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Gene Review

CEACAM6  -  carcinoembryonic antigen-related cell...

Homo sapiens

Synonyms: CD66c, CEAL, Carcinoembryonic antigen-related cell adhesion molecule 6, NCA, Non-specific crossreacting antigen, ...
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Disease relevance of CEACAM6

  • Expression of CEACAM6 in resectable colorectal cancer: a factor of independent prognostic significance [1].
  • Upregulation of CEACAM6 expression in hyperplastic polyps and early adenomas represents one of the earliest observable molecular events leading to colorectal tumors [1].
  • CEACAM6 revealed a broader expression zone in proliferating cells in hyperplastic polyps and adenomas compared with normal mucosa, whereas CEACAM7 was completely absent [2].
  • The results demonstrate that only E. coli expressing a subfamily of Afa/Dr adhesins, named here Afa/Dr-I, including Dr, F1845 and AfaE-III adhesins, bound onto CHO cells expressing CEACAM1, CEA or CEACAM6 [3].
  • This novel mouse will ensure better assessment than previously utilized models for the preclinical testing of CEA-targeted therapies and perhaps allow the testing of CEACAM6, which is overexpressed in many solid tumors and leukemias, as a therapeutic target [4].

Psychiatry related information on CEACAM6

  • All-night polysomnographic recordings of 10 JME patients were analyzed for variations of epileptiform EEG abnormalities in relation to sleep stages and to different microstructural variables (NCAP, CAP, phases A and B) [5].
  • Because panic disorder is highly disabling but responds well to psychological and pharmacologic treatments, screening NCA patients in the cardiology population for this disorder is recommended [6].
  • Statistical comparison between CAP and NCAP epochs revealed a significant difference for most of the frequency domain parameters (increase of the low-frequency band, increase of the low-frequency/high-frequency ratio and decrease in the high-frequency band during CAP) both in Stage 2 and in slow-wave sleep [7].
  • The objective of the current study was to compare psychosocial factors, clinical pain, and responses to experimental pain in NCA patients, patients with ischemic heart disease (IHD), and healthy control subjects [8].
  • Other diagnostic instruments exist which accomplish the same diagnostic task as the NCA diagnostic criteria, but in addition have more desirable psychometric qualities and are more utilitarian [9].

High impact information on CEACAM6

  • Moreover, CEACAM3 engagement triggers membrane recruitment and increased GTP loading of Rac that are not observed upon bacterial binding to CEACAM6 [10].
  • The ability to mediate invasion of the transfectant cells was (CGM1a >CEA >BGPa >NCA >CGM6 = Neo) [11].
  • The following antigenic systems were found in lung cancers: a) antigens specific for most squamous cell cancers and adenocarcinomas, which are undetectable in small cell cancers; b) NCA-type antigens; c) CEA-like antigens; and d) the antigen responsible for alpha-1-antichymotrypsin reactivity [12].
  • A simultaneous production of nonspecific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) by the same individual cells of an established human pancreatic cell line (QGP-1) was demonstrated by the immunoperoxidase method [13].
  • Kinetics of cell proliferation and production of CEA and NCA were analyzed, and active synthesis of both antigens was found to be accompanied with the active proliferation of cultured cells [13].

Chemical compound and disease context of CEACAM6


Biological context of CEACAM6

  • CONCLUSION: Expression of the cell adhesion molecule CEACAM6 in CRC is an independent prognostic factor allowing subdivision of patients into low- and high-risk groups [1].
  • CEACAM6 and CEACAM7 expression correlated with apoptosis at the table region of the normal colon, and both were absent from highly proliferating cells at the base of colonic crypts [2].
  • Thus, deregulated expression of CEA/CEACAM6 could directly contribute to colon tumorigenesis by the inhibition of terminal differentiation and anoikis [19].
  • Our data show that both the CEA and NCA polypeptides are organized into extracellular domains, some with cysteine-linked loops, that share extensive sequence homology (approximately 78% overall) with each other and appear similar to immunoglobulin superfamily members [20].
  • Stable overexpression of CEACAM6 in Capan2 increased gemcitabine chemoresistance, whereas CEACAM6 gene silencing in BxPC3 markedly increased the sensitivity of these cells to gemcitabine [21].

