The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Melioidosis


Psychiatry related information on Melioidosis


High impact information on Melioidosis


Chemical compound and disease context of Melioidosis


Biological context of Melioidosis

  • In a prospective study of 160 consecutive sera samples sent for melioidosis serology, respective specificities were 91, 90, and 69, positive predictive values were 41, 32, and 18, and negative predictive values were 99, 98, and 100% [15].
  • This was a study of IgG antibody responses to two S-type lipopolysaccharides (LPS I and LPS II) and flagellin of Burkholderia pseudomallei in patients with melioidosis [16].
  • We have previously shown that Burkholderia pseudomallei, the causative pathogen of melioidosis, may be discriminated from the closely related non-pathogenic species Burkholderia thailandensis by the presence of a 15 base pair deletion in the flagellin gene of B. thailandensis [17].
  • 0. Of greater importance, in tuberculous patients and patients with melioidosis treated with levamisole, 150 mg/day, twice a week, along with a specific antitubercular or antimicrobial agent for appropriate duration, improved faster both clinically, microbiologically and in cellular immunity [18].

Anatomical context of Melioidosis


Gene context of Melioidosis

  • Prognostic value of cytokine concentrations (tumor necrosis factor-alpha, interleukin-6, and interleukin-10) and clinical parameters in severe melioidosis [21].
  • Cytokine assays (TNF-alpha, IL-6, and IL-10) were performed on admission plasma samples from 172 adult Thai patients with severe melioidosis [21].
  • Among 24 DRB1 alleles, 7 DQA1 alleles, and 13 DQB1 alleles identified in this population, an association with melioidosis was observed with DRB1*1602 which was increased in melioidosis patients (10.1%) compared to normal controls (4.8%), p = 0.047 (odds ratio (OR) = 2.25) [22].
  • The CXC chemokines gamma interferon (IFN-gamma)-inducible protein 10 and monokine induced by IFN-gamma are released during severe melioidosis [1].
  • IP-10 and Mig were markedly elevated in patients with melioidosis on admission, particularly in blood culture-positive patients, and remained elevated during the 72-h study period [1].

