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Gene Review

Mog  -  myelin oligodendrocyte glycoprotein

Rattus norvegicus

Synonyms: Myelin-oligodendrocyte glycoprotein
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Disease relevance of Mog


High impact information on Mog


Chemical compound and disease context of Mog


Biological context of Mog

  • We colocalized the MOG and BT genes to the human MHC on chromosome 6p21.3-p22 [1].
  • The homology between MOG and B-G extends beyond their structure and genetic mapping to their ability to induce strong antibody responses and has implications for the role of MOG in pathological, autoimmune conditions [1].
  • The antibody 8-18C5 binds to three loops located at the membrane-distal side of MOG with a surprisingly dominant contribution made by MOG residues 101-108 containing a strained loop that forms the upper edge of the putative ligand binding site [2].
  • Moreover, MOG appears to represent a unique member of this superfamily in that it possesses two potential transmembrane domains, in contrast to a single membrane-spanning domain or glycophospholipid anchor found in all other members of Ig superfamily members [12].
  • The rat MOG sequence spanning amino acids 35-55 [rMOG-(35-55)-peptide] differs from the human sequence [hMOG-(35-55)-peptide] by a single amino acid substitution, i.e. Pro42-->Ser [13].

Anatomical context of Mog


Associations of Mog with chemical compounds

  • Human MOG 35-55 was only weakly encephalitogenic, and a proline substitution in rat MOG at position 42 severely attenuated its encephalitogenicity [15].
  • Specifically, substituting proline at position 42 with serine in human MOG (as in rat MOG) eliminates the B cell requirement for EAE [3].
  • A panel of 13 monoclonal antibodies (mAbs) has been raised to the central nervous system-specific glycoprotein, myelin oligodendrocyte glycoprotein; five of these mAbs recognize a carbohydrate epitope on the molecule [17].
  • We here explored the efficacy of treosulfan in the treatment of MOG-induced EAE in DA rats [8].
  • Therefore, pioglitazone protection seems to be linked to an inhibition of glial cell proinflammatory activities following anti-MOG induced demyelination [9].

