Disease relevance of Retinal Vasculitis

• Sera from 44 patients with isolated retinal vasculitis (RV), 38 patients with retinal vasculitis accompanying systemic inflammatory diseases (RV + SID), and 33 patients with a similar range of systemic inflammatory diseases without eye involvement (SID alone) were assayed for circulating immune complexes (CIC) and for anti-retinal autoantibodies [1].
• Idiopathic retinal vasculitis, aneurysms, and neuro-retinitis. Retinal Vasculitis Study [2].
• We describe two unusual young patients with intraocular lymphoma who presented clinically with "retinal vasculitis." Brain biopsy specimens in both showed an angiocentric pattern of lymphocytic infiltration [3].
• A 73-year-old woman with panuveitis and retinal vasculitis presented with a lump on her lip after 52 months of treatment with cyclosporin A [4].
• RESULTS: Lisinopril had no effect on cystoid macular edema, visual acuity, papillary leakage, retinal vasculitis, and choroidal leakage [5].

High impact information on Retinal Vasculitis

• Fluorescein angiography showed disruption of the blood-retinal barrier at the level of the retinal pigmented epithelium, and occasional retinal vasculitis and perivasculitis [6].
• Serum levels of the chemokines MIP-1beta and MIP-1alpha, but not MCP-1 were raised in patients with retinal vasculitis [7].
• Occlusive retinal vasculitis associated with systemic lupus erythematosus [8].
• Retinal vasculitis associated with HLA DR4. Brief definitive report [9].
• Hence in the present study we have investigated the role of MC activation and hydroxyl radicals (OH) production and its possible involvement in promoting the development of retinal vasculitis in patients with ED [10].

Chemical compound and disease context of Retinal Vasculitis

• The role of azathioprine in the management of retinal vasculitis [11].
• Ten patients with birdshot retinochoroidopathy, six with isolated retinal vasculitis and eight with Behçet's disease were treated with cyclosporine for one to three years [12].
• AIMS: To determine whether patients with idiopathic retinal vasculitis have altered production of cortisol and dehydroepiandrosterone sulphate (DHEA-S), and whether differences in these variables occur between those who are sensitive (SS) and resistant (SR) to steroids [13].
• RESULT: The retinal vasculitis and vitreitis resolved after three weeks of therapy with ciprofloxacin hydrochloride without concomitant anti-inflammatory therapy [14].
• The effects of dexamethasone, cyclosporin A and prazosin were investigated in an animal model of retinal vasculitis [15].

Biological context of Retinal Vasculitis

• Twenty-four to 48 hours after the onset of fever and rickettsemia, multifocal areas of retinal vasculitis were evident, which corresponded to areas of altered vascular permeability demonstrated by fluorescein angiography [16].
• Alpha 1 antitrypsin serum levels and phenotypes in patients with retinal vasculitis [17].
• Antibody affinity to retinal S-antigen in patients with retinal vasculitis [18].
• Amaurosis fugax and retinal vasculitis associated with methamphetamine inhalation [19].

Anatomical context of Retinal Vasculitis

• Cyclosporine effects on optic nerve and retinal vasculitis in Behçet's disease [20].
• Within a few days of her admission, following the commencement of steroid therapy, and a grand mal seizure, the patient developed paralysis of her lower limbs, due to an acute demyelinating polyneuropathy, and subsequently a retinal vasculitis [21].
• RESULTS: These patients had extensive unrewarding medical and neurological investigations because of suspected diagnoses, including central nervous system disorders, cancer-associated retinopathy, retinal vasculitis, diffuse unilateral subacute neuroretinitis, and tapetoretinal degenerations [22].

Gene context of Retinal Vasculitis

• Retinal vasculitis in rheumatoid arthritis: an angiographic study [23].
• Using a modified enzyme-linked immunosorbent antibody method that included dissociation of antigen antibody complexes with sodium thiocyanate, we examined the functional affinity of antibody to retinal S-antigen in 48 patients with retinal vasculitis and 46 age-matched healthy control subjects [18].
• Soluble interleukin-2 receptors in retinal vasculitis [24].
• These diseases may represent a new clinical entity characterized by signs of retinal vasculitis and hyperimmunoglobulinemia D that results from abnormal B cell activation and immune complex-mediated responses [25].
• A form of experimental retinal vasculitis was induced in black hooded Lister rats by the inoculation of retinal S-antigen [26].

Analytical, diagnostic and therapeutic context of Retinal Vasculitis

• In a retrospective study of 345 angiograms of 135 patients with active non-occlusive retinal vasculitis 12 patients were identified by independent masked review as showing macular ischaemia on their fluorescein angiograms [27].
• The diagnosis of retinal vasculitis was made by ophthalmoscopy and fluorescein angiography, and patients with any identifiable cause (infection, ischaemia, or malignancy) were excluded from the study [28].
• Serum alpha-1 acid glycoprotein levels were measured in 27 patients with idiopathic peripheral retinal vasculitis (Eales' disease) and 31 healthy subjects by single radial immunodiffusion technique [29].
• RECENT FINDINGS: Novel imaging techniques such as indocyanine green angiography have made it possible to explore inflammation of choroidal vessels and of scleral vasculitis in addition to retinal vasculitis, contributing to the global concept of ocular vasculitis [30].

References