The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Cabin1  -  calcineurin binding protein 1

Rattus norvegicus

Synonyms: CAIN, Calcineurin inhibitor, Calcineurin-binding protein cabin-1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Cabin1


High impact information on Cabin1


Chemical compound and disease context of Cabin1


Biological context of Cabin1


Anatomical context of Cabin1


Associations of Cabin1 with chemical compounds


Regulatory relationships of Cabin1


Other interactions of Cabin1


Analytical, diagnostic and therapeutic context of Cabin1


  1. Death-associated protein kinase is activated by dephosphorylation in response to cerebral ischemia. Shamloo, M., Soriano, L., Wieloch, T., Nikolich, K., Urfer, R., Oksenberg, D. J. Biol. Chem. (2005) [Pubmed]
  2. Myocardial stiffness is determined by ventricular fibrosis, but not by compensatory or excessive hypertrophy in hypertensive heart. Yamamoto, K., Masuyama, T., Sakata, Y., Nishikawa, N., Mano, T., Yoshida, J., Miwa, T., Sugawara, M., Yamaguchi, Y., Ookawara, T., Suzuki, K., Hori, M. Cardiovasc. Res. (2002) [Pubmed]
  3. Direct biomechanical induction of endogenous calcineurin inhibitor Down Syndrome Critical Region-1 in cardiac myocytes. Wang, Y., De Keulenaer, G.W., Weinberg, E.O., Muangman, S., Gualberto, A., Landschulz, K.T., Turi, T.G., Thompson, J.F., Lee, R.T. Am. J. Physiol. Heart Circ. Physiol. (2002) [Pubmed]
  4. Gene expression profiling of exercise-induced cardiac hypertrophy in rats. Iemitsu, M., Maeda, S., Miyauchi, T., Matsuda, M., Tanaka, H. Acta Physiol. Scand. (2005) [Pubmed]
  5. Calcineurin plays a critical role in pressure overload-induced cardiac hypertrophy. Shimoyama, M., Hayashi, D., Takimoto, E., Zou, Y., Oka, T., Uozumi, H., Kudoh, S., Shibasaki, F., Yazaki, Y., Nagai, R., Komuro, I. Circulation (1999) [Pubmed]
  6. Calcineurin inhibition of dynamin I GTPase activity coupled to nerve terminal depolarization. Liu, J.P., Sim, A.T., Robinson, P.J. Science (1994) [Pubmed]
  7. Heterosynaptic interactions between LTP and LTD in CA1 hippocampal slices. Muller, D., Hefft, S., Figurov, A. Neuron (1995) [Pubmed]
  8. Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death. Kim, M.J., Jo, D.G., Hong, G.S., Kim, B.J., Lai, M., Cho, D.H., Kim, K.W., Bandyopadhyay, A., Hong, Y.M., Kim, d.o. .H., Cho, C., Liu, J.O., Snyder, S.H., Jung, Y.K. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  9. Calcineurin controls nerve activity-dependent specification of slow skeletal muscle fibers but not muscle growth. Serrano, A.L., Murgia, M., Pallafacchina, G., Calabria, E., Coniglio, P., Lømo, T., Schiaffino, S. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  10. Immunosuppression using the mTOR inhibition mechanism affects replacement of rat liver with transplanted cells. Wu, Y.M., Joseph, B., Gupta, S. Hepatology (2006) [Pubmed]
  11. Role of calcineurin in insulin-like growth factor-1-induced hypertrophy of cultured adult rat ventricular myocytes. Miyashita, T., Takeishi, Y., Takahashi, H., Kato, S., Kubota, I., Tomoike, H. Jpn. Circ. J. (2001) [Pubmed]
  12. Cain, a novel physiologic protein inhibitor of calcineurin. Lai, M.M., Burnett, P.E., Wolosker, H., Blackshaw, S., Snyder, S.H. J. Biol. Chem. (1998) [Pubmed]
  13. Differential effects of a calcineurin inhibitor on glutamate-induced phosphorylation of Ca2+/calmodulin-dependent protein kinases in cultured rat hippocampal neurons. Kasahara, J., Fukunaga, K., Miyamoto, E. J. Biol. Chem. (1999) [Pubmed]
  14. Tacrolimus ameliorates cerebral vasodilatation and intracranial hypertension in the rat with portacaval anastomosis and hyperammonemia. Dethloff, T., Hansen, B.A., Larsen, F.S. Liver Transpl. (2004) [Pubmed]
  15. Cyclosporin A-sensitive signaling pathway involving calcineurin regulates survival of reactive astrocytes. Pyrzynska, B., Lis, A., Mosieniak, G., Kaminska, B. Neurochem. Int. (2001) [Pubmed]
  16. Regulation of the phosphorylation of glial fibrillary acidic protein (GFAP) by glutamate and calcium ions in slices of immature rat spinal cord: comparison with immature hippocampus. Kommers, T., Vinadé, L., Pereira, C., Gonçalves, C.A., Wofchuk, S., Rodnight, R. Neurosci. Lett. (1998) [Pubmed]
