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Chemical Compound Review

CCRIS 300     1-ethyl-2-nitro-1-nitroso- guanidine

Synonyms: AC1NV8XO, 4245-77-6, EINECS 224-206-7, 1-Ethyl-3-nitro-1-nitrosoguanidine, 1-ethyl-2-nitro-1-nitrosoguanidine, ...
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Disease relevance of 1-ethyl-2-nitro-1-nitroso-guanidine


High impact information on 1-ethyl-2-nitro-1-nitroso-guanidine


Chemical compound and disease context of 1-ethyl-2-nitro-1-nitroso-guanidine


Biological context of 1-ethyl-2-nitro-1-nitroso-guanidine


Anatomical context of 1-ethyl-2-nitro-1-nitroso-guanidine


Associations of 1-ethyl-2-nitro-1-nitroso-guanidine with other chemical compounds


Gene context of 1-ethyl-2-nitro-1-nitroso-guanidine


Analytical, diagnostic and therapeutic context of 1-ethyl-2-nitro-1-nitroso-guanidine


  1. Histochemical patterns in early lesions and infiltrating adenocarcinomas induced in mouse duodenum by n-ethyl-n'-nitro-n-nitrosoguanidine. Matsuyama, M., Ito, M., Yamada, S., Nakamura, T., Nagayo, T. J. Natl. Cancer Inst. (1976) [Pubmed]
  2. Esophageal and gastric cancers with metastases induced in dogs by N-ethyl-N'-nitro-N-nitrosoguanidine. Sasajima, K., Kawachi, T., Sano, T., Sugimura, T., Shimosato, Y. J. Natl. Cancer Inst. (1977) [Pubmed]
  3. Induction of gastric carcinomas in nonhuman primates by N-ethyl-N'-nitro-N-nitrosoguanidine. Ohgaki, H., Hasegawa, H., Kusama, K., Morino, K., Matsukura, N., Sato, S., Maruyama, K., Sugimura, T. J. Natl. Cancer Inst. (1986) [Pubmed]
  4. Histopathological study on N-ethyl-N'-nitro-N-nitrosoguanidine-induced colon cancer in dogs. Kamano, T., Kishino, H., Mizukami, K., Azuma, N., Tamura, J., Katami, A., Kidokoro, T. Int. J. Cancer (1983) [Pubmed]
  5. Cell proliferation and cell loss in intramucosal signet ring cell carcinoma of canine stomachs induced by N-ethyl-N'-nitro-N-nitrosoguanidine. Sugihara, H., Tsuchihashi, Y., Hattori, T., Fukuda, M., Fujita, S. J. Cancer Res. Clin. Oncol. (1985) [Pubmed]
  6. Postreplication repair and the susceptibility of Chinese hamster cells to cytotoxic and mutagenic effects of alkylating agents. Friedman, J., Huberman, E. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  7. Mutagenic processing of ethylation damage in mammalian cells: the use of methoxyamine to study apurinic/apyrimidinic site-induced mutagenesis. Fortini, P., Calcagnile, A., Vrieling, H., van Zeeland, A.A., Bignami, M., Dogliotti, E. Cancer Res. (1993) [Pubmed]
  8. Promotion, but not progression, effects of tamoxifen on uterine carcinogenesis in mice initiated with N-ethyl-N'-nitro-N-nitrosoguanidine. Takahashi, M., Shimomoto, T., Miyajima, K., Iizuka, S., Watanabe, T., Yoshida, M., Kurokawa, Y., Maekawa, A. Carcinogenesis (2002) [Pubmed]
  9. Uterine adenocarcinoma in N-ethyl-N'-nitro-N-nitrosoguanidine-treated rats with high-dose exposure to p-tert-octylphenol during adulthood. Katsuda, S., Yoshida, M., Kuroda, H., Ando, J., Takahashi, M., Kurokawa, Y., Watanabe, G., Taya, K., Maekawa, A. Jpn. J. Cancer Res. (2002) [Pubmed]
  10. Morphology and modes of cell proliferation in earliest signet-ring-cell carcinomas induced in canine stomachs by N-ethyl-N'-nitro-N-nitrosoguanidine. Sugihara, H., Hattori, T., Imamura, Y., Noriki, S., Fukuda, M., Katsura, K., Tsuchihashi, Y., Fujita, S. J. Cancer Res. Clin. Oncol. (1991) [Pubmed]
  11. Molecular analysis of mutations induced by ethylating N-nitroso compounds in the lacI gene of Escherichia coli. Jiao, J., Pienkowska, M., Glickman, B.W., Zielenska, M. Mutat. Res. (1996) [Pubmed]
  12. Experimental induction of uterine cancer in rats by N-ethyl-N'-nitro-N-nitrosoguanidine dissolved in polyethylene glycol. Ogino, H., Fujimoto, M., Oshiro, H., Matsumoto, K., Funahashi, M., Kaneko, C., Hirono, I. Pathol. Res. Pract. (1989) [Pubmed]
  13. Modification of rat liver chromatin by N-methyl-N'-nitro-N-nitrosoguanidine or N-ethyl-N'-nitro-N-nitrosoguanidine and template activity for RNA synthesis by Escherichia coli RNA polymerase after reconstitution. Yoda, K., Sakiyama, S., Fujimura, S. Biochim. Biophys. Acta (1978) [Pubmed]
