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Gene Review

MCHR2  -  melanin-concentrating hormone receptor 2

Homo sapiens

Synonyms: G-protein coupled receptor 145, GPR145, GPRv17, MCH receptor 2, MCH-2R, ...
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Disease relevance of MCHR2


Psychiatry related information on MCHR2

  • Theory (SLT), which addresses both the psychosocial dynamics underlying health behavior and the methods of promoting behavior change, while emphasizing cognitive processes and their effect on behavior [6].
  • This was shown to hold more promise than the SLT in discriminating between dementia and depression [7].

High impact information on MCHR2

  • Why mice have lost genes for COL21A1, STK17A, GPR145 and AHRI: evidence for gene deletion at evolutionary breakpoints in the rodent lineage [8].
  • In contrast to MCHR1, which is intronless in the coding region and is located at the chromosomal locus 22q13.3, the MCHR2 gene has multiple exons and is mapped to locus 6q21 [9].
  • MCHR2 is specifically activated by nanomolar concentrations of MCH, binds to MCH with high affinity, and signals through Gq protein [9].
  • In addition, the human MCH-2R gene was mapped to the long arm of chromosome 6 at band 6q16.2-16.3, a region reported to be associated with cytogenetic abnormalities of obese patients [2].
  • MCH-2R displayed high-affinity MCH binding, resulting in inositol phosphate turnover and release of intracellular calcium in mammalian cells [2].

Chemical compound and disease context of MCHR2


Biological context of MCHR2


Anatomical context of MCHR2

  • DNA constructs containing MCH-R1 and MCH-R2 SNPs were generated and expressed in CHO cells [16].
  • In this MicroReview, we will briefly summarize recent progress in Shiga toxin- and SLT-related research and present evidence supporting the concept that these toxins contribute to pathogenesis by directly damaging vascular endothelial cells, thereby disrupting the homeostatic properties of these cells [17].
  • Mean pulmonary artery pressures fell from 55 +/- 6 mm Hg before SLT to 21 +/- 3 mm Hg after SLT; p less than 0.001 [18].
  • Seventy-six percent (26 of 34) of E. coli isolates that hybridized with the SLT II probe were cytotoxic to Vero but not to HeLa cells, suggesting that they produced the variant of SLT II [19].
  • To investigate possible changes following lung transplantation, the structure and in vitro ciliary beat frequency (CBF) of airway epithelium from the cytology brushings of 9 heart-lung (HLT) and 5 single-lung (SLT) transplant recipients were examined [20].

Associations of MCHR2 with chemical compounds

  • For example, peptide 26 with d-Arg in place of L-Arg in position 6 and Asn in place of Gly in position 10, Ac-dArg(6)-cyclo(S-S)(Cys(7)-Met(8)-Leu(9)-Asn(10)-Arg(11)-Val(12)-Tyr(13)-Arg(14)-Pro(15)-Cys(16))-NH(2), was a potent hMCH-1R agonist (IC(50) = 0.5 nm, EC(50) = 47 nm) with more than 200-fold selectivity with respect to hMCH-2R [21].
  • Similarly, serum sex hormone-binding globulin levels showed significant decreases with androgen replacement only in the TE and SLT 5.0 mg range groups [3].
  • After SLT administration, serum testosterone (T) levels peaked at 20 min and then fell, reaching baseline levels by 360 min [3].
  • SLT replacement in hypogonadal men led to small, but significant, decreases in serum Ca (P = 0.0029) and the urinary calcium/creatinine ratio (P = 0.0066), which were associated with increases in serum PTH (P = 0.0001) [22].
  • The central role of SLT in the virulence of the O91:H21 EHEC strains was supported by the finding that streptomycin-treated mice preinoculated with monoclonal antibody specific for SLT-II survived oral challenge with either B2F1 (Strr) or H414-36/89 (Strr) [23].

Physical interactions of MCHR2

  • Labeled Ala17 MCH had little demonstrable binding affinity for MCHR2 [24].

Regulatory relationships of MCHR2

  • DISCUSSION: These data indicate that potential therapeutics designed to act at the MCH receptor are unlikely to have altered effects in subpopulations that express variant forms of MCH-R1 or MCH-R2 [16].