Anatomical context of CEACAM6


Associations of CEACAM6 with chemical compounds

  • CEA and NCA mRNAs were clearly detectable in the cytoplasm of columnar and goblet cells at the free luminal surface and the upper crypts with low hybridization in the mid crypt and the crypt base [25].
  • The purpose of this study was to determine the role of CEACAM6 in cellular chemoresistance to gemcitabine [21].
  • Using confocal microscopy and specific antibodies, CEA and CEACAM6 were demonstrated to co-cluster with integrin alpha5beta1 on the cell surface [26].
  • Only 1 of 15 sera from pregnant women (chorionic gonadotropin > 1000 ng/ml) was positive in the NCA 50/90 ELISA, suggesting that this method does not detect pregnancy-specific glycoprotein [27].
  • As controls fluorescein-labelled CEA and NCA were used [28].
  • Our in vitro studies show that there is increased CEACAM6 expression in cultured intestinal epithelial cells after IFN-gamma or TNF-alpha stimulation and after infection with AIEC bacteria, indicating that AIEC can promote its own colonization in CD patients [29].

Regulatory relationships of CEACAM6


Other interactions of CEACAM6


Analytical, diagnostic and therapeutic context of CEACAM6


  1. Expression of CEACAM6 in resectable colorectal cancer: a factor of independent prognostic significance. Jantscheff, P., Terracciano, L., Lowy, A., Glatz-Krieger, K., Grunert, F., Micheel, B., Brümmer, J., Laffer, U., Metzger, U., Herrmann, R., Rochlitz, C. J. Clin. Oncol. (2003) [Pubmed]
  2. Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. Schölzel, S., Zimmermann, W., Schwarzkopf, G., Grunert, F., Rogaczewski, B., Thompson, J. Am. J. Pathol. (2000) [Pubmed]
  3. Differential recognition of members of the carcinoembryonic antigen family by Afa/Dr adhesins of diffusely adhering Escherichia coli (Afa/Dr DAEC). Berger, C.N., Billker, O., Meyer, T.F., Servin, A.L., Kansau, I. Mol. Microbiol. (2004) [Pubmed]
  4. Novel mouse model for carcinoembryonic antigen-based therapy. Chan, C.H., Stanners, C.P. Mol. Ther. (2004) [Pubmed]
  5. Sleep microstructure and EEG epileptiform activity in patients with juvenile myoclonic epilepsy. Gigli, G.L., Calia, E., Marciani, M.G., Mazza, S., Mennuni, G., Diomedi, M., Terzano, M.G., Janz, D. Epilepsia (1992) [Pubmed]
  6. Validating studies for panic disorder in patients with angiographically normal coronary arteries. Beitman, B.D., Mukerji, V., Kushner, M., Thomas, A.M., Russell, J.L., Logue, M.B. Med. Clin. North Am. (1991) [Pubmed]
  7. Cyclic alternating pattern and spectral analysis of heart rate variability during normal sleep. Ferri, R., Parrino, L., Smerieri, A., Terzano, M.G., Elia, M., Musumeci, S.A., Pettinato, S. Journal of sleep research. (2000) [Pubmed]
  8. Experimental pain and psychologic status of patients with chest pain with normal coronary arteries or ischemic heart disease. Zachariae, R., Melchiorsen, H., Frøbert, O., Bjerring, P., Bagger, J.P. Am. Heart J. (2001) [Pubmed]
  9. The NCA diagnostic criteria: critique, assessment, alternatives. Pattison, E.M. J. Stud. Alcohol (1980) [Pubmed]
  10. Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens. Schmitter, T., Agerer, F., Peterson, L., Munzner, P., Hauck, C.R. J. Exp. Med. (2004) [Pubmed]