  17. Phosphorylated neurofilament accumulation in neuronal perikarya by cyclosporin A injection in rat brain. Tanaka, T., Takeda, M., Niigawa, H., Hariguchi, S., Nishimura, T. Methods and findings in experimental and clinical pharmacology. (1993) [Pubmed]
  18. Lead and calcium produce rod photoreceptor cell apoptosis by opening the mitochondrial permeability transition pore. He, L., Poblenz, A.T., Medrano, C.J., Fox, D.A. J. Biol. Chem. (2000) [Pubmed]
  19. Tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) by oxidant stress in cerebellar granule neurons: modulation by N-methyl-D-aspartate through calcineurin activity. Hallak, H., Ramadan, B., Rubin, R. J. Neurochem. (2001) [Pubmed]
  20. Involvement of calcineurin in Ca2+ paradox-like injury of cultured rat astrocytes. Matsuda, T., Takuma, K., Asano, S., Kishida, Y., Nakamura, H., Mori, K., Maeda, S., Baba, A. J. Neurochem. (1998) [Pubmed]
  21. Effects of immunosuppressant FTY720 on renal and hepatic hemodynamics in the rat. Tawadrous, M.N., Mabuchi, A., Zimmermann, A., Wheatley, A.M. Transplantation (2002) [Pubmed]
  22. Strong expression of CD134 (OX40), a member of the TNF receptor family, in a T helper 2-type cytokine environment. Roos, A., Schilder-Tol, E.J., Weening, J.J., Aten, J. J. Leukoc. Biol. (1998) [Pubmed]
  23. Calcineurin controls the expression of isoform 4CII of the plasma membrane Ca(2+) pump in neurons. Guerini, D., Wang, X., Li, L., Genazzani, A., Carafoli, E. J. Biol. Chem. (2000) [Pubmed]
  24. Insulin-like growth factor-I induces renal cell hypertrophy via a calcineurin-dependent mechanism. Gooch, J.L., Tang, Y., Ricono, J.M., Abboud, H.E. J. Biol. Chem. (2001) [Pubmed]
  25. Heterologous desensitization of insulin secretion by GIP (glucose-dependent insulinotropic peptide) in INS-1 cells: the significance of Galphai2 and investigations on the mechanism involved. Rucha, A., Verspohl, E.J. Cell Biochem. Funct. (2005) [Pubmed]
  26. Calcineurin-mediated Bad translocation regulates cyanide-induced neuronal apoptosis. Shou, Y., Li, L., Prabhakaran, K., Borowitz, J.L., Isom, G.E. Biochem. J. (2004) [Pubmed]
  27. Calcineurin contributes to the enhancing effect of adenosine on nerve growth factor-induced neurite outgrowth via the decreased duration of p38 mitogen-activated protein kinase phosphorylation. Muroi, Y., Ishii, T., Teramoto, K., Hori, M., Nishimura, M. J. Pharmacol. Sci. (2004) [Pubmed]
  28. Characteristics of the inhibitory effect of calmodulin on specific [125i]omega-conotoxin GVIA binding to crude membranes from chick brain. Ichida, S., Abe, J., Zhang, Y.A., Sugihara, K., Imoto, K., Wada, T., Fujita, N., Sohma, H. Neurochem. Res. (2000) [Pubmed]
  29. Cardioprotective effects of the calcineurin inhibitor FK506 and the PAF receptor antagonist and free radical scavenger, EGb 761, in isolated ischemic/reperfused rat hearts. Haines, D.D., Bak, I., Ferdinandy, P., Mahmoud, F.F., Al-Harbi, S.A., Blasig, I.E., Tosaki, A. J. Cardiovasc. Pharmacol. (2000) [Pubmed]
  30. Change from cyclosporine to combination therapy of mycophenolic acid with the new sphingosine-1-phosphate receptor agonist, KRP-203, prevents host nephrotoxicity and transplant vasculopathy in rats. Fujishiro, J., Suzuki, C., Kudou, S., Yasue, T., Hakamata, Y., Takahashi, M., Murakami, T., Hashizume, K., Kobayashi, E. J. Heart Lung Transplant. (2006) [Pubmed]
  31. NMDA receptor regulation of nNOS phosphorylation and induction of neuron death. Rameau, G.A., Chiu, L.Y., Ziff, E.B. Neurobiol. Aging (2003) [Pubmed]
  32. Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors. Christians, U., Gottschalk, S., Miljus, J., Hainz, C., Benet, L.Z., Leibfritz, D., Serkova, N. Br. J. Pharmacol. (2004) [Pubmed]
  33. Apoptosis in Ca2 + reperfusion injury of cultured astrocytes: roles of reactive oxygen species and NF-kappaB activation. Takuma, K., Lee, E., Kidawara, M., Mori, K., Kimura, Y., Baba, A., Matsuda, T. Eur. J. Neurosci. (1999) [Pubmed]
WikiGenes - Universities