Gene Review:
DFFA - DNA fragmentation factor, 45kDa, alpha...
Homo sapiens
Synonyms:
DFF-45, DFF1, DFF45, DNA fragmentation factor 45 kDa subunit, DNA fragmentation factor subunit alpha, ...
- Analyses of apoptotic regulators CASP9 and DFFA at 1P36.2, reveal rare allele variants in human neuroblastoma tumours. Abel, F., Sjöberg, R.M., Ejeskär, K., Krona, C., Martinsson, T. Br. J. Cancer (2002)
- Expression of ICAD-l and ICAD-S in human brain tumor and its cleavage upon activation of apoptosis by anti-Fas antibody. Masuoka, J., Shiraishi, T., Ichinose, M., Mineta, T., Tabuchi, K. Jpn. J. Cancer Res. (2001)
- Expression, purification, crystallization of fragments from the C-terminal region of DFF45/ICAD. Ding, H., Qiu, S., Li, S., Symersky, J., Green, T.J., Luo, M. Acta Crystallogr. D Biol. Crystallogr. (2003)
- Decreased expression of DFF45/ICAD is correlated with a poor prognosis in patients with esophageal carcinoma. Konishi, S., Ishiguro, H., Shibata, Y., Kudo, J., Terashita, Y., Sugiura, H., Koyama, H., Kimura, M., Sato, A., Shinoda, N., Kuwabara, Y., Fujii, Y. Cancer (2002)
- Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis. Lugovskoy, A.A., Zhou, P., Chou, J.J., McCarty, J.S., Li, P., Wagner, G. Cell (1999)
- Activation of the innate immunity in Drosophila by endogenous chromosomal DNA that escaped apoptotic degradation. Mukae, N., Yokoyama, H., Yokokura, T., Sakoyama, Y., Nagata, S. Genes Dev. (2002)
- Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells. Alam, A., Cohen, L.Y., Aouad, S., Sékaly, R.P. J. Exp. Med. (1999)
- Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation. Sharif-Askari, E., Alam, A., Rhéaume, E., Beresford, P.J., Scotto, C., Sharma, K., Lee, D., DeWolf, W.E., Nuttall, M.E., Lieberman, J., Sékaly, R.P. EMBO J. (2001)
- Determinants of the nuclear localization of the heterodimeric DNA fragmentation factor (ICAD/CAD). Lechardeur, D., Drzymala, L., Sharma, M., Zylka, D., Kinach, R., Pacia, J., Hicks, C., Usmani, N., Rommens, J.M., Lukacs, G.L. J. Cell Biol. (2000)
- DNA fragmentation factor (DFF45): Expression and prognostic value in serous ovarian cancer. Brustmann, H. Pathol. Res. Pract. (2006)
- Method for efficient transfection of in vitro-transcribed mRNA into SK-N-AS and HEK293 cells: difference in the toxicity of nuclear EGFP compared to cytoplasmic EGFP. Ejeskär, K., Fransson, S., Zaibak, F., Ioannou, P.A. Int. J. Mol. Med. (2006)
- Assignment of the DNA fragmentation factor gene (DFFA) to human chromosome bands 1p36.3-->p36.2 by in situ hybridization. Leek, J.P., Carr, I.M., Bell, S.M., Markham, A.F., Lench, N.J. Cytogenet. Cell Genet. (1997)
- Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation. Wolf, B.B., Schuler, M., Echeverri, F., Green, D.R. J. Biol. Chem. (1999)
- Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis. Tang, D., Kidd, V.J. J. Biol. Chem. (1998)
- Oligomerization state of the DNA fragmentation factor in normal and apoptotic cells. Lechardeur, D., Dougaparsad, S., Nemes, C., Lukacs, G.L. J. Biol. Chem. (2005)
- Inhibition of apoptosis-associated DNA fragmentation activity in nonapoptotic cells: the role of DNA fragmentation factor-45 (DFF45/ICAD). Sabol, S.L., Li, R., Lee, T.Y., Abdul-Khalek, R. Biochem. Biophys. Res. Commun. (1998)
- Apoptotic nuclear morphological change without DNA fragmentation. Sakahira, H., Enari, M., Ohsawa, Y., Uchiyama, Y., Nagata, S. Curr. Biol. (1999)
