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Gene Review

Angpt2  -  angiopoietin 2

Mus musculus

Synonyms: ANG-2, Agpt2, Ang-2, Ang2, Angiopoietin-2
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Disease relevance of Angpt2


High impact information on Angpt2


Chemical compound and disease context of Angpt2

  • Pharmacologic Blockade of Angiopoietin-2 Is Efficacious against Model Hemangiomas in Mice [1].
  • Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway [10].

Biological context of Angpt2

  • Signal-transduction blockade targeting ang-2 production may be useful in the treatment of human hemangiomas in vivo.Journal of Investigative Dermatology (2006) 126, 2316-2322. doi:10.1038/sj.jid.5700413; published online 1 June 2006 [1].
  • The nephrogenic pattern of Ang-2 was documented in a mouse strain that expresses the LacZ reporter gene driven by the Ang-2 promoter [11].
  • Among the analyzed angiogenic factors, kringle 1-5 reduced angiopoietin-2 expression levels [12].
  • Hence, Ang-2 deficiency causes dysmorphogenesis of cortical peritubular capillaries, with adjacent cells expressing pericyte-like markers; we speculate the latter effect is caused by disturbed paracrine signaling between endothelial and surrounding mesenchymal precursor cells [13].
  • We used hydrophobic analysis and comparative sequence/structure analysis to select a minimal peptide based on angiopoietin-2 amino acid sequence [14].