Other interactions of MCHR2

  • Herein we identify and characterize a novel receptor for human MCH (MCH-R2) [25].

Analytical, diagnostic and therapeutic context of MCHR2


  1. Endogenous melanin-concentrating hormone receptor SLC-1 in human melanoma SK-MEL-37 cells. Saito, Y., Wang, Z., Hagino-Yamagishi, K., Civelli, O., Kawashima, S., Maruyama, K. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  2. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Sailer, A.W., Sano, H., Zeng, Z., McDonald, T.P., Pan, J., Pong, S.S., Feighner, S.D., Tan, C.P., Fukami, T., Iwaasa, H., Hreniuk, D.L., Morin, N.R., Sadowski, S.J., Ito, M., Ito, M., Bansal, A., Ky, B., Figueroa, D.J., Jiang, Q., Austin, C.P., MacNeil, D.J., Ishihara, A., Ihara, M., Kanatani, A., Van der Ploeg, L.H., Howard, A.D., Liu, Q. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  3. Pharmacokinetics, bioefficacy, and safety of sublingual testosterone cyclodextrin in hypogonadal men: comparison to testosterone enanthate--a clinical research center study. Salehian, B., Wang, C., Alexander, G., Davidson, T., McDonald, V., Berman, N., Dudley, R.E., Ziel, F., Swerdloff, R.S. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  4. In situ splitting of the liver in the heart-beating cadaveric organ donor for transplantation in two recipients. Rogiers, X., Malago, M., Habib, N., Knoefel, W.T., Pothmann, W., Burdelski, M., Meyer-Moldenhauer, W.H., Broelsch, C.E. Transplantation (1995) [Pubmed]
  5. Susceptibility to hemolytic-uremic syndrome relates to erythrocyte glycosphingolipid patterns. Newburg, D.S., Chaturvedi, P., Lopez, E.L., Devoto, S., Fayad, A., Cleary, T.G. J. Infect. Dis. (1993) [Pubmed]
  6. The students for peace project: a comprehensive violence-prevention program for middle school students. Kelder, S.H., Orpinas, P., McAlister, A., Frankowski, R., Parcel, G.S., Friday, J. American journal of preventive medicine. (1996) [Pubmed]
  7. Encoding in senile dementia and elderly depressives: a preliminary study.. Larner, S. The British journal of social and clinical psychology. (1977) [Pubmed]
  8. Why mice have lost genes for COL21A1, STK17A, GPR145 and AHRI: evidence for gene deletion at evolutionary breakpoints in the rodent lineage. Fitzgerald, J., Bateman, J.F. Trends Genet. (2004) [Pubmed]
  9. Identification and characterization of a melanin-concentrating hormone receptor. An, S., Cutler, G., Zhao, J.J., Huang, S.G., Tian, H., Li, W., Liang, L., Rich, M., Bakleh, A., Du, J., Chen, J.L., Dai, K. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  10. A randomised, prospective study comparing selective laser trabeculoplasty with latanoprost for the control of intraocular pressure in ocular hypertension and open angle glaucoma. Nagar, M., Ogunyomade, A., O'Brart, D.P., Howes, F., Marshall, J. The British journal of ophthalmology. (2005) [Pubmed]
  11. Detection and characterization of enterohaemorrhagic Escherichia coli in slaughtered cattle. Borie, C.F., Monreal, Z., Martinez, J., Arellano, C., Prado, V. Zentralblatt Veterinarmedizin Reihe B (1997) [Pubmed]
  12. SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor. Audinot, V., Lahaye, C., Suply, T., Rovère-Jovène, C., Rodriguez, M., Nicolas, J.P., Beauverger, P., Cardinaud, B., Galizzi, J.P., Fauchère, J.L., Nahon, J.L., Boutin, J.A. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  13. Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor. Mori, M., Harada, M., Terao, Y., Sugo, T., Watanabe, T., Shimomura, Y., Abe, M., Shintani, Y., Onda, H., Nishimura, O., Fujino, M. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  14. Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression. Tan, C.P., Sano, H., Iwaasa, H., Pan, J., Sailer, A.W., Hreniuk, D.L., Feighner, S.D., Palyha, O.C., Pong, S.S., Figueroa, D.J., Austin, C.P., Jiang, M.M., Yu, H., Ito, J., Ito, M., Ito, M., Guan, X.M., MacNeil, D.J., Kanatani, A., Van der Ploeg, L.H., Howard, A.D. Genomics (2002) [Pubmed]
