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MBP  -  myelin basic protein

Sus scrofa

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Disease relevance of MBP


Psychiatry related information on MBP

  • In comparison with both saline solution (0.1 ml) and 10 micrograms basic proteins (protamines and histones), MBP specifically produced a rebound-like pattern of the REM sleep (REMS); it decreased the REMS latency, increased the number of REMS episodes and dramatically increased the REMS percent during the 3rd and 6th hour of recording [5].

High impact information on MBP


Chemical compound and disease context of MBP


Biological context of MBP


Anatomical context of MBP

  • Two such I-Au-restricted T-cell clones that proliferate in response to the encephalitogenic N-terminal MBP peptide and recognize a shared determinant with mouse (self) MBP cause paralysis in 100% of (PLSJ)F1 mice tested [7].
  • In sensitized, but not in nonsensitized animals, virus-induced hyperresponsiveness and M(2)R dysfunction were blocked by depletion of eosinophils with antibody to interleukin (IL)-5 or treatment with antibody to MBP [9].
  • To test the hypothesis that the acidic pro-part of proMBP inhibits the toxicity of mature MBP, acidic polyamino acids (aa) were used as antagonists of MBP toxicity to K562 cells and guinea pig tracheal epithelium and used as antagonists of MBP airway hyperresponsiveness in primates [2].
  • Prior addition of ganglioside to myelin inhibited the phosphorylation of MBP [18].
  • Lymphocyte transformation tests carried out in parallel with soluble MBP and with MBP-liposomes indicated that animals in certain groups responded preferentially to 1 form or the other of the antigen [4].

Associations of MBP with chemical compounds

  • This inhibition was not limited to MBP, but also applied to polyarginine and eosinophil cationic protein [2].
  • Analyses of granule lysates by gel filtration and by polyacrylamide gel electrophoresis revealed the presence of peroxidase and MBP with properties similar to that previously found in guinea pig eosinophil granules [19].
  • Compared with prevailing procedures, the single i.v. injection of a relatively small amount of liposome-associated MBP appears to represent a promising approach for the antigen-specific suppression of EAE [4].
  • These data also demonstrate that insulin and TPA activate MBP/MAP2 kinase activity by de novo phosphorylation of threonine and tyrosine residues via a very similar pathway [16].
  • Phosphorylation of isolated MBP by protein kinase C was stimulated by gangliosides, provided phosphatidylserine was present [18].

