Disease relevance of Metandienone

• Spontaneous hydrolysis of methandrostenolone sulphate gave 17-epimethandrostenolone and several dehydration products [1].
• Although this action of methandienone might be described as anabolic, the weight gain produced is not normal muscle [2].
• Acute hereditary coproporphyria induced by the androgenic/anabolic steroid methandrostenolone (Dianabol) [3].
• Thus these data strongly suggest that long-term use of methandrostenolone in postmenopausal osteoporosis prevented bone loss; the possibility that it increased bone mass above initial values is less certain [4].
• In conclusion, long-term methandienone treatment results in cardiac hypertrophy in dogs, reduces its response to an inotropic loads and leads to working on larger ventricular volumes [5].

Psychiatry related information on Metandienone

• Investigations of anabolic drug abuse in athletics and cattle feed. II. Specific determination of methandienone (Dianabol) in urine in nanogram amounts [6].
• In the first experiment, treatment for 2 weeks with the AAS methandrostenolone had no effect on either the reward or performance components of intracranial self-stimulation [7].
• Anabolic and androgenic effects of methandrostenolone ("Nerobol") during systematic physical activity in rats [8].

High impact information on Metandienone

• Although the weight and body-composition changes may demonstrate an anabolic action of methandienone in man, they may alternatively have been caused by an increase in intracellular fluid, and the question of anabolic action therefore remains open [9].
• The present study compared the effects of chronic exposure to three individual AASs, stanozolol (0.05-5 mg/kg), 17alpha-methyltestosterone (0.5-5 mg/kg), and methandrostenolone (0.5-5 mg/kg) on the onset of puberty and estrous cyclicity in the rat [10].
• The day of first vaginal estrus was delayed in rats receiving stanozolol (5 mg/kg) or 17alpha-methyltestosterone (0.5-5 mg/kg) but not in rats receiving methandrostenolone [10].
• After incubation of bovine hepatocytes with methandienone, samples were taken at different times [11].
• Monolayer cultures of bovine hepatocytes were used to investigate the biotransformation of methandienone in vitro [11].

Chemical compound and disease context of Metandienone

• Testosterone- and methandrostenolone-treated rats ingested less water than controls in response to acute extracellular dehydration but not after cellular dehydration [12].
• Anabolic steroids (methandrostenolone, methylandrostendiole, and Retabolil) were injected in doses of 0.5 mg/kg body weight [13].

Biological context of Metandienone

• The biotransformation of methandienone (17 beta-hydroxy-17 alpha-methylandrosta-1,4-dien-3-one) in human adults, more particularly the sequential reduction of its A-ring substituents, was investigated by gas chromatography-mass spectrometry [14].
• Effects of an anabolic steroid (metandienone) on spermatogenesis [15].
• Testosterone had a stronger androgenic effect than methandrostenolone in terms of disrupting the estrous cycle [12].
• The effects of six week, high-dose anabolic steroid treatment (methandienone, 1.5 mg/kg/day) on the changes in left ventricular function induced in dogs by endurance training were studied by a catheterization technique under anaesthesia [16].
• During metandienone treatment the total blood volume increased by about 15%, and the heart rate decreased significantly both at rest and during exercise [17].

Anatomical context of Metandienone

• Rats were maintained for 8 weeks on a program of twice weekly subcutaneous injections of 0.075 mg Dianabol (methandrostenolone) and treadmill running to investigate the ability of this compound to increase skeletal muscle contractility [18].
• Bone marrow culture in a patient with aplastic anaemia responding to anabolic steroid (methandienone) therapy, showed an unusually high degree of growth in unstimulated cultures [19].

Associations of Metandienone with other chemical compounds

• In a series of 3 experiments, adult male Long-Evans rats were castrated and treated with 1 of 3 different anabolic-androgenic steroid (AAS) compounds (17 alpha-methyltestosterone, methandrostenolone, or nandrolone decanoate) for 6 weeks [20].
• The major excreted metabolites of methandrostenolone, nandrolone, oxandrolone and oxymetholone were identified by gas chromatography-mass spectrometry based on the major mass spectral ion peaks [21].
• The mean values of the dosages of self-administration during the 24-week period were 31.0 +/- 14.3 mg/day for anabolic steroids (methandienone, stanozolol, nandrolone) and 178.4 +/- 82.7 mg/week for testosterone [22].
• It was found that the increased cataleptic action of thioridazine (20 mg per kg), during radiation disease was inhibited ater metanabol premedication [23].
• Less convincing but suggestive evidence exists for colaspase, chlorthalidone, combination cancer chemotherapy, cimetidine, cisplatin, corticosteroids, cytosine arabinoside, diphenoxylate, ethacrynic acid, iatrogenic hypercalcaemia, methandienone, metronidazole, nitrofurantoin, pentamidine, phenformin, piroxicam and procainamide [24].

Gene context of Metandienone

• In contrast, the 17alpha-alkylated compounds that were tested (stanozolol, danazol, methandrostenolone) modestly stimulated aromatase and were weak competitors for the androgen receptor [25].

Analytical, diagnostic and therapeutic context of Metandienone

• Combined assay, identification, and foreign related steroids test for methandrostenolone by high-speed liquid chromatography [26].
• The use of 17-epimethyltestosterone radioimmunoassay in following excretion of methandienone metabolites in urine [27].
• The determination of methandienone (I) (17 alpha-methyl-17 beta-hydroxyandrosta-1,4-dien-3-one) in human urine by gas chromatography and capillary column gas chromatography--mass spectrometry has been studied [28].
• After oral administration of metandienone (17 alpha-methyl-androsta-1,4-dien-17 beta-ol-3-one) to male volunteers conjugated metabolites are isolated from urine via XAD-2-adsorption, enzymatic hydrolysis and preparative high-performance liquid chromatography (HPLC) [29].
• To assess the efficacy of methandrostenolone in the treatment of osteoporosis a 26-mo double-blind study was performed with 13 treated and 13 control (placebo) postmenopausal osteoporotic females [4].

References