeder, J., Wang, N. Cancer Genet. Cytogenet. (2005) [Pubmed]
  13. A conjugate of adriamycin and monoclonal antibodies to Thy-1 antigen inhibits human neuroblastoma cells in vitro. Hurwitz, E., Arnon, R., Sahar, E., Danon, Y. Ann. N. Y. Acad. Sci. (1983) [Pubmed]
  14. Isolation, characterization, gene modification, and nuclear reprogramming of porcine mesenchymal stem cells. Bosch, P., Pratt, S.L., Stice, S.L. Biol. Reprod. (2006) [Pubmed]
  15. Detection of MspI RFLP in human THY1 gene by the polymerase chain reaction. Fu, J., Ikegami, H., Yamato, E., Kawaguchi, Y., Takekawa, K., Fujisawa, T., Nakagawa, Y., Hamada, Y., Ueda, H., Shen, G.Q. Jpn. J. Hum. Genet. (1995) [Pubmed]
  16. Chromosomal localization of the human Thy-1 gene. van Rijs, J., Giguère, V., Hurst, J., van Agthoven, T., Geurts van Kessel, A., Goyert, S., Grosveld, F. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  17. Thy-1 expression is linked to functional properties of primitive hematopoietic progenitor cells from human umbilical cord blood. Mayani, H., Lansdorp, P.M. Blood (1994) [Pubmed]
  18. Lateral diffusion and retrograde movements of individual cell surface components on single motile cells observed with Nanovid microscopy. de Brabander, M., Nuydens, R., Ishihara, A., Holifield, B., Jacobson, K., Geerts, H. J. Cell Biol. (1991) [Pubmed]
  19. Transfection of human skeletal muscle cells with SV40 large T antigen gene coupled to a metallothionein promoter. Hurko, O., McKee, L., Zuurveld, J.G. Ann. Neurol. (1986) [Pubmed]
  20. Characterization of two distinct liver progenitor cell subpopulations of hematopoietic and hepatic origins. Corcelle, V., Stieger, B., Gjinovci, A., Wollheim, C.B., Gauthier, B.R. Exp. Cell Res. (2006) [Pubmed]
  21. The primordial, blue-cone color system of the mouse retina. Haverkamp, S., Wässle, H., Duebel, J., Kuner, T., Augustine, G.J., Feng, G., Euler, T. J. Neurosci. (2005) [Pubmed]
  22. Non-HLA genetic factors and insulin dependent diabetes mellitus in the Japanese: TCRA, TCRB and TCRG, INS, THY1, CD3D and ETS1. Aparicio, J.M., Wakisaka, A., Takada, A., Matsuura, N., Yoshiki, T. Dis. Markers (1990) [Pubmed]
  23. Physical linkage of the fragile site FRA11B and a Jacobsen syndrome chromosome deletion breakpoint in 11q23.3. Jones, C., Slijepcevic, P., Marsh, S., Baker, E., Langdon, W.Y., Richards, R.I., Tunnacliffe, A. Hum. Mol. Genet. (1994) [Pubmed]
  24. Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: increased expression of inflammation-related genes. Lee, Y.H., Nair, S., Rousseau, E., Allison, D.B., Page, G.P., Tataranni, P.A., Bogardus, C., Permana, P.A. Diabetologia (2005) [Pubmed]
  25. The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase. Day, I.N., Hinks, L.J., Thompson, R.J. Biochem. J. (1990) [Pubmed]
  26. Phenotypic, molecular, and functional characterization of human peripheral blood CD34+/THY1+ cells. Humeau, L., Bardin, F., Maroc, C., Alario, T., Galindo, R., Mannoni, P., Chabannon, C. Blood (1996) [Pubmed]
  27. Regional and subcellular distribution of Thy-1 in human brain assayed by a solid-phase radioimmunoassay. Almqvist, P., Carlsson, S.R., Hardy, J.A., Winblad, B. J. Neurochem. (1986) [Pubmed]
  28. Feasibility and safety of G-CSF administration to induce bone marrow-derived cells mobilization in patients with end stage liver disease. Gaia, S., Smedile, A., Omedè, P., Olivero, A., Sanavio, F., Balzola, F., Ottobrelli, A., Abate, M.L., Marzano, A., Rizzetto, M., Tarella, C. J. Hepatol. (2006) [Pubmed]
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