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Chemical Compound Review

Clofencet     2-(4-chlorophenyl)-3-ethyl-5- oxo...

Synonyms: Genesis, SureCN122191, AG-D-59372, ACMC-20mt22, HSDB 7008, ...
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Disease relevance of Genesis


Psychiatry related information on Genesis


High impact information on Genesis


Biological context of Genesis


Anatomical context of Genesis

  • To explore that possibility in a heterologous system of differentiation, Genesis was stably transduced into the IL-3-dependent myeloid cell line 32D using a retroviral expression vector [15].
  • To activate expression of the gene of interest in a tissue-specific fashion, founder mice were mated to the Cre mouse line 2.5P-Cre previously shown to mediate 100% Cre recombination exclusively in podocytes (Moeller MJ, Sanden SK, Soofi A, Wiggins RC, and Holzman LB. Genesis 35: 39-42, 2003) [16].
  • In this study in situ cRNA hybridization experiments revealed that Genesis was expressed during embryogenesis only in developing neural crest cells [17].
  • Microemboli during coronary artery bypass grafting. Genesis and effect on outcome [18].
  • 6-OHDA-induced ectopia of external granule cells in the subarachnoid space covering the cerebellum. Genesis and topography [19].

Associations of Genesis with other chemical compounds

  • A chromatographic run on a C8 Genesis (150 mm x 4.6 mm, 5 microm) column maintained at 30 degrees C lasts about 17 min, using a mobile phase composed of ACN (12%) and a pH 2.5 phosphate buffer (88%) containing 0.3% triethylamine [20].

Gene context of Genesis

  • Therefore, Genesis may play a role in the regulation of primitive neural crest development by preventing terminal quiescence through inhibition of p21 protein expression [17].
  • We report our findings of an NMR structural study performed on an HNF-3/fkh family member (Genesis, formerly HFH-2) and compare it to that of another family member (HNF-3gamma) complexed to DNA and determined by X-ray crystallography [21].
  • Zebrafish crestin was identified in a screen for genes dependent on cyclops function and is a member of a family of retroelements (Rubinstein et al. [2000] Genesis 26:86-97) [22].
  • A novel member of the winged helix (formerly HNF-3/Forkhead) transcriptional regulatory family, termed Genesis, was isolated and characterized [1].
  • Despite rather low sequence identity for a protein within the forkhead family, the structure is remarkably similar to those of the DNA binding domains of HNF3-gamma and FREAC-11, and to a lesser extent the DNA binding domain of Genesis which displays a slightly altered orientation of the DNA recognition helix [23].