Analytical, diagnostic and therapeutic context of Melioidosis


  1. The CXC chemokines gamma interferon (IFN-gamma)-inducible protein 10 and monokine induced by IFN-gamma are released during severe melioidosis. Lauw, F.N., Simpson, A.J., Prins, J.M., van Deventer, S.J., Chaowagul, W., White, N.J., van der Poll, T. Infect. Immun. (2000) [Pubmed]
  2. Pseudomonas pseudomallei resistance to beta-lactam antibiotics due to alterations in the chromosomally encoded beta-lactamase. Godfrey, A.J., Wong, S., Dance, D.A., Chaowagul, W., Bryan, L.E. Antimicrob. Agents Chemother. (1991) [Pubmed]
  3. Outcomes of patients with melioidosis treated with meropenem. Cheng, A.C., Fisher, D.A., Anstey, N.M., Stephens, D.P., Jacups, S.P., Currie, B.J. Antimicrob. Agents Chemother. (2004) [Pubmed]
  4. Comparison of efficacy of ciprofloxacin and doxycycline against experimental melioidosis and glanders. Russell, P., Eley, S.M., Ellis, J., Green, M., Bell, D.L., Kenny, D.J., Titball, R.W. J. Antimicrob. Chemother. (2000) [Pubmed]
  5. Neurological melioidosis. Currie, B.J., Fisher, D.A., Howard, D.M., Burrow, J.N. Acta Trop. (2000) [Pubmed]
  6. Sudden unexplained death syndrome. A review and update. Wong, M.L., Ong, C.N., Tan, T.C., Phua, K.H., Goh, L.G., Koh, K., Lee, H.P., Chawalit, S., Orapun, M. Tropical and geographical medicine. (1992) [Pubmed]
  7. Chronic prostatic melioidosis treated with trimethoprim-sulfamethoxazole. Morrison, R.E., Young, E.J., Harper, W.K., Maldonado, L. JAMA (1979) [Pubmed]
  8. Melioidosis. White, N.J. Lancet (2003) [Pubmed]
  9. Ceftazidime for melioidosis. Lam, W.K., Chau, P.Y., So, S.Y., Leung, Y.K. Lancet (1989) [Pubmed]
  10. Halving of mortality of severe melioidosis by ceftazidime. White, N.J., Dance, D.A., Chaowagul, W., Wattanagoon, Y., Wuthiekanun, V., Pitakwatchara, N. Lancet (1989) [Pubmed]
  11. A type IV pilin, PilA, Contributes To Adherence of Burkholderia pseudomallei and virulence in vivo. Essex-Lopresti, A.E., Boddey, J.A., Thomas, R., Smith, M.P., Hartley, M.G., Atkins, T., Brown, N.F., Tsang, C.H., Peak, I.R., Hill, J., Beacham, I.R., Titball, R.W. Infect. Immun. (2005) [Pubmed]
  12. Open-label randomized trial of oral trimethoprim-sulfamethoxazole, doxycycline, and chloramphenicol compared with trimethoprim-sulfamethoxazole and doxycycline for maintenance therapy of melioidosis. Chaowagul, W., Chierakul, W., Simpson, A.J., Short, J.M., Stepniewska, K., Maharjan, B., Rajchanuvong, A., Busarawong, D., Limmathurotsakul, D., Cheng, A.C., Wuthiekanun, V., Newton, P.N., White, N.J., Day, N.P., Peacock, S.J. Antimicrob. Agents Chemother. (2005) [Pubmed]
  13. Tumor necrosis factor in septicemic melioidosis. Suputtamongkol, Y., Kwiatkowski, D., Dance, D.A., Chaowagul, W., White, N.J. J. Infect. Dis. (1992) [Pubmed]
  14. A comparison of chloramphenicol, trimethoprim-sulfamethoxazole, and doxycycline with doxycycline alone as maintenance therapy for melioidosis. Chaowagul, W., Simpson, A.J., Suputtamongkol, Y., Smith, M.D., Angus, B.J., White, N.J. Clin. Infect. Dis. (1999) [Pubmed]
  15. Further evaluation of a rapid diagnostic test for melioidosis in an area of endemicity. O'Brien, M., Freeman, K., Lum, G., Cheng, A.C., Jacups, S.P., Currie, B.J. J. Clin. Microbiol. (2004) [Pubmed]
  16. Antilipopolysaccharide II: an antibody protective against fatal melioidosis. Charuchaimontri, C., Suputtamongkol, Y., Nilakul, C., Chaowagul, W., Chetchotisakd, P., Lertpatanasuwun, N., Intaranongpai, S., Brett, P.J., Woods, D.E. Clin. Infect. Dis. (1999) [Pubmed]
  17. A simple method to detect and differentiate Burkholderia pseudomallei and Burkholderia thailandensis using specific flagellin gene primers. Sonthayanon, P., Krasao, P., Wuthiekanun, V., Panyim, S., Tungpradabkul, S. Mol. Cell. Probes (2002) [Pubmed]
  18. Cellular immunity (T-cell subset using monoclonal antibody) in tuberculosis, melioidosis, pasteurellosis, penicilliosis; and role of levamisole and isoprinosine. Tanphaichitra, D., Srimuang, S. Dev. Biol. Stand. (1984) [Pubmed]
  19. Assessment of the extent and activity of melioidosis with Technetium labelled leukocyte scanning. Ramsay, S.C., LaBrooy, J., Ketharanathan, S., Matthiesson, T. Australian and New Zealand journal of medicine. (1999) [Pubmed]
  20. Pyogenic vertebral osteomyelitis: a review of 14 cases. Nather, A., David, V., Hee, H.T., Thambiah, J. Journal of orthopaedic surgery (Hong Kong) (2005) [Pubmed]
  21. Prognostic value of cytokine concentrations (tumor necrosis factor-alpha, interleukin-6, and interleukin-10) and clinical parameters in severe melioidosis. Simpson, A.J., Smith, M.D., Weverling, G.J., Suputtamongkol, Y., Angus, B.J., Chaowagul, W., White, N.J., van Deventer, S.J., Prins, J.M. J. Infect. Dis. (2000) [Pubmed]
  22. HLA-DR and -DQ associations with melioidosis. Dharakul, T., Vejbaesya, S., Chaowagul, W., Luangtrakool, P., Stephens, H.A., Songsivilai, S. Hum. Immunol. (1998) [Pubmed]
  23. Identification of specific antigens of Pseudomonas pseudomallei and evaluation of their efficacies for diagnosis of melioidosis. Anuntagool, N., Rugdech, P., Sirisinha, S. J. Clin. Microbiol. (1993) [Pubmed]
  24. Evaluation of a new commercially available immunoglobulin M and immunoglobulin G immunochromatographic test for diagnosis of melioidosis infection. Cuzzubbo, A.J., Chenthamarakshan, V., Vadivelu, J., Puthucheary, S.D., Rowland, D., Devine, P.L. J. Clin. Microbiol. (2000) [Pubmed]
  25. Cloning and characterization of a nonhemolytic phospholipase C gene from Burkholderia pseudomallei. Korbsrisate, S., Suwanasai, N., Leelaporn, A., Ezaki, T., Kawamura, Y., Sarasombath, S. J. Clin. Microbiol. (1999) [Pubmed]
  26. Ceftazidime vs. amoxicillin/clavulanate in the treatment of severe melioidosis. Suputtamongkol, Y., Rajchanuwong, A., Chaowagul, W., Dance, D.A., Smith, M.D., Wuthiekanun, V., Walsh, A.L., Pukrittayakamee, S., White, N.J. Clin. Infect. Dis. (1994) [Pubmed]
  27. A comparison of antibiotic regimens in the treatment of acute melioidosis in a mouse model. Ulett, G.C., Hirst, R., Bowden, B., Powell, K., Norton, R. J. Antimicrob. Chemother. (2003) [Pubmed]
WikiGenes - Universities