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Gene Review

Cfd  -  complement factor D (adipsin)

Rattus norvegicus

Synonyms: Adipsin, Adn, C3 convertase activator, Complement factor D, Df, ...
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Disease relevance of Cfd


High impact information on Cfd


Biological context of Cfd


Anatomical context of Cfd


Associations of Cfd with chemical compounds

  • An appreciable amount of Df-protease was recovered in the house dust extract, and the house dust protease caused C5a release from C5 [5].
  • OBJECTIVE: The purpose of this study was to determine whether Df-protease could enzymatically generate anaphylatoxins from complement components C3 and C5 [5].
  • RESULTS: Df-protease showed strong activation of C3 and C5, producing C3a and C5a by proteolytic cleavage of the complements [5].
  • We previously showed that the 30 kd protease from Dermatophagoides farinae (Df-protease) could activate the bradykinin-generating cascade and exacerbate inflammatory reactions [5].
  • Adenosine (Adn; 10(-4) M), an endothelium-independent agent, produced similar dilation (127% of control) but did not alter endothelial cell calcium [10].

Regulatory relationships of Cfd


Other interactions of Cfd


Analytical, diagnostic and therapeutic context of Cfd


  1. The endogenous vascular elastase that governs development and progression of monocrotaline-induced pulmonary hypertension in rats is a novel enzyme related to the serine proteinase adipsin. Zhu, L., Wigle, D., Hinek, A., Kobayashi, J., Ye, C., Zuker, M., Dodo, H., Keeley, F.W., Rabinovitch, M. J. Clin. Invest. (1994) [Pubmed]
  2. Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor. Searfoss, G.H., Jordan, W.H., Calligaro, D.O., Galbreath, E.J., Schirtzinger, L.M., Berridge, B.R., Gao, H., Higgins, M.A., May, P.C., Ryan, T.P. J. Biol. Chem. (2003) [Pubmed]
  3. Adipsin expression and growth in rats as influenced by insulin and somatotropin. Miner, J.L., Byatt, J.C., Baile, C.A., Krivi, G.G. Physiol. Behav. (1993) [Pubmed]
  4. Elastase and cell matrix interactions in the pathobiology of vascular disease. Rabinovitch, M. Acta paediatrica Japonica; Overseas edition. (1995) [Pubmed]
  5. Generation of anaphylatoxins through proteolytic processing of C3 and C5 by house dust mite protease. Maruo, K., Akaike, T., Ono, T., Okamoto, T., Maeda, H. J. Allergy Clin. Immunol. (1997) [Pubmed]
  6. Fatty acid synthase and adipsin mRNA levels in obese and lean JCR:LA-cp rats: effect of diet. Shillabeer, G., Hornford, J., Forden, J.M., Wong, N.C., Russell, J.C., Lau, D.C. J. Lipid Res. (1992) [Pubmed]
  7. Regulation of gene expression by insulin in adipose cells: opposite effects on adipsin and glycerophosphate dehydrogenase genes. Dani, C., Bertrand, B., Bardon, S., Doglio, A., Amri, E., Grimaldi, P. Mol. Cell. Endocrinol. (1989) [Pubmed]
  8. Induction of adipocyte-specific gene expression is correlated with mammary tumor regression by the retinoid X receptor-ligand LGD1069 (targretin). Agarwal, V.R., Bischoff, E.D., Hermann, T., Lamph, W.W. Cancer Res. (2000) [Pubmed]
  9. Expression of beta 3-adrenoceptor mRNA in rat tissues. Evans, B.A., Papaioannou, M., Bonazzi, V.R., Summers, R.J. Br. J. Pharmacol. (1996) [Pubmed]
  10. Endothelial cell calcium and vascular control. Falcone, J.C. Medicine and science in sports and exercise. (1995) [Pubmed]
  11. Regulation of metallothionein gene expression and secretion in rat adipocytes differentiated from preadipocytes in primary culture. Trayhurn, P., Duncan, J.S., Wood, A.M., Beattie, J.H. Horm. Metab. Res. (2000) [Pubmed]
  12. Retinoids and retinoid-binding protein expression in rat adipocytes. Tsutsumi, C., Okuno, M., Tannous, L., Piantedosi, R., Allan, M., Goodman, D.S., Blaner, W.S. J. Biol. Chem. (1992) [Pubmed]
  13. Adiponutrin mRNA expression in white adipose tissue is rapidly induced by meal-feeding a high-sucrose diet. Polson, D.A., Thompson, M.P. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  14. Beta 3-adrenoceptor in rat aorta: molecular and biochemical characterization and signalling pathway. Rautureau, Y., Toumaniantz, G., Serpillon, S., Jourdon, P., Trochu, J.N., Gauthier, C. Br. J. Pharmacol. (2002) [Pubmed]
  15. Reduced adipsin mRNA and circulating adipsin protein are modulated by adrenal steroids in obese Zucker rats. Johnson, P.R., Spiegelman, B., Rosen, B., Turkenkopf, I., Ree, H., Greenwood, M.R. Am. J. Physiol. (1990) [Pubmed]
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