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Chemical Compound Review

Isoetarin     4-[1-hydroxy-2-(propan-2...

Synonyms: Dilabron, Bronkosol, Isoetarina, Isoetarine, Neoisuprel, ...
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Disease relevance of isoetharine


High impact information on isoetharine

  • PATIENTS AND METHODS: Fifty-one adults presenting with severe asthma exacerbations (forced expiratory volumes in the first second of exhalation [FEV1] <40% of predicted) to the emergency department were randomized (double-blind) to receive hourly inhaled nebulization treatment with either isoetharine (5 mg) or albuterol (2.5 mg) [5].
  • Based on clinical criteria and the ability to raise and maintain for four hours an FEV, by 15% above baseline, ten (50%) of the patients who received isoetharine and 16 (80%) of the patients who received fenoterol therapy were successes [6].
  • Heart rate was not increased after Bronkosol or isoetharine, confirming its selective beta-2 action [7].
  • MEASUREMENTS AND MAIN RESULTS: During the first test, isoetharine produced a mild increase in maximum expiratory flows at 25% (MEF25) of forced vital capacity (FVC) (48 +/- 27% compared with baseline values), without significant change in the MEF25 to FVC ratio [3].
  • All patients received nebulized isoetharine inhalations and continuous IV aminophylline infusion [8].

Chemical compound and disease context of isoetharine


Biological context of isoetharine


Anatomical context of isoetharine


Associations of isoetharine with other chemical compounds


Gene context of isoetharine

  • Pulmonary function testing after nebulized 0.1% isoetharine (a bronchodilator), to test for bronchial reactivity, began midway during the study period in 15 patients [21].

Analytical, diagnostic and therapeutic context of isoetharine

  • Lung mechanics and lower airway function were measured and compared before and after administration of aerosolized isoetharine early in the course of ECMO and again several days after ECMO [3].


  1. Dose-dependent bronchospasm from sulfites in isoetharine. Koepke, J.W., Christopher, K.L., Chai, H., Selner, J.C. JAMA (1984) [Pubmed]
  2. Anaphylaxis to a component of isoetharine (sodium bisulfite). Twarog, F.J., Leung, D.Y. JAMA (1982) [Pubmed]
  3. Contribution of airway hyperresponsiveness to lower airway obstruction after extracorporeal membrane oxygenation for meconium aspiration syndrome. Koumbourlis, A.C., Mutich, R.L., Motoyama, E.K. Crit. Care Med. (1995) [Pubmed]
  4. Effect of isoetharine on cardiac conduction in man. Gould, L., Reddy, C.V., Patel, S., Gomes, G., Macklin, E. Pacing and clinical electrophysiology : PACE. (1982) [Pubmed]
  5. Isoetharine versus albuterol for acute asthma: greater immediate effect, but more side effects. Shrestha, M., Gourlay, S., Robertson, S., Bidadi, K., Wainscott, M., Hayes, J. Am. J. Med. (1996) [Pubmed]
  6. Nebulized isoetharine and fenoterol in acute attacks of asthma. König, P., Hurst, D.J. Arch. Intern. Med. (1983) [Pubmed]
  7. Effect of bronkosol and its components on cardiopulmonary parameters in asthmatic patients. Spector, S.L., Hudson, L., Petty, T.L. J. Allergy Clin. Immunol. (1977) [Pubmed]
  8. Intravenous methylprednisolone efficacy in status asthmaticus of childhood. Younger, R.E., Gerber, P.S., Herrod, H.G., Cohen, R.M., Crawford, L.V. Pediatrics (1987) [Pubmed]
  9. Bronchoconstrictor additives in bronchodilator solutions. Asmus, M.J., Sherman, J., Hendeles, L. J. Allergy Clin. Immunol. (1999) [Pubmed]
  10. Comparison of metaproterenol, isoetharine and salbutamol in the relief of methacholine-induced bronchospasm in dogs. Casthely, P.A., Cottrell, J.E., Urquhart, P.A. Canadian Anaesthetists' Society journal. (1985) [Pubmed]
  11. Status Asthmaticus: use of acetylcysteine during bronchoscopy and lavage to remove mucous plugs. Millman, M., Goodman, A.H., Goldstein, I.M., Millman, F.M., Van Campen, S.S. Annals of allergy. (1983) [Pubmed]
  12. A randomized, controlled comparison of isoetharine and albuterol in the treatment of acute asthma. Emerman, C.L., Cydulka, R.K., Effron, D., Lukens, T.W., Gershman, H., Boehm, S.P. Annals of emergency medicine. (1991) [Pubmed]
  13. Non-cAMP-mediated bronchial arterial vasodilation in response to inhaled beta-agonists. Carvalho, P., Johnson, S.R., Charan, N.B. J. Appl. Physiol. (1998) [Pubmed]
  14. Determination of isoetharine in plasma by reversed-phase chromatography with amperometric detection. Park, G.B., Koss, R.F., Utter, J., Mayes, B.A., Edelson, J. Journal of pharmaceutical sciences. (1982) [Pubmed]
  15. Administration of metered-dose inhalers: comparison of open- and closed-mouth techniques in childhood asthmatics. Unzeitig, J.C., Richards, W., Church, J.A. Annals of allergy. (1983) [Pubmed]
  16. The contribution of extraneuronal uptake to the trachea-blood vessel selectivity of beta-adrenoceptor stimulants in vitro in guinea-pigs. O'Donnell, S.R., Wanstall, J.C. Br. J. Pharmacol. (1976) [Pubmed]
  17. Decreased duration of emergency department treatment of chronic obstructive pulmonary disease exacerbations with the addition of ipratropium bromide to beta-agonist therapy. Shrestha, M., O'Brien, T., Haddox, R., Gourlay, H.S., Reed, G. Annals of emergency medicine. (1991) [Pubmed]
  18. Combination of atropine and isoetharine aerosol therapy in pediatric acute asthma. Lew, D.B., Herrod, H.G., Crawford, L.V. Annals of allergy. (1990) [Pubmed]
  19. Physical-chemical compatibility of cromolyn sodium nebulizer solution--bronchodilator inhalant solution admixtures. Lesko, L.J., Miller, A.K. Annals of allergy. (1984) [Pubmed]
  20. Isoetharine-isoproterenol: a comparison of effects in childhood status asthmaticus. Newman, L.J., Richards, W., Church, J.A. Annals of allergy. (1982) [Pubmed]
  21. Pulmonary dysfunction after primary closure of an abdominal wall defect and its improvement with bronchodilators. Nakayama, D.K., Mutich, R., Motoyama, E.K. Pediatr. Pulmonol. (1992) [Pubmed]
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