Disease relevance of RCP9

• Overexpression and purification of human calcitonin gene-related peptide-receptor component protein in Escherichia coli [1].
• We performed a mutation screening by PCR exon amplification, single-strand conformation polymorphism (SSCP) and sequencing in four candidate genes, CgRPs (alphaCgRP, betaCgRP), their receptor (CgRPR) and the receptor component protein (CgRP-RCP), in 90 selected cases of idiopathic unilateral or bilateral cryptorchidism [2].
• Our data reveal that the serum RCP levels in cycling breast cancer patients are 3- to 4-fold higher (p < 0.01) than those in their normal counterparts [3].
• In this prospective blinded study, patients with breast cancer, benign breast disease, and healthy controls were analyzed for RCP levels [4].
• In the event that the only clinical benefits of RCP are the maintenance of cerebral hypothermia and the flushing of air and particulate debris from the arterial circulation, consequently reducing the risk of embolism, then the continued use and investigation of RCP techniques is justified [5].

Psychiatry related information on RCP9

• The pulmonary rehabilitation RCP effectively implemented the following strategies: biofeedback by using a flow-volume display, positive reinforcement, teaching about dyspnea and weaning, and use of the modified Borg scale [6].

High impact information on RCP9

• In situ hybridization demonstrated that the CGRP receptor component protein is expressed in outer hair cells of the organ of Corti and is colocalized with CGRP-containing efferent nerve terminals [7].
• However, mammalian homologues of C17 (named CGRP-RCP) are known to be involved in a signal transduction pathway related to G protein-coupled receptors, not in transcription [8].
• Generally, it is found that while polyamino acid repeats are extremely rare in prokaryotes, several eukaryote putative homologs of prokaryote RCP-involved in important housekeeping processes-retain the repetitive region, suggesting an ancient origin for certain repeats [9].
• The significant increase in expression of the pain-related neurotransmitter calcitonin gene-related peptide (CGRP) in the sensory ganglia as well as the auxiliary protein CGRP receptor component protein of the calcitonin-like receptor in the brainstem further substantiated the induction of pain [10].
• Here we show that the CGRP-binding protein referred to as the calcitonin receptor-like receptor is highly concentrated at the avian neuromuscular junction together with its two accessory proteins, receptor activity modifying protein 1 and CGRP-receptor component protein, required for ligand specificity and signal transduction [11].

Chemical compound and disease context of RCP9

• Patients of group II had higher systolic blood pressure, glucose, total cholesterol, LDL cholesterol, triglycerides, lipoprotein (a), RCP levels and HOMA index than patients in group I. ANOVA analysis did not show differences among weight loss in tertiles of HOMA and glucose [12].
• Evaluation of the occlusion showed a strong correlation between the crossbite side and the direction of the RCP-ICP slide and with the side of first occlusal contact in RCP [13].

Biological context of RCP9

• In this study stable cell lines were made that express antisense RCP RNA, and CGRP- and adrenomedullin-mediated signal transduction were greatly reduced [14].
• Human RCP was cloned and overexpressed with a poly-histidine tag and as a maltose binding protein (MBP) fusion in Escherichia coli using commercially available expression vectors [1].
• No CGRP-RCP immunoreactivity was observed in other cells at less mature stages of sperm maturation, in Sertoli or interstitial (Leydig) cells, or in human spermatozoa [15].
• Using probes based on the isolation of CGRP-RCP complementary DNA (cDNA) from a guinea pig organ of Corti cDNA library, we cloned human (h) and mouse (m) CGRP-RCP cDNAs, both of which encode 148-residue proteins that at the amino acid levels are approximately 88% identical to each other and to the 146-residue guinea pig CGRP-RCP [15].
• Accumulating clinical evidence has confirmed that RCP is safe, provided flow rates and central venous (intracerebral) pressures are maintained at relatively low levels [5].

Anatomical context of RCP9

• The presence of mRNA encoding the guinea pig CRLR and the guinea pig CGRP receptor component protein (RCP) in the guinea pig basilar artery was demonstrated by RT-PCR methods [16].
• Numerous antisera generated against hCGRP-RCP, including one to recombinant hCGRP-RCP, exhibited strong immunoreactivity localized to the head region of spermatozoa [15].
• In these human tissues, hCGRP-RCP messenger RNA (major band at approximately 3.1 kb, minor band at approximately 7.5 kb) was most prevalent in the testis [15].
• Therefore, it appears that CGRP-RCP is associated with the acrosome, suggesting that it may play an important role in reproduction [15].
• We have earlier shown that the estrogen-modulated riboflavin carrier protein (RCP) first isolated from the chicken egg is evolutionarily conserved in mammals and is elaborated by lactating mammary gland as demonstrated with rat mammary epithelial cells in culture and confirmed by isolation of the vitamin carrier from bovine milk [3].

Associations of RCP9 with chemical compounds

• Bacterial diversity increased upon cadmium addition for both EPA and RCP libraries [17].
• RCP levels following intravenous glucose tolerance test in diabetic and nondiabetic rats were consistent with expected patterns [18].
• It has been suggested that an approximate angle of displacement of over 45 degree or a ratio of 1 or less acting over a significant distance between RCP and IC, may need further study before occlusal adjustment by selective grinding is attempted [19].
• An audit of RCP guidelines on DMSA scanning after urinary tract infection [20].

Other interactions of RCP9

• 2. AST, EC and SMC all expressed mRNAs for RAMP1, RAMP2 and RCP [21].
• Together, these results suggest the presence of CGRP(1) and/or CGRP(2) receptors in human brain AST, EC and SMC, and of an additional population of CGRP receptors in AST, possibly associated to the combined expression of RAMP3 and RCP in these cells, for which BIBN4096BS exhibits an exquisitely high affinity [21].
• Furthermore, signalling at two other endogenous G-protein-coupled receptors was unaffected, suggesting that RCP was specific for a limited subset of receptors [22].

Analytical, diagnostic and therapeutic context of RCP9

• The reactivities of these antigenic determinants have been confirmed with polyclonal anti-human RCP sera by using synthetic peptides harbouring these chicken RCP sequences in inhibition ELISA [23].
• 1. The levels of RCP in maternal serum during pregnancy were monitored using a sensitive heterologous radioimmunoassay system, using cRCP as standard and anti serum to cRCP [24].
• 111In-DOTA-NCS-ST was produced as a single species (>80% RCP) and purified by HPLC [25].
• The number of patients' CRCP problems correlated with the DAS (p<0.0001), and the number of partners' CRCP problems correlated with the HADS (p<0.0001) and the DAS (p<0.0001).Conclusion: Analyses supported the CRCP Scale's reliability and validity for female cancer patients and male partners [26].
• This article discusses the causes and effects of stroke and outlines the role of the nurse in the rehabilitation of a patient after stroke with reference to the National Clinical Guidelines for Stroke (RCP 2002) [27].

References