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MeSH Review

Sarcoma, Granulocytic

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Disease relevance of Sarcoma, Granulocytic


High impact information on Sarcoma, Granulocytic

  • Mzf1(-/-) mice develop lethal neoplasias characterized by the infiltration and complete disruption of the liver architecture by a monomorphic population of cells of myeloid origin reminiscent of human chloromas [5].
  • Re: Response of aleukemic granulocytic sarcoma to all-trans-retinoic acid plus interferon alfa-2a [6].
  • A multivariate model of survival adjusted for age group, sex, WBC count, chloroma, CNS involvement, and French-American-British group confirmed the increased risk of death in the GSTT1-null cases (relative risk, AQ 1.6; P =.02) [7].
  • Although the overall biosynthesis of prostaglandin E2 (PGE2) was higher in the hyperplastic bone marrow than in the chloroma tumor, the PGF2alpha:PGE2 ratio was markedly higher (8-fold) in the chloroma tissue [8].
  • Regarding the findings of our study and those of other reports, we would guess that the incidence of granulocytic sarcoma in pediatric MLL-positive AML may be equal to or greater than the 18 to 24% described in AML with t(8;21) [9].

Chemical compound and disease context of Sarcoma, Granulocytic


Biological context of Sarcoma, Granulocytic


Anatomical context of Sarcoma, Granulocytic


Gene context of Sarcoma, Granulocytic


Analytical, diagnostic and therapeutic context of Sarcoma, Granulocytic


  1. Prominent glutamine oxidation activity in mitochondria of hematopoietic tumors. Abou-Khalil, W.H., Yunis, A.A., Abou-Khalil, S. Cancer Res. (1983) [Pubmed]
  2. Immunohistochemical evaluation of myeloid leukemia infiltrates (granulocytic sarcomas) in formaldehyde-fixed, paraffin-embedded tissue. Hudock, J., Chatten, J., Miettinen, M. Am. J. Clin. Pathol. (1994) [Pubmed]
  3. Cutaneous promyelocytic sarcoma at sites of vascular access and marrow aspiration. A characteristic localization of chloromas in acute promyelocytic leukemia? Sanz, M.A., Larrea, L., Sanz, G., Martín, G., Sempere, A., Gomis, F., Martínez, J., Regadera, A., Saavedra, S., Jarque, I., Jiménez, C., Cervera, J., de La Rubia, J. Haematologica (2000) [Pubmed]
  4. Granulocytic sarcoma presenting as a mediastinal tumor. Report of a case and cytological and cytochemical studies of tumor cells in vivo and in vitro. Kubonishi, I., Ohtsuki, Y., Machida, K., Agatsuma, Y., Tokuoka, H., Iwata, K., Miyoshi, I. Am. J. Clin. Pathol. (1984) [Pubmed]
  5. Mzf1 controls cell proliferation and tumorigenesis. Gaboli, M., Kotsi, P.A., Gurrieri, C., Cattoretti, G., Ronchetti, S., Cordon-Cardo, C., Broxmeyer, H.E., Hromas, R., Pandolfi, P.P. Genes Dev. (2001) [Pubmed]
  6. Re: Response of aleukemic granulocytic sarcoma to all-trans-retinoic acid plus interferon alfa-2a. Fleming, G.F., Waggoner, S.E., Wu, S., Rotmensch, J., Conley, B.A. J. Natl. Cancer Inst. (1997) [Pubmed]
  7. Glutathione S-transferase polymorphisms and outcome of chemotherapy in childhood acute myeloid leukemia. Davies, S.M., Robison, L.L., Buckley, J.D., Tjoa, T., Woods, W.G., Radloff, G.A., Ross, J.A., Perentesis, J.P. J. Clin. Oncol. (2001) [Pubmed]
  8. Alteration of prostaglandin biosynthesis in rat chloroleukemic tumor. Ziboh, V.A., Lord, J.T., Blick, G., Kursunoglu, I., Poitier, J., Yunis, A.A. Cancer Res. (1977) [Pubmed]
  9. Granulocytic sarcoma in MLL-positive infant acute myelogenous leukemia: fluorescence in situ hybridization study of childhood acute myelogenous leukemia for detecting MLL rearrangement. Park, K.U., Lee, D.S., Lee, H.S., Kim, C.J., Cho, H.I. Am. J. Pathol. (2001) [Pubmed]
  10. Treatment of cutaneous granulocytic sarcoma in a patient with myelodysplasia. Prystowsky, J.H., Johnson, B.L., Bolwell, B.J., Lazarus, G.S. Am. J. Med. (1989) [Pubmed]
  11. Bacterial infection stimulating granulocytic sarcoma of the small bowel. Kraemer, B.B., Foucar, K., Osborne, B., Butler, J.J. Am. J. Clin. Pathol. (1981) [Pubmed]
