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Gene Review

Cx3cr1  -  chemokine (C-X3-C motif) receptor 1

Rattus norvegicus

Synonyms: C-X3-C CKR-1, CX3C chemokine receptor 1, CX3CR1, Fractalkine receptor, RBS11, ...
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Disease relevance of Cx3cr1


High impact information on Cx3cr1


Biological context of Cx3cr1


Anatomical context of Cx3cr1


Associations of Cx3cr1 with chemical compounds


Physical interactions of Cx3cr1


Regulatory relationships of Cx3cr1

  • Taken together, our results demonstrate that TNF-alpha induces the expression of fractalkine and CX3CR1 in rat aortic SMCs and that this induction is mediated by NF-kappaB activation [3].
  • TGF-beta1 upregulates CX3CR1 expression and inhibits fractalkine-stimulated signaling in rat microglia [10].

Other interactions of Cx3cr1


Analytical, diagnostic and therapeutic context of Cx3cr1


  1. Fractalkine and its receptor, CX3CR1, upregulation in streptozotocin-induced diabetic kidneys. Kikuchi, Y., Ikee, R., Hemmi, N., Hyodo, N., Saigusa, T., Namikoshi, T., Yamada, M., Suzuki, S., Miura, S. Nephron Exp. Nephrol. (2004) [Pubmed]
  2. Differential expression of the chemokine receptors CX3CR1 and CCR1 by microglia and macrophages in myelin-oligodendrocyte-glycoprotein-induced experimental autoimmune encephalomyelitis. Sunnemark, D., Eltayeb, S., Wallström, E., Appelsved, L., Malmberg, A., Lassmann, H., Ericsson-Dahlstrand, A., Piehl, F., Olsson, T. Brain Pathol. (2003) [Pubmed]
  3. Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway. Chandrasekar, B., Mummidi, S., Perla, R.P., Bysani, S., Dulin, N.O., Liu, F., Melby, P.C. Biochem. J. (2003) [Pubmed]
  4. Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats. Milligan, E.D., Zapata, V., Chacur, M., Schoeniger, D., Biedenkapp, J., O'Connor, K.A., Verge, G.M., Chapman, G., Green, P., Foster, A.C., Naeve, G.S., Maier, S.F., Watkins, L.R. Eur. J. Neurosci. (2004) [Pubmed]
  5. Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. Verge, G.M., Milligan, E.D., Maier, S.F., Watkins, L.R., Naeve, G.S., Foster, A.C. Eur. J. Neurosci. (2004) [Pubmed]
  6. Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. Harrison, J.K., Jiang, Y., Chen, S., Xia, Y., Maciejewski, D., McNamara, R.K., Streit, W.J., Salafranca, M.N., Adhikari, S., Thompson, D.A., Botti, P., Bacon, K.B., Feng, L. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  7. Induction of Fractalkine and CX3CR1 mediated by host CD8+ T cells in allograft tolerance induced by donor specific blood transfusion. Louvet, C., Heslan, J.M., Merieau, E., Soulillou, J.P., Cuturi, M.C., Chiffoleau, E. Transplantation (2004) [Pubmed]
  8. cDNA cloning of a G-protein-coupled receptor expressed in rat spinal cord and brain related to chemokine receptors. Harrison, J.K., Barber, C.M., Lynch, K.R. Neurosci. Lett. (1994) [Pubmed]
  9. Proline 326 in the C terminus of murine CX3CR1 prevents G-protein and phosphatidylinositol 3-kinase-dependent stimulation of Akt and extracellular signal-regulated kinase in Chinese hamster ovary cells. Davis, C.N., Harrison, J.K. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  10. TGF-beta1 upregulates CX3CR1 expression and inhibits fractalkine-stimulated signaling in rat microglia. Chen, S., Luo, D., Streit, W.J., Harrison, J.K. J. Neuroimmunol. (2002) [Pubmed]
  11. Induction of CX3CL1 expression in astrocytes and CX3CR1 in microglia in the spinal cord of a rat model of neuropathic pain. Lindia, J.A., McGowan, E., Jochnowitz, N., Abbadie, C. The journal of pain : official journal of the American Pain Society. (2005) [Pubmed]
  12. Comparison of Cyclosporine Versus Mycophenolate Mofetil on Expression of Fractalkine and CX3CR1 in Chronic Allograft Nephropathy. Cao, G., Lu, Y., Gao, R., Xin, Y., Teng, D., Wang, J., Wang, L., Li, Y. Transplant. Proc. (2006) [Pubmed]
  13. Functional expression of the fractalkine (CX3C) receptor and its regulation by lipopolysaccharide in rat microglia. Boddeke, E.W., Meigel, I., Frentzel, S., Biber, K., Renn, L.Q., Gebicke-Härter, P. Eur. J. Pharmacol. (1999) [Pubmed]
  14. Expressions of cytokines and chemokines in the dorsal motor nucleus of the vagus nerve after right vagotomy. Ji, J.F., Dheen, S.T., Kumar, S.D., He, B.P., Tay, S.S. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  15. Interleukin-10 inhibits endotoxin-induced pro-inflammatory cytokines in microglial cell cultures. Kremlev, S.G., Palmer, C. J. Neuroimmunol. (2005) [Pubmed]
  16. A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine. Johnston, I.N., Milligan, E.D., Wieseler-Frank, J., Frank, M.G., Zapata, V., Campisi, J., Langer, S., Martin, D., Green, P., Fleshner, M., Leinwand, L., Maier, S.F., Watkins, L.R. J. Neurosci. (2004) [Pubmed]
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