- Frequent nuclear localization of ICAD and cytoplasmic co-expression of caspase-8 and caspase-3 in human lymphomas. Xerri, L., Palmerini, F., Devilard, E., Defrance, T., Bouabdallah, R., Hassoun, J., Birg, F. J. Pathol. (2000)
- ICAD/DFF regulator of apoptotic nuclease is nuclear. Samejima, K., Earnshaw, W.C. Exp. Cell Res. (1998)
- Activation of apoptotic and inflammatory pathways in dysfunctional donor hearts. Birks, E.J., Yacoub, M.H., Burton, P.S., Owen, V., Pomerance, A., O'Halloran, A., Banner, N.R., Khaghani, A., Latif, N. Transplantation (2000)
- Growth phase-dependent expression of ICAD-L/DFF45 modulates the pattern of apoptosis in human colonic cancer cells. Charrier, L., Jarry, A., Toquet, C., Bou-Hanna, C., Chedorge, M., Denis, M., Vallette, G., Laboisse, C.L. Cancer Res. (2002)
- Merbarone induces activation of caspase-activated DNase and excision of chromosomal DNA loops from the nuclear matrix. Otake, Y., Mims, A., Fernandes, D.J. Mol. Pharmacol. (2006)
- MST1-JNK promotes apoptosis via caspase-dependent and independent pathways. Ura, S., Masuyama, N., Graves, J.D., Gotoh, Y. Genes Cells (2001)
- Antiapoptotic regulation by hepatitis C virus core protein through up-regulation of inhibitor of caspase-activated DNase. Sacco, R., Tsutsumi, T., Suzuki, R., Otsuka, M., Aizaki, H., Sakamoto, S., Matsuda, M., Seki, N., Matsuura, Y., Miyamura, T., Suzuki, T. Virology (2003)
- Identification of the nuclear factor HMG2 as an activator for DFF nuclease activity. Toh, S.Y., Wang, X., Li, P. Biochem. Biophys. Res. Commun. (1998)
- The contribution of apoptosis-inducing factor, caspase-activated DNase, and inhibitor of caspase-activated DNase to the nuclear phenotype and DNA degradation during apoptosis. Yuste, V.J., Sánchez-López, I., Solé, C., Moubarak, R.S., Bayascas, J.R., Dolcet, X., Encinas, M., Susin, S.A., Comella, J.X. J. Biol. Chem. (2005)
- Ectopic expression of Hsp70 confers resistance and silencing its expression sensitizes human colon cancer cells to curcumin-induced apoptosis. Rashmi, R., Kumar, S., Karunagaran, D. Carcinogenesis (2004)
- The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects. Dahlman, I., Kaaman, M., Jiao, H., Kere, J., Laakso, M., Arner, P. Diabetes (2005)
- Homozygous deletion in a neuroblastoma cell line defined by a high-density STS map spanning human chromosome band 1p36. Chen, Y.Z., Soeda, E., Yang, H.W., Takita, J., Chai, L., Horii, A., Inazawa, J., Ohki, M., Hayashi, Y. Genes Chromosomes Cancer (2001)
- Renal carcinoma cells undergo apoptosis without oligonucleosomal DNA fragmentation. Yamaguchi, K., Uzzo, R., Dulin, N., Finke, J.H., Kolenko, V. Biochem. Biophys. Res. Commun. (2004)
- Mutations in the N-terminal domain of DFF45 in a primary germ cell tumor and in neuroblastoma tumors. Abel, F., Sjöberg, R.M., Krona, C., Nilsson, S., Martinsson, T. Int. J. Oncol. (2004)
- Genetic characterization and molecular mapping of Hessian fly resistance genes derived from Aegilops tauschii in synthetic wheat. Wang, T., Xu, S.S., Harris, M.O., Hu, J., Liu, L., Cai, X. Theor. Appl. Genet. (2006)
- Extracranial internal carotid and vertebral artery dissections: angiographic spectrum, course and prognosis. Pelkonen, O., Tikkakoski, T., Leinonen, S., Pyhtinen, J., Lepojärvi, M., Sotaniemi, K. Neuroradiology. (2003)