  12. Megakaryoblastic transformation of chronic granulocytic leukemia. Travis, W.D., Li, C.Y., Banks, P.M., Nichols, W.L. Cancer (1987) [Pubmed]
  13. High dose Ara-C related leukoencephalopathy. Hwang, T.L., Yung, W.K., Lee, Y.Y., Borit, A., Fields, W.S. J. Neurooncol. (1986) [Pubmed]
  14. Megadose methylprednisolone for granulocytic sarcoma. Ozsoylu, S. Acta Haematol. (2001) [Pubmed]
  15. Detection of myeloperoxidase gene expression by in situ hybridization in a case of granulocytic sarcoma associated with AML-MO. Miyazato, H., Sono, H., Naiki, Y., Miyatake, J., Nozaki, Y., Yamaguchi, T., Matsuda, M., Tatsumi, Y., Maeda, Y., Kanamaru, A. Leukemia (2001) [Pubmed]
  16. Detection of AML1/MTG8 fusion gene of spinal granulocytic sarcoma in a nonleukemic patient using the real-time polymerase chain reaction. Nakashima, S., Suzuki, K., Watanabe, K., Urata, S., Mizuta, S., Matsuyama, Y., Ishiguro, N. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association. (2005) [Pubmed]
  17. Direct tissue visualization of normal cross-reacting antigen in neoplastic granulocytes. Pattengale, P.K., Taylor, C.R., Engvall, E., Ruoslahti, E. Am. J. Clin. Pathol. (1980) [Pubmed]
  18. Megakaryoblastic leukemia presenting as a temporal bone granulocytic sarcoma. Case report. Kaufman, B.A., Jones, L., Zutter, M.M., Park, T.S. J. Neurosurg. (1993) [Pubmed]
  19. Granulocytic sarcoma preceding AML M0 and the diagnostic value of CD34. Astall, E., Yarranton, H., Arno, J., Marcus, R. J. Clin. Pathol. (1999) [Pubmed]
  20. Acute myeloid leukemia with t(8;21)(q22;q22) manifesting as granulocytic sarcomas in the rhinopharynx and external acoustic meatus at relapse after high-dose cytarabine: case report and review of the literature. Sugimoto, Y., Nishii, K., Sakakura, M., Araki, H., Usui, E., Lorenzo V, F., Hoshino, N., Miyashita, H., Ohishi, K., Katayama, N., Shiku, H. Hematol. J. (2004) [Pubmed]
  21. Immunohistochemical characterization of mast cell disease in paraffin sections using tryptase, CD68, myeloperoxidase, lysozyme, and CD20 antibodies. Li, W.V., Kapadia, S.B., Sonmez-Alpan, E., Swerdlow, S.H. Mod. Pathol. (1996) [Pubmed]
  22. Monoclonal antibody (UCHL1) that recognises normal and neoplastic T cells in routinely fixed tissues. Norton, A.J., Ramsay, A.D., Smith, S.H., Beverley, P.C., Isaacson, P.G. J. Clin. Pathol. (1986) [Pubmed]
  23. c-Kit (CD117) reactivity in extramedullary myeloid tumor/granulocytic sarcoma. Chen, J., Yanuck, R.R., Abbondanzo, S.L., Chu, W.S., Aguilera, N.S. Arch. Pathol. Lab. Med. (2001) [Pubmed]
  24. Early detection of AML1/MTG8 fusion mRNA by RT-PCR in the bone marrow cells from a patient with isolated granulocytic sarcoma. Hayashi, T., Kimura, M., Satoh, S., Tajima, K., Yahagi, A., Akiba, J., Suzuki, K., Sasaki, H. Leukemia (1998) [Pubmed]
  25. Intradural granulocytic sarcoma presenting as a lumbar radiculopathy. Case report. Kim, F.S., Rutka, J.T., Bernstein, M., Resch, L., Warner, E., Pantalony, D. J. Neurosurg. (1990) [Pubmed]
  26. Idiopathic myelofibrosis developing isolated granulocytic sarcoma with der (1;7)(q10; p10) after splenectomy and finally transforming to acute myelogenous leukemia. Kasahara, S., Tsurumi, H., Hara, T., Goto, H., Moriwaki, H. Leuk. Lymphoma (2000) [Pubmed]
  27. Isolated granulocytic sarcoma of the skin in an elderly patient: good response to treatment with local radiotherapy and low-dose methotrexate. Pulsoni, A., Falcucci, P., Anghel, G., Ribersani, M., Petrucci, M.T., Pescarmona, E., Muscardin, L. Journal of the European Academy of Dermatology and Venereology : JEADV. (2000) [Pubmed]
  28. Tumor-host cell interactions in rats bearing Shay chloroma--ultrastructural observations in animals receiving specific and nonspecific cancer immunotherapy. Syrjänen, K.J., Soimakallio, S. Experimental pathology. (1981) [Pubmed]
  29. Isolated extramedullary relapse of acute myelogenous leukemia as a uterine granulocytic sarcoma in an allogeneic hematopoietic stem cell transplantation recipient. Maeng, H., Cheong, J.W., Lee, S.T., Yang, W.I., Hahn, J.S., Ko, Y.W., Min, Y.H. Yonsei Med. J. (2004) [Pubmed]
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