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Chemical Compound Review

NSC-38297     5-bromo-1-[4-hydroxy-5...

Synonyms: SureCN27756, ACMC-209mat, CHEBI:127287, AC1Q1GND, AC1Q7CBZ, ...
 
 
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Disease relevance of Broxuridine

  • Female A/J mice (6 weeks old) were treated with a single dose of NNK (103 mg/kg of body weight, i.p.) on day 0, and the cell proliferation index was measured by the incorporation of bromodeoxyuridine (BrdUrd) immunohistochemically [1].
  • Multiploid tumors showed the highest median BrdUrd LI associated with the most frequent peritoneal dissemination and liver metastasis [2].
  • To determine this, we labeled 55 breast carcinomas with BRDU in vivo and correlated the results with mitotic figure content [3].
  • Primary infiltrating ductal carcinomas (n = 142) and primary lobular carcinomas (n = 6) showed mean and median BRDU labeling of 4.63% and 3%, 1.3% and 1%, respectively, with a range of 0-28% [4].
  • Cases of papillary or nodular (PN) hyperplasia were divided into two types according to the localization of the BrdUrd-labeled cells [5].
 

High impact information on Broxuridine

  • An avian muscle factor related to MyoD1 activates muscle-specific promoters in nonmuscle cells of different germ-layer origin and in BrdU-treated myoblasts [6].
  • Based on mathematical modeling of the dynamics of BrdU-labeled cells in the blood, we identified rapidly and slowly proliferating subpopulations of CD4 and CD8 T lymphocytes [7].
  • Heritable fragile sites on human chromosomes. V. A new class of fragile site requiring BrdU for expression [8].
  • Normal cycling patterns of hematopoietic stem cell subpopulations: an assay using long-term in vivo BrdU infusion [9].
  • Proliferation of epithelial cells in the mammary tissue and adjacent skin was examined by in vivo labeling of proliferating cells with bromodeoxyuridine (BrdUrd) and in situ labeling of the nuclear proliferation-associated Ki-67 protein by the antibody MIB-5 [10].
 

Chemical compound and disease context of Broxuridine

 

Biological context of Broxuridine

  • MF exposure significantly enhanced BrdUrd and Ki-67 labeling in the mammary epithelium, indicating a marked increase in cell proliferation [10].
  • Proliferation kinetics and cell lineages can be studied in whole mounts and macerates by means of BrdU/anti-BrdU technique [13].
  • These results indicate that DNA ploidy and BrdUrd labeling indices may be possibly useful prognostic factors for gastric carcinoma [2].
  • Neurons undergoing terminal cell division were identified by injecting tadpoles repeatedly with 5'-bromodeoxyuridine (BRDU) for one to six developmental stages between III and XXI [14].
  • Namely, DNA diploid, together with low BrdUrd LIs, was associated with favorable prognosis, whereas DNA aneuploid with high BrdUrd LIs was related to the poorest prognosis [2].
 

Anatomical context of Broxuridine

 

Associations of Broxuridine with other chemical compounds

 

Gene context of Broxuridine

  • MATERIALS AND METHODS: The skeletal growth was monitored by X-ray and dynamic histomorphometry, and the growth plates were analyzed by quantitative histology, calcein double labeling, bromodeoxyuridine (BrdU) incorporation, and TUNEL assay in 4- and 18-month-old female ER beta-/-, ER alpha-/-, and ER alpha-/- beta-/- mice [22].
  • BrdU uptake studies showed that BrdU+ve MMC were increased by 20-40% (P<0.05) after Ha-ras AS-oligo at 24 h; other ras AS-oligos were inactive [23].
  • BrdU and PCNA were found to have distribution patterns similar to those of EGF, TGF-alpha, and EGF-R, with intense staining at the tips and peripheral regions of the facial prominences [24].
  • PYY in developing murine islet cells: comparisons to development of islet hormones, NPY, and BrdU incorporation [25].
  • IL-6-/- mice were treated with an MMP-2 inhibitor and assessment of injury (histology and serum ALT levels), apoptosis by TUNEL assay, and hepatocyte proliferation by BRDU-labeling was performed [26].
 

