The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PLS3  -  plastin 3

Homo sapiens

Synonyms: BMND18, Plastin-3, T-plastin
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PLS3


Psychiatry related information on PLS3

  • The findings suggest that the PLS-3 is generally an informative language test for African American preschoolers; however, scores should be interpreted with caution [6].
  • At 21 months, child cognitive and language development and parent-child interaction were assessed by the Bayley Mental Development Index (MDI), the Preschool Language Scale-3 (PLS-3), and the Caregiver-Child Interaction Rating Scale, respectively [7].

High impact information on PLS3


Biological context of PLS3

  • L- and T-plastin genes were also mapped to chromosomes 13 and X, respectively, using polymerase chain reaction amplification with isoform-specific probes [10].
  • Here, we analyse the effects of T-plastin/T-fimbrin, a representative member of an important actin-filament cross-linking protein by combining a quantitative biomimetic motility assay with biochemical and cell-based approaches [11].
  • The down-regulation of T-plastin expression is further demonstrated in human trophoblastic BeWo cells induced to differentiate using transforming growth factor (TGF)beta1, a growth factor known for its anti-proliferative and anti-invasive response in placental cells [2].
  • Using this approach, T-plastin was initially identified as being differentially expressed in the human first-trimester placenta [2].
  • Expression of PLS3(T21A) in cells could not enhance AD198-induced apoptosis compared with expression of the wild-type PLS3 [12].
  • PLS3 is highly expressed in spinal cord and motor neurons, particularly in the filopodia of the growth cones [5].

Anatomical context of PLS3


Associations of PLS3 with chemical compounds


Regulatory relationships of PLS3


Other interactions of PLS3


Analytical, diagnostic and therapeutic context of PLS3




  1. Aberrant expression of T-plastin in Sezary cells. Su, M.W., Dorocicz, I., Dragowska, W.H., Ho, V., Li, G., Voss, N., Gascoyne, R., Zhou, Y. Cancer Res. (2003) [Pubmed]
  2. Changes in T-plastin expression with human trophoblast differentiation. Rao, R.M., Rama, S., Rao, A.J. Reprod. Biomed. Online (2003) [Pubmed]
  3. Cytoskeletal rearrangements and the functional role of T-plastin during entry of Shigella flexneri into HeLa cells. Adam, T., Arpin, M., Prévost, M.C., Gounon, P., Sansonetti, P.J. J. Cell Biol. (1995) [Pubmed]
  4. An invasion-associated Salmonella protein modulates the actin-bundling activity of plastin. Zhou, D., Mooseker, M.S., Galán, J.E. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  5. Plastin 3 is a protective modifier of autosomal recessive spinal muscular atrophy. Oprea, G.E., Kröber, S., McWhorter, M.L., Rossoll, W., Müller, S., Krawczak, M., Bassell, G.J., Beattie, C.E., Wirth, B. Science. (2008) [Pubmed]
  6. The performance of low-income, African American children on the Preschool Language Scale-3. Qi, C.H., Kaiser, A.P., Milan, S.E., Yzquierdo, Z., Hancock, T.B. J. Speech Lang. Hear. Res. (2003) [Pubmed]
  7. Books, toys, parent-child interaction, and development in young Latino children. Tomopoulos, S., Dreyer, B.P., Tamis-LeMonda, C., Flynn, V., Rovira, I., Tineo, W., Mendelsohn, A.L. Ambulatory pediatrics : the official journal of the Ambulatory Pediatric Association. (2006) [Pubmed]
  8. Functional differences between L- and T-plastin isoforms. Arpin, M., Friederich, E., Algrain, M., Vernel, F., Louvard, D. J. Cell Biol. (1994) [Pubmed]
  9. Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney. Lin, C.S., Shen, W., Chen, Z.P., Tu, Y.H., Matsudaira, P. Mol. Cell. Biol. (1994) [Pubmed]
  10. Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells. Lin, C.S., Park, T., Chen, Z.P., Leavitt, J. J. Biol. Chem. (1993) [Pubmed]
  11. Actin-filament cross-linking protein T-plastin increases Arp2/3-mediated actin-based movement. Giganti, A., Plastino, J., Janji, B., Van Troys, M., Lentz, D., Ampe, C., Sykes, C., Friederich, E. J. Cell. Sci. (2005) [Pubmed]
  12. N-benzyladriamycin-14-valerate (AD198) induces apoptosis through protein kinase C-delta-induced phosphorylation of phospholipid scramblase 3. He, Y., Liu, J., Durrant, D., Yang, H.S., Sweatman, T., Lothstein, L., Lee, R.M. Cancer Res. (2005) [Pubmed]
  13. Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain. Lin, C.S., Aebersold, R.H., Leavitt, J. Mol. Cell. Biol. (1990) [Pubmed]
  14. Phospholipid scramblase-3 regulates cardiolipin de novo biosynthesis and its resynthesis in growing HeLa cells. Van, Q., Liu, J., Lu, B., Feingold, K.R., Shi, Y., Lee, R.M., Hatch, G.M. Biochem. J. (2007) [Pubmed]
  15. Molecular basis for dissimilar nuclear trafficking of the actin-bundling protein isoforms T- and L-plastin. Delanote, V., Van Impe, K., De Corte, V., Bruyneel, E., Vetter, G., Boucherie, C., Mareel, M., Vandekerckhove, J., Friederich, E., Gettemans, J. Traffic (2005) [Pubmed]
  16. Differential regulation of human T-plastin gene in leukocytes and non-leukocytes: identification of the promoter, enhancer, and CpG island. Lin, C.S., Lau, A., Huynh, T., Lue, T.F. DNA Cell Biol. (1999) [Pubmed]
  17. Increased expression of T-plastin gene in cisplatin-resistant human cancer cells: identification by mRNA differential display. Hisano, T., Ono, M., Nakayama, M., Naito, S., Kuwano, M., Wada, M. FEBS Lett. (1996) [Pubmed]
WikiGenes - Universities