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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Selection Bias

 
 
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Disease relevance of Selection Bias

 

High impact information on Selection Bias

  • We cannot exclude some degree of selection bias among the women who received estrogen-replacement therapy [6].
  • Previously reported increased frequencies of these abnormalities in diethylstilbestrol-exposed men may have resulted from selection biases or differences in diethylstilbestrol use, or both [7].
  • IMPLICATIONS: Differences in the pattern of p53 mutation in breast cancers in Midwestern women and in breast cancers in other populations may reflect selection bias or small sample sizes currently available [8].
  • CONCLUSIONS: Histologic lesions of NASH are unevenly distributed throughout the liver parenchyma; therefore, sampling error of liver biopsy can result in substantial misdiagnosis and staging inaccuracies [9].
  • To avoid selection bias, we confined analysis of total and free protein S levels and thrombotic risk to the patients' relatives [10].
 

Chemical compound and disease context of Selection Bias

 

Biological context of Selection Bias

 

Anatomical context of Selection Bias

  • Testosterone level as a potential selection bias for semen donors in assessing population fertility [18].
  • The result are consistent with current theories of the role of the basal ganglia in cognition, and suggest specific impairments in response selection mechanisms in HD, in particular, in overcoming selection biases based on prior reinforcement [19].
  • Because the monkey studies are not hampered by selection bias, the data are supportive of the tentative conclusions from epidemiological studies indicating that the association between postmenopausal estrogen use and reduced coronary artery atherosclerosis is real [20].
  • Failure to consider such a stable rosette structure would result in sampling biases when purifying thymic B cell populations and could also contribute to some of the more unusual phenotypic findings such as the expression of CD2 [21].
  • Because these results are based on examination of feces or cytologic specimens with an inherent sampling bias, it would be ideal to have autopsy data on the complete tissue evaluation of major organ systems of patients who had antemortem E intestinalis infection treated with albendazole [22].
 

Associations of Selection Bias with chemical compounds

 

Gene context of Selection Bias

  • Thus, there were significantly more specimens converting from PCNA-positive to PCNA-negative after preoperative radiation than would be expected solely on the basis of sampling errors (P = 0.004) [28].
  • CONCLUSIONS: Publication and selection biases make existing studies of APOE and stroke unreliable [29].
  • The risks (penetrance) of breast and ovarian cancer in carriers of the BRCA1 or BRCA2 genes are high, but it is likely that estimates based on selected large multicase families are inflated by selection bias [30].
  • Heterogeneity of 67LR expression and biopsy sampling errors most likely represented the main reasons for discordant results between biopsy and RP specimens [31].
  • Wrong interpretation of the results for ER and PR status in cytology was a far more frequent cause of clinically relevant discrepancies than sampling errors [32].
 

Analytical, diagnostic and therapeutic context of Selection Bias

References

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  20. The nonhuman primate model of the relationship between gonadal steroids and coronary heart disease. Clarkson, T.B., Hughes, C.L., Klein, K.P. Progress in cardiovascular diseases. (1995) [Pubmed]
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  22. Autopsy verification of Encephalitozoon intestinalis (microsporidiosis) eradication following albendazole therapy. Joste, N.E., Rich, J.D., Busam, K.J., Schwartz, D.A. Arch. Pathol. Lab. Med. (1996) [Pubmed]
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  26. Adrenocortical secretion of dehydroepiandrosterone in healthy women: highly variable response to adrenocorticotropin. Azziz, R., Fox, L.M., Zacur, H.A., Parker, C.R., Boots, L.R. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
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