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Gene Review

ACSM1  -  acyl-CoA synthetase medium-chain family...

Homo sapiens

Synonyms: Acyl-CoA synthetase medium-chain family member 1, Acyl-coenzyme A synthetase ACSM1, mitochondrial, BUCS1, Butyrate--CoA ligase 1, Butyryl-coenzyme A synthetase 1, ...
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Disease relevance of ACSM1

  • Two medium-chain acyl-coenzyme A synthetase genes, SAH and MACS1, are associated with plasma high-density lipoprotein cholesterol levels, but they are not associated with essential hypertension [1].
  • Adhesion of mononuclear phagocytes (Macs) to extracellular matrices containing oxidized low-density lipoproteins (oxLDL) stimulates these cells to secrete reactive oxygen species (e.g., O2-, H2O2) that are believed to promote atherogenesis [2].
  • To enhance the education experience and reduce the health risks for the participants, the ACSM recommends measures to educate coaches and wrestlers toward sound nutrition and weight control behaviors, to curtail "weight cutting," and to enact rules that limit weight loss [3].
  • The HR/VO2 relationship and four ACSM recommended methods of exercise prescription were evaluated in 11 individuals with quadriplegia during intermittent progressive peak exercise tests [4].
  • The purposes of this symposium are 1) to convey essential information to the members of ACSM who are involved in exercise prescription, patient care, or athletic training; and 2) to disseminate recent scientific theories and research concerning exertional heatstroke [5].

Psychiatry related information on ACSM1

  • Statistically significant measurement effects were found for meeting the ACSM/CDC guideline (self-reported), self-efficacy for resisting relapse, knowledge, and on awareness [6].

High impact information on ACSM1

  • Is the AHA/ACSM Scientific Statement "Recommendations for Cardiovascular Screening, Staffing, and Emergency Policies at Health/Fitness Facilities" in need of revision? American Heart Association. American College of Sports Medicine [7].
  • In both the aortas and the coronary lesions the T cells and mono/macs were often closely associated with one another [8].
  • T cells of both T4 and T8 subsets and mono/macs were also demonstrated in areas of eccentric intimal thickening in coronary arteries and in raised coronary lesions [8].
  • From SMMC-7721 cell line, CD133(+) cells isolated by MACS manifested high tumorigenecity and clonogenicity as compared with CD133(-) HCC cells [9].
  • We conclude that matrix-bound and oxidized lipoproteins stimulate Macs to produce H2O2 continuously and in large quantities via a pathway that involves PAF receptors and PTK and is reversibly blocked by inhibitors of protein prenylation [2].

Chemical compound and disease context of ACSM1


Biological context of ACSM1

  • CONCLUSIONS: SNPs in the MACS1 and SAH genes contribute to plasma levels of high-density lipoprotein cholesterol [1].
  • SAH and MACS1 are located within a 150-kb region on human chromosome 16p13.11 [1].
  • For running, the Leger equation and ACSM prediction model appear to be the most suitable for the prediction of running energy expenditure [11].
  • These data suggest that the Latin equation is more accurate than the ACSM formula for estimating oxygen consumption of loaded cycling in obese women [12].
  • We conclude that HIV-1+ men, including those symptomatic for AIDS-related complex, can experience significant increases in neuromuscular strength and cardiorespiratory fitness without changes in lymphocyte phenotypes or clinical diagnosis when the exercise regimen is prescribed and monitored in accordance with ACSM guidelines for healthy adults [13].

Anatomical context of ACSM1

  • MATERIALS AND METHODS: Purified B cells and basophils were obtained from normal human volunteers by using a MACS magnetic cell sorting system and anti-CD19 and anti-Fc epsilon R1 antibodies, respectively [14].
  • We report here salutary results using a simple density-based depletion method that requires neither MACS (magnetic-activated cell sorting) nor flow cytometric separation for enrichment of progenitor cells [15].
  • Regulation of oxidative metabolism and blood flow in skeletal muscle. Summary report of the first ACSM Basic Science Specialty Conference, Indianapolis, IN, September 28-30, 1995 [16].
  • When blood from HIV-1-infected patients was used, neither the depletion of unwanted cell lineages by erythrocyte crosslinking (RosetteSep) nor the enrichment of CD4(+) cells by immunomagnetic beads (MACS) individually resulted in sufficient purity [17].
  • Importantly, a modest increase over the CDC/ACSM exercise recommendations resulted in significant decreases in visceral, subcutaneous, and total abdominal fat without changes in caloric intake [18].

