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Chemical Compound Review

D01030     bis[(2S,3R,4S,5R,6R)-3,4,5- trihydroxy-6...

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Disease relevance of D01030

  • Feeding experiments demonstrated that crocin dyes at 0.1% in the diet could suppress partially the chronic hepatic damage induced by multiple dosages of AFB1 or DMN, but at a higher concentration of 1% crocin dye failed to do so because of their host toxicity [1].
  • Intracerebroventricular injection of crocin (51.2 nmol) alone did not affect the synaptic potential evoked by single stimulation of the medial perforant path, and neither inhibited nor facilitated the LTP induced by strong (30 pulses at 60 Hz) or weak (20 pulses at 60 Hz) tetanus [2].
  • In conclusion, long-term treatment with crocin enhances survival selectively in female rats with colon cancer without major toxic effects [3].
  • In assays in vitro, crocin had a potent cytotoxic effect on human and animal adenocarcinoma cells (HT-29 and DHD/K12-PROb cells, 50% lethal dose = 0.4 and 1.0 mM, respectively) [3].
  • We report here the effects of crocin on neuronally differentiated pheochromocytoma (PC-12) cells deprived of serum/glucose [4].

Psychiatry related information on D01030


High impact information on D01030

  • This procedure is based on the "crocin bleaching test" (Bors, W., et al. Biochim. Biophys. Acta 796:312-319; 1984) modified for analyzing the antioxidant capacity of complex mixtures (Tubaro, F., et al. J. Am. Oil Chem. Soc. 73:173-179; 1996) [7].
  • The elevated rate constant for the interaction with peroxyl radicals, analysed by the kinetics of inhibition of crocin bleaching in the presence of a diazo initiator, gives an account for the observed antioxidant capacity [8].
  • Crocin protects retinal photoreceptors against light-induced cell death [9].
  • TUNEL assays confirmed that crocin protected photoreceptors from light damage [9].
  • In a previous study, we demonstrated that crocin inhibits apoptosis in PC-12 cells by affecting the function of tumor necrosis factor-alpha [10].