Physical interactions of MBP


Regulatory relationships of MBP


Other interactions of MBP


Analytical, diagnostic and therapeutic context of MBP


  1. In vivo neutralization of eosinophil-derived major basic protein inhibits antigen-induced bronchial hyperreactivity in sensitized guinea pigs. Lefort, J., Nahori, M.A., Ruffie, C., Vargaftig, B.B., Pretolani, M. J. Clin. Invest. (1996) [Pubmed]
  2. Acidic polyamino acids inhibit human eosinophil granule major basic protein toxicity. Evidence of a functional role for ProMBP. Barker, R.L., Gundel, R.H., Gleich, G.J., Checkel, J.L., Loegering, D.A., Pease, L.R., Hamann, K.J. J. Clin. Invest. (1991) [Pubmed]
  3. Neural antigens and the development of autoimmunity. Hashim, G.A. J. Immunol. (1985) [Pubmed]
  4. Suppression of experimental allergic encephalomyelitis in guinea/pigs by liposome-associated human myelin basic protein. Strejan, G.H., Percy, D.H., St Louis, J., Surlan, D., Paty, D.W. J. Immunol. (1981) [Pubmed]
  5. A rebound-like pattern of REM sleep induced by guinea pig myelin basic protein (MBP) in cats. Goldstein, R. Endocrinologie. (1990) [Pubmed]
  6. A suppressor T-lymphocyte cell line for autoimmune encephalomyelitis. Ellerman, K.E., Powers, J.M., Brostoff, S.W. Nature (1988) [Pubmed]
  7. T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination. Zamvil, S., Nelson, P., Trotter, J., Mitchell, D., Knobler, R., Fritz, R., Steinman, L. Nature (1985) [Pubmed]
  8. Transfer of experimental allergic encephalomyelitis with guinea pig peritoneal exudate cells. Driscoll, B.F., Kies, M.W., Alvord, E.C. Science (1979) [Pubmed]
  9. Ovalbumin sensitization changes the inflammatory response to subsequent parainfluenza infection. Eosinophils mediate airway hyperresponsiveness, m(2) muscarinic receptor dysfunction, and antiviral effects. Adamko, D.J., Yost, B.L., Gleich, G.J., Fryer, A.D., Jacoby, D.B. J. Exp. Med. (1999) [Pubmed]
  10. Role of eosinophil activation in the bronchial reactivity of allergic guinea pigs. Pretolani, M., Ruffié, C., Joseph, D., Campos, M.G., Church, M.K., Lefort, J., Vargaftig, B.B. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  11. Myelin basic protein: interaction with calmodulin and gangliosides. Chan, K.F., Robb, N.D., Chen, W.H. J. Neurosci. Res. (1990) [Pubmed]
  12. Induction of experimental autoimmune encephalomyelitis in guinea pigs using myelin basic protein and myelin glycolipids. Kusunoki, S., Yu, R.K., Kim, J.H. J. Neuroimmunol. (1988) [Pubmed]
  13. Oxygen immunosuppression: modification of experimental allergic encephalomyelitis in rodents. Warren, J., Sacksteder, M.R., Thuning, C.A. J. Immunol. (1978) [Pubmed]
  14. Linkage mapping of the porcine myelin basic protein gene to chromosome 1. Kim, J.G., Nonneman, D., Vallet, J.L., Rohrer, G.A., Christenson, R.K. Anim. Genet. (2005) [Pubmed]
  15. Elevated serum levels in human pregnancy of a molecule immunochemically similar to eosinophil granule major basic protein. Maddox, D.E., Butterfield, J.H., Ackerman, S.J., Coulam, C.B., Gleich, G.J. J. Exp. Med. (1983) [Pubmed]
  16. Insulin and 12-O-tetradecanoylphorbol-13-acetate activation of two immunologically distinct myelin basic protein/microtubule-associated protein 2 (MBP/MAP2) kinases via de novo phosphorylation of threonine and tyrosine residues. Tobe, K., Kadowaki, T., Tamemoto, H., Ueki, K., Hara, K., Koshio, O., Momomura, K., Gotoh, Y., Nishida, E., Akanuma, Y. J. Biol. Chem. (1991) [Pubmed]
  17. The role of myelin lipids in experimental allergic encephalomyelitis. Part 2. Influence on disease production by encephalitogenic doses of myelin basic protein. Hosein, Z.Z., Gilbert, J.J., Strejan, G.H. J. Neuroimmunol. (1986) [Pubmed]
  18. Ganglioside-modulated protein phosphorylation in myelin. Chan, K.F. J. Biol. Chem. (1987) [Pubmed]
  19. Comparative properties of the Charcot-Leyden crystal protein and the major basic protein from human eosinophils. Gleich, G.J., Loegering, D.A., Mann, K.G., Maldonado, J.E. J. Clin. Invest. (1976) [Pubmed]
  20. Calcium and calmodulin inhibit phosphorylation of a novel auditory nerve protein. Coling, D.E., Naik, R.M., Schacht, J. Hear. Res. (1994) [Pubmed]
  21. Effects of epidermal growth factor on the tyrosine phosphorylation of mitogen-activated protein kinases in monolayer cultures of porcine granulosa cells. Keel, B.A., Hildebrandt, J.M., May, J.V., Davis, J.S. Endocrinology (1995) [Pubmed]
  22. Effects of trichinellosis on levels of eosinophils, eosinophil major basic protein, creatine kinase and basophils in the guinea pig. Lindor, L.J., Wassom, D.L., Gleich, G.J. Parasite Immunol. (1983) [Pubmed]
  23. Ozone-induced hyperresponsiveness and blockade of M2 muscarinic receptors by eosinophil major basic protein. Yost, B.L., Gleich, G.J., Fryer, A.D. J. Appl. Physiol. (1999) [Pubmed]
  24. Activation of mitogen-activated protein kinase during meiotic maturation in porcine oocytes. Inoue, M., Naito, K., Aoki, F., Toyoda, Y., Sato, E. Zygote (1995) [Pubmed]
  25. Localization of the guinea pig eosinophil major basic protein to the core of the granule. Lewis, D.M., Lewis, J.C., Loegering, D.A., Gleich, G.J. J. Cell Biol. (1978) [Pubmed]
  26. Bulk separation and long-term culture of oligodendrocytes from adult pig brain. II. Some biochemical data. Gebicke-Härter, P.J., Althaus, H.H., Neuhoff, V. J. Neurochem. (1984) [Pubmed]
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