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Gene Review

DNAJB7  -  DnaJ (Hsp40) homolog, subfamily B, member 7

Homo sapiens

Synonyms: DJ5, DnaJ homolog subfamily B member 7, HSC3
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Disease relevance of DNAJB7


High impact information on DNAJB7

  • In this study, we analyzed the correlation between nm23 expression, cell motility, and the invasive abilities of six different oral squamous cell carcinoma cell lines (HSC2, HSC3, HSC4, KB, OSC19, and OSC20) [5].
  • We found that HSC-3 human squamous carcinoma cells survived and grew readily as monolayers, but when they were suspended as single cells, they ceased proliferating and entered into the apoptotic death pathway, characterized by DNA fragmentation [6].
  • Anchorage independence and resistance to apoptosis of HSC-3 cell aggregates required high levels of extracellular Ca2+ and was inhibited with function-perturbing anti-E-cadherin antibody [6].
  • We attempted to investigate the relationship between E1A-F mRNA expression and MMP protein expression in four different types of oral squamous-cell-carcinoma-derived cell lines (HSC 3, SAS, KB, and Ca 9.22) [7].
  • Introduction of exogenous p53 neither induced apoptosis nor suppressed colony formation in HSC-3 cells lacking any detectable p53 and HSC-4 cells expressing mutant p53R248Q protein [8].

Chemical compound and disease context of DNAJB7


Biological context of DNAJB7

  • We found that phosphorylation of exogenous p53 on serine 46 (Ser46) was severely impaired in HSC-3 but not HSC-4 cells [8].
  • In contrast, transfer of chromosome 7 had no effect on HSC-2 and HSC-4 cells, although it suppressed the tumorigenicity of HSC-3 cells without modifying their in vitro growth properties [14].
  • In this study, we examined the effects of introducing human chromosome 3 or 7 by microcell hybridization on the tumor-associated phenotypes of three different human oral SCC cell lines, HSC-2, HSC-3 and HSC-4 [14].
  • Dose-dependent inhibition of cell growth and [3H]thymidine incorporation of HSC-4 were observed by the addition of TGF-beta, whereas growth inhibitory effects on HSC-2 and HSC-3 were marginal [15].
  • Bisulfite sequencing analysis revealed that various CpG sites around the transcription start site were abnormally methylated in cells with low DPYD expression: Reversal of hypermethylation by 5-azacytidine treatment significantly increased DPYD expression in HSC3 and HepG2 cells that showed strong promoter activity [16].

Anatomical context of DNAJB7

  • Nanorods are synthesized and conjugated to anti-epidermal growth factor receptor (anti-EGFR) monoclonal antibodies and incubated in cell cultures with a nonmalignant epithelial cell line (HaCat) and two malignant oral epithelial cell lines (HOC 313 clone 8 and HSC 3) [17].
  • To study TN-C matrix production in vitro, we used an invasive oral SCC cell line (HSC-3) and peri-tumor fibroblasts (PTF) [18].
  • NK cells showed up-regulated cytotoxic activity toward various squamous oral cell carcinoma (OSC-70, HSC-2, HSC-3), and we determined that both IL-12 and IFN-gamma contributed to the CD40L-DC-mediated NK cell activation [19].
  • When wt p53 was induced in HSC3 cells cultured in medium containing 5% fetal bovine serum, cell growth was suppressed through G1 arrest [20].
  • An in vitro invasion assay through matrigel in the transwell chamber revealed that HSC-3 cells were most invasive, OSC-19 cells moderately invasive and KB cells least invasive [21].

Associations of DNAJB7 with chemical compounds


Regulatory relationships of DNAJB7

  • Addition of 10(-7) M 1,25(OH)2D3 or 10(-7) M 9cRA to HSC-3 cells significantly suppressed PTHrp transcription within 1 h and the PTHrP secretion within 12 h [2].

Other interactions of DNAJB7

  • In addition, a significant level of SCCA2 mRNA expression was detected in the HSC-4 cell line, but not in Ca9, HeLa, SKG-IIIa, or HSC-3 cells [27].
  • 9-cis-RA induced accumulation of cell population in G1 phase in HSC-3 cells on the 6th day of the treatment, followed by a marked reduction in the levels of hyperphosphorylated pRB, whereas p53 level was not altered [28].
  • When HSC-3 cells were incubated with TIMP-2 protein or transfected with TIMP-2 cDNA, the proGelA activation was strongly inhibited [29].
  • Moreover, PTF were induced to assemble TN-C matrices when grown in medium conditioned by both the PTF and HSC-3 cells [18].
  • To investigate expression levels of galectin-9 mRNA and protein, we performed qRT-PCR and Western blot analyses on OSCC cell lines (Ca9-22, HSC-2, and HSC-3) and normal oral keratinocytes (NOKs) [30].