Chemical compound and disease context of D01030


Biological context of D01030


Anatomical context of D01030


Associations of D01030 with other chemical compounds


Gene context of D01030


Analytical, diagnostic and therapeutic context of D01030


  1. Protection of crocin dyes on the acute hepatic damage induced by aflatoxin B1 and dimethylnitrosamine in rats. Lin, J.K., Wang, C.J. Carcinogenesis (1986) [Pubmed]
  2. Crocin (crocetin di-gentiobiose ester) prevents the inhibitory effect of ethanol on long-term potentiation in the dentate gyrus in vivo. Sugiura, M., Shoyama, Y., Saito, H., Abe, K. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  3. Effects of long-term treatment of colon adenocarcinoma with crocin, a carotenoid from saffron (Crocus sativus L.): an experimental study in the rat. García-Olmo, D.C., Riese, H.H., Escribano, J., Ontañón, J., Fernandez, J.A., Atiénzar, M., García-Olmo, D. Nutrition and cancer. (1999) [Pubmed]
  4. Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of alpha-tocopherol. Ochiai, T., Ohno, S., Soeda, S., Tanaka, H., Shoyama, Y., Shimeno, H. Neurosci. Lett. (2004) [Pubmed]
  5. The evidence base of complementary and alternative therapies in depression. Thachil, A.F., Mohan, R., Bhugra, D. Journal of affective disorders (2007) [Pubmed]
  6. Children of homosexual parents report childhood difficulties. Cameron, P., Cameron, K. Psychological reports. (2002) [Pubmed]
  7. Analysis of plasma antioxidant capacity by competition kinetics. Tubaro, F., Ghiselli, A., Rapuzzi, P., Maiorino, M., Ursini, F. Free Radic. Biol. Med. (1998) [Pubmed]
  8. A novel antioxidant flavonoid (IdB 1031) affecting molecular mechanisms of cellular activation. Ursini, F., Maiorino, M., Morazzoni, P., Roveri, A., Pifferi, G. Free Radic. Biol. Med. (1994) [Pubmed]
  9. Protective effect of crocin against blue light- and white light-mediated photoreceptor cell death in bovine and primate retinal primary cell culture. Laabich, A., Vissvesvaran, G.P., Lieu, K.L., Murata, K., McGinn, T.E., Manmoto, C.C., Sinclair, J.R., Karliga, I., Leung, D.W., Fawzi, A., Kubota, R. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  10. Crocin prevents the death of PC-12 cells through sphingomyelinase-ceramide signaling by increasing glutathione synthesis. Ochiai, T., Soeda, S., Ohno, S., Tanaka, H., Shoyama, Y., Shimeno, H. Neurochem. Int. (2004) [Pubmed]
  11. Measurement of antipyretic activity of ibuprofen and paracetamol in children. Sheth, U.K., Gupta, K., Paul, T., Pispati, P.K. Journal of clinical pharmacology. (1980) [Pubmed]
  12. Membrane associated antitumor effects of crocine-, ginsenoside- and cannabinoid derivates. Molnár, J., Szabó, D., Pusztai, R., Mucsi, I., Berek, L., Ocsovszki, I., Kawata, E., Shoyama, Y. Anticancer Res. (2000) [Pubmed]
  13. Evidence of crocin against endothelial injury induced by hydrogen peroxide in vitro. Xu, G.L., Qian, Z.Y., Yu, S.Q., Gong, Z.N., Shen, X.C. Journal of Asian natural products research. (2006) [Pubmed]
  14. Crocin antagonizes ethanol inhibition of NMDA receptor-mediated responses in rat hippocampal neurons. Abe, K., Sugiura, M., Shoyama, Y., Saito, H. Brain Res. (1998) [Pubmed]
  15. Mechanism of hypolipidemic effect of crocin in rats: crocin inhibits pancreatic lipase. Sheng, L., Qian, Z., Zheng, S., Xi, L. Eur. J. Pharmacol. (2006) [Pubmed]
  16. Effect of crocin on experimental atherosclerosis in quails and its mechanisms. He, S.Y., Qian, Z.Y., Tang, F.T., Wen, N., Xu, G.L., Sheng, L. Life Sci. (2005) [Pubmed]
  17. Glucosylation of the saffron apocarotenoid crocetin by a glucosyltransferase isolated from Crocus sativus stigmas. Moraga, A.R., Nohales, P.F., Pérez, J.A., Gómez-Gómez, L. Planta (2004) [Pubmed]
  18. C-phycocyanin: a potent peroxyl radical scavenger in vivo and in vitro. Bhat, V.B., Madyastha, K.M. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  19. Antioxidant effect of manganese. Coassin, M., Ursini, F., Bindoli, A. Arch. Biochem. Biophys. (1992) [Pubmed]
  20. Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Escribano, J., Alonso, G.L., Coca-Prados, M., Fernandez, J.A. Cancer Lett. (1996) [Pubmed]
  21. Crocin suppresses tumor necrosis factor-alpha-induced cell death of neuronally differentiated PC-12 cells. Soeda, S., Ochiai, T., Paopong, L., Tanaka, H., Shoyama, Y., Shimeno, H. Life Sci. (2001) [Pubmed]
  22. Kinetics of reduction of hypervalent iron in myoglobin by crocin in aqueous solution. Jørgensen, L.V., Andersen, H.J., Skibsted, L.H. Free Radic. Res. (1997) [Pubmed]
  23. Hydrogen peroxide-dependent generation of singlet molecular oxygen by human saliva: its detection by chemiluminescence from a Cypridina luciferin analog. Takahama, U. Photochem. Photobiol. (1993) [Pubmed]
  24. Simultaneous quantification of five major biologically active ingredients of saffron by high-performance liquid chromatography. Li, N., Lin, G., Kwan, Y.W., Min, Z.D. Journal of chromatography. A. (1999) [Pubmed]
  25. Use of non-aqueous capillary electrophoresis for the quality control of commercial saffron samples. Zougagh, M., Simonet, B.M., Ríos, A., Valcárcel, M. Journal of chromatography. A. (2005) [Pubmed]
  26. Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study. Céspedes, C.L., Uchoa, A., Salazar, J.R., Perich, F., Pardo, F. J. Agric. Food Chem. (2002) [Pubmed]
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