  15. The melanin-concentrating hormone receptor 2 (MCH-R2) mediates the effect of MCH to control body color for background adaptation in the barfin flounder. Takahashi, A., Kosugi, T., Kobayashi, Y., Yamanome, T., Schiöth, H.B., Kawauchi, H. Gen. Comp. Endocrinol. (2007) [Pubmed]
  16. Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2. Hawes, B.E., Green, B., O'Neill, K., Fried, S., Arreaza, M.G., Qiu, P., Simon, J.S. Obes. Res. (2004) [Pubmed]
  17. The pathogenic mechanisms of Shiga toxin and the Shiga-like toxins. Tesh, V.L., O'Brien, A.D. Mol. Microbiol. (1991) [Pubmed]
  18. Lung and heart-lung transplantation. Evolution and new applications. Bolman, R.M., Shumway, S.J., Estrin, J.A., Hertz, M.I. Ann. Surg. (1991) [Pubmed]
  19. Shiga-like-toxin-producing Escherichia coli in retail meats and cattle in Thailand. Suthienkul, O., Brown, J.E., Seriwatana, J., Tienthongdee, S., Sastravaha, S., Echeverria, P. Appl. Environ. Microbiol. (1990) [Pubmed]
  20. Ciliary beat frequency and structure of recipient and donor epithelia following lung transplantation. Read, R.C., Shankar, S., Rutman, A., Feldman, C., Yacoub, M., Cole, P.J., Wilson, R. Eur. Respir. J. (1991) [Pubmed]
  21. Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. Bednarek, M.A., Tan, C., Hreniuk, D.L., Palyha, O.C., MacNeil, D.J., Van Der Ploeg, L.H., Howard, A.D., Feighner, S.D. J. Biol. Chem. (2002) [Pubmed]
  22. Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption, and increases bone formation markers in hypogonadal men--a clinical research center study. Wang, C., Eyre, D.R., Clark, R., Kleinberg, D., Newman, C., Iranmanesh, A., Veldhuis, J., Dudley, R.E., Berman, N., Davidson, T., Barstow, T.J., Sinow, R., Alexander, G., Swerdloff, R.S. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  23. Virulence of enterohemorrhagic Escherichia coli O91:H21 clinical isolates in an orally infected mouse model. Lindgren, S.W., Melton, A.R., O'Brien, A.D. Infect. Immun. (1993) [Pubmed]
  24. Europium-labeled melanin-concentrating hormone analogues: ligands for measuring binding to melanin-concentrating hormone receptors 1 and 2. Gao, X., Hsu, C.K., Heinz, L.J., Morin, J., Shi, Y., Shukla, N.K., Smiley, D.L., Xu, J., Zhong, B., Slieker, L.J. Anal. Biochem. (2004) [Pubmed]
  25. Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2. Wang, S., Behan, J., O'Neill, K., Weig, B., Fried, S., Laz, T., Bayne, M., Gustafson, E., Hawes, B.E. J. Biol. Chem. (2001) [Pubmed]
  26. Molecular cloning and functional characterization of MCH2, a novel human MCH receptor. Hill, J., Duckworth, M., Murdock, P., Rennie, G., Sabido-David, C., Ames, R.S., Szekeres, P., Wilson, S., Bergsma, D.J., Gloger, I.S., Levy, D.S., Chambers, J.K., Muir, A.I. J. Biol. Chem. (2001) [Pubmed]
  27. Continuous peritoneal infusion of Shiga-like toxin II (SLT II) as a model for SLT II-induced diseases. Barrett, T.J., Potter, M.E., Wachsmuth, I.K. J. Infect. Dis. (1989) [Pubmed]
  28. Cadaveric full-size liver transplantation and the graft alternatives in adults: a comparative study from a single centre. Sebagh, M., Yilmaz, F., Karam, V., Falissard, B., Ichaï, P., Roche, B., Castaing, D., Guettier, C., Samuel, D., Azoulay, D. J. Hepatol. (2006) [Pubmed]
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