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Gene Review

GLG1  -  golgi glycoprotein 1

Gallus gallus

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Disease relevance of GLG1


High impact information on GLG1


Biological context of GLG1

  • These findings suggest that subunit assembly occurs in the Golgi apparatus and that phosphorylation/dephosphorylation mechanisms play a role in the control of AChR subunit assembly [7].
  • While over 20 intrinsic proteins of the Golgi apparatus have been identified and sequenced, there is no information on their developmental history, i.e., whether all Golgi proteins are expressed simultaneously or whether there is a hierarchical or stage-specific order of their expression during embryonic development [8].
  • The levels of CFR transcripts were high during the proliferation and the subsequent differentiation phases of retinal neurogenesis, reached a maximum around E11 during the onset of the major period of retinal cell death, and then declined progressively [9].
  • In prolonged primary cell cultures of chicken embryo retina, CFR expression showed a similar down-regulation to that seen with increasing age in vivo [9].
  • Intracellular immunoreactivity was present in the granular and agranular endoplasmic reticulum, Golgi apparatus and in lysosomes, representing the sites of synthesis, glycosylation and degradation of the protein [10].

Anatomical context of GLG1


Associations of GLG1 with chemical compounds

  • The cysteine-rich FGF receptor (CFR) is a 150-kD membrane-associated glycoprotein that specifically binds FGFs [14].
  • The rate of AChR assembly is decreased by metabolic inhibitors and by monensin, an ionophore that impairs the Golgi apparatus [7].
  • In regard to a progressive increase in the expression of their ligands during retinal development, we suggest that CFR may have a role distinct from that of the tyrosine kinase FGF receptors during retinogenesis [9].
  • Golgi apparatus fractions were prepared by flotation of microsomes, obtained from the same homogenate as the low-speed pellet, in a discontinuous sucrose gradient [15].
  • At the ultrastructural level, GABA treatment also led to an increased density of neurotubules, rough endoplasmic reticulum (RER), Golgi apparatus, coated vesicles, and other vesicles [16].

Physical interactions of GLG1


Regulatory relationships of GLG1

  • During the last week of incubation, which is the final third of the incubation period, the digestion seemed to progress rapidly in the yolk drops, which came to resemble lipolysosomes; lipoprotein production became active as expressed by an enlarged Golgi apparatus [18].
  • Monensin, which is known to cause dilatation of the Golgi apparatus and to inhibit sulfation of proteoglycan, was found to affect the release of the sulfotransferases [19].

