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MCTS1  -  malignant T cell amplified sequence 1

Homo sapiens

Synonyms: MCT-1, MCT1, Malignant T-cell-amplified sequence 1, Multiple copies T-cell malignancies
 
 
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Disease relevance of MCTS1

 

High impact information on MCTS1

 

Chemical compound and disease context of MCTS1

 

Biological context of MCTS1

 

Anatomical context of MCTS1

 

Associations of MCTS1 with chemical compounds

 

Regulatory relationships of MCTS1

  • Forced expression of MCT-1 significantly increases the number of DNA damage-induced foci involving gamma-H2AX and 53BP1 [7].
  • The phosphorylation of genomic stabilizers H2AX and NBS1 are enhanced in MCT-1-overexpressing cells [7].
 

Other interactions of MCTS1

  • This relationship between MCT-1 and cyclin H implied a potential role for MCT-1 in cell cycle regulation [4].
  • Constitutive expression of MCT-1 results in a strong proliferative signal and is associated with deregulation of protein kinase-mediated G1/S phase checkpoints [5].
  • Knockdown of endogenous MCT-1 using an siRNA approach attenuates the H2AX phosphorylation and the G1/S checkpoint defect [7].
 

Analytical, diagnostic and therapeutic context of MCTS1

  • Using mobility shift assays with a 26-mer oligonucleotide, which contains this fragment and its flanking regions, we demonstrated the presence of sequence-specific DNA-binding protein in both Jurkat and Hela nuclear extracts that we designated as LMBF (for lymphoid MCT-1 binding factor) [6].
  • MCT-1 maximal velocity increased in the rHuEPO group (P < 0.05), reaching higher values than in the placebo group (P < 0.05) after treatment [15].
  • Development of MCTS technique for 3-PM liquid scintillation counting [16].

References

  1. Expression of the candidate MCT-1 oncogene in B- and T-cell lymphoid malignancies. Shi, B., Hsu, H.L., Evens, A.M., Gordon, L.I., Gartenhaus, R.B. Blood (2003) [Pubmed]
  2. The H+-Linked Monocarboxylate Transporter (MCT1/SLC16A1): A Potential Therapeutic Target for High-Risk Neuroblastoma. Fang, J., Quinones, Q.J., Holman, T.L., Morowitz, M.J., Wang, Q., Zhao, H., Sivo, F., Maris, J.M., Wahl, M.L. Mol. Pharmacol. (2006) [Pubmed]
  3. Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Fleischer, T.C., Weaver, C.M., McAfee, K.J., Jennings, J.L., Link, A.J. Genes Dev. (2006) [Pubmed]
  4. A novel candidate oncogene, MCT-1, is involved in cell cycle progression. Prosniak, M., Dierov, J., Okami, K., Tilton, B., Jameson, B., Sawaya, B.E., Gartenhaus, R.B. Cancer Res. (1998) [Pubmed]
  5. Expression and stabilization of the MCT-1 protein by DNA damaging agents. Herbert, G.B., Shi, B., Gartenhaus, R.B. Oncogene (2001) [Pubmed]
  6. Identification and characterization of a novel enhancer for the human MCT-1 oncogene promoter. Shi, B., Levenson, V., Gartenhaus, R.B. J. Cell. Biochem. (2003) [Pubmed]
  7. The MCT-1 oncogene product impairs cell cycle checkpoint control and transforms human mammary epithelial cells. Hsu, H.L., Shi, B., Gartenhaus, R.B. Oncogene (2005) [Pubmed]
  8. A model system for the study of human retinal angiogenesis: activation of monocytes and endothelial cells and the association with the expression of the monocarboxylate transporter type 1 (MCT-1). Knott, R.M., Robertson, M., Muckersie, E., Folefac, V.A., Fairhurst, F.E., Wileman, S.M., Forrester, J.V. Diabetologia (1999) [Pubmed]
  9. Immunohistology of the nasal mucosa in seasonal allergic rhinitis: increases in activated eosinophils and epithelial mast cells. Bentley, A.M., Jacobson, M.R., Cumberworth, V., Barkans, J.R., Moqbel, R., Schwartz, L.B., Irani, A.M., Kay, A.B., Durham, S.R. J. Allergy Clin. Immunol. (1992) [Pubmed]
  10. Activation of mitochondrial lactate uptake by flavone induces apoptosis in human colon cancer cells. Wenzel, U., Schoberl, K., Lohner, K., Daniel, H. J. Cell. Physiol. (2005) [Pubmed]
  11. Optimization of monocarboxylate transporter 1 blockers through analysis and modulation of atropisomer interconversion properties. Guile, S.D., Bantick, J.R., Cooper, M.E., Donald, D.K., Eyssade, C., Ingall, A.H., Lewis, R.J., Martin, B.P., Mohammed, R.T., Potter, T.J., Reynolds, R.H., St-Gallay, S.A., Wright, A.D. J. Med. Chem. (2007) [Pubmed]
  12. Monocarboxylate Transporter 1 Mediates DL-2-Hydroxy-(4-Methylthio)Butanoic Acid Transport across the Apical Membrane of Caco-2 Cell Monolayers. Mart??n-Venegas, R., Rodr??guez-Lagunas, M.J., Geraert, P.A., Ferrer, R. J. Nutr. (2007) [Pubmed]
  13. Role of USF1 and USF2 as potential repressor proteins for human intestinal monocarboxylate transporter 1 promoter. Hadjiagapiou, C., Borthakur, A., Dahdal, R.Y., Gill, R.K., Malakooti, J., Ramaswamy, K., Dudeja, P.K. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  14. Flavonoids Modulate Monocarboxylate Transporter-1-Mediated Transport of {gamma}-Hydroxybutyrate in Vitro and in Vivo. Wang, Q., Morris, M.E. Drug Metab. Dispos. (2007) [Pubmed]
  15. Injections of recombinant human erythropoietin increases lactate influx into erythrocytes. Connes, P., Caillaud, C., Mercier, J., Bouix, D., Casties, J.F. J. Appl. Physiol. (2004) [Pubmed]
  16. Development of MCTS technique for 3-PM liquid scintillation counting. Hwang, H.Y., Park, J.H., Park, T.S., Lee, J.M., Cho, Y.H., Byun, J.I., Choi, O., Jun, J.S., Lee, M.H., Lee, C.W. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. (2002) [Pubmed]
 
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