Anatomical context of Angpt2


Associations of Angpt2 with chemical compounds


Regulatory relationships of Angpt2


Other interactions of Angpt2


Analytical, diagnostic and therapeutic context of Angpt2


  1. Pharmacologic Blockade of Angiopoietin-2 Is Efficacious against Model Hemangiomas in Mice. Perry, B.N., Govindarajan, B., Bhandarkar, S.S., Knaus, U.G., Valo, M., Sturk, C., Carrillo, C.O., Sohn, A., Cerimele, F., Dumont, D., Losken, A., Williams, J., Brown, L.F., Tan, X., Ioffe, E., Yancopoulos, G.D., Arbiser, J.L. J. Invest. Dermatol. (2006) [Pubmed]
  2. Angiopoietin 2 expression in the retina: upregulation during physiologic and pathologic neovascularization. Hackett, S.F., Ozaki, H., Strauss, R.W., Wahlin, K., Suri, C., Maisonpierre, P., Yancopoulos, G., Campochiaro, P.A. J. Cell. Physiol. (2000) [Pubmed]
  3. Differential expression of angiopoietin-1 and angiopoietin-2 may enhance recruitment of bone-marrow-derived endothelial precursor cells into brain tumors. Udani, V., Santarelli, J., Yung, Y., Cheshier, S., Andrews, A., Kasad, Z., Tse, V. Neurol. Res. (2005) [Pubmed]
  4. Angiopoietin-1, angiopoietin-2 and Tie-2 in tumour and non-tumour tissues during growth of experimental melanoma. Pomyje, J., Zivný, J.H., Stopka, T., Simák, J., Vanková, H., Necas, E. Melanoma Res. (2001) [Pubmed]
  5. Expression of angiopoietin-2 and vascular endothelial growth factor in mice cerebral cortex after permanent focal cerebral ischemia. Wang, R.G., Zhu, X.Z. Acta Pharmacol. Sin. (2002) [Pubmed]
  6. Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription. Yao, D., Taguchi, T., Matsumura, T., Pestell, R., Edelstein, D., Giardino, I., Suske, G., Ahmed, N., Thornalley, P.J., Sarthy, V.P., Hammes, H.P., Brownlee, M. Cell (2006) [Pubmed]
  7. Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Fiedler, U., Reiss, Y., Scharpfenecker, M., Grunow, V., Koidl, S., Thurston, G., Gale, N.W., Witzenrath, M., Rosseau, S., Suttorp, N., Sobke, A., Herrmann, M., Preissner, K.T., Vajkoczy, P., Augustin, H.G. Nat. Med. (2006) [Pubmed]
  8. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Bhandari, V., Choo-Wing, R., Lee, C.G., Zhu, Z., Nedrelow, J.H., Chupp, G.L., Zhang, X., Matthay, M.A., Ware, L.B., Homer, R.J., Lee, P.J., Geick, A., de Fougerolles, A.R., Elias, J.A. Nat. Med. (2006) [Pubmed]
  9. Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha. Elson, D.A., Thurston, G., Huang, L.E., Ginzinger, D.G., McDonald, D.M., Johnson, R.S., Arbeit, J.M. Genes Dev. (2001) [Pubmed]
  10. Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway. Hu, B., Jarzynka, M.J., Guo, P., Imanishi, Y., Schlaepfer, D.D., Cheng, S.Y. Cancer Res. (2006) [Pubmed]
  11. Angiopoietin-2 is a site-specific factor in differentiation of mouse renal vasculature. Yuan, H.T., Suri, C., Landon, D.N., Yancopoulos, G.D., Woolf, A.S. J. Am. Soc. Nephrol. (2000) [Pubmed]
  12. Gene transfer of kringle 1-5 suppresses tumor development and improves prognosis of mice with hepatocellular carcinoma. Torimura, T., Ueno, T., Kin, M., Taniguchi, E., Nakamura, T., Inoue, K., Sakata, R., Hashimoto, O., Sakamoto, M., Ohira, H., Kumashiro, R., Sata, M., Yano, H., Kojiro, M., Veitonmaki, N., Cao, Y. Gastroenterology (2006) [Pubmed]
  13. Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient mice. Pitera, J.E., Woolf, A.S., Gale, N.W., Yancopoulos, G.D., Yuan, H.T. Am. J. Pathol. (2004) [Pubmed]
  14. A novel small peptide as a targeting ligand for receptor tyrosine kinase Tie2. Wu, X., Zhao, R., Li, Z., Yao, M., Wang, H., Han, J., Qu, S., Chen, X., Qian, L., Sun, Y., Xu, Y., Gu, J. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  15. Angiopoietin 2 stimulates migration and tube-like structure formation of murine brain capillary endothelial cells through c-Fes and c-Fyn. Mochizuki, Y., Nakamura, T., Kanetake, H., Kanda, S. J. Cell. Sci. (2002) [Pubmed]
  16. Angiopoietin-1 and -2 mRNA and protein expression in mouse preimplantation embryos and uteri suggests a role in angiogenesis during implantation. Hess, A.P., Hirchenhain, J., Schanz, A., Talbi, S., Hamilton, A.E., Giudice, L.C., Krüssel, J.S. Reprod. Fertil. Dev. (2006) [Pubmed]
  17. Expression of angiopoietin-1, angiopoietin-2, and the Tie-2 receptor tyrosine kinase during mouse kidney maturation. Yuan, H.T., Suri, C., Yancopoulos, G.D., Woolf, A.S. J. Am. Soc. Nephrol. (1999) [Pubmed]
  18. Androgens modulate the balance between VEGF and angiopoietin expression in prostate epithelial and smooth muscle cells. Richard, C., Kim, G., Koikawa, Y., Salm, S.N., Tsujimura, A., Wilson, E.L., Moscatelli, D. Prostate (2002) [Pubmed]
  19. Vascular apoptosis and involution in gliomas precede neovascularization: a novel concept for glioma growth and angiogenesis. Zagzag, D., Amirnovin, R., Greco, M.A., Yee, H., Holash, J., Wiegand, S.J., Zabski, S., Yancopoulos, G.D., Grumet, M. Lab. Invest. (2000) [Pubmed]
  20. Vascular endothelial growth factor is expressed in endothelial cells isolated from skeletal muscles of nitric oxide synthase knockout mice during prazosin-induced angiogenesis. Da Silva-Azevedo, L., Baum, O., Zakrzewicz, A., Pries, A.R. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  21. Leptin induces angiopoietin-2 expression in adipose tissues. Cohen, B., Barkan, D., Levy, Y., Goldberg, I., Fridman, E., Kopolovic, J., Rubinstein, M. J. Biol. Chem. (2001) [Pubmed]
  22. Placental defects in ARNT-knockout conceptus correlate with localized decreases in VEGF-R2, Ang-1, and Tie-2. Abbott, B.D., Buckalew, A.R. Dev. Dyn. (2000) [Pubmed]
  23. Vascular endothelial growth factor-A, vascular endothelial growth factor receptor-2 and angiopoietin-2 expression in the mouse choroid plexuses. Nico, B., Mangieri, D., Corsi, P., De Giorgis, M., Vacca, A., Roncali, L., Ribatti, D. Brain Res. (2004) [Pubmed]
  24. Vascular development in the mouse embryonic pancreas and lung. Colen, K.L., Crisera, C.A., Rose, M.I., Connelly, P.R., Longaker, M.T., Gittes, G.K. J. Pediatr. Surg. (1999) [Pubmed]
  25. Interleukin 12-activated lymphocytes influence tumor genetic programs. Cavallo, F., Quaglino, E., Cifaldi, L., Di Carlo, E., André, A., Bernabei, P., Musiani, P., Forni, G., Calogero, R.A. Cancer Res. (2001) [Pubmed]
  26. Angiopoietin-2 enhances retinal vessel sensitivity to vascular endothelial growth factor. Oshima, Y., Deering, T., Oshima, S., Nambu, H., Reddy, P.S., Kaleko, M., Connelly, S., Hackett, S.F., Campochiaro, P.A. J. Cell. Physiol. (2004) [Pubmed]
  27. Abnormal recruitment of periendothelial cells to lymphatic capillaries in digestive organs of angiopoietin-2-deficient mice. Shimoda, H., Bernas, M.J., Witte, M.H., Gale, N.W., Yancopoulos, G.D., Kato, S. Cell Tissue Res. (2007) [Pubmed]
  28. Senescent impairment in synergistic cytokine pathways that provide rapid cardioprotection in the rat heart. Xaymardan, M., Zheng, J., Duignan, I., Chin, A., Holm, J.M., Ballard, V.L., Edelberg, J.M. J. Exp. Med. (2004) [Pubmed]
  29. Neutrophils promote experimental choroidal neovascularization. Zhou, J., Pham, L., Zhang, N., He, S., Gamulescu, M.A., Spee, C., Ryan, S.J., Hinton, D.R. Mol. Vis. (2005) [Pubmed]
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