Other interactions of GLG1


Analytical, diagnostic and therapeutic context of GLG1


  1. Isolation and characterization of chicken liver and hepatoma Mc-29 endoplasmic reticulum and Golgi apparatus membranes and biosynthesis of their glycoconjugates. Gavazova, E., Ivanov, S., Chelibonova-Lorer, H. J. Natl. Cancer Inst. (1987) [Pubmed]
  2. Labelling of an intermediate saccule of the Golgi apparatus and of parts of the endoplasmic reticulum by a lectin (soybean agglutinin) in the chick ciliary ganglion. Philippe, E., Tremblay, J.P. Neurosci. Lett. (1983) [Pubmed]
  3. Biosynthesis of high density lipoprotein by chicken liver: conjugation of nascent lipids with apoprotein A1. Banerjee, D., Redman, C.M. J. Cell Biol. (1984) [Pubmed]
  4. Golgi organelle response to the antibiotic X537A. Somlyo, A.P., Garfield, R.E., Chacko, S., Somlyo, A.V. J. Cell Biol. (1975) [Pubmed]
  5. Possible role of the Golgi apparatus in the assembly of very low density lipoprotein. Bamberger, M.J., Lane, M.D. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  6. Cysteine-rich fibroblast growth factor receptor alters secretion and intracellular routing of fibroblast growth factor 3. Köhl, R., Antoine, M., Olwin, B.B., Dickson, C., Kiefer, P. J. Biol. Chem. (2000) [Pubmed]
  7. Phosphorylation and assembly of nicotinic acetylcholine receptor subunits in cultured chick muscle cells. Ross, A.F., Rapuano, M., Schmidt, J.H., Prives, J.M. J. Biol. Chem. (1987) [Pubmed]
  8. MG160, a membrane protein of the Golgi apparatus which is homologous to a fibroblast growth factor receptor and to a ligand for E-selectin, is found only in the Golgi apparatus and appears early in chicken embryo development. Stieber, A., Mourelatos, Z., Chen, Y.J., Le Douarin, N., Gonatas, N.K. Exp. Cell Res. (1995) [Pubmed]
  9. Expression of the chicken cysteine-rich fibroblast growth factor receptor (CFR) during embryogenesis and retina development. Fayein, N.A., Head, M.W., Jeanny, J.C., Courtois, Y., Fuhrmann, G. J. Neurosci. Res. (1996) [Pubmed]
  10. Subcellular localization of a putative kainate receptor in Bergmann glial cells using a monoclonal antibody in the chick and fish cerebellar cortex. Somogyi, P., Eshhar, N., Teichberg, V.I., Roberts, J.D. Neuroscience (1990) [Pubmed]
  11. The (Na+ + K+)-ATPase of chick sensory neurons. Studies on biosynthesis and intracellular transport. Tamkun, M.M., Fambrough, D.M. J. Biol. Chem. (1986) [Pubmed]
  12. Newly synthesized calsequestrin, destined for the sarcoplasmic reticulum, is contained in early/intermediate Golgi-derived clathrin-coated vesicles. Thomas, K., Navarro, J., Benson, R.J., Campbell, K.P., Rotundo, R.L., Fine, R.E. J. Biol. Chem. (1989) [Pubmed]
  13. Synthesis of N- and O-linked glycopeptides in oviduct membrane preparations. Hanover, J.A., Lennarz, W.J., Young, J.D. J. Biol. Chem. (1980) [Pubmed]
  14. Cysteine-rich FGF receptor regulates intracellular FGF-1 and FGF-2 levels. Zuber, M.E., Zhou, Z., Burrus, L.W., Olwin, B.B. J. Cell. Physiol. (1997) [Pubmed]
  15. Isolation of plasma membranes and Golgi apparatus from a single chicken liver homogenate. Vleurick, L., Kühn, E.R., Decuypere, E., Van Veldhoven, P.P. J. Cell. Biochem. (1999) [Pubmed]
  16. Neurotrophic effects of GABA in cultures of embryonic chick brain and retina. Spoerri, P.E. Synapse (1988) [Pubmed]
  17. Internalization of the chicken growth hormone receptor complex and its effect on biological functions. Kühn, E.R., Vleurick, L., Edery, M., Decuypere, E., Darras, V.M. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2002) [Pubmed]
  18. Participation of endodermal epithelial cells on the synthesis of plasma LDL and HDL in the chick yolk sac. Kanai, M., Soji, T., Sugawara, E., Watari, N., Oguchi, H., Matsubara, M., Herbert, D.C. Microsc. Res. Tech. (1996) [Pubmed]
  19. Secretion of chondroitin 6-sulfotransferase and chondroitin 4-sulfotransferase from cultured chick embryo chondrocytes. Habuchi, O., Tsuzuki, M., Takeuchi, I., Hara, M., Matsui, Y., Ashikari, S. Biochim. Biophys. Acta (1991) [Pubmed]
  20. The state of differentiation of embryonic chicken lens cells determines insulin-like growth factor I internalization. Soler, A.P., Alemany, J., Smith, R.M., de Pablo, F., Jarett, L. Endocrinology (1990) [Pubmed]
  21. Neuronal ultrastructure and somatostatin immunolocalization in the ciliary ganglion of chicken and quail. De Stefano, M.E., Ciofi Luzzatto, A., Mugnaini, E. J. Neurocytol. (1993) [Pubmed]
  22. Acetylcholinesterase distribution in chick spinal cord cultures. A light and electron microscope study. Kim, S.U. Histochemistry (1976) [Pubmed]
  23. Coalescence of membrane tethers: experiments, theory, and applications. Cuvelier, D., Derényi, I., Bassereau, P., Nassoy, P. Biophys. J. (2005) [Pubmed]
  24. A quantitative study of the position of the Golgi apparatus in the early developing chick eye. García-Porrero, J.A., Icardo, J.M., Ojeda, J.L. Anat. Embryol. (1981) [Pubmed]
  25. Ultrastructural immunolocalization of a major phosphoprotein in embryonic chick bone. McKee, M.D., Nanci, A., Landis, W.J., Gerstenfeld, L.C., Gotoh, Y., Glimcher, M.J. Connect. Tissue Res. (1989) [Pubmed]
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