Analytical, diagnostic and therapeutic context of Broxuridine

References

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  2. Retrospective analysis of the prognostic significance of DNA ploidy patterns and S-phase fraction in gastric carcinoma. Yonemura, Y., Ooyama, S., Sugiyama, K., Kamata, T., De Aretxabala, X., Kimura, H., Kosaka, T., Yamaguchi, A., Miwa, K., Miyazaki, I. Cancer Res. (1990) [Pubmed]
  3. Correlation of bromodeoxyuridine (BRDU) labeling of breast carcinoma cells with mitotic figure content and tumor grade. Weidner, N., Moore, D.H., Ljung, B.M., Waldman, F.M., Goodson, W.H., Mayall, B., Chew, K., Smith, H.S. Am. J. Surg. Pathol. (1993) [Pubmed]
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  5. The kinetics of cellular proliferation in rat urinary bladder treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Tsujihashi, H., Matsuda, H., Uejima, S., Akiyama, T., Kurita, T. J. Urol. (1990) [Pubmed]
  6. An avian muscle factor related to MyoD1 activates muscle-specific promoters in nonmuscle cells of different germ-layer origin and in BrdU-treated myoblasts. Lin, Z.Y., Dechesne, C.A., Eldridge, J., Paterson, B.M. Genes Dev. (1989) [Pubmed]
  7. Identification of dynamically distinct subpopulations of T lymphocytes that are differentially affected by HIV. Kovacs, J.A., Lempicki, R.A., Sidorov, I.A., Adelsberger, J.W., Herpin, B., Metcalf, J.A., Sereti, I., Polis, M.A., Davey, R.T., Tavel, J., Falloon, J., Stevens, R., Lambert, L., Dewar, R., Schwartzentruber, D.J., Anver, M.R., Baseler, M.W., Masur, H., Dimitrov, D.S., Lane, H.C. J. Exp. Med. (2001) [Pubmed]
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  9. Normal cycling patterns of hematopoietic stem cell subpopulations: an assay using long-term in vivo BrdU infusion. Pietrzyk, M.E., Priestley, G.V., Wolf, N.S. Blood (1985) [Pubmed]
  10. Magnetic field exposure increases cell proliferation but does not affect melatonin levels in the mammary gland of female Sprague Dawley rats. Fedrowitz, M., Westermann, J., Löscher, W. Cancer Res. (2002) [Pubmed]
  11. The epidermal cell kinetic response to ultraviolet B irradiation combines regenerative proliferation and carcinogen associated cell cycle delay. Olsen, W.M., Kirkhus, B. Photochem. Photobiol. (1989) [Pubmed]
  12. Melatonin inhibits growth of cultured human uveal melanoma cells. Hu, D.N., Roberts, J.E. Melanoma Res. (1997) [Pubmed]
  13. Proliferation kinetics and cell lineages can be studied in whole mounts and macerates by means of BrdU/anti-BrdU technique. Plickert, G., Kroiher, M. Development (1988) [Pubmed]
  14. Neurogenesis and differentiation of sympathetic B and C cells in the bullfrog tadpole. Stofer, W.D., Horn, J.P. J. Neurosci. (1993) [Pubmed]
  15. Differential proliferative response of gastric mucosa during carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in susceptible ACI rats, resistant Buffalo rats, and their hybrid F1 cross. Ohgaki, H., Tomihari, M., Sato, S., Kleihues, P., Sugimura, T. Cancer Res. (1988) [Pubmed]
  16. Cell proliferation in the gastrulating chick embryo: a study using BrdU incorporation and PCNA localization. Sanders, E.J., Varedi, M., French, A.S. Development (1993) [Pubmed]
  17. Isopycnic centrifugation of mammalian metaphase chromosomes in Nycodenz. Gollin, S.M., Wray, W. Exp. Cell Res. (1984) [Pubmed]
  18. Allergen-induced traffic of bone marrow eosinophils, neutrophils and lymphocytes to airways. Johansson, A.K., Sergejeva, S., Sjöstrand, M., Lee, J.J., Lötvall, J. Eur. J. Immunol. (2004) [Pubmed]
  19. Hyperoxia increases airway cell S-phase traversal in immature rats in vivo. Hershenson, M.B., Kelleher, M.D., Naureckas, E.T., Abe, M.K., Rubinstein, V.J., Zimmermann, A., Bendele, A.M., McNulty, J.A., Panettieri, R.A., Solway, J. Am. J. Respir. Cell Mol. Biol. (1994) [Pubmed]
  20. Olomoucine, an inhibitor of the cdc2/cdk2 kinases activity, blocks plant cells at the G1 to S and G2 to M cell cycle transitions. Glab, N., Labidi, B., Qin, L.X., Trehin, C., Bergounioux, C., Meijer, L. FEBS Lett. (1994) [Pubmed]
  21. Lack of endothelial nitric oxide synthase decreases cardiomyocyte proliferation and delays cardiac maturation. Lepic, E., Burger, D., Lu, X., Song, W., Feng, Q. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  22. Estrogen receptor-beta inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice. Chagin, A.S., Lindberg, M.K., Andersson, N., Moverare, S., Gustafsson, J.A., Sävendahl, L., Ohlsson, C. J. Bone Miner. Res. (2004) [Pubmed]
  23. Distinct functions for Ras GTPases in the control of proliferation and apoptosis in mouse and human mesangial cells. Hendry, B.M., Khwaja, A., Qu, Q.Y., Shankland, S.J. Kidney Int. (2006) [Pubmed]
  24. Cell proliferation and expression of EGF, TGF-alpha, and EGF receptor in the developing primary palate. Iamaroon, A., Tait, B., Diewert, V.M. J. Dent. Res. (1996) [Pubmed]
  25. PYY in developing murine islet cells: comparisons to development of islet hormones, NPY, and BrdU incorporation. Jackerott, M., Oster, A., Larsson, L.I. J. Histochem. Cytochem. (1996) [Pubmed]
  26. Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression. Bansal, M.B., Kovalovich, K., Gupta, R., Li, W., Agarwal, A., Radbill, B., Alvarez, C.E., Safadi, R., Fiel, M.I., Friedman, S.L., Taub, R.A. J. Hepatol. (2005) [Pubmed]
  27. Estimation of the dividing fraction and potential doubling time of tumors using cytochalasin B. Shibamoto, Y., Streffer, C. Cancer Res. (1991) [Pubmed]
  28. BrdU immunohistochemistry for studying adult neurogenesis: Paradigms, pitfalls, limitations, and validation. Taupin, P. Brain Res. Brain Res. Rev. (2007) [Pubmed]
  29. Interleukin-1beta and TNF-alpha act in synergy to inhibit longitudinal growth in fetal rat metatarsal bones. Mårtensson, K., Chrysis, D., Sävendahl, L. J. Bone Miner. Res. (2004) [Pubmed]
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