  11. Several carcinoembryonic antigens (CD66) serve as receptors for gonococcal opacity proteins. Chen, T., Grunert, F., Medina-Marino, A., Gotschlich, E.C. J. Exp. Med. (1997) [Pubmed]
  12. Antigenic heterogeneity of human lung cancers. Harłozińska, A., Richter, R., Albert, Z., Zawadzka, H. J. Natl. Cancer Inst. (1983) [Pubmed]
  13. Coproduction of carcinoembryonic antigen and nonspecific cross-reacting antigen by a continuous cell line from a human pancreatic tumor. Kuroki, M., Ichiki, S., Kuroki, M., Matsuoka, Y. J. Natl. Cancer Inst. (1982) [Pubmed]
  14. CEACAM6 gene expression in intrahepatic cholangiocarcinoma. Ieta, K., Tanaka, F., Utsunomiya, T., Kuwano, H., Mori, M. Br. J. Cancer (2006) [Pubmed]
  15. c-Src-dependent cross-talk between CEACAM6 and alphavbeta3 integrin enhances pancreatic adenocarcinoma cell adhesion to extracellular matrix components. Duxbury, M.S., Ito, H., Ashley, S.W., Whang, E.E. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  16. The 95-kilodalton membrane glycoprotein overexpressed in novel multidrug-resistant breast cancer cells is NCA, the nonspecific cross-reacting antigen of carcinoembryonic antigen. Ross, D.D., Gao, Y., Yang, W., Leszyk, J., Shively, J., Doyle, L.A. Cancer Res. (1997) [Pubmed]
  17. Serological and biochemical characterization of recombinant baculovirus carcinoembryonic antigen. Bei, R., Kantor, J., Kashmiri, S.V., Schlom, J. Mol. Immunol. (1994) [Pubmed]
  18. The putative role of members of the CEA-gene family (CEA, NCA an BGP) as ligands for the bacterial colonization of different human epithelial tissues. Leusch, H.G., Drzeniek, Z., Hefta, S.A., Markos-Pusztai, Z., Wagener, C. Zentralbl. Bakteriol. (1991) [Pubmed]
  19. Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation. Ilantzis, C., DeMarte, L., Screaton, R.A., Stanners, C.P. Neoplasia (2002) [Pubmed]
  20. Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains. Barnett, T., Goebel, S.J., Nothdurft, M.A., Elting, J.J. Genomics (1988) [Pubmed]
  21. A novel role for carcinoembryonic antigen-related cell adhesion molecule 6 as a determinant of gemcitabine chemoresistance in pancreatic adenocarcinoma cells. Duxbury, M.S., Ito, H., Benoit, E., Waseem, T., Ashley, S.W., Whang, E.E. Cancer Res. (2004) [Pubmed]
  22. Distinct mechanisms of internalization of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Rac1- and Cdc42-dependent and -independent pathways. Billker, O., Popp, A., Brinkmann, V., Wenig, G., Schneider, J., Caron, E., Meyer, T.F. EMBO J. (2002) [Pubmed]
  23. Identification and comparison of residues critical for cell-adhesion activities of two neutrophil CD66 antigens, CEACAM6 and CEACAM8. Kuroki, M., Abe, H., Imakiirei, T., Liao, S., Uchida, H., Yamauchi, Y., Oikawa, S., Kuroki, M. J. Leukoc. Biol. (2001) [Pubmed]
  24. Expression of the CEA gene family members NCA-50/90 and NCA-160 (CD66) in childhood acute lymphoblastic leukemias (ALLs) and in cell lines of B-cell origin. Hanenberg, H., Baumann, M., Quentin, I., Nagel, G., Grosse-Wilde, H., von Kleist, S., Göbel, U., Burdach, S., Grunert, F. Leukemia (1994) [Pubmed]
