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Gene Review

DHX9  -  DEAH (Asp-Glu-Ala-His) box helicase 9

Homo sapiens

Synonyms: ATP-dependent RNA helicase A, DDX9, DEAH box protein 9, LKP, Leukophysin, ...
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Disease relevance of DHX9


Psychiatry related information on DHX9

  • Moreover, horizontal, vertical, and total motor activities throughout the 120-min observation period that followed the administration of vehicle tended to be larger in RHA/Verh rats, although the difference between the two lines was not statistically significant [6].
  • Consummatory behavior elicited by mild tail pinch in the presence of solid food was studied in male Roman high-avoidance (RHA/Verh) and Roman low-avoidance (RLA/Verh) rats [7].
  • Mental health censuses in Mersey RHA [8].
  • Clinical decision-making: a study of general surgery within Trent RHA [9].

High impact information on DHX9


Chemical compound and disease context of DHX9

  • In RHA/Verh rats, locomotion, rearing, and total motor activity were significantly more intense after acute cocaine and morphine challenges than after vehicle administration, whereas no significant differences in motor activity were observed between control and cocaine- or morphine-treated RLA/Verh rats [6].

Biological context of DHX9


Anatomical context of DHX9


Associations of DHX9 with chemical compounds

  • Congruently, after actinomycin D treatment, NDH II accumulated in RNA-containing nuclear bodies that predominantly co-localized with gamma-H2AX foci [15].
  • These findings provide evidence for a novel arginine methylation-dependent regulatory pathway controlling the nuclear import of RHA [21].
  • Our results suggested that an altered conformation of the A/B region induced by aldosterone, but not hydrocortisone, might determine the accessibility of MR AF-1a to RHA/CBP complexes [22].
  • These results indicate that aromatic characteristics of tryptophan residues in MTAD are important for CREB-dependent transcription via RHA [23].
  • Type II NAD(P)H:quinone oxidoreductases (NDH-2) catalyze the two-electron transfer from NAD(P)H to quinones, without any energy-transducing site [12].

Physical interactions of DHX9


Enzymatic interactions of DHX9


Co-localisations of DHX9

  • Immunofluorescence and ultrastructural studies showed that NDH II colocalizes with a small subset of PML NBs in control cells, however, colocalizes with practically all bodies in interferon-alpha-stimulated cells [28].

Regulatory relationships of DHX9

  • Furthermore, NDH II enhanced the degradation of D-loop DNA by the WRN exonuclease [1].
  • Taken together, these results suggest that histone gamma-H2AX promotes binding of NDH II to transcriptionally stalled sites on chromosomal DNA [15].
  • Overexpression of RHA inhibited the activity of TonEBP; however, catalytic activity of RHA was dispensable for the inhibition [26].

Other interactions of DHX9

  • On the other hand, the 3' --> 5' exonuclease activity of WRN was increased by the presence of NDH II [1].
  • Chromatin immunoprecipitation revealed that RHA occupies the MDR1 promoter in vivo [14].
  • Interestingly, coimmunoprecipitation assays demonstrated that MBD2a binding to RHA was not associated with histone deacetylase 1 [16].
  • Here, we report for the first time that some NDH II/RNA helicase A is a component of promyelocytic leukemia nuclear bodies (PML NBs) [28].
  • An in vivo binding assay revealed that MBD2a selectively interacted with RNA helicase A (RHA), a component of CREB transcriptional coactivator complexes [16].

