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ITGB2  -  integrin, beta 2 (complement component 3...

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Disease relevance of CD18

  • OBJECTIVE: The expression of the leukocyte CD18 adhesion complex on polymorphonuclear leukocytes (PMNs) was measured, and the physiologic effects of blockade of the complex were studied after trauma and sepsis [1].
  • Where indicated, CD18 antibody IB4 was infused systemically at 30 min of ischemia [2].
  • Retroinfusion of NFkappaB decoy oligonucleotide extends cardioprotection achieved by CD18 inhibition in a preclinical study of myocardial ischemia and retroinfusion in pigs [2].
  • 3. These data suggest that, in this model of septic ALI, neutropenia is, in part, CD18 dependent and that blocking CD18-dependent PMN adhesion protects the alveolar-capillary membrane independently of altered hemodynamic status [3].
  • Transient inhibition of CD18-dependent leukocyte functions after hemorrhage and polymicrobial sepsis [4].

High impact information on CD18

  • Blockade of CD18 showed this adhesion molecule to be critical for eosinophil accumulation, and LPS-primed sites were inhibited as effectively as nonprimed sites [5].
  • The CD18 receptors were blocked with monoclonal antibodies either immediately before trauma or immediately before an endotoxin (lipopolysaccharide [LPS]) challenge that was administered to all groups 3 days after the shock episode [1].
  • We conclude that NFkappaB decoy ODN transfection by retroinfusion is feasible in pig hearts and provides postischemic cardioprotection in addition to CD18 blockade [2].
  • Additional systemic application of CD18-antibody IB4 (1.5 mg/kg) did not alter infarct size or SES in comparison to GSH/cariporide retroinfusion alone [6].
  • Pretreatment with anti-CD11/CD18 monoclonal antibody and superoxide dismutase-polyethylene glycol significantly reduced neutrophil infiltration and normalized transepithelial electrical resistance and mannitol fluxes [7].

Chemical compound and disease context of CD18

  • METHODS: Pigs were pretreated with anti-CD11/CD18 monoclonal antibody, superoxide dismutase-polyethylene glycol, or saline solution before inducing 1 hour of ischemia [7].

Biological context of CD18


Anatomical context of CD18

  • The results suggest that the CD18 integrin is involved in the recruitment of leukocytes to the airways, but increased numbers of eosinophils in lavage fluid are not an essential correlate of bronchial hyperresponsiveness in this model [13].
  • Here we demonstrate the involvement of ICAM-1-, CD18- and RGD-dependent adhesion mechanisms in chondrocyte-T-cell adhesion and in cell-mediated killing of chondrocytes in vitro [14].
  • The adhesion molecules CD18 and CD62 on lymphocytes were measured using monoclonal antibodies, and the lymphocyte proliferation was measured without stimulation and in response to mitogens [10].
  • Significant numbers of the histiocytes were positive for the integrins CD18 and VLA-4 (CD49d), indicating involvement of integrin pathways in the spread or growth, or both, of the leiomyofibrosarcoma [15].

Associations of CD18 with chemical compounds


Other interactions of CD18

  • Flow cytometric measurements of CD18 and CD45 expression were performed [21].
  • Systemic neutrophil surface receptor (CD18) expression was analyzed with monoclonal antibodies, and flap skin biopsy specimens were analyzed for neutrophil infiltration [22].
  • In the absence of cytokine stimulation, chondrocyte-peripheral blood mononuclear cell (PBMC) interactions were unaffected by inhibition of ICAM-1-dependent pathways but were significantly reduced by blockade of CD18- and RGD-dependent pathways [14].
  • Two minutes after protamine administration, CD18 (beta-subunit of Mac-1) expression measured by immunofluorescence flow cytometry increased 128 +/- 9% (mean +/- SEM) over preprotamine levels in control piglets but remained unchanged in NPC piglets (99 +/- 2%, P < 0.05) [23].

