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Gene Review

MAPK1  -  mitogen-activated protein kinase 1

Sus scrofa

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Disease relevance of MAPK1


High impact information on MAPK1


Chemical compound and disease context of MAPK1


Biological context of MAPK1


Anatomical context of MAPK1


Associations of MAPK1 with chemical compounds


Regulatory relationships of MAPK1


Other interactions of MAPK1


Analytical, diagnostic and therapeutic context of MAPK1


  1. Effect of hypoxia on the expression and activity of mitogen-activated protein (MAP) kinase-phosphatase-1 (MKP-1) and MKP-3 in neuronal nuclei of newborn piglets: the role of nitric oxide. Mishra, O.P., Delivoria-Papadopoulos, M. Neuroscience (2004) [Pubmed]
  2. Differential regulation of p90 ribosomal S6 kinase and big mitogen-activated protein kinase 1 by ischemia/reperfusion and oxidative stress in perfused guinea pig hearts. Takeishi, Y., Abe, J., Lee, J.D., Kawakatsu, H., Walsh, R.A., Berk, B.C. Circ. Res. (1999) [Pubmed]
  3. Differential intracellular signaling of the GalR1 and GalR2 galanin receptor subtypes. Wang, S., Hashemi, T., Fried, S., Clemmons, A.L., Hawes, B.E. Biochemistry (1998) [Pubmed]
  4. PTK, MAPK, and NOC/oFQ impair hypercapnic cerebrovasodilation after hypoxia/ischemia. Jagolino, A.L., Armstead, W.M. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  5. Resveratrol inhibits MAPK activity and nuclear translocation in coronary artery smooth muscle: reversal of endothelin-1 stimulatory effects. El-Mowafy, A.M., White, R.E. FEBS Lett. (1999) [Pubmed]
  6. Pivotal role of Harakiri in the induction and prevention of gentamicin-induced hearing loss. Kalinec, G.M., Fernandez-Zapico, M.E., Urrutia, R., Esteban-Cruciani, N., Chen, S., Kalinec, F. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  7. Activation of MAP kinase in vivo follows balloon overstretch injury of porcine coronary and carotid arteries. Pyles, J.M., March, K.L., Franklin, M., Mehdi, K., Wilensky, R.L., Adam, L.P. Circ. Res. (1997) [Pubmed]
  8. Activation of mitogen-activated protein kinase in porcine carotid arteries. Adam, L.P., Franklin, M.T., Raff, G.J., Hathaway, D.R. Circ. Res. (1995) [Pubmed]
  9. Effects of vibration and hyaluronic acid on activation of three-dimensional cultured chondrocytes. Takeuchi, R., Saito, T., Ishikawa, H., Takigami, H., Dezawa, M., Ide, C., Itokazu, Y., Ikeda, M., Shiraishi, T., Morishita, S. Arthritis Rheum. (2006) [Pubmed]
  10. Protein tyrosine kinase and mitogen-activated protein kinase activation contribute to K(ATP) and K(ca) channel impairment after brain injury. Armstead, W.M. Brain Res. (2002) [Pubmed]
  11. Differential activation of ERK, p38, and JNK MAPK by nociceptin/orphanin FQ in the potentiation of prostaglandin cerebrovasoconstriction after brain injury. Armstead, W.M. Eur. J. Pharmacol. (2006) [Pubmed]
  12. PTK, ERK and p38 MAPK contribute to impaired NMDA-induced vasodilation after brain injury. Armstead, W.M. Eur. J. Pharmacol. (2003) [Pubmed]
  13. NOC/oFQ activates ERK and JNK but not p38 MAPK to impair prostaglandin cerebrovasodilation after brain injury. Ross, J., Armstead, W.M. Brain Res. (2005) [Pubmed]
  14. A neuroactive steroid inhibits guinea pig airway sensory nerves via Maxi-K channel activation. Yoshihara, S., Morimoto, H., Ohori, M., Yamada, Y., Abe, T., Arisaka, O. Int. Arch. Allergy Immunol. (2006) [Pubmed]
  15. The chemotactic and mitogenic responses of vascular smooth muscle cells to insulin-like growth factor-I require the activation of ERK1/2. Duan, C. Mol. Cell. Endocrinol. (2003) [Pubmed]
  16. COM crystals activate the p38 mitogen-activated protein kinase signal transduction pathway in renal epithelial cells. Koul, H.K., Menon, M., Chaturvedi, L.S., Koul, S., Sekhon, A., Bhandari, A., Huang, M. J. Biol. Chem. (2002) [Pubmed]
  17. Platelet-derived growth factor activates p38 mitogen-activated protein kinase through a Ras-dependent pathway that is important for actin reorganization and cell migration. Matsumoto, T., Yokote, K., Tamura, K., Takemoto, M., Ueno, H., Saito, Y., Mori, S. J. Biol. Chem. (1999) [Pubmed]
