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Gene Review

Enpep  -  glutamyl aminopeptidase

Rattus norvegicus

Synonyms: AP-A, Aminopeptidase A, EAP, Glutamyl aminopeptidase
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Disease relevance of Enpep


High impact information on Enpep


Chemical compound and disease context of Enpep

  • Because clipped kidneys are not exposed to high blood pressure, these results suggest that glomerular APA expression is positively regulated and tubular APA negatively regulated by Ang II [2].

Biological context of Enpep


Anatomical context of Enpep


Associations of Enpep with chemical compounds

  • Previously, we reported that mesangial cells were positively immunostained with antiserum directed against aminopeptidase A, the principal angiotensinase in the metabolism of angiotensin II [12].
  • Aminopeptidase-A. I. CDNA cloning and expression and localization in rat tissues [9].
  • These results indicate that rat kidney EAP is a species homologue of the murine BP-1/6C3 and human gp160 antigens [13].
  • Changes in transmembrane potential relative to action potential amplitude (delta Vm/APA) were measured in patterned cultures of neonatal rat myocytes, stained with voltage-sensitive dye (RH-237), by optical mapping (96-channel photodiode array, 6- to 30-micron resolution) during the application of EES (field strength, 8 to 22 V/cm; duration, 6 ms) [14].
  • RESULTS: APA activity was found all along the nephron but was higher in the cortex than in the medulla [15].

Other interactions of Enpep


Analytical, diagnostic and therapeutic context of Enpep


  1. Discrepancy between plasma and lung angiotensin-converting enzyme activity in experimental congestive heart failure. A novel aspect of endothelium dysfunction. Huang, H., Arnal, J.F., Llorens-Cortes, C., Challah, M., Alhenc-Gelas, F., Corvol, P., Michel, J.B. Circ. Res. (1994) [Pubmed]
  2. Kidney aminopeptidase A and hypertension, part II: effects of angiotensin II. Song, L., Healy, D.P. Hypertension (1999) [Pubmed]
  3. Action potentials of the rabbit, guinea pig, dog and albino rat working ventricular myocardium under interpolated extrasystole conditions during postnatal ontogenesis. Pucelík, P., Holická, M., Lässigová, M., Jezek, K. Physiologia Bohemoslovaca. (1984) [Pubmed]
  4. Aminopeptidase activity in the livers of rats with experimental chronic renal failure. Ogura, M., Hazato, T., Katayama, T. Biochem. Int. (1984) [Pubmed]
  5. Enzyme cytochemistry of rat organs after uremia with special reference to proteases. Gossrau, R., Heidland, A., Haunschild, J. Histochemistry (1988) [Pubmed]
  6. Evidence for the role of angiotensin II biosynthesis in the rat internal anal sphincter tone. De Godoy, M.A., Dunn, S., Rattan, S. Gastroenterology (2004) [Pubmed]
  7. Activation of cardiac tissue by extracellular electrical shocks: formation of 'secondary sources' at intercellular clefts in monolayers of cultured myocytes. Fast, V.G., Rohr, S., Gillis, A.M., Kléber, A.G. Circ. Res. (1998) [Pubmed]
  8. Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate. Identification and characterization of a novel N-acetylated alpha-linked acidic dipeptidase activity from rat brain. Robinson, M.B., Blakely, R.D., Couto, R., Coyle, J.T. J. Biol. Chem. (1987) [Pubmed]
  9. Aminopeptidase-A. I. CDNA cloning and expression and localization in rat tissues. Troyanovskaya, M., Jayaraman, G., Song, L., Healy, D.P. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2000) [Pubmed]
  10. Kidney aminopeptidase A and hypertension, part I: spontaneously hypertensive rats. Healy, D.P., Song, L. Hypertension (1999) [Pubmed]
  11. Purification and characterization of an enkephalin aminopeptidase from rat brain membranes. Hui, K.S., Wang, Y.J., Lajtha, A. Biochemistry (1983) [Pubmed]
  12. Expression of aminopeptidase A, an angiotensinase, in glomerular mesangial cells. Troyanovskaya, M., Song, L., Jayaraman, G., Healy, D.P. Hypertension (1996) [Pubmed]
  13. Rat kidney glutamyl aminopeptidase (aminopeptidase A): molecular identity and cellular localization. Song, L., Ye, M., Troyanovskaya, M., Wilk, E., Wilk, S., Healy, D.P. Am. J. Physiol. (1994) [Pubmed]
  14. Spatial changes in transmembrane potential during extracellular electrical shocks in cultured monolayers of neonatal rat ventricular myocytes. Gillis, A.M., Fast, V.G., Rohr, S., Kléber, A.G. Circ. Res. (1996) [Pubmed]
  15. Aminopeptidase A activity and angiotensin III effects on [Ca2+]i along the rat nephron. Hus-Citharel, A., Gasc, J.M., Zini, S., Marchetti, J., Roques, B., Corvol, P., Llorens-Cortes, C. Kidney Int. (1999) [Pubmed]
  16. Oleate, linoleate and cholesterol differently modify aspartyl- and glutamyl-aminopeptidase activities in primary cultures of rat astrocytes. Ramírez-Expósito, M.J., Martínez-Martos, J.M., Mayas, M.D., García, M.J., Prieto, I., Aréchaga, G., Ramírez, M. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2001) [Pubmed]
  17. Maleate effects on kidney peptidases and proteinuria of male and female rats. Histochemical and biochemical studies. Asan, E., Kugler, P. Histochemistry (1985) [Pubmed]
  18. Possible involvement of aminopeptidase A in hypertension in spontaneously hypertensive rats (SHRs) and change of refractoriness in response to angiotensin II in pregnant SHRs. Nakashima, Y., Ohno, Y., Itakura, A., Takeuchi, M., Murata, Y., Kuno, N., Mizutani, S. J. Hypertens. (2002) [Pubmed]
  19. Quantitative histochemistry of the angiotensinase A (APA) in the renal glomeruli of rats after stimulation of the renin-angiotensin system. Kugler, P., Schiebler, T.H. Cytometry. (1984) [Pubmed]
  20. Possible involvement of aminopeptidase A in hypertension and renal damage in Dahl salt-sensitive rats. Nomura, M., Nomura, S., Mitsui, T., Suzuki, M., Kobayashi, H., Ito, T., Itakura, A., Kikkawa, F., Mizutani, S. Am. J. Hypertens. (2005) [Pubmed]
  21. Amastatin potentiates drinking elicited by osmotic stimuli: evidence for peptidergic mediation of intracellular dehydration-induced thirst. Sullivan, M.J., Johnson, A.K. Brain Res. (1992) [Pubmed]
  22. Reticular formation influence on neuronal transmission from perforant pathway through dentate gyrus. Winson, J. Brain Res. (1981) [Pubmed]
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