Analytical, diagnostic and therapeutic context of CD18


  1. Neutrophil CD18 expression and blockade after traumatic shock and endotoxin challenge. Fabian, T.C., Croce, M.A., Stewart, R.M., Dockter, M.E., Proctor, K.G. Ann. Surg. (1994) [Pubmed]
  2. Retroinfusion of NFkappaB decoy oligonucleotide extends cardioprotection achieved by CD18 inhibition in a preclinical study of myocardial ischemia and retroinfusion in pigs. Kupatt, C., Wichels, R., Deiss, M., Molnar, A., Lebherz, C., Raake, P., von Degenfeld, G., Hahnel, D., Boekstegers, P. Gene Ther. (2002) [Pubmed]
  3. Anti-CD18 antibody attenuates neutropenia and alveolar capillary-membrane injury during gram-negative sepsis. Walsh, C.J., Carey, P.D., Cook, D.J., Bechard, D.E., Fowler, A.A., Sugerman, H.J. Surgery (1991) [Pubmed]
  4. Transient inhibition of CD18-dependent leukocyte functions after hemorrhage and polymicrobial sepsis. Lyden, S.P., Patton, J.H., Ragsdale, D.N., Croce, M.A., Fabian, T.C., Proctor, K.G. Surgery (1998) [Pubmed]
  5. Priming of eosinophil recruitment in vivo by LPS pretreatment. Macari, D.M., Teixeira, M.M., Hellewell, P.G. J. Immunol. (1996) [Pubmed]
  6. Selective retroinfusion of GSH and cariporide attenuates myocardial ischemia-reperfusion injury in a preclinical pig model. Kupatt, C., Hinkel, R., Horstkotte, J., Deiss, M., von Brühl, M.L., Bilzer, M., Boekstegers, P. Cardiovasc. Res. (2004) [Pubmed]
  7. Neutrophils increase paracellular permeability of restituted ischemic-injured porcine ileum. Gayle, J., Jones, S.L., Argenzio, R.A., Blikslager, A.T. Surgery (2002) [Pubmed]
  8. Platelet activating factor inhibition reduces lung injury after cardiopulmonary bypass. Zehr, K.J., Poston, R.S., Lee, P.C., Uthoff, K., Kumar, P., Cho, P.W., Gillinov, A.M., Redmond, J.M., Winkelstein, J.A., Herskowitz, A. Ann. Thorac. Surg. (1995) [Pubmed]
  9. The effect of CVVHD and endotoxin on the oxidative burst, adhesion molecules and distribution in tissues of granulocytes. Toft, P., Krog, J., Brix-Christensen, V., Beck, J., Dagnaes-Hansen, F., Obel, N., Bendix-Hansen, K., Jørgensen, H.S. Intensive care medicine. (2000) [Pubmed]
  10. Effect of hemodiafiltration and sepsis on chemotaxis of granulocytes and the release of IL-8 and IL-10. Toft, P., Brix-Christensen, V., Baech, J., Krog, J., Jørgensen, H.S., Tønnesen, E., Petersen, T.K., Dagnaes-Hansen, F. Acta anaesthesiologica Scandinavica. (2002) [Pubmed]
  11. CD11/CD18 panel report for swine CD workshop. Kim, Y.B., Zhang, J., Davis, W.C., Lunney, J.K. Vet. Immunol. Immunopathol. (1994) [Pubmed]
  12. Inhibition of CD18-dependent adherence of polymorphonuclear leukocytes does not affect liver oxygen consumption in fecal peritonitis in pigs. Wollert, S., Rasmussen, I., Lundberg, C., Gerdin, B., Arvidsson, D., Haglund, U. Circ. Shock (1993) [Pubmed]
  13. The effects of two anti-CD18 antibodies on antigen-induced airway hyperresponsiveness and leukocyte accumulation in the guinea pig. Milne, A.A., Piper, P.J. Am. J. Respir. Cell Mol. Biol. (1994) [Pubmed]
  14. Chondrocyte-peripheral blood mononuclear cell interactions: the role of ICAM-1. Horner, A., Davies, M.E., Franz, B. Immunology (1995) [Pubmed]
  15. Leucocyte and endothelial cell adhesion molecule expression in porcine histiocytic leiomyofibrosarcoma. Whyte, A., Ockleford, C.D., Byrne, S., Hubbard, A., Woolley, S.T. J. Comp. Pathol. (1996) [Pubmed]
  16. Survival of guinea pig cardiac xenografts in C6-deficient PVG rats treated with monoclonal antibody to CD18. Brauer, R.B., Baldwin, W.M., Pruitt, S.K., Sanfilippo, F. Transplant. Proc. (1994) [Pubmed]
  17. Differential activation of alveolar, pulmonary arterial, and systemic arterial neutrophils demonstrates the existence of distinct neutrophil subpopulations in experimental sepsis. Windsor, A.C., Carey, P.D., Sugerman, H.J., Mullen, P.G., Walsh, C.J., Fisher, B.J., Blocher, C.R., Fowler, A.A. Shock (1994) [Pubmed]
  18. Unexpected action of platelet activating factor antagonism after fluid resuscitation from traumatic shock. Schurr, M.J., Fabian, T.C., Croce, M.A., Geraci, S.A., Proctor, K.G. Surgery (1997) [Pubmed]
  19. Beneficial cardiopulmonary effects of pentoxifylline in experimental sepsis are lost once septic shock is established. Ridings, P.C., Windsor, A.C., Sugerman, H.J., Kennedy, E., Sholley, M.M., Blocher, C.R., Fisher, B.J., Fowler, A.A. Archives of surgery (Chicago, Ill. : 1960) (1994) [Pubmed]
  20. Role of granulocytes and C5a in myocardial response to zymosan-activated serum. Stahl, G.L., Fletcher, M.P., Amsterdam, E.A., Longhurst, J.C. Am. J. Physiol. (1991) [Pubmed]
  21. Postnatal functional maturation of blood phagocytes in pig. Zelnickova, P., Kovaru, H., Pesak, S., Lojek, A., Matalova, E., Ondracek, J., Kovaru, F. Vet. Immunol. Immunopathol. (2006) [Pubmed]
  22. Circulating neutrophil CD18 receptor expression and ischemic flap neutrophil infiltration in a guinea pig model. Dolan, R., Hartshorn, K., McAvoy, D. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (2000) [Pubmed]
  23. Neutrophil activation mediates protamine-induced pulmonary hypertension. Cho, P.W., Gillinov, A.M., Zehr, K.J., Burch, R.M., Winkelstein, J.A., Cameron, D.E. J. Surg. Res. (1993) [Pubmed]
  24. Major long-term changes in gamma delta T-cell receptor-positive and CD2+ T-cell subsets after neonatal thymectomy in the pig: a longitudinal study lasting nearly 2 years. Licence, S.T., Binns, R.M. Immunology (1995) [Pubmed]
  25. Systemic neutrophil intrinsic 5-lipoxygenase activity and CD18 receptor expression linked to reperfusion injury. Dolan, R., Hartshorn, K., Andry, C., McAvoy, D. Laryngoscope (1998) [Pubmed]
  26. Effects of anti-CD18 monoclonal antibody, R15.7, on the cardiopulmonary manifestations of group B streptococcal sepsis in piglets. Bandel, J.W., Goldberg, R.N., Suguihara, C., Nagoshi, R., Martinez, O., Rothlein, R., Ruiz, P., Bancalari, E. Biol. Neonate (2000) [Pubmed]
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