Analytical, diagnostic and therapeutic context of Genesis


  1. Genesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cells. Sutton, J., Costa, R., Klug, M., Field, L., Xu, D., Largaespada, D.A., Fletcher, C.F., Jenkins, N.A., Copeland, N.G., Klemsz, M., Hromas, R. J. Biol. Chem. (1996) [Pubmed]
  2. Tumor Necrosis Factor-{alpha} and Interleukin-1{beta} Regulate Interleukin-8 Expression in Third Trimester Decidual Cells: Implications for the Genesis of Chorioamnionitis. Lockwood, C.J., Arcuri, F., Toti, P., Felice, C.D., Krikun, G., Guller, S., Buchwalder, L.F., Schatz, F. Am. J. Pathol. (2006) [Pubmed]
  3. The Association of Obesity and Hyperandrogenemia during the Pubertal Transition in Girls: Obesity as a Potential Factor in the Genesis of Postpubertal Hyperandrogenism. McCartney, C.R., Prendergast, K.A., Chhabra, S., Eagleson, C.A., Yoo, R., Chang, R.J., Foster, C.M., Marshall, J.C. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  4. Evaluation of an automated liquid-handling system (Tecan Genesis RSP 100) in the Abbott LCx assay for Chlamydia trachomatis. Hanson, K.L., Cartwright, C.P. J. Clin. Microbiol. (2001) [Pubmed]
  5. Crimping and repositioning of a maldeployed balloon-expandable arterial stent using a gooseneck snare. Portugaller, H.R., Pabst, E., Doerfler, O.C., Tauss, J., Zangrando, M., Pilger, E., Klein, G.E. J. Endovasc. Ther. (2005) [Pubmed]
  6. Project Genesis: assessing the efficacy of problem-solving therapy for distressed adult cancer patients. Nezu, A.M., Nezu, C.M., Felgoise, S.H., McClure, K.S., Houts, P.S. Journal of consulting and clinical psychology. (2003) [Pubmed]
  7. Letter: Genesis of Dandy-Walker syndrome. Smith, M.T., Huntington, H.W. N. Engl. J. Med. (1976) [Pubmed]
  8. The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression. Guo, Y., Costa, R., Ramsey, H., Starnes, T., Vance, G., Robertson, K., Kelley, M., Reinbold, R., Scholer, H., Hromas, R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  9. Visual cortex development in the ferret. I. Genesis and migration of visual cortical neurons. Jackson, C.A., Peduzzi, J.D., Hickey, T.L. J. Neurosci. (1989) [Pubmed]
  10. The transcription factors steroidogenic factor-1 and SOX9 regulate expression of Vanin-1 during mouse testis development. Wilson, M.J., Jeyasuria, P., Parker, K.L., Koopman, P. J. Biol. Chem. (2005) [Pubmed]
  11. Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin. Fan, B., Wu, T.D., Li, W., Kirchhofer, D. J. Biol. Chem. (2005) [Pubmed]
  12. Nucleotide sequence and topography of chicken c-fps. Genesis of a retroviral oncogene encoding a tyrosine-specific protein kinase. Huang, C.C., Hammond, C., Bishop, J.M. J. Mol. Biol. (1985) [Pubmed]
  13. Dynamic DNA contacts observed in the NMR structure of winged helix protein-DNA complex. Jin, C., Marsden, I., Chen, X., Liao, X. J. Mol. Biol. (1999) [Pubmed]
  14. Different patterns of insulin resistance in relatives of type 1 diabetic patients with retinopathy or nephropathy: the Genesis France-Belgium Study. Hadjadj, S., Péan, F., Gallois, Y., Passa, P., Aubert, R., Weekers, L., Rigalleau, V., Bauduceau, B., Bekherraz, A., Roussel, R., Dussol, B., Rodier, M., Marechaud, R., Lefebvre, P.J., Marre, M. Diabetes Care (2004) [Pubmed]
  15. Forced expression of Genesis, a winged helix transcriptional repressor isolated from embryonic stem cells, blocks granulocytic differentiation of 32D myeloid cells. Xu, D., Yoder, M., Sutton, J., Hromas, R. Leukemia (1998) [Pubmed]
  16. An efficient system for tissue-specific overexpression of transgenes in podocytes in vivo. Moeller, M.J., Soofi, A., Sanden, S., Floege, J., Kriz, W., Holzman, L.B. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  17. Genesis, a Winged Helix transcriptional repressor, has embryonic expression limited to the neural crest, and stimulates proliferation in vitro in a neural development model. Hromas, R., Ye, H., Spinella, M., Dmitrovsky, E., Xu, D., Costa, R.H. Cell Tissue Res. (1999) [Pubmed]
  18. Microemboli during coronary artery bypass grafting. Genesis and effect on outcome. Clark, R.E., Brillman, J., Davis, D.A., Lovell, M.R., Price, T.R., Magovern, G.J. J. Thorac. Cardiovasc. Surg. (1995) [Pubmed]
  19. 6-OHDA-induced ectopia of external granule cells in the subarachnoid space covering the cerebellum. Genesis and topography. Sievers, J., Mangold, U., Berry, M. Cell Tissue Res. (1983) [Pubmed]
  20. Determination of amphetamines in human urine by liquid chromatography with fluorimetric detection using a solid-phase extraction procedure. Bugamelli, F., Mandrioli, R., Cavallini, A., Baccini, C., Conti, M., Raggi, M.A. Journal of separation science (2006) [Pubmed]
  21. Structural changes in the region directly adjacent to the DNA-binding helix highlight a possible mechanism to explain the observed changes in the sequence-specific binding of winged helix proteins. Marsden, I., Jin, C., Liao, X. J. Mol. Biol. (1998) [Pubmed]
  22. Specific pan-neural crest expression of zebrafish Crestin throughout embryonic development. Luo, R., An, M., Arduini, B.L., Henion, P.D. Dev. Dyn. (2001) [Pubmed]
  23. Solution structure of the DNA binding domain of the human forkhead transcription factor AFX (FOXO4). Weigelt, J., Climent, I., Dahlman-Wright, K., Wikström, M. Biochemistry (2001) [Pubmed]
  24. Amino acid substitutions in a long flexible sequence influence thermodynamics and internal dynamic properties of winged helix protein genesis and its DNA complex. Yan, H., Liao, X. Biophys. J. (2003) [Pubmed]
  25. Restenosis in gold-coated renal artery stents. Nolan, B.W., Schermerhorn, M.L., Powell, R.J., Rowell, E., Fillinger, M.F., Rzucidlo, E.M., Wyers, M.C., Whittaker, D., Zwolak, R.M., Walsh, D.B., Cronenwett, J.L. J. Vasc. Surg. (2005) [Pubmed]
  26. The combined (Genesis) technique of radial keratotomy. A prospective, multicenter study. Refractive Keratoplasty Study Group. Verity, S.M., Talamo, J.H., Chayet, A., Wolf, T.C., Rapoza, P., Schanzlin, D.J., Lane, S., Kenyon, K., Assil, K.K. Ophthalmology (1995) [Pubmed]
  27. Removal of short-term isolation stress differentially influences prepulse inhibition in APO-SUS and APO-UNSUS rats. Sontag, T.A., Cools, A.R., Ellenbroek, B.A. Behav. Brain Res. (2003) [Pubmed]
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