  14. Evidence for AP site formation related to DNA-oxygen alkylation in CHO cells treated with ethylating agents. Fortini, P., Bignami, M., Dogliotti, E. Mutat. Res. (1990) [Pubmed]
  15. Induction of endometrial adenocarcinomas by a single intra-uterine administration of N-ethyl-N'-nitro-N-nitrosoguanidine to aged Donryu rats showing spontaneously persistent estrus. Takahashi, M., Ando-Lu, J., Yoshida, M., Iijima, T., Ishihara, R., Imai, S., Kitamura, T., Suzuki, K., Nishiyama, K., Nishimura, S. Cancer Lett. (1995) [Pubmed]
  16. Antitumor effect of RBS (rice bran saccharide) on ENNG-induced carcinogenesis. Takeshita, M., Nakamura, S., Makita, F., Ohwada, S., Miyamoto, Y., Morishita, Y. Biotherapy (Dordrecht, Netherlands) (1992) [Pubmed]
  17. Reduction of primordial follicles caused by maternal treatment with busulfan promotes endometrial adenocarcinoma development in donryu rats. Yoshida, M., Watanabe, G., Shirota, M., Maekawa, A., Taya, K. J. Reprod. Dev. (2005) [Pubmed]
  18. Preliminary observation on pancreatic duct adenocarcinoma induced by intraductal administration of N-ethyl-N'-nitro-N-nitrosoguanidine in dogs. Kamano, T., Azuma, N., Katami, A., Tamura, J., Sakakibara, N., Matsumoto, M., Mizumoto, K., Kitazawa, S., Konishi, Y. Jpn. J. Cancer Res. (1988) [Pubmed]
  19. Individual levels of activity of O6-alkylguanine-DNA alkyltransferase in monkey gastric mucosa during chronic exposure to a gastrocarcinogen N-ethyl-N'-nitro-N-nitrosoguanidine. Loktionova, N.A., Beniashvili, D.S.h., Sartania, M.S., Zabezhinski, M.A., Kazanova, O.I., Petrov, A.S., Likhachev, A.J. Biochimie (1993) [Pubmed]
  20. Inhibitory effect of (-)-epigallocatechin gallate on carcinogenesis with N-ethyl-N'-nitro-N-nitrosoguanidine in mouse duodenum. Fujita, Y., Yamane, T., Tanaka, M., Kuwata, K., Okuzumi, J., Takahashi, T., Fujiki, H., Okuda, T. Jpn. J. Cancer Res. (1989) [Pubmed]
  21. Early gastric cancer induced by N-ethyl-N'-nitro-N-nitrosoguanidine in a cynomolgus monkey six years after initial diagnosis of the lesion. Szentirmay, Z., Ohgaki, H., Maruyama, K., Esumi, H., Takayama, S., Sugimura, T. Jpn. J. Cancer Res. (1990) [Pubmed]
  22. Early changes of dog esophageal mucosa induced by N-ethyl-N'-nitro-N-nitrosoguanidine. Takubo, K., Shisa, H., Futatsuki, K., Sasajima, K. Gann = Gan. (1981) [Pubmed]
  23. Effect of age on the induction of endometrial lesions by a single intra-uterine administration of N-ethyl-N'-nitro-N-nitrosoguanidine in F344 rats. Kitamura, T., Ando-Lu, J., Ishihara, R., Imai, S., Takano, S., Iijima, T., Nishiyama, K., Suzuki, K., Takahashi, M., Maekawa, A. In Vivo (1995) [Pubmed]
  24. Effects of DNA repair deficiency on the mutational specificity in the lacZ gene of Escherichia coli. Watanabe-Akanuma, M., Ohta, T. Mutat. Res. (1994) [Pubmed]
  25. Biomarkers of individual susceptibility to carcinogens: application for biological monitoring. Likhachev, A.J., Beniashvili, D.S.h., Bykov, V.J., Kazanova, O.I., Loktionova, N.A., Tyndyk, M.L., Yatsuk, O.S., Yermilov, V.B., Zabezhinski, M.A. International archives of occupational and environmental health. (1993) [Pubmed]
  26. Sequential histopathological changes in vivo after suicide gene therapy of gastric cancer induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats. Okino, T., Onda, M., Matsukura, N., Inada, K.I., Tatematsu, M., Suzuki, S., Shimada, T. Jpn. J. Cancer Res. (2001) [Pubmed]
  27. Adenocarcinomas of the stomach induced in beagle dogs by oral administration of N-ethyl-N'-nitro-N-nitrosoguanidine. Kurihara, M., Shirakabe, H., Izumi, T., Miyasaka, K., Yamaya, F., Maruyama, T., Yasui, A. Zeitschrift für Krebsforschung und klinische Onkologie. Cancer research and clinical oncology. (1977) [Pubmed]
  28. N-ethyl-N'-nitro-N-nitrosoguanidine induced gastric carcinoma in wolfdogs--useful animal model for tracing gastric malignancy transformation. Xiao, S.D., Jiang, S.J., Wang, R.N., Hu, Y.B., Liu, W.Z., Tang, X.M. Chin. Med. J. (1986) [Pubmed]
  29. Cytophotometric DNA analysis on canine stomach carcinogenesis induced by ENNG. Zhu, R.M., Xiao, S.D., Jiang, S.J., Wang, R.M., Liu, W.Z., Hu, Y.B. Chin. Med. J. (1990) [Pubmed]
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