Analytical, diagnostic and therapeutic context of DNAJB7


  1. Involvement of TWEAK in interferon gamma-stimulated monocyte cytotoxicity. Nakayama, M., Kayagaki, N., Yamaguchi, N., Okumura, K., Yagita, H. J. Exp. Med. (2000) [Pubmed]
  2. Inhibitory effects of 1,25-dihydroxyvitamin D3 and 9-cis-retinoic acid on parathyroid hormone-related protein expression by oral cancer cells (HSC-3). Abe, M., Akeno, N., Ohida, S., Horiuchi, N. J. Endocrinol. (1998) [Pubmed]
  3. Clinical significance of metabotropic glutamate receptor 5 expression in oral squamous cell carcinoma. Park, S.Y., Lee, S.A., Han, I.H., Yoo, B.C., Lee, S.H., Park, J.Y., Cha, I.H., Kim, J., Choi, S.W. Oncol. Rep. (2007) [Pubmed]
  4. Structure-cytotoxic activity relationships of simple hydroxylated coumarins. Kawase, M., Sakagami, H., Hashimoto, K., Tani, S., Hauer, H., Chatterjee, S.S. Anticancer Res. (2003) [Pubmed]
  5. nm23-H1 suppresses invasion of oral squamous cell carcinoma-derived cell lines without modifying matrix metalloproteinase-2 and matrix metalloproteinase-9 expression. Khan, M.H., Yasuda, M., Higashino, F., Haque, S., Kohgo, T., Nakamura, M., Shindoh, M. Am. J. Pathol. (2001) [Pubmed]
  6. E-cadherin regulates anchorage-independent growth and survival in oral squamous cell carcinoma cells. Kantak, S.S., Kramer, R.H. J. Biol. Chem. (1998) [Pubmed]
  7. Correlated expression of matrix metalloproteinases and ets family transcription factor E1A-F in invasive oral squamous-cell-carcinoma-derived cell lines. Shindoh, M., Higashino, F., Kaya, M., Yasuda, M., Funaoka, K., Hanzawa, M., Hida, K., Kohgo, T., Amemiya, A., Yoshida, K., Fujinaga, K. Am. J. Pathol. (1996) [Pubmed]
  8. Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells. Ichwan, S.J., Yamada, S., Sumrejkanchanakij, P., Ibrahim-Auerkari, E., Eto, K., Ikeda, M.A. Oncogene (2006) [Pubmed]
  9. Sequence-dependent interaction between cisplatin and histone deacetylase inhibitors in human oral squamous cell carcinoma cells. Sato, T., Suzuki, M., Sato, Y., Echigo, S., Rikiishi, H. Int. J. Oncol. (2006) [Pubmed]
  10. Chemosensitization of oral squamous cell carcinoma cells to cisplatin by histone deacetylase inhibitor, suberoylanilide hydroxamic acid. Rikiishi, H., Shinohara, F., Sato, T., Sato, Y., Suzuki, M., Echigo, S. Int. J. Oncol. (2007) [Pubmed]
  11. Serum-resistant gene transfer to oral cancer cells by Metafectene and GeneJammer: application to HSV-tk/ganciclovir-mediated cytotoxicity. Konopka, K., Fallah, B., Monzon-Duller, J., Overlid, N., Düzgünes, N. Cell. Mol. Biol. Lett. (2005) [Pubmed]
  12. Transfection of oral cancer cells mediated by transferrin-associated lipoplexes: Mechanisms of cell death induced by herpes simplex virus thymidine kinase/ganciclovir therapy. Neves, S.S., Sarmento-Ribeiro, A.B., Sim??es, S.P., Pedroso de Lima, M.C. Biochim. Biophys. Acta (2006) [Pubmed]
  13. Influence of antifungal polyenes on the adhesion of Candida albicans and Candida glabrata to human epithelial cells in vitro. Dorocka-Bobkowska, B., Konopka, K., Düzgüneş, N. Arch. Oral Biol. (2003) [Pubmed]
  14. Suppression of tumorigenicity in three different cell lines of human oral squamous cell carcinoma by introduction of chromosome 3p via microcell-mediated chromosome transfer. Uzawa, N., Yoshida, M.A., Oshimura, M., Ikeuchi, T. Oncogene (1995) [Pubmed]
  15. Biological effects and binding properties of transforming growth factor-beta on human oral squamous cell carcinoma cells. Ichijo, H., Momose, F., Miyazono, K. Exp. Cell Res. (1990) [Pubmed]
  16. Aberrant methylation of DPYD promoter, DPYD expression, and cellular sensitivity to 5-fluorouracil in cancer cells. Noguchi, T., Tanimoto, K., Shimokuni, T., Ukon, K., Tsujimoto, H., Fukushima, M., Noguchi, T., Kawahara, K., Hiyama, K., Nishiyama, M. Clin. Cancer Res. (2004) [Pubmed]
  17. Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. Huang, X., El-Sayed, I.H., Qian, W., El-Sayed, M.A. J. Am. Chem. Soc. (2006) [Pubmed]