Associations of ACSM1 with chemical compounds


Other interactions of ACSM1

  • SNP in exon 8 of the A/G polymorphism of the MACS1 gene and the G/T SNP in intron 3 of the SAH gene were associated with plasma levels of plasma high-density lipoprotein cholesterol [1].
  • Ex vivo-derived monocytes could be used in additional studies for analyzing differences in genotype-dependent expression levels of genes involved in fat assimilation such as ACBP, MACS1 or PPARgamma [22].
  • This protein bears 56.2% amino acid homology to the MACS1 (medium-chain acyl-CoA synthetase) enzyme, 58.7% homology to the bovine XL-III XM-ligase, and 81.5% homology to the bovine XL-I XM-ligase [23].

Analytical, diagnostic and therapeutic context of ACSM1

  • The accuracy of the ACSM cycle ergometry equation [24].
  • RESULTS: Quantum Simply Cellular (QSC) microbeads were immunomagnetically labeled with anti-CD2 fluorescein isothiocyanate (FITC) antibodies and anti-FITC MACS paramagnetic nanoparticles [25].
  • The purpose of this investigation was to assess the reliability and validity of maximal oxygen uptake estimates (ESTmax) from the ACSM submaximal cycle ergometer test [26].
  • Both subsets were characterized as [lin](-)CD4(+)ILT3(+)HLA-DR(+)CD11c(+) by flow cytometry, and CD163 mRNA was readily detectable in MACS purified human DCs [27].
  • Total RNA was isolated from MACS purified DCs and CD163 mRNA was determined with real-time reverse transcriptase polymerase chain reaction [27].