  18. Insulin-like growth factor (IGF)-I regulates IGF-binding protein-5 gene expression through the phosphatidylinositol 3-kinase, protein kinase B/Akt, and p70 S6 kinase signaling pathway. Duan, C., Liimatta, M.B., Bottum, O.L. J. Biol. Chem. (1999) [Pubmed]
  19. Wortmannin inhibits mitogen-activated protein kinase activation induced by platelet-activating factor in guinea pig neutrophils. Ferby, I.M., Waga, I., Sakanaka, C., Kume, K., Shimizu, T. J. Biol. Chem. (1994) [Pubmed]
  20. Oxalate selectively activates p38 mitogen-activated protein kinase and c-Jun N-terminal kinase signal transduction pathways in renal epithelial cells. Chaturvedi, L.S., Koul, S., Sekhon, A., Bhandari, A., Menon, M., Koul, H.K. J. Biol. Chem. (2002) [Pubmed]
  21. Protection of renal epithelial cells against oxidative injury by endoplasmic reticulum stress preconditioning is mediated by ERK1/2 activation. Hung, C.C., Ichimura, T., Stevens, J.L., Bonventre, J.V. J. Biol. Chem. (2003) [Pubmed]
  22. Control of actin dynamics by p38 MAP kinase - Hsp27 distribution in the lamellipodium of smooth muscle cells. Pichon, S., Bryckaert, M., Berrou, E. J. Cell. Sci. (2004) [Pubmed]
  23. Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor. Chen, J.K., Wang, D.W., Falck, J.R., Capdevila, J., Harris, R.C. J. Biol. Chem. (1999) [Pubmed]
  24. Transforming growth factor beta 1 inhibits mitogen-activated protein kinase induced by basic fibroblast growth factor in smooth muscle cells. Berrou, E., Fontenay-Roupie, M., Quarck, R., McKenzie, F.R., Lévy-Toledano, S., Tobelem, G., Bryckaert, M. Biochem. J. (1996) [Pubmed]
  25. Activation of p38 MAPK and increased glucose transport in chronic hibernating swine myocardium. McFalls, E.O., Hou, M., Bache, R.J., Best, A., Marx, D., Sikora, J., Ward, H.B. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  26. Inhibition of mitogen activated protein kinase activity induces parthenogenetic activation and increases cyclin B accumulation during porcine oocyte maturation. Takakura, I., Naito, K., Iwamori, N., Yamashita, M., Kume, S., Tojo, H. J. Reprod. Dev. (2005) [Pubmed]
  27. Evidence of nuclear PKC/MAP-kinase cascade in guinea pig model of epidermal hyperproliferation. Mani, I., Iversen, L., Ziboh, V.A. J. Invest. Dermatol. (1999) [Pubmed]
  28. Concerted transcriptional activation of the low density lipoprotein receptor gene by insulin and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase a, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase signaling pathways. Sekar, N., Veldhuis, J.D. Endocrinology (2001) [Pubmed]
  29. p38 MAPK mediates renal tubular cell TNF-alpha production and TNF-alpha-dependent apoptosis during simulated ischemia. Meldrum, K.K., Meldrum, D.R., Hile, K.L., Yerkes, E.B., Ayala, A., Cain, M.P., Rink, R.C., Casale, A.J., Kaefer, M.A. Am. J. Physiol., Cell Physiol. (2001) [Pubmed]
  30. Intracellular signaling by 8-epi-prostaglandin F2 alpha is mediated by thromboxane A2/prostaglandin endoperoxide receptors in porcine carotid arteries. Mohler, E.R., Franklin, M.T., Adam, L.P. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  31. P2Y receptor-mediated stimulation of Müller glial cell DNA synthesis: dependence on EGF and PDGF receptor transactivation. Milenkovic, I., Weick, M., Wiedemann, P., Reichenbach, A., Bringmann, A. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  32. Cyclic adenosine 3',5'-monophosphate-dependent activation of mitogen-activated protein kinase in cumulus cells is essential for germinal vesicle breakdown of porcine cumulus-enclosed oocytes. Liang, C.G., Huo, L.J., Zhong, Z.S., Chen, D.Y., Schatten, H., Sun, Q.Y. Endocrinology (2005) [Pubmed]
  33. Reduced expression of MAD2, BCL2, and MAP kinase activity in pig oocytes after in vitro aging are associated with defects in sister chromatid segregation during meiosis II and embryo fragmentation after activation. Ma, W., Zhang, D., Hou, Y., Li, Y.H., Sun, Q.Y., Sun, X.F., Wang, W.H. Biol. Reprod. (2005) [Pubmed]
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