Regulatory relationships of Mog


Other interactions of Mog


Analytical, diagnostic and therapeutic context of Mog


  1. Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex. Pham-Dinh, D., Mattei, M.G., Nussbaum, J.L., Roussel, G., Pontarotti, P., Roeckel, N., Mather, I.H., Artzt, K., Lindahl, K.F., Dautigny, A. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein. Breithaupt, C., Schubart, A., Zander, H., Skerra, A., Huber, R., Linington, C., Jacob, U. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. Pathogenic myelin oligodendrocyte glycoprotein antibodies recognize glycosylated epitopes and perturb oligodendrocyte physiology. Marta, C.B., Oliver, A.R., Sweet, R.A., Pfeiffer, S.E., Ruddle, N.H. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology. Storch, M.K., Stefferl, A., Brehm, U., Weissert, R., Wallström, E., Kerschensteiner, M., Olsson, T., Linington, C., Lassmann, H. Brain Pathol. (1998) [Pubmed]
  5. Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2. Kumanogoh, A., Marukawa, S., Suzuki, K., Takegahara, N., Watanabe, C., Ch'ng, E., Ishida, I., Fujimura, H., Sakoda, S., Yoshida, K., Kikutani, H. Nature (2002) [Pubmed]
  6. The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis. Kawakami, N., Lassmann, S., Li, Z., Odoardi, F., Ritter, T., Ziemssen, T., Klinkert, W.E., Ellwart, J.W., Bradl, M., Krivacic, K., Lassmann, H., Ransohoff, R.M., Volk, H.D., Wekerle, H., Linington, C., Flügel, A. J. Exp. Med. (2004) [Pubmed]
  7. MHC haplotype-dependent regulation of MOG-induced EAE in rats. Weissert, R., Wallström, E., Storch, M.K., Stefferl, A., Lorentzen, J., Lassmann, H., Linington, C., Olsson, T. J. Clin. Invest. (1998) [Pubmed]
  8. Action of treosulfan in myelin-oligodendrocyte-glycoprotein-induced experimental autoimmune encephalomyelitis and human lymphocytes. Weissert, R., Wiendl, H., Pfrommer, H., Storch, M.K., Schreiner, B., Barth, S., Seifert, T., Melms, A., Dichgans, J., Weller, M. J. Neuroimmunol. (2003) [Pubmed]
  9. Inhibition of glial cell proinflammatory activities by peroxisome proliferator-activated receptor gamma agonist confers partial protection during antimyelin oligodendrocyte glycoprotein demyelination in vitro. Duvanel, C.B., Honegger, P., Pershadsingh, H., Feinstein, D., Matthieu, J.M. J. Neurosci. Res. (2003) [Pubmed]
  10. Simvastatin treatment does not protect retinal ganglion cells from degeneration in a rat model of autoimmune optic neuritis. Sättler, M.B., Diem, R., Merkler, D., Demmer, I., Boger, I., Stadelmann, C., Bähr, M. Exp. Neurol. (2005) [Pubmed]
  11. Combined therapy with methylprednisolone and erythropoietin in a model of multiple sclerosis. Diem, R., Sättler, M.B., Merkler, D., Demmer, I., Maier, K., Stadelmann, C., Ehrenreich, H., Bähr, M. Brain (2005) [Pubmed]
  12. Myelin/oligodendrocyte glycoprotein is a unique member of the immunoglobulin superfamily. Gardinier, M.V., Amiguet, P., Linington, C., Matthieu, J.M. J. Neurosci. Res. (1992) [Pubmed]
  13. A conformational study of the human and rat encephalitogenic myelin oligodendrocyte glycoprotein peptides 35-55. Albouz-Abo, S., Wilson, J.C., Bernard, C.C., von Itzstein, M. Eur. J. Biochem. (1997) [Pubmed]
  14. Oligodendrocyte progenitor cells in the adult rat CNS express myelin oligodendrocyte glycoprotein (MOG). Li, G., Crang, A.J., Rundle, J.L., Blakemore, W.F. Brain Pathol. (2002) [Pubmed]
  15. Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL/6 mice. Oliver, A.R., Lyon, G.M., Ruddle, N.H. J. Immunol. (2003) [Pubmed]
  16. Tolerance induction by bone marrow transplantation in a multiple sclerosis model. Herrmann, M.M., Gaertner, S., Stadelmann, C., van den Brandt, J., Böscke, R., Budach, W., Reichardt, H.M., Weissert, R. Blood (2005) [Pubmed]
  17. The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement. Piddlesden, S.J., Lassmann, H., Zimprich, F., Morgan, B.P., Linington, C. Am. J. Pathol. (1993) [Pubmed]
  18. Linkage analysis of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in the rat identifies a locus controlling demyelination on chromosome 18. Dahlman, I., Wallström, E., Weissert, R., Storch, M., Kornek, B., Jacobsson, L., Linington, C., Luthman, H., Lassmann, H., Olsson, T. Hum. Mol. Genet. (1999) [Pubmed]
  19. Neuroprotective effects and intracellular signaling pathways of erythropoietin in a rat model of multiple sclerosis. Sättler, M.B., Merkler, D., Maier, K., Stadelmann, C., Ehrenreich, H., Bähr, M., Diem, R. Cell Death Differ. (2004) [Pubmed]
  20. Differential expression of the chemokine receptors CX3CR1 and CCR1 by microglia and macrophages in myelin-oligodendrocyte-glycoprotein-induced experimental autoimmune encephalomyelitis. Sunnemark, D., Eltayeb, S., Wallström, E., Appelsved, L., Malmberg, A., Lassmann, H., Ericsson-Dahlstrand, A., Piehl, F., Olsson, T. Brain Pathol. (2003) [Pubmed]
  21. Changes in the G-protein-coupled receptor desensitization machinery during relapsing-progressive experimental allergic encephalomyelitis. Vroon, A., Lombardi, M.S., Kavelaars, A., Heijnen, C.J. J. Neuroimmunol. (2003) [Pubmed]
  22. The remyelinating potential and in vitro differentiation of MOG-expressing oligodendrocyte precursors isolated from the adult rat CNS. Crang, A.J., Gilson, J.M., Li, W.W., Blakemore, W.F. Eur. J. Neurosci. (2004) [Pubmed]
  23. Immunohistochemical analysis of myelination following hemicranial irradiation in neonatal rats. Sato, G., Tanaka, R., Akiyama, K., Yamanaka, R., Sato, M. Neurosci. Lett. (2003) [Pubmed]
  24. Human myelin/oligodendrocyte glycoprotein: a new member of the L2/HNK-1 family. Burger, D., Steck, A.J., Bernard, C.C., Kerlero de Rosbo, N. J. Neurochem. (1993) [Pubmed]
  25. ES cell-derived glial precursors contribute to remyelination in acutely demyelinated spinal cord lesions. Perez-Bouza, A., Glaser, T., Brüstle, O. Brain Pathol. (2005) [Pubmed]
  26. Myelin oligodendrocyte glycoprotein induces experimental autoimmune encephalomyelitis in the "resistant" Brown Norway rat: disease susceptibility is determined by MHC and MHC-linked effects on the B cell response. Stefferl, A., Brehm, U., Storch, M., Lambracht-Washington, D., Bourquin, C., Wonigeit, K., Lassmann, H., Linington, C. J. Immunol. (1999) [Pubmed]
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