  1. Two medium-chain acyl-coenzyme A synthetase genes, SAH and MACS1, are associated with plasma high-density lipoprotein cholesterol levels, but they are not associated with essential hypertension. Haketa, A., Soma, M., Nakayama, T., Sato, M., Kosuge, K., Aoi, N., Matsumoto, K. J. Hypertens. (2004) [Pubmed]
  2. PAF-receptor antagonists, lovastatin, and the PTK inhibitor genistein inhibit H2O2 secretion by macrophages cultured on oxidized-LDL matrices. Sethy-Coraci, I., Crock, L.W., Silverstein, S.C. J. Leukoc. Biol. (2005) [Pubmed]
  3. American College of Sports Medicine position stand. Weight loss in wrestlers. Oppliger, R.A., Case, H.S., Horswill, C.A., Landry, G.L., Shelter, A.C. Medicine and science in sports and exercise. (1996) [Pubmed]
  4. Exercise prescription for sitting and supine exercise in subjects with quadriplegia. McLean, K.P., Jones, P.P., Skinner, J.S. Medicine and science in sports and exercise. (1995) [Pubmed]
  5. The role of exercise in the etiology of exertional heatstroke. Hubbard, R.W. Medicine and science in sports and exercise. (1990) [Pubmed]
  6. Physical activity measurements affected participants' behavior in a randomized controlled trial. van Sluijs, E.M., van Poppel, M.N., Twisk, J.W., van Mechelen, W. Journal of clinical epidemiology. (2006) [Pubmed]
  7. Is the AHA/ACSM Scientific Statement "Recommendations for Cardiovascular Screening, Staffing, and Emergency Policies at Health/Fitness Facilities" in need of revision? American Heart Association. American College of Sports Medicine. Cardinal, B.J. Circulation (1999) [Pubmed]
  8. T lymphocytes in aortic and coronary intimas. Their potential role in atherogenesis. Emeson, E.E., Robertson, A.L. Am. J. Pathol. (1988) [Pubmed]
  9. CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity. Yin, S., Li, J., Hu, C., Chen, X., Yao, M., Yan, M., Jiang, G., Ge, C., Xie, H., Wan, D., Yang, S., Zheng, S., Gu, J. Int. J. Cancer (2007) [Pubmed]
  10. Efficacy of an individualized, motivationally-tailored physical activity intervention. Marcus, B.H., Bock, B.C., Pinto, B.M., Forsyth, L.H., Roberts, M.B., Traficante, R.M. Annals of behavioral medicine : a publication of the Society of Behavioral Medicine. (1998) [Pubmed]
  11. Energy expenditure of walking and running: comparison with prediction equations. Hall, C., Figueroa, A., Fernhall, B., Kanaley, J.A. Medicine and science in sports and exercise. (2004) [Pubmed]
  12. Validation of a cycle ergometry equation for predicting steady-rate VO2 in obese women. Andersen, R.E., Wadden, T.A. Medicine and science in sports and exercise. (1995) [Pubmed]
  13. Effects of exercise training on men seropositive for the human immunodeficiency virus-1. Rigsby, L.W., Dishman, R.K., Jackson, A.W., Maclean, G.S., Raven, P.B. Medicine and science in sports and exercise. (1992) [Pubmed]
  14. Difference in CD22 molecules in human B cells and basophils. Toba, K., Hanawa, H., Fuse, I., Sakaue, M., Watanabe, K., Uesugi, Y., Higuchi, W., Takahashi, M., Aizawa, Y. Exp. Hematol. (2002) [Pubmed]
  15. Intact fetal cell isolation from maternal blood: improved isolation using a simple whole blood progenitor cell enrichment approach (RosetteSep). Bischoff, F.Z., Marquéz-Do, D.A., Martinez, D.I., Dang, D., Horne, C., Lewis, D., Simpson, J.L. Clin. Genet. (2003) [Pubmed]
  16. Regulation of oxidative metabolism and blood flow in skeletal muscle. Summary report of the first ACSM Basic Science Specialty Conference, Indianapolis, IN, September 28-30, 1995. Johnson, P.C., Wagner, P.D., Wilson, D.F. Medicine and science in sports and exercise. (1996) [Pubmed]
  17. Isolation of peripheral blood CD4(+) T cells using RosetteSep and MACS for studies of DNA turnover by deuterium labeling. Busch, R., Cesar, D., Higuera-Alhino, D., Gee, T., Hellerstein, M.K., McCune, J.M. J. Immunol. Methods (2004) [Pubmed]
  18. Inactivity, exercise, and visceral fat. STRRIDE: a randomized, controlled study of exercise intensity and amount. Slentz, C.A., Aiken, L.B., Houmard, J.A., Bales, C.W., Johnson, J.L., Tanner, C.J., Duscha, B.D., Kraus, W.E. J. Appl. Physiol. (2005) [Pubmed]
  19. ACSM Fellow Ken Baldwin and Colleagues Discover a New Antisense Retrograde Mechanism of Gene Regulation. Brooks, G.A. Exercise and sport sciences reviews. (2006) [Pubmed]
  20. The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population. Lindner, I., Rubin, D., Helwig, U., Nitz, I., Hampe, J., Schreiber, S., Schrezenmeir, J., Döring, F. Molecular nutrition & food research. (2006) [Pubmed]
  21. ACSM/AHA Release Recommendations for fitness facilities. American College of Sports Medicine / American Heart Association. Morey, S.S. American family physician. (1999) [Pubmed]
  22. Expression analysis of genes involved in fat assimilation in human monocytes. Klapper, M., Döpner, M., Vock, C., Nitz, I., Helwig, U., Schrezenmeir, J., Döring, F. IUBMB Life (2006) [Pubmed]
  23. Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria. Vessey, D.A., Lau, E., Kelley, M., Warren, R.S. J. Biochem. Mol. Toxicol. (2003) [Pubmed]
  24. The accuracy of the ACSM cycle ergometry equation. Lang, P.B., Latin, R.W., Berg, K.E., Mellion, M.B. Medicine and science in sports and exercise. (1992) [Pubmed]
  25. Magnetophoretic mobilities correlate to antibody binding capacities. McCloskey, K.E., Chalmers, J.J., Zborowski, M. Cytometry. (2000) [Pubmed]
  26. Evaluation of the ACSM submaximal ergometer test for estimating VO2max. Greiwe, J.S., Kaminsky, L.A., Whaley, M.H., Dwyer, G.B. Medicine and science in sports and exercise. (1995) [Pubmed]
  27. CD163 positive subsets of blood dendritic cells: The scavenging macrophage receptors CD163 and CD91 are coexpressed on human dendritic cells and monocytes. Maniecki, M.B., Møller, H.J., Moestrup, S.K., Møller, B.K. Immunobiology (2006) [Pubmed]
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