Analytical, diagnostic and therapeutic context of DHX9


  1. Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity. Friedemann, J., Grosse, F., Zhang, S. J. Biol. Chem. (2005) [Pubmed]
  2. A role for RNA helicase A in post-transcriptional regulation of HIV type 1. Li, J., Tang, H., Mullen, T.M., Westberg, C., Reddy, T.R., Rose, D.W., Wong-Staal, F. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  3. The human RNA helicase A (DDX9) gene maps to the prostate cancer susceptibility locus at chromosome band 1q25 and its pseudogene (DDX9P) to 13q22, respectively. Lee, C.G., Eki, T., Okumura, K., Nogami, M., Soares, V.d.a. .C., Murakami, Y., Hanaoka, F., Hurwitz, J. Somat. Cell Mol. Genet. (1999) [Pubmed]
  4. Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A. Toretsky, J.A., Erkizan, V., Levenson, A., Abaan, O.D., Parvin, J.D., Cripe, T.P., Rice, A.M., Lee, S.B., Uren, A. Cancer Res. (2006) [Pubmed]
  5. Association of RNA helicase a with human immunodeficiency virus type 1 particles. Roy, B.B., Hu, J., Guo, X., Russell, R.S., Guo, F., Kleiman, L., Liang, C. J. Biol. Chem. (2006) [Pubmed]
  6. Effects of cocaine and morphine in rats from two psychogenetically selected lines: a behavioral and brain dialysis study. Giorgi, O., Corda, M.G., Carboni, G., Frau, V., Valentini, V., Di Chiara, G. Behav. Genet. (1997) [Pubmed]
  7. Tail pinch induced eating: psychogenetic comparison of Roman high- and low-avoidance rats. Martin, J.R. Physiol. Behav. (1984) [Pubmed]
  8. Mental health censuses in Mersey RHA. Clark, G. Health and social service journal. (1984) [Pubmed]
  9. Clinical decision-making: a study of general surgery within Trent RHA. Frost, C.E., Francis, B.J. Social science & medicine. (1979) [Pubmed]
  10. BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Anderson, S.F., Schlegel, B.P., Nakajima, T., Wolpin, E.S., Parvin, J.D. Nat. Genet. (1998) [Pubmed]
  11. RNA helicase A mediates association of CBP with RNA polymerase II. Nakajima, T., Uchida, C., Anderson, S.F., Lee, C.G., Hurwitz, J., Parvin, J.D., Montminy, M. Cell (1997) [Pubmed]
  12. New insights into type II NAD(P)H:quinone oxidoreductases. Melo, A.M., Bandeiras, T.M., Teixeira, M. Microbiol. Mol. Biol. Rev. (2004) [Pubmed]
  13. First trimester chromosomal analysis of complex structural rearrangements with RHA banding on chorionic villi. Sachs, E.S., Van Hemel, J.O., Galjaard, H., Niermeijer, M.F., Jahoda, M.G. Lancet (1983) [Pubmed]
  14. RNA helicase A in the MEF1 transcription factor complex up-regulates the MDR1 gene in multidrug-resistant cancer cells. Zhong, X., Safa, A.R. J. Biol. Chem. (2004) [Pubmed]
  15. Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II. Mischo, H.E., Hemmerich, P., Grosse, F., Zhang, S. J. Biol. Chem. (2005) [Pubmed]
  16. Antithetic effects of MBD2a on gene regulation. Fujita, H., Fujii, R., Aratani, S., Amano, T., Fukamizu, A., Nakajima, T. Mol. Cell. Biol. (2003) [Pubmed]
  17. Overexpression of a protein fragment of RNA helicase A causes inhibition of endogenous BRCA1 function and defects in ploidy and cytokinesis in mammary epithelial cells. Schlegel, B.P., Starita, L.M., Parvin, J.D. Oncogene (2003) [Pubmed]
  18. DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner. Zhang, S., Schlott, B., Görlach, M., Grosse, F. Nucleic Acids Res. (2004) [Pubmed]
  19. RNA helicase A is essential for normal gastrulation. Lee, C.G., da Costa Soares, V., Newberger, C., Manova, K., Lacy, E., Hurwitz, J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  20. The localization of nuclear DNA helicase II in different nuclear compartments is linked to transcription. Fuchsová, B., Hozák, P. Exp. Cell Res. (2002) [Pubmed]
  21. Arginine methylation of RNA helicase a determines its subcellular localization. Smith, W.A., Schurter, B.T., Wong-Staal, F., David, M. J. Biol. Chem. (2004) [Pubmed]
  22. Ligand-selective potentiation of rat mineralocorticoid receptor activation function 1 by a CBP-containing histone acetyltransferase complex. Kitagawa, H., Yanagisawa, J., Fuse, H., Ogawa, S., Yogiashi, Y., Okuno, A., Nagasawa, H., Nakajima, T., Matsumoto, T., Kato, S. Mol. Cell. Biol. (2002) [Pubmed]
  23. Aromatic residues are required for RNA helicase A mediated transactivation. Aratani, S., Fujii, R., Fujita, H., Fukamizu, A., Nakajima, T. Int. J. Mol. Med. (2003) [Pubmed]
  24. Sam68, RNA helicase A and Tap cooperate in the post-transcriptional regulation of human immunodeficiency virus and type D retroviral mRNA. Reddy, T.R., Tang, H., Xu, W., Wong-Staal, F. Oncogene (2000) [Pubmed]
  25. Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses. Yang, J.P., Tang, H., Reddy, T.R., Wong-Staal, F. J. Biol. Chem. (2001) [Pubmed]
  26. TonEBP is inhibited by RNA helicase A via interaction involving the E'F loop. Colla, E., Lee, S.D., Sheen, M.R., Woo, S.K., Kwon, H.M. Biochem. J. (2006) [Pubmed]
  27. Noncoupled NADH:ubiquinone oxidoreductase of Azotobacter vinelandii is required for diazotrophic growth at high oxygen concentrations. Bertsova, Y.V., Bogachev, A.V., Skulachev, V.P. J. Bacteriol. (2001) [Pubmed]
  28. Nuclear DNA helicase II is recruited to IFN-alpha-activated transcription sites at PML nuclear bodies. Fuchsová, B., Novák, P., Kafková, J., Hozák, P. J. Cell Biol. (2002) [Pubmed]
  29. RNA helicase A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator. Tetsuka, T., Uranishi, H., Sanda, T., Asamitsu, K., Yang, J.P., Wong-Staal, F., Okamoto, T. Eur. J. Biochem. (2004) [Pubmed]
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