Disease relevance of Sarcoma, Granulocytic

• (a) Presence of a prominent glutaminase activity in erythroleukemia and chloroma mitochondria is evidenced by their active glutamine-supported respiratory state 3 [1].
• Immunohistochemical evaluation of myeloid leukemia infiltrates (granulocytic sarcomas) in formaldehyde-fixed, paraffin-embedded tissue [2].
• CD45 positivity was present in all lymphomas and 24 of 25 granulocytic sarcomas [2].
• Cutaneous promyelocytic sarcoma at sites of vascular access and marrow aspiration. A characteristic localization of chloromas in acute promyelocytic leukemia [3]?
• From these findings, the patient retrospectively was diagnosed as having mediastinal granulocytic sarcoma, which terminated in pleural effusion and acute promyelocytic leukemia [4].

High impact information on Sarcoma, Granulocytic

• Mzf1(-/-) mice develop lethal neoplasias characterized by the infiltration and complete disruption of the liver architecture by a monomorphic population of cells of myeloid origin reminiscent of human chloromas [5].
• Re: Response of aleukemic granulocytic sarcoma to all-trans-retinoic acid plus interferon alfa-2a [6].
• A multivariate model of survival adjusted for age group, sex, WBC count, chloroma, CNS involvement, and French-American-British group confirmed the increased risk of death in the GSTT1-null cases (relative risk, AQ 1.6; P =.02) [7].
• Although the overall biosynthesis of prostaglandin E2 (PGE2) was higher in the hyperplastic bone marrow than in the chloroma tumor, the PGF2alpha:PGE2 ratio was markedly higher (8-fold) in the chloroma tissue [8].
• Regarding the findings of our study and those of other reports, we would guess that the incidence of granulocytic sarcoma in pediatric MLL-positive AML may be equal to or greater than the 18 to 24% described in AML with t(8;21) [9].

Chemical compound and disease context of Sarcoma, Granulocytic

• In addition to hematoxylin and eosin, myeloperoxidase stain and specific stains for lysozyme and esterase were helpful in confirming the histologic diagnosis of granulocytic sarcoma [10].
• Intense naphthol AS-D chloroacetate esterase (NASD) positivity was observed within most of the cells, suggesting granulocytic sarcoma [11].
• In contrast to granulocytic sarcomas, the megakaryoblastic sarcoma did not stain cytochemically for chloroacetate esterase [12].
• The first patient had received 30 gm of intravenous Ara-C with cranial irradiation (1680 rad in 2 fractions) and intrathecal Ara-C (100 mg X twice) for an intracerebral chloroma and leptomeningeal leukemia [13].
• Megadose methylprednisolone for granulocytic sarcoma [14].

Biological context of Sarcoma, Granulocytic

• Detection of myeloperoxidase gene expression by in situ hybridization in a case of granulocytic sarcoma associated with AML-MO [15].
• Detection of AML1/MTG8 fusion gene of spinal granulocytic sarcoma in a nonleukemic patient using the real-time polymerase chain reaction [16].

Anatomical context of Sarcoma, Granulocytic

• These findings were in contrast to the findings of specific normal cross-reacting antigen positivity in neoplastic granulocytes from three patients who had acute granulocytic leukemia, three who had chronic granulocytic leukemia, and one who had a granulocytic sarcoma [17].
• The unusual presentation of acute megakaryoblastic leukemia as a temporal bone granulocytic sarcoma in an infant without systemic manifestations of leukemia is reviewed [18].
• The initial lymph node biopsy was reviewed and further immunohistochemical studies using antibodies against CD34 led to a revised diagnosis of primary granulocytic sarcoma [19].
• Acute myeloid leukemia with t(8;21)(q22;q22) manifesting as granulocytic sarcomas in the rhinopharynx and external acoustic meatus at relapse after high-dose cytarabine: case report and review of the literature [20].

Gene context of Sarcoma, Granulocytic

• CD68 showed similar to even stronger staining in all of the specimens of MCD, HCL, granulocytic sarcoma, and acute myeloid leukemia (M4 and M5 types) tested and in five of the six MBCL and/or MALT-type lymphomas [21].
• UCHL1 also stained neoplastic cells in four cases of granulocytic sarcoma [22].
• c-Kit (CD117) reactivity in extramedullary myeloid tumor/granulocytic sarcoma [23].
• Early detection of AML1/MTG8 fusion mRNA by RT-PCR in the bone marrow cells from a patient with isolated granulocytic sarcoma [24].
• Myeloperoxidase was identified in all of the granulocytic sarcomas and acute myeloid leukemias (M4 and M5 types) but not in any HCLs, MBCLs, or low-grade lymphomas of MALT type [21].

Analytical, diagnostic and therapeutic context of Sarcoma, Granulocytic

• Intradural granulocytic sarcoma of the L-2 and L-3 nerve roots with extradural extension was found at surgery and he was treated with incomplete resection and antileukemic chemotherapy [25].
• Idiopathic myelofibrosis developing isolated granulocytic sarcoma with der (1;7)(q10; p10) after splenectomy and finally transforming to acute myelogenous leukemia [26].
• Isolated granulocytic sarcoma of the skin in an elderly patient: good response to treatment with local radiotherapy and low-dose methotrexate [27].
• Tumors of the rats bearing Shay chloroma treated with specific (polymerised tumor particles) and nonspecific (PPD tuberculin) cancer immunotherapy were assessed on electron microscopy with special emphasis on the interactions between the host's effector cells and the tumor targets [28].
• Isolated extramedullary relapse of acute myelogenous leukemia as a uterine granulocytic sarcoma in an allogeneic hematopoietic stem cell transplantation recipient [29].

References