  25. Four carcinoembryonic antigen subfamily members, CEA, NCA, BGP and CGM2, selectively expressed in the normal human colonic epithelium, are integral components of the fuzzy coat. Frängsmyr, L., Baranov, V., Hammarström, S. Tumour Biol. (1999) [Pubmed]
  26. GPI-anchored CEA family glycoproteins CEA and CEACAM6 mediate their biological effects through enhanced integrin alpha5beta1-fibronectin interaction&. Ordonez, C., Zhai, A.B., Camacho-Leal, P., Demarte, L., Fan, M.M., Stanners, C.P. J. Cell. Physiol. (2007) [Pubmed]
  27. Nonspecific cross-reacting antigen 50/90 is elevated in patients with breast, lung, and colon cancer. Allard, W.J., Neaman, I.E., Elting, J.J., Barnett, T.R., Yoshimura, H., Fritsche, H.A., Yeung, K.K. Cancer Res. (1994) [Pubmed]
  28. Immunofluorescence studies on the occurrence and localization of the CEA-related biliary glycoprotein I (BGP I) in normal human gastrointestinal tissues. Svenberg, T., Hammarström, S., Zeromski, J. Clin. Exp. Immunol. (1979) [Pubmed]
  29. CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease. Barnich, N., Carvalho, F.A., Glasser, A.L., Darcha, C., Jantscheff, P., Allez, M., Peeters, H., Bommelaer, G., Desreumaux, P., Colombel, J.F., Darfeuille-Michaud, A. J. Clin. Invest. (2007) [Pubmed]
  30. Synovial PMN show a coordinated up-regulation of CD66 molecules. Hönig, M., Peter, H.H., Jantscheff, P., Grunert, F. J. Leukoc. Biol. (1999) [Pubmed]
  31. Induction of nonspecific cross-reacting antigen mRNA by interferon-gamma and anti-fibronectin receptor antibody in colon cancer cells. Hinoda, Y., Saito, T., Takahashi, H., Itoh, F., Adachi, M., Imai, K. J. Gastroenterol. (1997) [Pubmed]
  32. Immunological similarity of NCA (non-specific cross-reacting antigen) in feces with alpha 1-acid glycoprotein. Miyazaki, T., Hachiya, T., Kajita, Y., Ochi, Y., Fujiyama, Y., Hosoda, S. Clin. Chim. Acta (1982) [Pubmed]
  33. The critical role of residues 43R and 44Q of carcinoembryonic antigen cell adhesion molecules-1 in the protection from killing by human NK cells. Markel, G., Gruda, R., Achdout, H., Katz, G., Nechama, M., Blumberg, R.S., Kammerer, R., Zimmermann, W., Mandelboim, O. J. Immunol. (2004) [Pubmed]
  34. Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes. Singer, B.B., Scheffrahn, I., Heymann, R., Sigmundsson, K., Kammerer, R., Obrink, B. J. Immunol. (2002) [Pubmed]
  35. Search for new biomarkers of gastric cancer through serial analysis of gene expression and its clinical implications. Yasui, W., Oue, N., Ito, R., Kuraoka, K., Nakayama, H. Cancer Sci. (2004) [Pubmed]
  36. Myeloid antigens in childhood lymphoblastic leukemia: clinical data point to regulation of CD66c distinct from other myeloid antigens. Kalina, T., Vaskova, M., Mejstrikova, E., Madzo, J., Trka, J., Stary, J., Hrusak, O. BMC Cancer (2005) [Pubmed]
  37. Immunochemical analysis of carcinoembryonic antigen (CEA)-related antigens differentially localized in intracellular granules of human neutrophils. Kuroki, M., Yamanaka, T., Matsuo, Y., Oikawa, S., Nakazato, H., Matsuoka, Y. Immunol. Invest. (1995) [Pubmed]
  38. Systemic siRNA-mediated gene silencing: a new approach to targeted therapy of cancer. Duxbury, M.S., Matros, E., Ito, H., Zinner, M.J., Ashley, S.W., Whang, E.E. Ann. Surg. (2004) [Pubmed]
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