  18. Tenascin-C matrix assembly in oral squamous cell carcinoma. Ramos, D.M., Chen, B., Regezi, J., Zardi, L., Pytela, R. Int. J. Cancer (1998) [Pubmed]
  19. Gene transfer of the CD40-ligand to human dendritic cells induces NK-mediated antitumor effects against human carcinoma cells. Tomihara, K., Kato, K., Masuta, Y., Nakamura, K., Tanaka, T., Hiratsuka, H., Hamada, H. Int. J. Cancer (2007) [Pubmed]
  20. Induction of apoptosis by the p53-273L (Arg --> Leu) mutant in HSC3 cells without transactivation of p21Waf1/Cip1/Sdi1 and bax. Kaneuchi, M., Yamashita, T., Shindoh, M., Segawa, K., Takahashi, S., Furuta, I., Fujimoto, S., Fujinaga, K. Mol. Carcinog. (1999) [Pubmed]
  21. Inhibitory effects of adhesion oligopeptides on the invasion of squamous carcinoma cells with special reference to implication of alpha v integrins. Kawahara, E., Imai, K., Kumagai, S., Yamamoto, E., Nakanishi, I. J. Cancer Res. Clin. Oncol. (1995) [Pubmed]
  22. Enhancement of tumor radioresponse by combined treatment with gefitinib (Iressa, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, is accompanied by inhibition of DNA damage repair and cell growth in oral cancer. Shintani, S., Li, C., Mihara, M., Terakado, N., Yano, J., Nakashiro, K., Hamakawa, H. Int. J. Cancer (2003) [Pubmed]
  23. Role of the alpha(v)beta6 integrin in human oral squamous cell carcinoma growth in vivo and in vitro. Xue, H., Atakilit, A., Zhu, W., Li, X., Ramos, D.M., Pytela, R. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  24. Caspase-9 regulates cisplatin-induced apoptosis in human head and neck squamous cell carcinoma cells. Kuwahara, D., Tsutsumi, K., Kobayashi, T., Hasunuma, T., Nishioka, K. Cancer Lett. (2000) [Pubmed]
  25. Synergistic cytotoxic action of vitamin C and vitamin K3. Zhang, W., Negoro, T., Satoh, K., Jiang, Y., Hashimoto, K., Kikuchi, H., Nishikawa, H., Miyata, T., Yamamoto, Y., Nakano, K., Yasumoto, E., Nakayachi, T., Mineno, K., Satoh, T., Sakagami, H. Anticancer Res. (2001) [Pubmed]
  26. Human oral squamous cell carcinoma cell lines promote angiogenesis via expression of vascular endothelial growth factor and upregulation of KDR/flk-1 expression in endothelial cells. Michi, Y., Morita, I., Amagasa, T., Murota, S. Oral Oncol. (2000) [Pubmed]
  27. Aberrant expression of serpin squamous cell carcinoma antigen 2 in human tumor tissues and cell lines: evidence of protection from tumor necrosis factor-mediated apoptosis. Takeda, A., Kajiya, A., Iwasawa, A., Nakamura, Y., Hibino, T. Biol. Chem. (2002) [Pubmed]
  28. Effect of 9-cis-retinoic acid on oral squamous cell carcinoma cell lines. Hayashi, K., Yokozaki, H., Naka, K., Yasui, W., Yajin, K., Lotan, R., Tahara, E. Cancer Lett. (2000) [Pubmed]
  29. Role of tissue inhibitor of metalloproteinases-2 (TIMP-2) in regulation of pro-gelatinase A activation catalyzed by membrane-type matrix metalloproteinase-1 (MT1-MMP) in human cancer cells. Shofuda, K., Moriyama, K., Nishihashi, A., Higashi, S., Mizushima, H., Yasumitsu, H., Miki, K., Sato, H., Seiki, M., Miyazaki, K. J. Biochem. (1998) [Pubmed]
  30. Galectin-9 as a regulator of cellular adhesion in human oral squamous cell carcinoma cell lines. Kasamatsu, A., Uzawa, K., Nakashima, D., Koike, H., Shiiba, M., Bukawa, H., Yokoe, H., Tanzawa, H. Int. J. Mol. Med. (2005) [Pubmed]
  31. Expression and regulation of collagenase-2 (MMP-8) in head and neck squamous cell carcinomas. Moilanen, M., Pirilä, E., Grénman, R., Sorsa, T., Salo, T. J. Pathol. (2002) [Pubmed]
  32. Identification of candidate radioresistant genes in human squamous cell carcinoma cells through gene expression analysis using DNA microarrays. Higo, M., Uzawa, K., Kouzu, Y., Bukawa, H., Nimura, Y., Seki, N., Tanzawa, H. Oncol. Rep. (2005) [Pubmed]
  33. Involvement of NF-kappaB and mitochondrial pathways in docetaxel-induced apoptosis of human oral squamous cell carcinoma. Taniguchi, T., Takahashi, M., Shinohara, F., Sato, T., Echigo, S., Rikiishi, H. Int. J. Mol. Med. (2005) [Pubmed]
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